Home Other Building Blocks L-778123 hydrochloride

L-778123 hydrochloride

CAS No.:
253863-00-2
Catalog Number:
AG003R6Z
Molecular Formula:
C22H21Cl2N5O
Molecular Weight:
442.3410
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
99%
1 week
United States
$154
- +
10mg
99%
1 week
United States
$196
- +
50mg
99%
1 week
United States
$460
- +
100mg
99%
1 week
United States
$737
- +
Product Description
Catalog Number:
AG003R6Z
Chemical Name:
L-778123 hydrochloride
CAS Number:
253863-00-2
Molecular Formula:
C22H21Cl2N5O
Molecular Weight:
442.3410
MDL Number:
MFCD09970379
IUPAC Name:
4-[[5-[[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl]imidazol-1-yl]methyl]benzonitrile;hydrochloride
InChI:
InChI=1S/C22H20ClN5O.ClH/c23-19-2-1-3-20(10-19)28-9-8-26(15-22(28)29)14-21-12-25-16-27(21)13-18-6-4-17(11-24)5-7-18;/h1-7,10,12,16H,8-9,13-15H2;1H
InChI Key:
YNBSQYGTJLIPJS-UHFFFAOYSA-N
SMILES:
N#Cc1ccc(cc1)Cn1cncc1CN1CCN(C(=O)C1)c1cccc(c1)Cl.Cl
UNII:
2A2059P49U
Properties
Complexity:
614  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
441.112g/mol
Formal Charge:
0
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
442.344g/mol
Monoisotopic Mass:
441.112g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
65.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Modulation of anthracycline-induced cytotoxicity by targeting the prenylated proteome in myeloid leukemia cells. Journal of molecular medicine (Berlin, Germany) 20120201
ErbB-2 blockade and prenyltransferase inhibition alter epidermal growth factor and epidermal growth factor receptor trafficking and enhance (111)In-DTPA-hEGF Auger electron radiation therapy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20110501
A tagging-via-substrate approach to detect the farnesylated proteome using two-dimensional electrophoresis coupled with Western blotting. Molecular & cellular proteomics : MCP 20100401
Development of farnesyl transferase inhibitors: a review. The oncologist 20050901
Isoprenylation of intracellular proteins as a new target for the therapy of human neoplasms: preclinical and clinical implications. Current drug targets 20050501
[Farnesyltransferase inhibitors: preliminary results in acute myeloid leukemia]. Bulletin du cancer 20050301
Inhibition of lymphocyte activation and function by the prenylation inhibitor L-778,123. Investigational new drugs 20050101
Crystallographic analysis reveals that anticancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes. Biochemistry 20040720
Farnesyl transferase inhibitors for patients with lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 20040615
[Ras signaling pathway as a target for farnesyltransferase inhibitors--a new, promising prospects in the treatment for malignant disorders]. Wiadomosci lekarskie (Warsaw, Poland : 1960) 20040101
Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf. Oncogene 20030918
Farnesyltransferase inhibitors as radiation sensitizers. International journal of radiation biology 20030701
Farnesyl transferase inhibitors in the treatment of breast cancer. Expert opinion on investigational drugs 20030301
The effects of the farnesyl transferase inhibitor FTI L-778,123 on normal, myelodysplastic, and myeloid leukemia bone marrow progenitor proliferation in vitro. Leukemia & lymphoma 20030101
Farnesyl transferase inhibitors as anticancer agents. European journal of cancer (Oxford, England : 1990) 20020901
A phase I and pharmacological study of the farnesyl protein transferase inhibitor L-778,123 in patients with solid malignancies. Clinical cancer research : an official journal of the American Association for Cancer Research 20011201
Ras inhibitors and radiation therapy. Seminars in radiation oncology 20011001
Farnesyltransferase inhibitors. Seminars in oncology 20011001
Anions modulate the potency of geranylgeranyl-protein transferase I inhibitors. The Journal of biological chemistry 20010706
High-performance liquid chromatography/mass spectrometry characterization of Ki4B-Ras in PSN-1 cells treated with the prenyltransferase inhibitor L-778,123. Analytical biochemistry 20010301
Properties