Home Halogens 2-[(2E,4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-(1H-imidazol-1-yl)acetonitrile

2-[(2E,4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-(1H-imidazol-1-yl)acetonitrile

CAS No.:
187164-19-8
Catalog Number:
AG003RDP
Molecular Formula:
C14H9Cl2N3S2
Molecular Weight:
354.2774
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
50mg
98+%
1 week
United States
$59
- +
250mg
≥98%
1 week
United States
$153
- +
500mg
≥98%
1 week
United States
$229
- +
1g
≥98%
1 week
United States
$383
- +
5g
≥98%
1 week
United States
$1398
- +
Product Description
Catalog Number:
AG003RDP
Chemical Name:
2-[(2E,4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-(1H-imidazol-1-yl)acetonitrile
CAS Number:
187164-19-8
Molecular Formula:
C14H9Cl2N3S2
Molecular Weight:
354.2774
MDL Number:
MFCD00953915
IUPAC Name:
(2E)-2-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-imidazol-1-ylacetonitrile
InChI:
InChI=1S/C14H9Cl2N3S2/c15-9-1-2-10(11(16)5-9)13-7-20-14(21-13)12(6-17)19-4-3-18-8-19/h1-5,8,13H,7H2/b14-12+/t13-/m0/s1
InChI Key:
YTAOBBFIOAEMLL-REQDGWNSSA-N
SMILES:
N#C/C(=C\1/SC[C@H](S1)c1ccc(cc1Cl)Cl)/n1cncc1
UNII:
RE91AN4S8G
Properties
Complexity:
476  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
1  
Exact Mass:
352.961g/mol
Formal Charge:
0
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
354.267g/mol
Monoisotopic Mass:
352.961g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
92.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4  
Literature
Title Journal
Antimycotics suppress the Malassezia extract-induced production of CXC chemokine ligand 10 in human keratinocytes. The Journal of dermatology 20140201
Suppressive effects of antimycotics on thymic stromal lymphopoietin production in human keratinocytes. Journal of dermatological science 20130901
Childhood tinea incognito caused by Trichophyton mentagrophytes var. interdigitale mimicking pustular psoriasis. Pediatric dermatology 20110101
Efficacy of terbinafine compared to lanoconazole and luliconazole in the topical treatment of dermatophytosis in a guinea pig model. Medical mycology 20100501
In vitro antifungal activities of luliconazole, a new topical imidazole. Medical mycology 20090101
[Fungicidal activity of liranaftate against dermatophytes]. Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20090101
Allergic contact dermatitis from luliconazole. Contact dermatitis 20070501
Allergic contact dermatitis from luliconazole: implication of the dithioacetal structure. Acta dermato-venereologica 20070101
[Pharmacological and clinical properties of luliconazole (Lulicon Cream 1%, Lulicon Solution 1%), a novel topical antifungal agent]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060501
In vitro antifungal activity of luliconazole (NND-502), a novel imidazole antifungal agent. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20040801
In vitro activity of novel imidazole antifungal agent NND-502 against Malassezia species. International journal of antimicrobial agents 20030301
Achievement of complete mycological cure by topical antifungal agent NND-502 in guinea pig model of tinea pedis. Microbiology and immunology 20030101
Efficacy of NND-502, a novel imidazole antimycotic agent, in experimental models of Candida albicans and Aspergillus fumigatus infections. International journal of antimicrobial agents 19990801
In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent. Antimicrobial agents and chemotherapy 19980401
Properties