Name: Name:Dolastatin 10
Brand: Angene
SKU: AG003PVY
Rating: 90 (10 reviews)

Catalog Number:

AG003PVY

Chemical Name:

Dolastatin 10

CAS Number:

110417-88-4

MDL Number:

MFCD00870128

IUPAC Name:

(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-N-[(3R,4S,5S)-3-methoxy-1-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide

InChI:

InChI=1S/C42H68N6O6S/c1-13-28(6)37(47(10)42(52)35(26(2)3)45-40(51)36(27(4)5)46(8)9)33(53-11)25-34(49)48-22-17-20-32(48)38(54-12)29(7)39(50)44-31(41-43-21-23-55-41)24-30-18-15-14-16-19-30/h14-16,18-19,21,23,26-29,31-33,35-38H,13,17,20,22,24-25H2,1-12H3,(H,44,50)(H,45,51)/t28-,29+,31-,32-,33+,35-,36-,37-,38+/m0/s1

InChI Key:

OFDNQWIFNXBECV-VFSYNPLYSA-N

UNII:

EI946JT51X

Complexity:

1220

Compound Is Canonicalized:

Yes

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Defined Bond Stereocenter Count:

Exact Mass:

784.492g/mol

Formal Charge:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Isotope Atom Count:

Molecular Weight:

785.102g/mol

Monoisotopic Mass:

784.492g/mol

Rotatable Bond Count:

Topological Polar Surface Area:

162A^2

Undefined Atom Stereocenter Count:

Undefined Bond Stereocenter Count:

XLogP3:

5.8

Title	Journal
Antineoplastic agents. 592. Highly effective cancer cell growth inhibitory structural modifications of dolastatin 10.	Journal of natural products 20110527
[Advance of several types of important marine antitumor drugs].	Yao xue xue bao = Acta pharmaceutica Sinica 20080501
Visualisation of a kinesin-13 motor on microtubule end mimics.	Journal of molecular biology 20080328
Structure-activity and high-content imaging analyses of novel tubulysins.	Chemical biology & drug design 20070801
Total synthesis and biological evaluation of ustiloxin natural products and two analogs.	Bioorganic & medicinal chemistry letters 20060915
Reference profiling of the genomic response induced by an antimicrotubule agent, TZT-1027 (Soblidotin), in vitro.	The pharmacogenomics journal 20060101
Antineoplastic agents. 515. Synthesis of human cancer cell growth inhibitors derived from 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene.	Journal of natural products 20050801
Two photoaffinity analogues of the tripeptide, hemiasterlin, exclusively label alpha-tubulin.	Biochemistry 20050510
Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in alpha-tubulin.	Molecular cancer therapeutics 20041001
Direct photoaffinity labeling by dolastatin 10 of the amino-terminal peptide of beta-tubulin containing cysteine 12.	The Journal of biological chemistry 20040716
Progress in the development and acquisition of anticancer agents from marine sources.	Annals of oncology : official journal of the European Society for Medical Oncology 20031101
Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography.	European journal of biochemistry 20030901
Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin.	Molecular pharmacology 20030601
Inhibition of tubulin polymerization by vitilevuamide, a bicyclic marine peptide, at a site distinct from colchicine, the vinca alkaloids, and dolastatin 10.	Biochemical pharmacology 20020215
Anticancer therapy with novel tubulin-interacting drugs.	Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20011201
Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1.	Journal of natural products 20010701
Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.	The Journal of biological chemistry 19901005