Home Halogens 2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline hydrochloride

2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline hydrochloride

CAS No.:
611-75-6
Catalog Number:
AG003OJX
Molecular Formula:
C14H21Br2ClN2
Molecular Weight:
412.5909
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5g
98%
In Stock USA
United States
$13
- +
25g
98%
In Stock USA
United States
$25
- +
100g
98%
In Stock USA
United States
$63
- +
500g
98%
In Stock USA
United States
$163
- +
Product Description
Catalog Number:
AG003OJX
Chemical Name:
2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline hydrochloride
CAS Number:
611-75-6
Molecular Formula:
C14H21Br2ClN2
Molecular Weight:
412.5909
MDL Number:
MFCD00056626
IUPAC Name:
2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline;hydrochloride
InChI:
InChI=1S/C14H20Br2N2.ClH/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17;/h7-8,12H,2-6,9,17H2,1H3;1H
InChI Key:
UCDKONUHZNTQPY-UHFFFAOYSA-N
SMILES:
Brc1cc(CN(C2CCCCC2)C)c(c(c1)Br)N.Cl
EC Number:
210-280-8
UNII:
YC2ZOM3Z8V
NSC Number:
758383
Properties
Complexity:
256  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
411.974g/mol
Formal Charge:
0
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
412.594g/mol
Monoisotopic Mass:
409.976g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
29.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Solubility and solution stability studies of different amino acid prodrugs of bromhexine. Drug development and industrial pharmacy 20121101
Nuclear medicine imaging of neuroendocrine tumours. Clinical medicine (London, England) 20120801
Endonasal endoscopic approach for removal of intranasal nasal glial heterotopias. Rhinology 20120601
Increase in posterior tibial slope would result in correction loss in frontal plane after medial open-wedge high tibial osteotomy. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 20120301
Cyclodextrins: Efficient biocompatible solubilizing excipients for bromhexine liquid and semi-solid drug delivery systems. International journal of pharmaceutics 20120117
[Treatment of mild exacerbations of chronic obstructive pulmonary disease]. Klinicheskaia meditsina 20120101
74-year-old man from the pacific northwest with fever and a lung mass. Chest 20110901
The syntheses and characterization of molecularly imprinted polymers for the controlled release of bromhexine. Applied biochemistry and biotechnology 20110501
Pulmonary artery leiomyosarcoma: an unusual cause of shortness of breath. Irish journal of medical science 20110301
[Abdominal splenosis: an often underdiagnosed entity]. Revista espanola de medicina nuclear 20110101
Tuberculosis should not be ignored in patients with peripheral gangrene. Journal of vascular surgery 20101201
Diffuse lung disease in children. Pediatric annals 20101201
[Juvenile Gougerot Sjögren syndrome: report of 3 cases]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20101101
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
Superior mesenteric artery aneurysm: importance of sonography as the primary imaging technique for detection. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 20101001
[Comparative analysis of linear morphometric parameters of the humane mandibula obtained by direct and indirect measurement]. Vojnosanitetski pregled 20101001
Contaminations of herbal products determined by NMR fingerprint. Natural product research 20100901
Anatomical suitability for endovascular AAA repair may affect outcomes following rupture. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 20100801
Predicting prognosis in idiopathic pulmonary fibrosis. Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG 20100701
[Codeine and cutaneous drug reactions: Absence of cross-allergy with tramadol and fentanyl]. Annales de dermatologie et de venereologie 20100501
Efficacy, safety and tolerability of salbutamol + guaiphenesin + bromhexine (Ascoril) expectorant versus expectorants containing salbutamol and either guaiphenesin or bromhexine in productive cough: a randomised controlled comparative study. Journal of the Indian Medical Association 20100501
Quantification of the major metabolites of bromhexine in human plasma using RRLC-MS/MS and its application to pharmacokinetics. Journal of pharmaceutical and biomedical analysis 20100406
Effect of drug content and agglomerate size on tabletability and drug release characteristics of bromhexine hydrochloridetalc agglomerates prepared by crystallo-co-agglomeration. Acta pharmaceutica (Zagreb, Croatia) 20100301
Growing skull fracture in a 5-month old child: a case report. The West Virginia medical journal 20100101
Molecularly imprinted solid-phase extraction for the selective determination of bromhexine in human serum and urine with high performance liquid chromatography. Talanta 20091115
Solitary fibrous tumor of the lung: three rare cases of intraparenchymal nodules. Acta radiologica (Stockholm, Sweden : 1987) 20090501
[Acute mediastinitis--optimum diagnostic and therapeutic measures]. Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti 20090501
[Traumatic perforation of the duodenum--a case review]. Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti 20090201
Foetus-in-fetu: an unusual cause of abdominal mass in the newborn. Acta chirurgica Belgica 20090101
Pancreatic cancer metastasis to the rectum detected on colonoscopy. Endoscopy 20090101
The effect of retroperitoneal fat tissue thickness on testicular venous drainage. Urologia internationalis 20090101
Differential modulation of IgE-dependent activation of human basophils by ambroxol and related secretolytic analogues. International journal of immunopathology and pharmacology 20090101
Bioequivalence study of bromhexine by liquid chromatography-electrospray ionization-mass spectrometry after oral administration of bromhexine hydrochloride tablets. Journal of pharmaceutical and biomedical analysis 20081201
Challenges of utilizing immunostains to facilitate the diagnosis and management of metastatic adenocarcinoma. Journal of the National Medical Association 20081201
Huge ascending aortic pseudoaneurysm caused by a penetrating atherosclerotic ulcer. Circulation. Cardiovascular imaging 20081101
Pharyngolaryngeal sarcoidosis: report of 12 cases. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20080901
Unsuspected breast carcinoma presenting as orbital complication of rhinosinusitis. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20080801
Perinatal tumours: the contribution of radiology to management. Pediatric radiology 20080601
Posterior impingement syndromes of the ankle. Seminars in musculoskeletal radiology 20080601
Malignant medulloepithelioma of optic nerve head. Journal of pediatric hematology/oncology 20080601
Recent developments in the treatment of alcoholic chronic pancreatitis. Current drug abuse reviews 20080601
Oromandibular dystonia and persistent psychiatric symptoms in extra-pontine myelinolysis. The Journal of the Association of Physicians of India 20080401
The role of (124)I-PET in diagnosis and treatment of thyroid carcinoma. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... 20080301
Subjective pulsatile tinnitus associated with extensive pneumatization of temporal bone. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20080101
Chemiluminescence determination of bromhexine hydrochloride with morin as chemiluminescent reagent. Luminescence : the journal of biological and chemical luminescence 20080101
Successful resection of dermatomyositis associated with thymic carcinoma: report of a case. Surgery today 20080101
Three case reports of laparoscopic management of granulosa cell tumor with intraoperative rupture and subsequent upstaging. Journal of minimally invasive gynecology 20080101
[The history of antitussive and expectorants]. Pharmazie in unserer Zeit 20080101
Pulmonary Paragonimus westermani with false-positive fluorodeoxyglucose positron emission tomography mimicking primary lung cancer. General thoracic and cardiovascular surgery 20071101
Pharmacokinetic interaction between cefaclor and bromhexine in healthy Chinese volunteers. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20071001
Simultaneous determination of salbutamol sulphate, bromhexine hydrochloride and etofylline in pharmaceutical formulations with the use of four rapid derivative spectrophotometric methods. Analytica chimica acta 20070730
Design and evaluation of deformable talc agglomerates prepared by crystallo-co-agglomeration technique for generating heterogeneous matrix. AAPS PharmSciTech 20070727
Growth rate of locally recurrent hepatocellular carcinoma after transcatheter arterial chemoembolization: comparing the growth rate of locally recurrent tumor with that of primary hepatocellular carcinoma. Digestive diseases and sciences 20070301
Development and validation of chemometrics-assisted spectrophotometric and liquid chromatographic methods for the simultaneous determination of two multicomponent mixtures containing bronchodilator drugs. Journal of pharmaceutical and biomedical analysis 20070219
[Revision of the recommendations of the Commission on Pharmacotherapy of the German Society for Rheumatology. Recommendations for supportive therapy for Sjögren's syndrome]. Zeitschrift fur Rheumatologie 20070201
Acute cholecystitis due to strangulation of a floating gallbladder by the lesser omentum. Abdominal imaging 20070101
Hemorrhage into pancreatic pseudocyst. Abdominal imaging 20070101
Intravesical fat entrapment as a cause of failure of extraperitoneal bladder perforation to heal spontaneously. International urology and nephrology 20070101
[Abdominal tuberculosis in CT imaging]. Casopis lekaru ceskych 20070101
Kinetics of bromhexine-mediated down-regulation of focal adhesive molecules of uterus and trophectoderm affecting conception in the rat. Contraception 20060601
Cost-effectiveness of routine mediastinoscopy in computed tomography- and positron emission tomography-screened patients with stage I lung cancer. The Journal of thoracic and cardiovascular surgery 20060401
Plant-based formulation in the management of chronic obstructive pulmonary disease: a randomized double-blind study. Respiratory medicine 20060101
Progress and regression within primary Sjögren's syndrome. Scandinavian journal of rheumatology 20060101
Colovesical fistula complicating diverticular disease: one-stage resection. International surgery 20060101
Congenital aorto-azygous fistula treated with coil embolization: case report and review of the literature. Cardiovascular and interventional radiology 20060101
[Imaging of metabolic bone diseases]. Reumatizam 20060101
Effect of bromhexine hydrochloride therapy for alcoholic chronic pancreatitis. Alcoholism, clinical and experimental research 20051201
Congenital chylothorax associated with isolated congenital hypoplastic superior caval vein: a case report. Acta paediatrica (Oslo, Norway : 1992) 20051201
Gastrointestinal stromal tumor in a child and review of the literature. Pediatric surgery international 20051101
[A case of hepatocellular carcinoma complicating cardiac cirrhosis caused by constrictive pericarditis]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20050601
A case of a GH-producing pituitary adenoma associated with a unilateral headache with autonomic signs. The journal of headache and pain 20050601
Synchronous germinomas in the pineal and suprasellar region. Indian pediatrics 20050401
Simultaneous spectrophotometric determination of salbutamol and bromhexine in tablets. Farmaco (Societa chimica italiana : 1989) 20050301
Mediastinal pancreatic pseudocyst caused by obstruction of the pancreatic duct was eliminated by bromhexine hydrochloride. Internal medicine (Tokyo, Japan) 20041101
Metabolism of bromhexine in pig hepatocyte cultures. Journal of veterinary pharmacology and therapeutics 20040801
Three simultaneous dissolution profiles on a solid pharmaceutical formulation by a FIA manifold provided with a single spectrophotometric detector. Journal of pharmaceutical and biomedical analysis 20031204
In vitro inhibition of human neutrophil histotoxicity by ambroxol: evidence for a multistep mechanism. British journal of pharmacology 20031001
Simultaneous high-throughput determination of clenbuterol, ambroxol and bromhexine in pharmaceutical formulations by HPLC with potentiometric detection. Journal of pharmaceutical and biomedical analysis 20030808
[Use of mucoregulating drugs in combined therapy of exudative otitis media]. Vestnik otorinolaringologii 20030101
Stevens-Johnson syndrome presumably induced by bromhexine. A case report. Minerva stomatologica 20020401
Changing paradigms in the diagnosis and management of bronchiectasis. American journal of respiratory medicine : drugs, devices, and other interventions 20020101
Solubilization of bromhexine hydrochloride in aqueous lecithin dispersions. Physicochemical characterization of interactions between drug and carrier. Die Pharmazie 20010901
Efficacy and safety of Ascoril in the management of cough--National Study Group report. Journal of the Indian Medical Association 20010201
Determination of ambroxol or bromhexine in pharmaceuticals by capillary isotachophoresis. Journal of pharmaceutical and biomedical analysis 20010101
Mucolytics for bronchiectasis. The Cochrane database of systematic reviews 20010101
Activity of bromhexine and ambroxol, semi-synthetic derivatives of vasicine from the Indian shrub Adhatoda vasica, against Mycobacterium tuberculosis in vitro. Journal of ethnopharmacology 19960101
Systemic therapy of salivary gland hypofunction. Journal of dental research 19870201
[Cutaneous coumarin necrosis of the breast]. Deutsche medizinische Wochenschrift (1946) 19830916
Properties