Dichloroacetic acid
| Title | Journal |
|---|---|
| Metabolic Disruption Early in Life is Associated With Latent Carcinogenic Activity of Dichloroacetic Acid in Mice. | Toxicological sciences : an official journal of the Society of Toxicology 20171001 |
| Disinfection By-Product Exposures and the Risk of Specific Cardiac Birth Defects. | Environmental health perspectives 20170201 |
| Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1. | Pharmacology & therapeutics 20170201 |
| Trichloroethylene and Its Oxidative Metabolites Enhance the Activated State and Th1 Cytokine Gene Expression in Jurkat Cells. | International journal of environmental research and public health 20150901 |
| Silencing gastrin-releasing peptide receptor suppresses key regulators of aerobic glycolysis in neuroblastoma cells. | Pediatric blood & cancer 20150401 |
| Dichloroacetate and cancer: new home for an orphan drug? | Biochimica et biophysica acta 20141201 |
| Long-term dietary exposure to low concentration of dichloroacetic acid promoted longevity and attenuated cellular and functional declines in aged Drosophila melanogaster. | Age (Dordrecht, Netherlands) 20140601 |
| Chloride and other anions inhibit dichloroacetate-induced inactivation of human liver GSTZ1 in a haplotype-dependent manner. | Chemico-biological interactions 20140525 |
| Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum. | Archives of toxicology 20131101 |
| Design, synthesis and biological evaluation of N-arylphenyl-2,2-dichloroacetamide analogues as anti-cancer agents. | Bioorganic & medicinal chemistry letters 20121201 |
| Influence of bacterial extracellular polymeric substances on the formation of carbonaceous and nitrogenous disinfection byproducts. | Environmental science & technology 20121016 |
| Application of hyperpolarized [1-¹³C]lactate for the in vivo investigation of cardiac metabolism. | NMR in biomedicine 20121001 |
| Unusual complex formation and chemical reaction of haloacetate anion on the exterior surface of cucurbit[6]uril in the gas phase. | Journal of the American Society for Mass Spectrometry 20121001 |
| Inactivation of the HIF-1α/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants. | Cancer research 20121001 |
| Tormentic acid derivatives: synthesis and apoptotic activity. | European journal of medicinal chemistry 20121001 |
| Comparison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications. | The Journal of biological chemistry 20120928 |
| Size-exclusion chromatography of poly(ethylene 2,6-naphthalate). | Journal of chromatography. A 20120921 |
| Prediction of death in the SMNΔ7 mouse model of spinal muscular atrophy: insight into disease stage and progression. | Journal of neuroscience methods 20120815 |
| Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation. | Chemico-biological interactions 20120730 |
| Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate. | Journal of clinical pharmacology 20120601 |
| Necrosis of cervical carcinoma by dichloroacetate released from electrospun polylactide mats. | Biomaterials 20120601 |
| Co-treatment of dichloroacetate, omeprazole and tamoxifen exhibited synergistically antiproliferative effect on malignant tumors: in vivo experiments and a case report. | Hepato-gastroenterology 20120601 |
| 2-Amino-4,6-dimeth-oxy-pyrimidin-1-ium 2,2-dichloro-acetate. | Acta crystallographica. Section E, Structure reports online 20120601 |
| Unilateral periventricular leukomalacia in association with pyruvate dehydrogenase deficiency. | Developmental medicine and child neurology 20120501 |
| Comparison of trihalomethanes in tap water and blood: a case study in the United States. | Environmental health perspectives 20120501 |
| The role of FOXO and PPAR transcription factors in diet-mediated inhibition of PDC activation and carbohydrate oxidation during exercise in humans and the role of pharmacological activation of PDC in overriding these changes. | Diabetes 20120501 |
| Effects of three modifiers of glycolysis on ATP, lactate, hypoxia, and growth in human tumor cell lines in vivo. | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20120501 |
| Inorganic arsenic and basal cell carcinoma in areas of Hungary, Romania, and Slovakia: a case-control study. | Environmental health perspectives 20120501 |
| Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury. | Cardiovascular research 20120501 |
| Treatment for mitochondrial disorders. | The Cochrane database of systematic reviews 20120418 |
| Photocatalytic production of 1O2 and *OH mediated by silver oxidation during the photoinactivation of Escherichia coli with TiO2. | Journal of hazardous materials 20120415 |
| Dichloroacetate inhibits neuroblastoma growth by specifically acting against malignant undifferentiated cells. | International journal of cancer 20120401 |
| Toxicological evaluation of paper mill sewage sediment treated by indigenous dibenzofuran-degrading Pseudomonas sp. | Bioresource technology 20120401 |
| Mitochondrial genome-knockout cells demonstrate a dual mechanism of action for the electron transport complex I inhibitor mycothiazole. | Marine drugs 20120401 |
| Predicting the safety and efficacy of buffer therapy to raise tumour pHe: an integrative modelling study. | British journal of cancer 20120327 |
| Lung ¹⁸F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension. | American journal of respiratory and critical care medicine 20120315 |
| Mitaplatin increases sensitivity of tumor cells to cisplatin by inducing mitochondrial dysfunction. | Molecular pharmaceutics 20120305 |
| Susceptibility to breast cancer and three polymorphisms of GSTZ1. | DNA and cell biology 20120301 |
| Vitamin E restriction in the diet enhances phagocytic activation by dichloroacetate and trichloroacetate in mice. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120301 |
| The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study. | Circulation. Cardiovascular imaging 20120301 |
| One-flask synthesis of cyclic diguanosine monophosphate (c-di-GMP). | Current protocols in nucleic acid chemistry 20120301 |
| The effects of a low vitamin E diet on dichloroacetate- and trichloroacetate-induced oxidative stress in the livers of mice. | Journal of biochemical and molecular toxicology 20120301 |
| Multi-substituted N-phenyl-2, 2-dichloroacetamide analogues as anti-cancer drugs: design, synthesis and biological evaluation. | Yao xue xue bao = Acta pharmaceutica Sinica 20120301 |
| Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1α gene. | Brain & development 20120201 |
| Prenatal and postnatal expression of glutathione transferase ζ 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate. | Drug metabolism and disposition: the biological fate of chemicals 20120201 |
| The role of low-level lactate production in airway inflammation in asthma. | American journal of physiology. Lung cellular and molecular physiology 20120201 |
| Dichloroacetic acid up-regulates hepatic glutathione synthesis via the induction of glutamate-cysteine ligase. | Biochemical pharmacology 20120201 |
| Formation of halogenated C-, N-DBPs from chlor(am)ination and UV irradiation of tyrosine in drinking water. | Environmental pollution (Barking, Essex : 1987) 20120201 |
| Flow cytometric evaluation of the effects of 3-bromopyruvate (3BP) and dichloracetate (DCA) on THP-1 cells: a multiparameter analysis. | Journal of bioenergetics and biomembranes 20120201 |
| Clinicopathologic Manifestations of Patients with Fordyce's Spots. | Annals of dermatology 20120201 |
| Cancer metabolism: current perspectives and future directions. | Cell death & disease 20120101 |
| Risk of stillbirth in the relation to water disinfection by-products: a population-based case-control study in Taiwan. | PloS one 20120101 |
| Correlation of diffusion and metabolic alterations in different clinical forms of multiple sclerosis. | PloS one 20120101 |
| Dichloroacetate induces different rates of cell death in cancer and noncancer cell lines in vitro. | Tumori 20120101 |
| Design and characterization of a silk-fibroin-based drug delivery platform using naproxen as a model drug. | Journal of drug delivery 20120101 |
| Synergistic effect of the combination of immobilized TiO2, UVA and ozone on the decomposition of dichloroacetic acid. | Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 20120101 |
| Influence of dichloroacetate (DCA) on lactate production and oxygen consumption in neuroblastoma cells: is DCA a suitable drug for neuroblastoma therapy? | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101 |
| Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis. | PloS one 20120101 |
| Protection of rat cardiac myocytes by fructose-1,6-bisphosphate and 2,3-butanedione. | PloS one 20120101 |
| Defluorination of sodium fluoroacetate by bacteria from soil and plants in Brazil. | TheScientificWorldJournal 20120101 |
| PPARs: Interference with Warburg' Effect and Clinical Anticancer Trials. | PPAR research 20120101 |
| EMT and stem cell-like properties associated with HIF-2α are involved in arsenite-induced transformation of human bronchial epithelial cells. | PloS one 20120101 |
| Enzymatic synthesis of DNA strands containing α-L-LNA (α-L-configured locked nucleic acid) thymine nucleotides. | Artificial DNA, PNA & XNA 20120101 |
| Mitochondrial metabolism - neglected link of cancer transformation and treatment. | Prague medical report 20120101 |
| The reproducibility of 31-phosphorus MRS measures of muscle energetics at 3 Tesla in trained men. | PloS one 20120101 |
| Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage. | PloS one 20120101 |
| Glucose is a pH-dependent motor for sperm beat frequency during early activation. | PloS one 20120101 |
| Dichloroacetate induces apoptosis of epithelial ovarian cancer cells through a mechanism involving modulation of oxidative stress. | Reproductive sciences (Thousand Oaks, Calif.) 20111201 |
| Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spain. | Environmental health perspectives 20111201 |
| In vitro effects of an in silico-modelled 17β-estradiol derivative in combination with dichloroacetic acid on MCF-7 and MCF-12A cells. | Cell proliferation 20111201 |
| The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37. | Experimental oncology 20111201 |
| Characteristic transformation of humic acid during photoelectrocatalysis process and its subsequent disinfection byproduct formation potential. | Water research 20111115 |
| Electromembrane extraction and HPLC analysis of haloacetic acids and aromatic acetic acids in wastewater. | Talanta 20111030 |
| Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling. | Aging 20111001 |
| Prospective power calculations for the Four Lab study of a multigenerational reproductive/developmental toxicity rodent bioassay using a complex mixture of disinfection by-products in the low-response region. | International journal of environmental research and public health 20111001 |
| Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate. | Oncogene 20110922 |
| Comparative electrochemical treatments of two chlorinated aliphatic hydrocarbons. Time course of the main reaction by-products. | Journal of hazardous materials 20110915 |
| Why are there no proven therapies for genetic mitochondrial diseases? | Mitochondrion 20110901 |
| Functionalized polystyrene supports for solid-phase synthesis of glycyl-, alanyl-, and isoleucyl-RNA conjugates as hydrolysis-resistant mimics of peptidyl-tRNAs. | Bioorganic & medicinal chemistry 20110901 |
| Structures of a putative ζ-class glutathione S-transferase from the pathogenic fungus Coccidioides immitis. | Acta crystallographica. Section F, Structural biology and crystallization communications 20110901 |
| Bis-(chloro-acetato-κO)bis(trimethyl-silylmethyl)tin(IV). | Acta crystallographica. Section E, Structure reports online 20110901 |
| Use of oral dichloroacetate for palliation of leg pain arising from metastatic poorly differentiated carcinoma: a case report. | Journal of palliative medicine 20110801 |
| Removal of dichloroacetic acid from drinking water by using adsorptive ozonation. | Ecotoxicology (London, England) 20110701 |
| Haloacetic acids in swimming pools: swimmer and worker exposure. | Environmental science & technology 20110701 |
| [Chlorination byproducts formation potentials of typical nitrogenous organic compounds in water]. | Huan jing ke xue= Huanjing kexue 20110701 |
| Inhibition of alanine aminotransferase in silico and in vivo promotes mitochondrial metabolism to impair malignant growth. | The Journal of biological chemistry 20110624 |
| Development and evaluation of a harmonized physiologically based pharmacokinetic (PBPK) model for perchloroethylene toxicokinetics in mice, rats, and humans. | Toxicology and applied pharmacology 20110615 |
| Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: a combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study. | Circulation 20110607 |
| Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex. | International journal of cancer 20110601 |
| The effect of dichloroacetate on health- and lifespan in C. elegans. | Biogerontology 20110601 |
| Development of a dichloroacetic acid-hemoglobin conjugate as a potential targeted anti-cancer therapeutic. | Biotechnology and bioengineering 20110601 |
| Metabolism and brain cancer. | Clinics (Sao Paulo, Brazil) 20110601 |
| Effects of iron and manganese on the formation of HAAs upon chlorinating Chlorella vulgaris. | Journal of hazardous materials 20110515 |
| Effects of chlorinated acetates on the glutathione metabolism and on glycolysis of cultured astrocytes. | Neurotoxicity research 20110501 |
| Glutathione transferase zeta: discovery, polymorphic variants, catalysis, inactivation, and properties of Gstz1-/- mice. | Drug metabolism reviews 20110501 |
| Chronic and acute exposure of mouse hearts to fatty acids increases oxygen cost of excitation-contraction coupling. | American journal of physiology. Heart and circulatory physiology 20110501 |
| Formation and modeling of disinfection by-products in drinking water of six cities in China. | Journal of environmental monitoring : JEM 20110501 |
| Degradation of dichloroacetic acid in homogeneous aqueous media employing ozone and UVC radiation. | Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20110302 |
| Dichloroacetate metabolically targeted therapy defeats cytotoxicity of standard anticancer drugs. | Cancer chemotherapy and pharmacology 20110301 |
| Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm? | International journal of cancer 20110301 |
| High concentrations of dichloroacetate have minor effects on the vitality of the mammalian nerve fibers: an ex-vivo electrophysiological study. | Anti-cancer drugs 20110301 |
| Effects of environmental endocrine disruptors on pubertal development. | Journal of clinical research in pediatric endocrinology 20110301 |
| Pros and cons of analytical methods to quantify surrogate contaminants from the challenge test in recycled polyethylene terephthalate. | Analytica chimica acta 20110214 |
| Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS. | NMR in biomedicine 20110201 |
| The dichloroacetate dilemma: environmental hazard versus therapeutic goldmine--both or neither? | Environmental health perspectives 20110201 |
| Dichloroacetate shifts the metabolism from glycolysis to glucose oxidation and exhibits synergistic growth inhibition with cisplatin in HeLa cells. | International journal of oncology 20110201 |
| Influence of soluble microbial products (SMP) on wastewater disinfection byproducts: trihalomethanes and haloacetic acid species from the chlorination of SMP. | Environmental science and pollution research international 20110101 |
| A screening level fate model of organic contaminants from advanced water treatment in a potable water supply reservoir. | Water research 20110101 |
| Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis. | Diabetes 20110101 |
| Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1. | The Journal of pharmacology and experimental therapeutics 20110101 |
| Metabolic-targeted therapy with dichloroacetate (DCA): a novel treatment strategy to improve the outcome of photodynamic therapy. | Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20110101 |
| Developing new anti-cancer drugs. | Recent patents on anti-cancer drug discovery 20110101 |
| In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines. | Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20110101 |
| On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate. | Neoplasia (New York, N.Y.) 20110101 |
| Further optimization of detritylation in solid-phase oligodeoxyribonucleotide synthesis. | Nucleosides, nucleotides & nucleic acids 20110101 |
| Chronic CSE treatment induces the growth of normal oral keratinocytes via PDK2 upregulation, increased glycolysis and HIF1α stabilization. | PloS one 20110101 |
| Efficacy of fumaric acid esters in the R6/2 and YAC128 models of Huntington's disease. | PloS one 20110101 |
| Skeletal muscle metabolic gene expression is not affected by dichloroacetate-mediated modulation of substrate utilisation. | Annals of nutrition & metabolism 20110101 |
| Synergistic antitumor effect of dichloroacetate in combination with 5-fluorouracil in colorectal cancer. | Journal of biomedicine & biotechnology 20110101 |
| Stereocomplexes Formed From Select Oligomers of Polymer d-lactic Acid (PDLA) and l-lactate May Inhibit Growth of Cancer Cells and Help Diagnose Aggressive Cancers-Applications of the Warburg Effect. | Perspectives in medicinal chemistry 20110101 |
| Amyloid beta resistance in nerve cell lines is mediated by the Warburg effect. | PloS one 20110101 |
| Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury. | Frontiers in physiology 20110101 |
| Mitochondrial changes in ageing Caenorhabditis elegans--what do we learn from superoxide dismutase knockouts? | PloS one 20110101 |
| The metabolic advantage of tumor cells. | Molecular cancer 20110101 |
| Bicarbonate and dichloroacetate: evaluating pH altering therapies in a mouse model for metastatic breast cancer. | BMC cancer 20110101 |
| Stage-related alterations in renal cell carcinoma--comprehensive quantitative analysis by 2D-DIGE and protein network analysis. | PloS one 20110101 |
| Exploiting mitochondrial dysfunction for effective elimination of imatinib-resistant leukemic cells. | PloS one 20110101 |
| Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review. | Frontiers in pharmacology 20110101 |
| Probucol attenuates oxidative stress, energy starvation, and nitric acid production following transient forebrain ischemia in the rat hippocampus. | Oxidative medicine and cellular longevity 20110101 |
| Hepatocyte Lysosomal Membrane Stabilization by Olive Leaves against Chemically Induced Hepatocellular Neoplasia in Rats. | International journal of hepatology 20110101 |
| Bioremediation via Methanotrophy: Overview of Recent Findings and Suggestions for Future Research. | Frontiers in microbiology 20110101 |
| Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure. | PloS one 20110101 |
| Screening for active small molecules in mitochondrial complex I deficient patient's fibroblasts, reveals AICAR as the most beneficial compound. | PloS one 20110101 |
| Formation of disinfection byproducts in typical Chinese drinking water. | Journal of environmental sciences (China) 20110101 |
| 8-Modified-2'-deoxyadenosine analogues induce delayed polymerization arrest during HIV-1 reverse transcription. | PloS one 20110101 |
| Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells. | Molecular cancer 20110101 |
| Ingestion exposure to nitrosamines in chlorinated drinking water. | Environmental health and toxicology 20110101 |
| The genetics of pulmonary arterial hypertension in the post-BMPR2 era. | Pulmonary circulation 20110101 |
| Arsenic exposure and the induction of human cancers. | Journal of toxicology 20110101 |
| Induction of human squamous cell-type carcinomas by arsenic. | Journal of skin cancer 20110101 |
| Biological roles and therapeutic potential of hydroxy-carboxylic Acid receptors. | Frontiers in endocrinology 20110101 |
| Glutathione s-transferases in pediatric cancer. | Frontiers in oncology 20110101 |
| Identification of radiolysis products of solid thiamphenicol. | Journal of pharmaceutical and biomedical analysis 20101201 |
| Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC. | International journal of cancer 20101201 |
| Severe encephalopathy and polyneuropathy induced by dichloroacetate. | Journal of neurology 20101201 |
| Acid-base disorders in ICU patients. | Electrolyte & blood pressure : E & BP 20101201 |
| Sodium dichloroacetate (DCA) reduces apoptosis in colorectal tumor hypoxia. | Cancer letters 20101101 |
| Polymorphisms in GSTT1, GSTZ1, and CYP2E1, disinfection by-products, and risk of bladder cancer in Spain. | Environmental health perspectives 20101101 |
| Differential response to trichloroethylene-induced hepatosteatosis in wild-type and PPARalpha-humanized mice. | Environmental health perspectives 20101101 |
| Genotoxic effects in swimmers exposed to disinfection by-products in indoor swimming pools. | Environmental health perspectives 20101101 |
| Production of various disinfection byproducts in indoor swimming pool waters treated with different disinfection methods. | International journal of hygiene and environmental health 20101101 |
| The serum metabolite response to diet intervention with probiotic acidified milk in irritable bowel syndrome patients is indistinguishable from that of non-probiotic acidified milk by 1H NMR-based metabonomic analysis. | Nutrients 20101101 |
| Enhanced production and isotope enrichment of recombinant glycoproteins produced in cultured mammalian cells. | Journal of biomolecular NMR 20101001 |
| 5'-Bis-conjugation of oligonucleotides by amidative oxidation and click chemistry. | The Journal of organic chemistry 20101001 |
| Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure. | Journal of molecular medicine (Berlin, Germany) 20101001 |
| Role of pyruvate dehydrogenase kinase 4 in regulation of blood glucose levels. | Korean diabetes journal 20101001 |
| Counteranion-dependent mechanisms of intramolecular proton transfer in aprotic solution. | Physical chemistry chemical physics : PCCP 20100921 |
| Potential of the TCE-degrading endophyte Pseudomonas putida W619-TCE to improve plant growth and reduce TCE phytotoxicity and evapotranspiration in poplar cuttings. | Environmental pollution (Barking, Essex : 1987) 20100901 |
| Novel N-phenyl dichloroacetamide derivatives as anticancer reagents: design, synthesis and biological evaluation. | European journal of medicinal chemistry 20100901 |
| Electromigration diffusivity spectrometry: a way for simultaneous determination of diffusion coefficients from mixed samples. | Electrophoresis 20100901 |
| Platinized WO3 as an environmental photocatalyst that generates OH radicals under visible light. | Environmental science & technology 20100901 |
| Oncology's energetic pipeline. | Nature biotechnology 20100901 |
| Lactic acidemia in the pathogenesis of mice carrying mitochondrial DNA with a deletion. | Human molecular genetics 20100815 |
| Pyruvate suppresses PGC1alpha expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes. | American journal of physiology. Cell physiology 20100801 |
| A simple and effective treatment for ectopic sebaceous glands on the areola. | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20100801 |
| Determination of haloacetic acids in water using solid-phase extraction/microchip capillary electrophoresis with capacitively coupled contactless conductivity detection. | Electrophoresis 20100801 |
| Dichloroacetate (DCA) enhances tumor cell death in combination with oncolytic adenovirus armed with MDA-7/IL-24. | Molecular and cellular biochemistry 20100701 |
| Dichloroacetate- and trichloroacetate-induced oxidative stress in the hepatic tissues of mice after long-term exposure. | Journal of applied toxicology : JAT 20100701 |
| Electrochemically assisted photocatalytic degradation of 4-chlorophenol by ZnFe2O4-modified TiO2 nanotube array electrode under visible light irradiation. | Environmental science & technology 20100701 |
| Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells. | British journal of cancer 20100608 |
| Oxidative stress therapy for solid tumors - a proposal. | Medical hypotheses 20100601 |
| Novel strategy for treatment of pulmonary arterial hypertension: enhancement of apoptosis. | Lung 20100601 |
| Change of purpose. | Nature 20100520 |
| The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts. | Cell cycle (Georgetown, Tex.) 20100515 |
| Targeting cell metabolism in cancer patients. | Science translational medicine 20100512 |
| Metabolic modulation of glioblastoma with dichloroacetate. | Science translational medicine 20100512 |
| Practical strategies for suppressing hypoxia-inducible factor activity in cancer therapy. | Medical hypotheses 20100501 |
| Analysis of metabolic remodeling in compensated left ventricular hypertrophy and heart failure. | Circulation. Heart failure 20100501 |
| Physiologically based pharmacokinetic modeling of dibromoacetic acid in F344 rats. | Toxicology and applied pharmacology 20100415 |
| Selection of cancer cells with repressed mitochondria triggers colon cancer progression. | Carcinogenesis 20100401 |
| New therapies for pulmonary arterial hypertension: an update on current bench to bedside translation. | Expert opinion on investigational drugs 20100401 |
| Metabolic network topology reveals transcriptional regulatory signatures of type 2 diabetes. | PLoS computational biology 20100401 |
| Demand-induced ischemia in volume expanded isolated rat heart; the effect of dichloroacetate and trimetazidine. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20100401 |
| Three-level topology switching in a molecular Möbius band. | Journal of the American Chemical Society 20100310 |
| Generation of disinfection by-products (DBPs) at two advanced water treatment plants. | Environmental monitoring and assessment 20100301 |
| Occurrence of haloacetic acids (HAAs) and trihalomethanes (THMs) in drinking water of Taiwan. | Environmental monitoring and assessment 20100301 |
| Treatment of mitochondrial electron transport chain disorders: a review of clinical trials over the past decade. | Molecular genetics and metabolism 20100301 |
| Emerging therapies for the treatment of pulmonary hypertension. | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20100301 |
| Expression and characterization of three new glutathione transferases, an epsilon (AcGSTE2-2), omega (AcGSTO1-1), and theta (AcGSTT1-1) from Anopheles cracens (Diptera: Culicidae), a major Thai malaria vector. | Journal of medical entomology 20100301 |
| The induction of tumor necrosis factor-alpha, superoxide anion, myeloperoxidase, and superoxide dismutase in the peritoneal lavage cells of mice after prolonged exposure to dichloroacetate and trichloroacetate. | Journal of biochemical and molecular toxicology 20100301 |
| [Determination of trihalomethanes and haloacetic acids in the sample holding time, and their stability in the extract]. | Wei sheng yan jiu = Journal of hygiene research 20100301 |
| Effect of zinc on the transformation of haloacetic acids (HAAs) in drinking water. | Journal of hazardous materials 20100215 |
| Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo. | Breast cancer research and treatment 20100201 |
| Bis(2,2'-bipyrid-yl)(dichloro-acetato)copper(II) dichloro-acetate dihydrate. | Acta crystallographica. Section E, Structure reports online 20100201 |
| Formation of haloacetamides during chlorination of dissolved organic nitrogen aspartic acid. | Journal of hazardous materials 20100115 |
| The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle. | Journal of molecular medicine (Berlin, Germany) 20100101 |
| Polymerase-endonuclease amplification reaction (PEAR) for large-scale enzymatic production of antisense oligonucleotides. | PloS one 20100101 |
| Gene expression in a Drosophila model of mitochondrial disease. | PloS one 20100101 |
| Cancer proliferation and therapy: the Warburg effect and quantum metabolism. | Theoretical biology & medical modelling 20100101 |
| Bacteria in cancer therapy: a novel experimental strategy. | Journal of biomedical science 20100101 |
| [Cytotoxicity of dichloroacetic acid in lymphocyte and expression of chemokine receptor CXCR2 and chemokine receptor CXCR3 mRNA]. | Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20100101 |
| Synthesis and photocatalytic activity of boron-doped TiO(2) in aqueous suspensions under UV-A irradiation. | Water science and technology : a journal of the International Association on Water Pollution Research 20100101 |
| Degradation of a mixture of pollutants in water using the UV/H2O2 process. | Water science and technology : a journal of the International Association on Water Pollution Research 20100101 |
| Mammalian cell cytotoxicity and genotoxicity of the haloacetic acids, a major class of drinking water disinfection by-products. | Environmental and molecular mutagenesis 20100101 |
| Non-Hodgkin's Lymphoma Reversal with Dichloroacetate. | Journal of oncology 20100101 |
| The assessment of population exposure to chlorination by-products: a study on the influence of the water distribution system. | Environmental health : a global access science source 20100101 |
| Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure. | Cardiovascular diabetology 20100101 |
| Enhanced ozonation of dichloroacetic acid in aqueous solution using nanometer ZnO powders. | Journal of environmental sciences (China) 20100101 |
| Development of a less toxic dichloroacetate analogue by docking and descriptor analysis. | Bioinformation 20100101 |
| Diaqua-hexa-μ(2)-dichloro-acetato-μ(3)-oxido-tetra-hydro-furan-diiron(III)manganese(II). | Acta crystallographica. Section E, Structure reports online 20100101 |
| In vitro cytotoxicity of combinations of dichloroacetate with anticancer platinum compounds. | Clinical pharmacology : advances and applications 20100101 |
| Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate. | The Journal of biological chemistry 20091204 |
| Hypoxia and the metabolic phenotype of prostate cancer cells. | Biochimica et biophysica acta 20091201 |
| Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20091201 |
| Both substrate availability and utilisation contribute to the defence of core temperature in response to acute cold. | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20091201 |
| Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104. | Clinical cancer research : an official journal of the American Association for Cancer Research 20091201 |
| Effects of crystalline structures and surface functional groups on the adsorption of haloacetic acids by inorganic materials. | Journal of hazardous materials 20091115 |
| In vitro effects of dichloroacetate and CO2 on hypoxic HeLa cells. | Anticancer research 20091101 |
| A reexamination of the PPAR-alpha activation mode of action as a basis for assessing human cancer risks of environmental contaminants. | Environmental health perspectives 20091101 |
| Depressive episode with catatonic features in a case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). | Journal of child neurology 20091001 |
| Quantitative mitochondrial phosphoproteomics using iTRAQ on an LTQ-Orbitrap with high energy collision dissociation. | Journal of proteome research 20091001 |
| Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses. | Environmental health perspectives 20091001 |
| Aqua-tris(1H-benzimidazole-κN)(dichloro-acetato-κO)copper(II) dichloro-acetate dihydrate. | Acta crystallographica. Section E, Structure reports online 20091001 |
| Influence of dichloroacetate on pulmonary gas exchange and ventilation during incremental exercise in healthy humans. | Respiratory physiology & neurobiology 20090930 |
| Zero-valent aluminum for oxidative degradation of aqueous organic pollutants. | Environmental science & technology 20090915 |
| Kinetics and effects of dichloroacetic acid in rainbow trout. | Aquatic toxicology (Amsterdam, Netherlands) 20090914 |
| Dichloroacetate modulates the oxidative stress and inflammatory response to exercise in COPD. | Chest 20090901 |
| Peripheral neuropathy in rats exposed to dichloroacetate. | Journal of neuropathology and experimental neurology 20090901 |
| Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine. | Toxicology 20090821 |
| From proton nuclear magnetic resonance spectra to pH. Assessment of 1H NMR pH indicator compound set for deuterium oxide solutions. | Analytica chimica acta 20090819 |
| Glycerol-induced folding of unstructured disulfide-deficient lysozyme into a native-like conformation. | Biopolymers 20090801 |
| Disinfection byproduct formation and fractionation behavior of natural organic matter surrogates. | Environmental science & technology 20090801 |
| Experimental and theoretical investigation of the catalytic ozonation on the surface of NiO-CuO nanoparticles. | Langmuir : the ACS journal of surfaces and colloids 20090721 |
| Reduction of protons assisted by a hexanuclear nickel thiolate metallacrown: protonation and electrocatalytic dihydrogen evolution. | Physical chemistry chemical physics : PCCP 20090721 |
| High rates of residual fatty acid oxidation during mild ischemia decrease cardiac work and efficiency. | Journal of molecular and cellular cardiology 20090701 |
| Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine. | Toxicology and applied pharmacology 20090701 |
| Formation of chlorinated disinfection by-products in viticulture. | Environmental science and pollution research international 20090701 |
| Monitoring phosphorylation of the pyruvate dehydrogenase complex. | Analytical biochemistry 20090615 |
| Augmented cerebellar lactate in copper deficient rat pups originates from both blood and cerebellum. | Metabolic brain disease 20090601 |
| 1,3-Dihydr-oxy-2-(hydroxy-meth-yl)propan-2-aminium 2,2-dichloro-acetate. | Acta crystallographica. Section E, Structure reports online 20090601 |
| Evidence of autoimmune-related effects of trichloroethylene exposure from studies in mice and humans. | Environmental health perspectives 20090501 |
| Biodegradation of haloacetic acids by bacterial isolates and enrichment cultures from drinking water systems. | Environmental science & technology 20090501 |
| Phenylalanine-induced leucopenia in genetic and dichloroacetic acid generated deficiency of glutathione transferase Zeta. | Biochemical pharmacology 20090415 |
| Pyruvate dehydrogenase phosphatase 1 (PDP1) null mutation produces a lethal infantile phenotype. | Human genetics 20090401 |
| Treatment for Leigh syndrome by monitoring dichloroacetate concentration. | Pediatrics international : official journal of the Japan Pediatric Society 20090401 |
| Epigenetics and environmental chemicals. | Current opinion in pediatrics 20090401 |
| Substrate-enzyme competition attenuates upregulated anaplerotic flux through malic enzyme in hypertrophied rat heart and restores triacylglyceride content: attenuating upregulated anaplerosis in hypertrophy. | Circulation research 20090327 |
| Innate short-circuiting of mitochondrial metabolism in cardiac hypertrophy: identification of novel consequences of enhanced anaplerosis. | Circulation research 20090327 |
| Decomposition of two haloacetic acids in water using UV radiation, ozone and advanced oxidation processes. | Journal of hazardous materials 20090315 |
| Chloroform- and water-soluble sol-gel derived Eu+++/Y2O3 (red) and Tb+++/Y2O3 (green) nanophosphors: synthesis, characterization, and surface modification. | IEEE transactions on nanobioscience 20090301 |
| Central nervous system imaging in mitochondrial disorders. | The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20090301 |
| Biological Basis of Differential Susceptibility to Hepatocarcinogenesis among Mouse Strains. | Journal of toxicologic pathology 20090301 |
| N2'-->p3' phosphoramidate glycerol nucleic acid as a potential alternative genetic system. | Journal of the American Chemical Society 20090218 |
| Fate of THMs and HAAs in low TOC surface water. | Environmental research 20090201 |
| Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinoma. | Clinical cancer research : an official journal of the American Association for Cancer Research 20090115 |
| The kinetics and mechanism of the acid-catalysed detritylation of nucleotides in non-aqueous solution. | Organic & biomolecular chemistry 20090107 |
| Stimulation-induced increases of astrocytic oxidative metabolism in rats and humans investigated with 1-11C-acetate. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20090101 |
| Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient mice. | Toxicological sciences : an official journal of the Society of Toxicology 20090101 |
| Therapeutic targets in pulmonary arterial hypertension. | Pharmacology & therapeutics 20090101 |
| Update on medication-induced peripheral neuropathy. | Current neurology and neuroscience reports 20090101 |
| Determination of ten haloacetic acids in drinking water using high-performance and ultra-performance liquid chromatography-tandem mass spectrometry. | Journal of chromatographic science 20090101 |
| The metabolic treatment of patients with coronary artery disease: effects on quality of life and effort angina. | Current pharmaceutical design 20090101 |
| Acetoacetate reduces growth and ATP concentration in cancer cell lines which over-express uncoupling protein 2. | Cancer cell international 20090101 |
| Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 mice. | Arthritis research & therapy 20090101 |
| Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis. | BMC systems biology 20090101 |
| Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect. | PloS one 20090101 |
| Interferon for the treatment of genital warts: a systematic review. | BMC infectious diseases 20090101 |
| PathBinder--text empirics and automatic extraction of biomolecular interactions. | BMC bioinformatics 20090101 |
| Trichloroethylene risk assessment: a review and commentary. | Critical reviews in toxicology 20090101 |
| A systematic review of the reporting of Data Monitoring Committees' roles, interim analysis and early termination in pediatric clinical trials. | BMC pediatrics 20090101 |
| Aqua-bis(dichloro-acetato-κO)(1,10-phenanthroline-κN,N')copper(II). | Acta crystallographica. Section E, Structure reports online 20090101 |
| Dichloroacetate-induced modulation of cellular antioxidant enzyme activities and glutathione level in the J774A.1 cells. | Journal of applied toxicology : JAT 20081101 |
| Visible light photo-oxidations in the presence of alpha-Bi(2)O(3). | Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20081101 |
| Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer. | British journal of cancer 20081007 |
| Differential effects of in vivo and in vitro lactate treatments on liver carbohydrate metabolism of rainbow trout. | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20081001 |
| Theoretical studies of different tautomers of anti cancer drug: dichloroacetate. | Pakistan journal of pharmaceutical sciences 20081001 |
| Trichloroethylene transformation by natural mineral pyrite: the deciding role of oxygen. | Environmental science & technology 20081001 |
| Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity. | The Journal of biological chemistry 20080912 |
| Pyruvate dehydrogenase kinase 4: regulation by thiazolidinediones and implication in glyceroneogenesis in adipose tissue. | Diabetes 20080901 |
| The heme precursor delta-aminolevulinate blocks peripheral myelin formation. | Journal of neurochemistry 20080901 |
| Comparison of H2O2/UV and heterogeneous photocatalytic processes for the degradation of dichloroacetic acid in water. | Environmental science & technology 20080815 |
| Allosteric coupling in pyruvate dehydrogenase kinase 2. | Biochemistry 20080812 |
| Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation. | The Prostate 20080801 |
| Case: asymptomatic lesions on eyelids. | Geriatrics 20080801 |
| Characterization of Ser73 in Arabidopsis thaliana Glutathione S-transferase zeta class. | Journal of genetics and genomics = Yi chuan xue bao 20080801 |
| Analysis of in vivo mutation data can inform cancer risk assessment. | Regulatory toxicology and pharmacology : RTP 20080701 |
| ECVAM retrospective validation of in vitro micronucleus test (MNT). | Mutagenesis 20080701 |
| Domoic acid excretion in dungeness crabs, razor clams and mussels. | Marine environmental research 20080701 |
| Human health risk assessment of chlorinated disinfection by-products in drinking water using a probabilistic approach. | Water research 20080701 |
| Dichloroacetate stabilizes the intraoperative acid-base balance during liver transplantation. | Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20080701 |
| A dynamic and chamber-specific mitochondrial remodeling in right ventricular hypertrophy can be therapeutically targeted. | The Journal of thoracic and cardiovascular surgery 20080701 |
| Metabolic agents in the management of diabetic coronary patients: a new era. | International journal of cardiology 20080623 |
| Metabolic agents in the management of diabetic coronary patients: a new era. | International journal of cardiology 20080623 |
| Role of glucose metabolism in the recovery of postischemic LV mechanical function: effects of insulin and other metabolic modulators. | American journal of physiology. Heart and circulatory physiology 20080601 |
| Dichloroacetate induces apoptosis in endometrial cancer cells. | Gynecologic oncology 20080601 |
| Oxidoreductase regulation of Kv currents in rat ventricle. | Journal of molecular and cellular cardiology 20080601 |
| Dichloroacetate enhances performance and reduces blood lactate during maximal cycle exercise in chronic obstructive pulmonary disease. | American journal of respiratory and critical care medicine 20080515 |
| Halogenated derivatives QSAR model using spectral moments to predict haloacetic acids (HAA) mutagenicity. | Bioorganic & medicinal chemistry 20080515 |
| Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate. | Pediatrics 20080501 |
| Haloacetic acid and trihalomethane formation from the chlorination and bromination of aliphatic beta-dicarbonyl acid model compounds. | Environmental science & technology 20080501 |
| A combined therapeutic approach for pyruvate dehydrogenase deficiency using self-complementary adeno-associated virus serotype-specific vectors and dichloroacetate. | Molecular genetics and metabolism 20080401 |
| Correlations between organic matter properties and DBP formation during chloramination. | Water research 20080401 |
| Glucose-insulin therapy, plasma substrate levels and cardiac recovery after cardiac ischemic events. | Cardiovascular drugs and therapy 20080401 |
| In situ derivatization/solid-phase microextraction coupled with gas chromatography/negative chemical ionization mass spectrometry for the determination of trichloroethylene metabolites in rat blood. | Rapid communications in mass spectrometry : RCM 20080401 |
| Involvement of lactate in glucose metabolism and glucosensing function in selected tissues of rainbow trout. | The Journal of experimental biology 20080401 |
| The formation and distribution of haloacetic acids in copper pipe during chlorination. | Journal of hazardous materials 20080321 |
| Quantitative evaluation of dichloroacetic acid kinetics in human--a physiologically based pharmacokinetic modeling investigation. | Toxicology 20080312 |
| Kinetics of chloral hydrate and its metabolites in male human volunteers. | Toxicology 20080312 |
| Difficulty of mode of action determination for trichloroethylene: An example of complex interactions of metabolites and other chemical exposures. | Environmental and molecular mutagenesis 20080301 |
| Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity. | The Journal of pharmacology and experimental therapeutics 20080301 |
| Treatment of Fordyce spots with bichloracetic acid. | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20080301 |
| RNA interference in mammalia cells by RNA-3'-PNA chimeras. | International journal of molecular sciences 20080301 |
| A refined radio-telemetry technique to monitor right ventricle or pulmonary artery pressures in rats: a useful tool in pulmonary hypertension research. | Pflugers Archiv : European journal of physiology 20080201 |
| Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer. | American journal of physiology. Heart and circulatory physiology 20080201 |
| Dichloroacetate- and trichloroacetate-induced phagocytic activation and production of oxidative stress in the hepatic tissues of mice after acute exposure. | Journal of biochemical and molecular toxicology 20080201 |
| [Determination of five halogenated acetic acids in water using ion chromatography]. | Se pu = Chinese journal of chromatography 20080101 |
| Water disinfection by-products and the risk of specific birth defects: a population-based cross-sectional study in Taiwan. | Environmental health : a global access science source 20080101 |
| Role of dichloroacetate in the treatment of genetic mitochondrial diseases. | Advanced drug delivery reviews 20080101 |
| Effect of streptozotocin-induced diabetes on myocardial blood flow reserve assessed by myocardial contrast echocardiography in rats. | Cardiovascular diabetology 20080101 |
| Evaluation of the role of peroxisome proliferator-activated receptor alpha (PPARalpha) in mouse liver tumor induction by trichloroethylene and metabolites. | Critical reviews in toxicology 20080101 |
| Gateways to clinical trials. July-August 2008. | Methods and findings in experimental and clinical pharmacology 20080101 |
| Metformin-associated lactic acidosis in an intensive care unit. | Critical care (London, England) 20080101 |
| Abstracts of papers presented at the 2008 pittsburgh conference. | Journal of automated methods & management in chemistry 20080101 |
| Total excision and V-Y plasty technique in the anal area condyloma acuminatum. | Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India 20080101 |
| Don't take vitals, take a lactate. | Intensive care medicine 20071101 |
| Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20071101 |
| MALDI-linear ion trap microprobe MS/MS studies of the effects of dichloroacetate on lipid content of nerve tissue. | Analytical chemistry 20071101 |
| Wolff-Parkinson-White syndrome in Patients With MELAS. | Archives of neurology 20071101 |
| Formation and fate of haloacetic acids (HAAs) within the water treatment plant. | Water research 20071001 |
| A general, positive ion mode ESI-MS approach for the analysis of singly charged inorganic and organic anions using a dicationic reagent. | Analytical chemistry 20071001 |
| The ultrafast dynamics of hydrogen-bonded liquids: molecular structure-dependent occurrence of normal arrhenius or fractional Stokes-Einstein-Debye rotational diffusive relaxation. | The journal of physical chemistry. B 20070816 |
| Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol. | Structure (London, England : 1993) 20070801 |
| The healthy men study: an evaluation of exposure to disinfection by-products in tap water and sperm quality. | Environmental health perspectives 20070801 |
| Amino acid residues responsible for the recognition of dichloroacetate by pyruvate dehydrogenase kinase 2. | FEBS letters 20070626 |
| Lactate interferes with ATP release from red blood cells. | American journal of physiology. Heart and circulatory physiology 20070601 |
| Functional diagnostics in mitochondrial diseases. | Bioscience reports 20070601 |
| The beneficial effects of dichloroacetate in acute limb ischemia. | Military medicine 20070601 |
| Trials and tribulations. | Nature reviews. Drug discovery 20070501 |
| Examination of NOM chlorination reactions by conventional and stop-flow differential absorbance spectroscopy. | Environmental science & technology 20070415 |
| Metabolic targeting as an anticancer strategy: dawn of a new era? | Science's STKE : signal transduction knowledge environment 20070410 |
| Toxicology and carcinogenesis studies of dibromoacetic acid (Cas No. 631-64-1) in F344/N rats and B6C3F1 mice (drinking water studies). | National Toxicology Program technical report series 20070401 |
| NTP report on the toxicology studies of dichloroacetic acid (CAS No. 79-43-6) in genetically modified (FVB Tg.AC hemizygous) mice (dermal and drinking water studies) and carcinogenicity studies of dichloroacetic acid in genetically modified [B6.129-Trp53(tm1Brd) (N5) haploinsufficient] mice (drinking water studies). | National Toxicology Program genetically modified model report 20070401 |
| Immuno- and hepato-toxicity of dichloroacetic acid in MRL(+/+) and B(6)C(3)F(1) mice. | Journal of immunotoxicology 20070401 |
| Cancer patients opt for unapproved drug. | Nature 20070329 |
| Insulin regulation of glutathione and contractile phenotype in diabetic rat ventricular myocytes. | American journal of physiology. Heart and circulatory physiology 20070301 |
| Modulation of the expression of peroxisome proliferators-activated receptors in human fibroblasts. | Fertility and sterility 20070301 |
| Myocardial lactate deprivation is associated with decreased cardiovascular performance, decreased myocardial energetics, and early death in endotoxic shock. | Intensive care medicine 20070301 |
| The use of Markov chain Monte Carlo uncertainty analysis to support a Public Health Goal for perchloroethylene. | Regulatory toxicology and pharmacology : RTP 20070201 |
| Malonyl coenzyme A affects insulin-stimulated glucose transport in myotubes. | Archives of physiology and biochemistry 20070201 |
| Dichloroacetic acid degradation employing hydrogen peroxide and UV radiation. | Chemosphere 20070101 |
| Reductive dehalogenation of haloacetic acids by hemoglobin-loaded carbon nanotube electrode. | Water research 20070101 |
| A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. | Cancer cell 20070101 |
| Dichloroacetate causes reversible demyelination in vitro: potential mechanism for its neuropathic effect. | Journal of neurochemistry 20070101 |
| Modelling the kinetics of UV/H2O2 oxidation of dichloroacetic acid. | Water science and technology : a journal of the International Association on Water Pollution Research 20070101 |
| Effect of streptozotocin-induced diabetes on left ventricular function in adult rats: an in vivo Pinhole Gated SPECT study. | Cardiovascular diabetology 20070101 |
| Determination of haloacetic acids in hospital effluent after chlorination by ion chromatography. | Journal of environmental sciences (China) 20070101 |
| Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research. | Mutation research 20070101 |
| Abstracts of papers presented at the 2007 pittsburgh conference. | Journal of automated methods & management in chemistry 20070101 |
| The role of glucose metabolism and glucose-associated signalling in cancer. | Perspectives in medicinal chemistry 20070101 |
| The role of k+ channels in determining pulmonary vascular tone, oxygen sensing, cell proliferation, and apoptosis: implications in hypoxic pulmonary vasoconstriction and pulmonary arterial hypertension. | Microcirculation (New York, N.Y. : 1994) 20061201 |
| Human kinetics of orally and intravenously administered low-dose 1,2-(13)C-dichloroacetate. | Journal of clinical pharmacology 20061201 |
| [Study on rat's DNA damage of p53 induced by chlorinated acetic acids of drinking water disinfection by-products]. | Wei sheng yan jiu = Journal of hygiene research 20061101 |
| Autoimmune response in MRL+/+ mice following treatment with dichloroacetyl chloride or dichloroacetic anhydride. | Toxicology and applied pharmacology 20061015 |
| Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial. | Neurology 20061010 |
| Short-term exposures to dihaloacetic acids produce dysmorphogenesis in mouse conceptuses in vitro. | Reproductive toxicology (Elmsford, N.Y.) 20061001 |
| Bayesian population analysis of a harmonized physiologically based pharmacokinetic model of trichloroethylene and its metabolites. | Regulatory toxicology and pharmacology : RTP 20061001 |
| Severe malaria: lessons learned from the management of critical illness in children. | Trends in parasitology 20061001 |
| New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 2): Identification of nephrotoxic metabolites. | Anesthesiology 20061001 |
| A Korean female patient with thiamine-responsive pyruvate dehydrogenase complex deficiency due to a novel point mutation (Y161C)in the PDHA1 gene. | Journal of Korean medical science 20061001 |
| Tricarboxylic acid cycle intermediates accumulate at the onset of intense exercise in man but are not essential for the increase in muscle oxygen uptake. | Pflugers Archiv : European journal of physiology 20060901 |
| The key role of apoptosis in the pathogenesis and treatment of pulmonary hypertension. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060901 |
| Optimizing cardiac fatty acid and glucose metabolism as an approach to treating heart failure. | Seminars in cardiothoracic and vascular anesthesia 20060901 |
| Key scientific issues in the health risk assessment of trichloroethylene. | Environmental health perspectives 20060901 |
| Issues in the pharmacokinetics of trichloroethylene and its metabolites. | Environmental health perspectives 20060901 |
| Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis. | Environmental health perspectives 20060901 |
| Key issues in the role of peroxisome proliferator-activated receptor agonism and cell signaling in trichloroethylene toxicity. | Environmental health perspectives 20060901 |
| Volume expansion with albumin compared to gelofusine in children with severe malaria: results of a controlled trial. | PLoS clinical trials 20060901 |
| Modeling dichloroacetic acid formation from the reaction of monochloramine with natural organic matter. | Water research 20060801 |
| Application of cryopreserved human hepatocytes in trichloroethylene risk assessment: relative disposition of chloral hydrate to trichloroacetate and trichloroethanol. | Environmental health perspectives 20060801 |
| Effects of indoor drinking water handling on trihalomethanes and haloacetic acids. | Water research 20060801 |
| Trichloroethylene uptake by apple and peach trees and transfer to fruit. | Environmental science & technology 20060801 |
| [Impact of catalytic ozonation with ferric hydroxide on HAAs formation potential of a filtered surface water]. | Huan jing ke xue= Huanjing kexue 20060801 |
| Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial. | Neurology 20060711 |
| Effect of short-term drinking water exposure to dichloroacetate on its pharmacokinetics and oral bioavailability in human volunteers: a stable isotope study. | Toxicological sciences : an official journal of the Society of Toxicology 20060701 |
| An evidence-based approach to the management of pulmonary arterial hypertension. | Current opinion in cardiology 20060701 |
| A GC-MS/MS method for the quantitative analysis of low levels of the tyrosine metabolites maleylacetone, succinylacetone, and the tyrosine metabolism inhibitor dichloroacetate in biological fluids and tissues. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060606 |
| An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. | Circulation 20060606 |
| THM, HAA and CNCl formation from UV irradiation and chlor(am)ination of selected organic waters. | Water research 20060601 |
| Therapeutic potential of dichloroacetate for pyruvate dehydrogenase complex deficiency. | Mitochondrion 20060601 |
| Trichloroethylene exposure during cardiac valvuloseptal morphogenesis alters cushion formation and cardiac hemodynamics in the avian embryo. | Environmental health perspectives 20060601 |
| [Effect of preozonation on disinfection by-products formation potential of algae cells and extracellular organic matter]. | Huan jing ke xue= Huanjing kexue 20060601 |
| Evaluation of dichloroacetate treatment in a murine model of hereditary tyrosinemia type 1. | Biochemical pharmacology 20060528 |
| Photocatalytic hydrogen generation in the presence of chloroacetic acids over Pt/TiO2. | Chemosphere 20060501 |
| Polymorphisms in the human glutathione transferase zeta promoter. | Pharmacogenetics and genomics 20060501 |
| Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children. | Pediatrics 20060501 |
| [Expression of glutathione S-transferase zeta class genes in Saccharomyces cerevisiae]. | Yi chuan = Hereditas 20060501 |
| [Determination of trace haloacetic acids in drinking water using ion chromatography coupled with solid phase extraction]. | Se pu = Chinese journal of chromatography 20060501 |
| Dichloroacetate reduces tissue necrosis in a rat transverse rectus abdominis musculocutaneous flap model. | Annals of plastic surgery 20060301 |
| Severe malaria: metabolic complications. | Current molecular medicine 20060301 |
| Determination of mono- and dichloroacetic acids in betaine media by liquid chromatography. | Talanta 20060215 |
| Trial of dichloroacetate in MELAS: toxicity overshadows the assessment of potential benefit. | Neurology 20060214 |
| Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial. | Neurology 20060214 |
| Pulmonary bronchiolar cytotoxicity and formation of dichloroacetyl lysine protein adducts in mice treated with trichloroethylene. | The Journal of pharmacology and experimental therapeutics 20060201 |
| Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways. | Molecular pharmacology 20060201 |
| Optical density and photonic efficiency of silica-supported TiO2 photocatalysts. | Water research 20060201 |
| Peripheral neuropathy in genetic mitochondrial diseases. | Pediatric neurology 20060201 |
| Treatment for mitochondrial disorders. | The Cochrane database of systematic reviews 20060125 |
| 9-(4-Bromophenyl)-9-fluorenyl as a safety-catch nitrogen protecting group. | The Journal of organic chemistry 20060120 |
| Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands. | Biochemistry 20060117 |
| Inhibition and recovery of rat hepatic glutathione S-transferase zeta and alteration of tyrosine metabolism following dichloroacetate exposure and withdrawal. | Drug metabolism and disposition: the biological fate of chemicals 20060101 |
| The effects of cyanobacterial exudates on bacterial growth and biodegradation of organic contaminants. | Microbial ecology 20060101 |
| Pulmonary arterial hypertension: new insights and new hope. | Respirology (Carlton, Vic.) 20060101 |
| A case of Melas (A3243G) on chronic dichloroacetate treatment. | European neurology 20060101 |
| Different net effect of TiO2 sintering temperature on the photocatalytic removal rates of 4-chlorophenol, 4-chlorobenzoic acid and dichloroacetic acid in water. | Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 20060101 |
| Interaction between organic species in the formation of haloacetic acids following disinfection. | Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 20060101 |
| Magnetic resonance spectroscopic investigation of mitochondrial fuel metabolism and energetics in cultured human fibroblasts: effects of pyruvate dehydrogenase complex deficiency and dichloroacetate. | Molecular genetics and metabolism 20060101 |
| Trichloroethylene, trichloroacetic acid, and dichloroacetic acid: do they affect eye development in the Sprague-Dawley rat? | International journal of toxicology 20060101 |
| [Analysis of haloacetic acids in drinking water by gas chromatography-mass spectrometry]. | Se pu = Chinese journal of chromatography 20060101 |
| Modulation by ellagic acid of DCA-induced developmental toxicity in the zebrafish (Danio rerio). | Journal of biochemical and molecular toxicology 20060101 |
| Human malarial disease: a consequence of inflammatory cytokine release. | Malaria journal 20060101 |
| Visible light active platinum-ion-doped TiO2 photocatalyst. | The journal of physical chemistry. B 20051229 |
| Malaria and fluids--balancing acts. | Trends in parasitology 20051201 |
| Platelet mitochondrial evaluation during cytochrome c and dichloroacetate treatments of MELAS. | Mitochondrion 20051201 |
| Late pregnancy exposures to disinfection by-products and growth-related birth outcomes. | Environmental health perspectives 20051201 |
| Mitochondrial myopathies: diagnosis, exercise intolerance, and treatment options. | Medicine and science in sports and exercise 20051201 |
| Metabolic modulators for chronic cardiac ischemia. | Journal of cardiovascular pharmacology and therapeutics 20051201 |
| Comparison of haloacetic acids in the environment of the Northern and Southern Hemispheres. | Environmental science & technology 20051115 |
| Lung preservation solution substrate composition affects rat lung oxidative metabolism during hypothermic storage. | Respiratory physiology & neurobiology 20051012 |
| A review of analytical methods for the determination of trichloroethylene and its major metabolites chloral hydrate, trichloroacetic acid and dichloroacetic acid. | Biomedical chromatography : BMC 20051001 |
| DNA hypomethylation induced by drinking water disinfection by-products in mouse and rat kidney. | Toxicological sciences : an official journal of the Society of Toxicology 20051001 |
| The relevance of malaria pathophysiology to strategies of clinical management. | Current opinion in infectious diseases 20051001 |
| Trichloroacetaldehyde modified oligonucleotides. | Bioorganic & medicinal chemistry letters 20050915 |
| Fructose-1,6-bisphosphate enhances hypothermic preservation of cardiac myocytes. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050901 |
| Lack of direct mitogenic activity of dichloroacetate and trichloroacetate in cultured rat hepatocytes. | Toxicology 20050801 |
| Pyruvate dehydrogenase phosphatase deficiency: identification of the first mutation in two brothers and restoration of activity by protein complementation. | The Journal of clinical endocrinology and metabolism 20050701 |
| The impacts of cyanobacteria on pulp-and-paper wastewater toxicity and biodegradation of wastewater contaminants. | Canadian journal of microbiology 20050701 |
| Photocatalytic reactivities of Nafion-coated TiO2 for the degradation of charged organic compounds under UV or visible light. | The journal of physical chemistry. B 20050616 |
| Myocardial metabolism and improved outcomes after high risk heart surgery. | Seminars in cardiothoracic and vascular anesthesia 20050601 |
| Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). | Journal of medicinal chemistry 20050505 |
| Determination of dichloroacetic acid and trichloroacetic acid in drinking water by acidic methanol esterification and headspace gas chromatography. | Water research 20050501 |
| [Adsorption performance of haloacetic acids onto 5 GACs from water]. | Huan jing ke xue= Huanjing kexue 20050501 |
| Impact of high glucose/high insulin and dichloroacetate treatment on carbohydrate oxidation and functional recovery after low-flow ischemia and reperfusion in the isolated perfused rat heart. | Circulation 20050426 |
| Photocatalytic reactivity of surface platinized TiO2: substrate specificity and the effect of Pt oxidation state. | The journal of physical chemistry. B 20050421 |
| Toxicokinetics and oral bioavailability of halogenated acetic acids mixtures in naïve and GSTzeta-depleted rats. | Toxicological sciences : an official journal of the Society of Toxicology 20050401 |
| Visible-light-induced photocatalytic degradation of 4-chlorophenol and phenolic compounds in aqueous suspension of pure titania: demonstrating the existence of a surface-complex-mediated path. | The journal of physical chemistry. B 20050324 |
| Hydrogen-deuterium (H/D) exchange mapping of Abeta 1-40 amyloid fibril secondary structure using nuclear magnetic resonance spectroscopy. | Biochemistry 20050322 |
| Redox regulation of Ito remodeling in diabetic rat heart. | American journal of physiology. Heart and circulatory physiology 20050301 |
| Characterization of the metabolic interaction between trihalomethanes and chloroacetic acids using rat liver microsomes. | Journal of toxicology and environmental health. Part A 20050227 |
| Haloacetic acids in drinking water and risk for stillbirth. | Occupational and environmental medicine 20050201 |
| Fatty acid oxidation inhibitors in the management of chronic complications of atherosclerosis. | Current atherosclerosis reports 20050201 |
| Modulation of the expression of vascular endothelial growth factor in human fibroblasts. | Fertility and sterility 20050201 |
| [Diisopropylamine dichloroacetate in the treatment of nonalcoholic fatty liver disease: a multicenter random double-blind controlled trial]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20050201 |
| Chasing the 'ghost' of the acetyl group deficit. | Medicine and science in sports and exercise 20050101 |
| Severe falciparum malaria in Gabonese children: clinical and laboratory features. | Malaria journal 20050101 |
| Dichloroacetate-induced developmental toxicity and production of reactive oxygen species in zebrafish embryos. | Journal of biochemical and molecular toxicology 20050101 |
| Analysis of dichloroacetic acid in rat blood and tissues by hydrophilic interaction liquid chromatography with tandem mass spectrometry. | Rapid communications in mass spectrometry : RCM 20050101 |
| Characterization of the fluoroacetate detoxication enzymes of rat liver cytosol. | Xenobiotica; the fate of foreign compounds in biological systems 20050101 |
| Human glutathione transferase zeta. | Methods in enzymology 20050101 |
| Acetyl group availability influences phosphocreatine degradation even during intense muscle contraction. | The Journal of physiology 20041215 |
| Kinetics of haloacetic acid reactions with Fe(0). | Environmental science & technology 20041215 |
| A quantitative description of suicide inhibition of dichloroacetic acid in rats and mice. | Toxicological sciences : an official journal of the Society of Toxicology 20041201 |
| Behavior of trihalomethanes and haloacetic acids in a drinking water distribution system. | Water research 20041201 |
| Developmental toxicity of mixtures: the water disinfection by-products dichloro-, dibromo- and bromochloro acetic acid in rat embryo culture. | Reproductive toxicology (Elmsford, N.Y.) 20041101 |
| Effect of dibromoacetic acid on DNA methylation, glycogen accumulation, and peroxisome proliferation in mouse and rat liver. | Toxicological sciences : an official journal of the Society of Toxicology 20041101 |
| Muscle mechanoreceptor sensitivity in heart failure. | American journal of physiology. Heart and circulatory physiology 20041101 |
| Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP. | Biochemistry 20041026 |
| Role of the peroxisome proliferator-activated receptor alpha (PPARalpha) in responses to trichloroethylene and metabolites, trichloroacetate and dichloroacetate in mouse liver. | Toxicology 20041015 |
| Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. | Circulation research 20041015 |
| Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS. | Brain & development 20041001 |
| Batch-test study on the dechlorination of 1,1,1-trichloroethane in contaminated aquifer material by zero-valent iron. | Journal of contaminant hydrology 20041001 |
| Assessment of volume depletion in children with malaria. | PLoS medicine 20041001 |
| Direct detection of trace haloacetates in drinking water using microbore ion chromatography. Improved detector sensitivity using a hydroxide gradient and a monolithic ion-exchange type suppressor. | Journal of chromatography. A 20040827 |
| Binding and kinetic mechanisms of the Zeta class glutathione transferase. | The Journal of biological chemistry 20040806 |
| Haloacetic acids in the aquatic environment. Part I: macrophyte toxicity. | Environmental pollution (Barking, Essex : 1987) 20040801 |
| Haloacetic acids in the aquatic environment. Part II: ecological risk assessment. | Environmental pollution (Barking, Essex : 1987) 20040801 |
| Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases. | The American journal of pathology 20040801 |
| Mechanism of dichloroacetate-induced hypolactatemia in humans with or without cirrhosis. | Metabolism: clinical and experimental 20040801 |
| Ischemic heart disease: metabolic approaches to management. | Clinical cardiology 20040801 |
| Interactions in the tumor-promoting activity of carbon tetrachloride, trichloroacetate, and dichloroacetate in the liver of male B6C3F1 mice. | Toxicology 20040701 |
| Influence of DCA on pulmonary (.-)V(O2) kinetics during moderate-intensity cycle exercise. | Medicine and science in sports and exercise 20040701 |
| Determination of bromate and chlorinated haloacetic acids in bottled drinking water with chromatographic methods. | Chemosphere 20040601 |
| The effect of disinfection by-products and mutagenic activity on birth weight and gestational duration. | Environmental health perspectives 20040601 |
| Effects of dichloroacetate and ubiquinone infusions on glycolysis activity and thermal sensitivity during sepsis. | The Journal of laboratory and clinical medicine 20040601 |
| Effects of superoxide dismutase and polyclonal tumor necrosis factor-alpha antibodies on chloroacetate-induced cellular death and superoxide anion production by J774.A1 macrophages. | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20040601 |
| Experimental cancer studies of chlorinated by-products. | Toxicology 20040520 |
| Induction of peroxisome proliferation in cultured hepatocytes by a series of halogenated acetates. | Toxicology 20040503 |
| Formation of haloacetic acids during monochloramination. | Water research 20040501 |
| Glutathione transferase zeta-catalyzed bioactivation of dichloroacetic acid: reaction of glyoxylate with amino acid nucleophiles. | Chemical research in toxicology 20040501 |
| Dichloroacetate therapy attenuates the blood lactate response to submaximal exercise in patients with defects in mitochondrial energy metabolism. | The Journal of clinical endocrinology and metabolism 20040401 |
| Regulation of expression of tissue plasminogen activator and plasminogen activator inhibitor-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions. | American journal of obstetrics and gynecology 20040401 |
| Accurate determination of low pK values by (1)H NMR titration. | Talanta 20040310 |
| Dichloroacetate does not speed phase-II pulmonary VO2 kinetics following the onset of heavy intensity cycle exercise. | Pflugers Archiv : European journal of physiology 20040301 |
| [Treatment for mitochondrial diseases]. | No to hattatsu = Brain and development 20040301 |
| Hypomethylation of DNA and the insulin-like growth factor-II gene in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors. | Toxicology 20040301 |
| [Heart disease and diabetes: from pathophysiology to therapeutic options]. | Italian heart journal : official journal of the Italian Federation of Cardiology 20040301 |
| [Investigation of bromate, haloacetic acids and perchlorate in Beijing's drinking water]. | Huan jing ke xue= Huanjing kexue 20040301 |
| Prevention by methionine of dichloroacetic acid-induced liver cancer and DNA hypomethylation in mice. | Toxicological sciences : an official journal of the Society of Toxicology 20040201 |
| Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis. | Human molecular genetics 20040201 |
| Therapeutic effect and [123I]IMP SPECT findings of sodium dichloroacetate in a patient with MELAS. | Neurology 20040127 |
| Regulation of matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions. | Fertility and sterility 20040101 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20040101 |
| DBP levels in chlorinated drinking water: effect of humic substances. | Environmental monitoring and assessment 20040101 |
| Mechanistic implications of the effect of TiO2 accessibility in TiO2-SiO2 coatings upon chlorinated organics photocatalytic removal in water. | Water science and technology : a journal of the International Association on Water Pollution Research 20040101 |
| Evaluation of the combined solar TiO2/photo-Fenton process using multivariate analysis. | Water science and technology : a journal of the International Association on Water Pollution Research 20040101 |
| Textile wastewater treatment and reuse by solar catalysis: results from a pilot plant in Tunisia. | Water science and technology : a journal of the International Association on Water Pollution Research 20040101 |
| Elevated blood lactate is not a primary cause of anorexia in tumor-bearing rats. | Nutrition and cancer 20040101 |
| POSaM: a fast, flexible, open-source, inkjet oligonucleotide synthesizer and microarrayer. | Genome biology 20040101 |
| Bench-to-bedside review: treating acid-base abnormalities in the intensive care unit - the role of buffers. | Critical care (London, England) 20040101 |
| Chronic treatment of mitochondrial disease patients with dichloroacetate. | Molecular genetics and metabolism 20040101 |
| Therapy of cutaneous human Papillomavirus infections. | Dermatologic therapy 20040101 |
| Some drinking-water disinfectants and contaminants, including arsenic. | IARC monographs on the evaluation of carcinogenic risks to humans 20040101 |
| Some drinking-water disinfectants and contaminants, including arsenic. Monographs on chloramine, chloral and chloral hydrate, dichloroacetic acid, trichloroacetic acid and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone. | IARC monographs on the evaluation of carcinogenic risks to humans 20040101 |
| Evaluation of the influence of chloroacetic acids on the pharmacokinetics of trihalomethanes in the rat. | Journal of toxicology and environmental health. Part A 20031212 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20031201 |
| Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents. | Biochemical pharmacology 20031115 |
| Lactate as a modulator of hypoxia-induced hyperventilation. | Respiratory physiology & neurobiology 20031016 |
| Improvement of thermal hydrolysis rate of dichloroacetic acid using alcohol. | Chemosphere 20031001 |
| Pyruvate and acetate metabolism in termite mitochondria. | Journal of insect physiology 20031001 |
| The effects of dichloroacetate in a rabbit model of acute hind-limb ischemia and reperfusion. | Journal of the American College of Surgeons 20031001 |
| Effects of dichloroacetate on VO2 and intramuscular 31P metabolite kinetics during high-intensity exercise in humans. | Journal of applied physiology (Bethesda, Md. : 1985) 20030901 |
| Low-frequency modes of peptides and globular proteins in solution observed by ultrafast OHD-RIKES spectroscopy. | Biophysical journal 20030901 |
| Evidence for rapid 'metabolic switching' through lipoprotein lipase occupation of endothelial-binding sites. | Journal of molecular and cellular cardiology 20030901 |
| Multinuclear NMR investigations on the metabolic recovery of the isolated perfused mouse liver after cold preservation. | Biochimie 20030901 |
| Design and synthesis of novel pyridoxine 5'-phosphonates as potential antiischemic agents. | Journal of medicinal chemistry 20030814 |
| Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase. | Circulation research 20030808 |
| Perturbation of maleylacetoacetic acid metabolism in rats with dichloroacetic Acid-induced glutathione transferase zeta deficiency. | Toxicological sciences : an official journal of the Society of Toxicology 20030701 |
| Formation of chloroacetic acids from soil, humic acid and phenolic moieties. | Chemosphere 20030701 |
| Differential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heart. | American journal of physiology. Heart and circulatory physiology 20030701 |
| Efficacy of dichloroacetate as a lactate-lowering drug. | Journal of clinical pharmacology 20030701 |
| Airborne haloacetic acids. | Environmental science & technology 20030701 |
| Impairment of glucose metabolism and energy transfer in the rat heart. | Molecular and cellular biochemistry 20030701 |
| Determination of chloroacetates in atmospheric particulate matter. | Environmental science & technology 20030601 |
| The induction of oxidative stress and cellular death by the drinking water disinfection by-products, dichloroacetate and trichloroacetate in J774.A1 cells. | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20030601 |
| Vacancy ion-exclusion chromatography of haloacetic acids on a weakly acidic cation-exchange resin. | Journal of chromatography. A 20030516 |
| Differential effect of DCA treatment on the pyruvate dehydrogenase complex in patients with severe PDHC deficiency. | Pediatric research 20030501 |
| Field level evaluation and risk assessment of the toxicity of dichloroacetic acid to the aquatic macrophytes Lemna gibba, Myriophyllum spicatum, and Myriophyllum sibiricum. | Ecotoxicology and environmental safety 20030501 |
| Regulation of transforming growth factor-beta, type III collagen, and fibronectin by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions. | Fertility and sterility 20030501 |
| Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children. | Journal of clinical pharmacology 20030401 |
| Chloroacetic acids in European soils and vegetation. | Journal of environmental monitoring : JEM 20030401 |
| [Dichloroacetate treatment for adult patients with mitochondrial disease]. | Rinsho shinkeigaku = Clinical neurology 20030401 |
| Identification of trichloroethylene and its metabolites in human seminal fluid of workers exposed to trichloroethylene. | Drug metabolism and disposition: the biological fate of chemicals 20030301 |
| Pyruvate-dependent preconditioning and cardioprotection in murine myocardium. | Clinical and experimental pharmacology & physiology 20030301 |
| Physicochemical characterization of phosphinic pseudopeptides by capillary zone electrophoresis in highly acidic background electrolytes. | Electrophoresis 20030301 |
| Altered gene expression in mouse livers after dichloroacetic acid exposure. | Mutation research 20030301 |
| Dichloroacetate accelerates the fall in intracellular PO2 at onset of contractions in Xenopus single muscle fibers. | American journal of physiology. Regulatory, integrative and comparative physiology 20030201 |
| Measurement of 13C/12C of chloroacetic acids by gas chromatography/combustion/isotope ratio mass spectrometry. | Chemosphere 20030201 |
| Synthesis and immunogenic properties of phosphopeptides related to the human insulin receptor. | The journal of peptide research : official journal of the American Peptide Society 20030101 |
| A 2-year dose-response study of lesion sequences during hepatocellular carcinogenesis in the male B6C3F(1) mouse given the drinking water chemical dichloroacetic acid. | Environmental health perspectives 20030101 |
| [Adverse effects of dichloroacetate in a girl with mitochondrial disorder]. | No to hattatsu = Brain and development 20030101 |
| Dichloroacetate increases skeletal muscle pyruvate dehydrogenase activity during acute limb ischemia. | Vascular and endovascular surgery 20030101 |
| The NO - K+ channel axis in pulmonary arterial hypertension. Activation by experimental oral therapies. | Advances in experimental medicine and biology 20030101 |
| Cloning and in vitro and in vivo expression of plant glutathione S-transferase zeta class genes. | Journal of bioscience and bioengineering 20030101 |
| Nephrotoxicity of chlorofluoroacetic acid in rats. | Toxicological sciences : an official journal of the Society of Toxicology 20021201 |
| Metabolic regulation of collagen I in fibroblasts isolated from normal peritoneum and adhesions by dichloroacetic acid. | American journal of obstetrics and gynecology 20021201 |
| Brief increase in carbohydrate oxidation after reperfusion reverses myocardial stunning in conscious pigs. | Circulation 20021126 |
| Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats. | Carcinogenesis 20021101 |
| Mass spectral characterization of dichloroacetic acid-modified human glutathione transferase zeta. | Chemical research in toxicology 20021101 |
| The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure. | Herz 20021101 |
| Time-resolved optical Kerr-effect spectroscopy of low-frequency dynamics in Di-L-alanine, poly-L-alanine, and lysozyme in solution. | Journal of the American Chemical Society 20021016 |
| The acetyl group deficit at the onset of contraction in ischaemic canine skeletal muscle. | The Journal of physiology 20021015 |
| [Acute complications due to diabetes mellitus: Lactic acidosis]. | Nihon rinsho. Japanese journal of clinical medicine 20021001 |
| Is lactate a mediator of hypoxia-induced anapyrexia? | Pflugers Archiv : European journal of physiology 20020901 |
| Dichloroacetate stimulates glycogen accumulation in primary hepatocytes through an insulin-independent mechanism. | Toxicological sciences : an official journal of the Society of Toxicology 20020801 |
| Low-dose pharmacokinetics and oral bioavailability of dichloroacetate in naive and GST-zeta-depleted rats. | Environmental health perspectives 20020801 |
| Synthesis of optically active homocysteine from methionine and its use in preparing four stereoisomers of cystathionine. | Chemical & pharmaceutical bulletin 20020801 |
| Skeletal muscle metabolism is unaffected by DCA infusion and hyperoxia after onset of intense aerobic exercise. | American journal of physiology. Endocrinology and metabolism 20020701 |
| Bromochloroacetic acid exerts qualitative effects on rat sperm: implications for a novel biomarker. | Toxicological sciences : an official journal of the Society of Toxicology 20020701 |
| Manipulations in glycogen metabolism and the failure to influence infarct size in the ischaemic rabbit heart. | European journal of anaesthesiology 20020701 |
| Kinetics of the biotransformation of maleylacetone and chlorofluoroacetic acid by polymorphic variants of human glutathione transferase zeta (hGSTZ1-1). | Chemical research in toxicology 20020701 |
| Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene. | Toxicology and applied pharmacology 20020701 |
| Solar photodegradation of dichloroacetic acid and 2,4-dichlorophenol using an enhanced photo-Fenton process. | Chemosphere 20020701 |
| Dichloroacetate therapy in Leigh syndrome with a mitochondrial T8993C mutation. | Pediatric neurology 20020701 |
| Glutathione and K(+) channel remodeling in postinfarction rat heart. | American journal of physiology. Heart and circulatory physiology 20020601 |
| Immunohistochemical localization and activity of glutathione transferase zeta (GSTZ1-1) in rat tissues. | Drug metabolism and disposition: the biological fate of chemicals 20020601 |
| Dichloroacetate toxicokinetics and disruption of tyrosine catabolism in B6C3F1 mice: dose-response relationships and age as a modifying factor. | Toxicology 20020501 |
| Alkylation and inactivation of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetone. | Chemical research in toxicology 20020501 |
| Distribution of haloacetic acids in the water columns of the Laurentian Great Lakes and Lake Malawi. | Environmental science & technology 20020501 |
| New large solar photocatalytic plant: set-up and preliminary results. | Chemosphere 20020401 |
| [Drug therapy for mitochondrial diseases]. | Nihon rinsho. Japanese journal of clinical medicine 20020401 |
| An acetyl group deficit limits mitochondrial ATP production at the onset of exercise. | Biochemical Society transactions 20020401 |
| Genetic polymorphisms in assessing interindividual variability in delivered dose. | Regulatory toxicology and pharmacology : RTP 20020401 |
| Glucose-stimulated insulin secretion does not require activation of pyruvate dehydrogenase: impact of adenovirus-mediated overexpression of PDH kinase and PDH phosphate phosphatase in pancreatic islets. | Biochemical and biophysical research communications 20020308 |
| Pyruvate dehydrogenase and the regulation of glucose oxidation in hypertrophied rat hearts. | Cardiovascular research 20020301 |
| High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation. | Journal of the American College of Cardiology 20020220 |
| Measurement of interstitial lactate during hypoxia-induced dilatation in isolated pressurised porcine coronary arteries. | The Journal of physiology 20020215 |
| Monochloramine loss in the presence of humic acid. | Journal of environmental monitoring : JEM 20020201 |
| Degradation pathways of trichloroethylene and 1,1,1-trichloroethane by Mycobacterium sp. TA27. | Bioscience, biotechnology, and biochemistry 20020201 |
| Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels. | Circulation 20020115 |
| Enhanced pyruvate dehydrogenase activity does not affect muscle O2 uptake at onset of intense exercise in humans. | American journal of physiology. Regulatory, integrative and comparative physiology 20020101 |
| Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate. | The Journal of physiology 20020101 |
| Renal manifestations of congenital lactic acidosis. | American journal of kidney diseases : the official journal of the National Kidney Foundation 20020101 |
| Mouse models of Huntington's disease. | Trends in pharmacological sciences 20020101 |
| Analysis of the cytotoxicity and mutagenicity of drinking water disinfection by-products in Salmonella typhimurium. | Teratogenesis, carcinogenesis, and mutagenesis 20020101 |
| Mammalian cell cytotoxicity and genotoxicity analysis of drinking water disinfection by-products. | Environmental and molecular mutagenesis 20020101 |
| Trichloroethylene oxidative metabolism in plants: the trichloroethanol pathway. | Phytochemistry 20011201 |
| GSTZ1d: a new allele of glutathione transferase zeta and maleylacetoacetate isomerase. | Pharmacogenetics 20011101 |
| Dichloroacetate reduces diaphragmatic lactate formation but impairs respiratory performance. | American journal of respiratory and critical care medicine 20011101 |
| Effect of chloroform on dichloroacetic acid and trichloroacetic acid-induced hypomethylation and expression of the c-myc gene and on their promotion of liver and kidney tumors in mice. | Carcinogenesis 20010901 |
| Stereospecific toxicokinetics of bromochloro- and chlorofluoroacetate: effect of GST-zeta depletion. | Toxicology and applied pharmacology 20010901 |
| Changes of activity inducing chromosomal aberrations and transformations of chlorinated humic acid. | Water research 20010801 |
| Detection of early gene expression changes by differential display in the livers of mice exposed to dichloroacetic acid. | Carcinogenesis 20010801 |
| Nerve conduction changes in patients with mitochondrial diseases treated with dichloroacetate. | Muscle & nerve 20010701 |
| Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease. | Annals of neurology 20010701 |
| Hepatic and renal toxicities associated with perchloroethylene. | Pharmacological reviews 20010601 |
| Pyruvate/dichloroacetate supply during reperfusion accelerates recovery of cardiac energetics and improves mechanical function following cardioplegic arrest. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20010601 |
| Oxygen supply and oxidative phosphorylation limitation in rat myocardium in situ. | American journal of physiology. Heart and circulatory physiology 20010501 |
| Postischemic Na(+)-K(+)-ATPase reactivation is delayed in the absence of glycolytic ATP in isolated rat hearts. | American journal of physiology. Heart and circulatory physiology 20010501 |
| Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders. | Annals of neurology 20010501 |
| Exercise intolerance in mitochondrial myopathy is not related to lactic acidosis. | Annals of neurology 20010501 |
| Dichloroacetate improves cardiac efficiency after ischemia independent of changes in mitochondrial proton leak. | American journal of physiology. Heart and circulatory physiology 20010401 |
| Direct imaging of dehydrogenase activity within living cells using enzyme-dependent fluorescence recovery after photobleaching (ED-FRAP). | Biophysical journal 20010401 |
| Identification of novel glutathione transferases and polymorphic variants by expressed sequence tag database analysis. | Drug metabolism and disposition: the biological fate of chemicals 20010401 |
| Haloacetates in fog and rain. | Environmental science & technology 20010401 |
| Dichloroacetate: population pharmacokinetics with a pharmacodynamic sequential link model. | Journal of clinical pharmacology 20010301 |
| Study on the cytochrome P-450- and glutathione-dependent biotransformation of trichloroethylene in humans. | International archives of occupational and environmental health 20010301 |
| Photocatalytic degradation of gaseous perchloroethylene: products and pathway. | Chemosphere 20010201 |
| Dichloroacetate treatment for severe refractory metabolic acidosis during neonatal sepsis. | The Pediatric infectious disease journal 20010201 |
| Lactic acidosis update for critical care clinicians. | Journal of the American Society of Nephrology : JASN 20010201 |
| Diffusion-weighted image and MR spectroscopic analysis of a case of MELAS with repeated attacks. | Yonsei medical journal 20010201 |
| The fate and persistence of trifluoroacetic and chloroacetic acids in pond waters. | Chemosphere 20010101 |
| Effects of dichloroacetate (DCA) on serum insulin levels and insulin-controlled signaling proteins in livers of male B6C3F1 mice. | Toxicological sciences : an official journal of the Society of Toxicology 20010101 |
| The effect of dichloroacetic acid and trichloroacetic acid on DNA methylation and cell proliferation in B6C3F1 mice. | Journal of biochemical and molecular toxicology 20010101 |
| Differential effects of dihalogenated and trihalogenated acetates in the liver of B6C3F1 mice. | Journal of applied toxicology : JAT 20010101 |
| Lack of IL-6 production during exercise in patients with mitochondrial myopathy. | European journal of applied physiology 20010101 |
| [Benign infantile mitochondrial myopathy]. | Ryoikibetsu shokogun shirizu 20010101 |
| Novel mutations in a boy with dihydrolipoamide dehydrogenase deficiency. | Medical science monitor : international medical journal of experimental and clinical research 20010101 |
| Solar detoxification of wastewater in a novel aerated cascade photoreactor (ACP). | Water science and technology : a journal of the International Association on Water Pollution Research 20010101 |
| Use of structure-activity relationships for probing biochemical mechanisms: glutathione transferase zeta conjugation of haloacids. | Advances in experimental medicine and biology 20010101 |
| Trichloroethylene, trichloroacetic acid, and dichloroacetic acid: do they affect fetal rat heart development? | International journal of toxicology 20010101 |
| Gene transfer and metabolic modulators as new therapies for pulmonary hypertension. Increasing expression and activity of potassium channels in rat and human models. | Advances in experimental medicine and biology 20010101 |
| Role of metabolically active drugs in the management of ischemic heart disease. | American journal of cardiovascular drugs : drugs, devices, and other interventions 20010101 |
| Effect of trichloroethylene and its metabolites, dichloroacetic acid and trichloroacetic acid, on the methylation and expression of c-Jun and c-Myc protooncogenes in mouse liver: prevention by methionine. | Toxicological sciences : an official journal of the Society of Toxicology 20000401 |
| Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis. | Pharmacogenetics 20000201 |
| The effect of the trichloroethylene metabolites trichloroacetate and dichloroacetate on peroxisome proliferation and DNA synthesis in cultured human hepatocytes. | Cell biology and toxicology 20000101 |
| Expression of PPAR(alpha) in human hepatocytes and activation by trichloroacetate and dichloroacetate. | Research communications in molecular pathology and pharmacology 20000101 |
| trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals. | Toxicology and applied pharmacology 19991201 |
| Inhibition of glutathione S-transferase zeta and tyrosine metabolism by dichloroacetate: a potential unifying mechanism for its altered biotransformation and toxicity. | Biochemical and biophysical research communications 19990907 |
| Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids. | Environmental health perspectives 19980801 |
| Loss of heterozygosity on chromosome 6 in dichloroacetic acid and trichloroacetic acid-induced liver tumors in female B6C3F1 mice. | Cancer letters 19961129 |
| Effects of chemical pretreatment on posttraumatic cortical edema in the rat. | The American journal of emergency medicine 19960101 |
| ras proto-oncogene activation in dichloroacetic acid-, trichloroethylene- and tetrachloroethylene-induced liver tumors in B6C3F1 mice. | Carcinogenesis 19941001 |
| The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver. | Toxicology and applied pharmacology 19870915 |
| Toxic effects of chlorinated and brominated alkanoic acids on Pseudomonas putida PP3: selection at high frequencies of mutations in genes encoding dehalogenases. | Applied and environmental microbiology 19850601 |