Home Halogens 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine

5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine

CAS No.:
59803-98-4
Catalog Number:
AG003OJU
Molecular Formula:
C11H10BrN5
Molecular Weight:
292.1346
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
98%
In Stock USA
United States
$113
- +
5g
98%
In Stock USA
United States
$338
- +
10g
98%
In Stock USA
United States
$563
- +
25g
98%
In Stock USA
United States
$1063
- +
Product Description
Catalog Number:
AG003OJU
Chemical Name:
5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine
CAS Number:
59803-98-4
Molecular Formula:
C11H10BrN5
Molecular Weight:
292.1346
MDL Number:
MFCD00153878
IUPAC Name:
5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine
InChI:
InChI=1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)
InChI Key:
XYLJNLCSTIOKRM-UHFFFAOYSA-N
SMILES:
Brc1c(ccc2c1nccn2)NC1=NCCN1
UNII:
E6GNX3HHTE
NSC Number:
318825
Properties
Complexity:
308  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
291.012g/mol
Formal Charge:
0
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
292.14g/mol
Monoisotopic Mass:
291.012g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
62.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.6  
Literature
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A randomized, controlled comparison of macroscopic conjunctival hyperemia in patients treated with bimatoprost 0.01% or vehicle who were previously controlled on latanoprost. Clinical ophthalmology (Auckland, N.Z.) 20100101
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A network meta-analysis combined direct and indirect comparisons between glaucoma drugs to rank effectiveness in lowering intraocular pressure. Journal of clinical epidemiology 20091201
Functional autoradiography and gene expression analysis applied to the characterization of the alpha2-adrenergic system in the chicken brain. Journal of chemical neuroanatomy 20091201
Retinal oxidative stress induced by intraocular hypertension in rats may be ameliorated by brimonidine treatment and N-acetyl cysteine supplementation. Journal of glaucoma 20091201
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From the bedside to the bench and back again: predicting and improving the outcomes of SLT glaucoma therapy. Transactions of the American Ophthalmological Society 20091201
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Analysis of alpha2-adrenergic receptors and effect of brimonidine on matrix metalloproteinases and their inhibitors in human ciliary body. Investigative ophthalmology & visual science 20090901
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Possible neuroprotective effect of brimonidine in a mouse model of ischaemic optic neuropathy. Clinical & experimental ophthalmology 20090901
Intravitreal bevacizumab for the treatment of neovascular glaucoma associated with central retinal artery occlusion. Korean journal of ophthalmology : KJO 20090901
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A medical device/drug delivery system for treatment of glaucoma. Clinical & experimental optometry 20090701
Meta-analysis of medical intervention for normal tension glaucoma. Ophthalmology 20090701
Safety and tolerability of brimonidine purite 0.1% and brimonidine purite 0.15%: a meta-analysis of two phase 3 studies. Current medical research and opinion 20090701
Three-month, randomized, parallel-group comparison of brimonidine-timolol versus dorzolamide-timolol fixed-combination therapy. Current medical research and opinion 20090701
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Buprenorphine is a weak partial agonist that inhibits opioid receptor desensitization. The Journal of neuroscience : the official journal of the Society for Neuroscience 20090603
Intravitreal bevacizumab (Avastin) treatment of neovascular glaucoma in ocular ischemic syndrome. Korean journal of ophthalmology : KJO 20090601
Differential involvement of alpha1-adrenoceptors in vasoconstrictor responses to cooling in mouse plantar arteries in vitro and in vivo. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20090601
Changes in visual function after intraocular pressure reduction using antiglaucoma medications. Eye (London, England) 20090501
Modulation of inflammatory response via alpha2-adrenoceptor blockade in acute murine colitis. Clinical and experimental immunology 20090501
Noradrenergic control of associative synaptic plasticity by selective modulation of instructive signals. Neuron 20090416
Treatment of patients with primary open-angle glaucoma with a fixed combination of brimonidine 0.2%/timolol 0.5%: multicenter, open-label, observational study in Germany. Current medical research and opinion 20090401
Experimental and clinical evidence for brimonidine as an optic nerve and retinal neuroprotective agent: an evidence-based review. Archives of ophthalmology (Chicago, Ill. : 1960) 20090401
[Development of conjunctival hyperemia with the use of a fixed combination of latanoprost/timolol: systematic review and meta-analysis of clinical trials]. Archivos de la Sociedad Espanola de Oftalmologia 20090401
Brimonidine and apraclonidine as vasoconstrictors in adjustable strabismus surgery. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 20090401
Inherited mitochondrial optic neuropathies. Journal of medical genetics 20090301
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Intravitreal triamcinolone acetonide injection at the time of pars plana vitrectomy for retained lens material. Korean journal of ophthalmology : KJO 20090301
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha2-adrenoceptor ligands: searching for structure-activity relationships. Journal of medicinal chemistry 20090212
Effect of brimonidine on retinal ganglion cell survival in an optic nerve crush model. American journal of ophthalmology 20090201
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A rapid and sensitive LC/MS/MS assay for the quantitation of brimonidine in ocular fluids and tissues. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090115
Aceclidine, brimonidine tartrate, and dapiprazole: comparison of miotic effect and tolerability under different lighting conditions. Journal of cataract and refractive surgery 20090101
Pediatric systemic poisoning resulting from brimonidine ophthalmic drops. Pediatric emergency care 20090101
Association between isotretinoin use and central retinal vein occlusion in an adolescent with minor predisposition for thrombotic incidents: a case report. Journal of medical case reports 20090101
Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature. Nutrition & metabolism 20090101
Challenging issues in molecular-targeted therapy. Therapeutics and clinical risk management 20090101
Exposure to topical apraclonidine in children with glaucoma. Journal of glaucoma 20090101
Systematic review of intraocular pressure-lowering effects of adjunctive medications added to latanoprost. Ophthalmic research 20090101
Ophthalmologist attitudes regarding fixed combination treatment for glaucoma in the European Union. European journal of ophthalmology 20090101
Cardiorespiratory depression and hyperglycemia after unintentional ingestion of brimonidine in a neonate. European journal of ophthalmology 20090101
Current concepts in the pathophysiology of glaucoma. Indian journal of ophthalmology 20090101
Bilateral granulomatous uveitis as a side effect of topical brimonidine: two case reports. Bulletin de la Societe belge d'ophtalmologie 20090101
Alpha2 adrenoceptors modulate histamine release from sympathetic nerves in the guinea pig vas deferens. Neuropharmacology 20090101
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Intravitreal injection of tissue plasminogen activator as treatment for an occluded pars plana glaucoma tube. Clinical ophthalmology (Auckland, N.Z.) 20090101
Clinical efficacy and neuroprotective effects of brimonidine in the management of glaucoma and ocular hypertension. Clinical ophthalmology (Auckland, N.Z.) 20090101
A comfort comparison of travoprost BAK-free 0.004% versus latanoprost 0.005% in patients with primary open-angle glaucoma or ocular hypertension. Clinical ophthalmology (Auckland, N.Z.) 20090101
Preliminary results following the use of a fixed combination of timolol-brimonidine in patients with ocular hypertension and primary open-angle glaucoma. Clinical ophthalmology (Auckland, N.Z.) 20090101
Administration of the fixed combination of latanoprost 0.005% and timolol 0.5% in glaucoma patients with an intraocular pressure over 30 mmHg. Clinical ophthalmology (Auckland, N.Z.) 20090101
Intracameral dexamethasone reduces inflammation on the first postoperative day after cataract surgery in eyes with and without glaucoma. Clinical ophthalmology (Auckland, N.Z.) 20090101
Aerobic exercise and intraocular pressure in normotensive and glaucoma patients. BMC ophthalmology 20090101
Efficacy and safety of prostaglandin analogues in patients with predominantly primary open-angle glaucoma or ocular hypertension: a meta-analysis. Clinical ophthalmology (Auckland, N.Z.) 20090101
Effects of brinzolamide vs timolol as an adjunctive medication to latanoprost on circadian intraocular pressure control in primary open-angle glaucoma Japanese patients. Clinical ophthalmology (Auckland, N.Z.) 20090101
Study of the effects of ocular hypotensive drugs on number of neurons in the retinal ganglion layer in a rat experimental glaucoma. European journal of ophthalmology 20090101
Intracameral recombinant tissue plasminogen activator for refractory glaucoma secondary to a fungal corneal abscess. The open ophthalmology journal 20090101
Extensive facial skin pigmentation after latanoprost treatment. Cutaneous and ocular toxicology 20090101
Astrocyte and microglial activation in the lateral geniculate nucleus and visual cortex of glaucomatous and optic nerve transected primates. Molecular vision 20090101
Short and long term axotomy-induced ERG changes in albino and pigmented rats. Molecular vision 20090101
First-year treatment costs among new initiators of topical prostaglandin analogs. Clinical ophthalmology (Auckland, N.Z.) 20090101
Functional and morphological effects of laser-induced ocular hypertension in retinas of adult albino Swiss mice. Molecular vision 20090101
Immunohistochemical changes in rat retinas at various time periods of elevated intraocular pressure. Molecular vision 20090101
Role of prostaglandins and specific place in therapy of bimatoprost in the treatment of elevated intraocular pressure and ocular hypertension: A closer look at the agonist properties of bimatoprost and the prostamides. Clinical ophthalmology (Auckland, N.Z.) 20090101
The efficacy and safety of two fixed combinations: timolol-dorzolamide-brimonidine versus timolol-dorzolamide. A prospective, randomized, double-masked, multi-center, 6-month clinical trial. Annals of ophthalmology (Skokie, Ill.) 20090101
An eight-week, multicentric, randomized, interventional, open-label, phase 4, parallel comparison of the efficacy and tolerability of the fixed combination of timolol maleate 0.5%/brimonidine tartrate 0.2% versus fixed combination of timolol maleate 0.5%/dorzolamide 2% in patients with elevated intraocular pressure. Journal of glaucoma 20081201
Pericardium plug in the repair of the corneoscleral fistula after Ahmed Glaucoma Valve explantation. Korean journal of ophthalmology : KJO 20081201
Latanoprost ophthalmic solution in the treatment of open angle glaucoma or raised intraocular pressure: a review. Clinical ophthalmology (Auckland, N.Z.) 20081201
The trabecular bypass stent in a pseudophakic glaucoma patient: A 1-year follow-up. Clinical ophthalmology (Auckland, N.Z.) 20081201
Twenty-four-hour efficacy of the brimonidine/timolol fixed combination versus therapy with the unfixed components. Eye (London, England) 20081101
Efficacy, safety, and current applications of brimonidine. Expert opinion on drug safety 20081101
Alpha2 adrenergic modulation of NMDA receptor function as a major mechanism of RGC protection in experimental glaucoma and retinal excitotoxicity. Investigative ophthalmology & visual science 20081001
Adrenergic regulation of cAMP/protein kinase A pathway in corneal epithelium and endothelium. Ophthalmic research 20081001
Recent advances in pharmacotherapy of glaucoma. Indian journal of pharmacology 20081001
Miscellaneous. Indian journal of pharmacology 20081001
Comparison of allergy rates in glaucoma patients receiving brimonidine 0.2% monotherapy versus fixed-combination brimonidine 0.2%-timolol 0.5% therapy. Current medical research and opinion 20080901
Effect of brimonidine tartrate 0.15% on night-vision difficulty and contrast testing after refractive surgery. Journal of cataract and refractive surgery 20080901
Neodymium YAG laser and surgical synechiolysis of iridocapsular adhesions. Korean journal of ophthalmology : KJO 20080901
Clinical Ophthalmology and PubMed. Clinical ophthalmology (Auckland, N.Z.) 20080901
Brinzolamide ophthalmic suspension: a review of its pharmacology and use in the treatment of open angle glaucoma and ocular hypertension. Clinical ophthalmology (Auckland, N.Z.) 20080901
Fixed combination of topical brimonidine 0.2% and timolol 0.5% for glaucoma and uncontrolled intraocular pressure. Clinical ophthalmology (Auckland, N.Z.) 20080901
Oxidative stress plays a permissive role in alpha2-adrenoceptor-mediated events in immortalized SHR proximal tubular epithelial cells. Molecular and cellular biochemistry 20080801
Effects of advanced glycation end products-inductor glyoxal and hydrogen peroxide as oxidative stress factors on rat retinal organ cultures and neuroprotection by UK-14,304. Journal of neurochemistry 20080801
[Brimonidine intoxication in paediatrics. A presentation as intracranial hypertension syndrome]. Anales de pediatria (Barcelona, Spain : 2003) 20080801
Meta-analysis of 24-hour intraocular pressure studies evaluating the efficacy of glaucoma medicines. Ophthalmology 20080701
Noradrenergic and GABA B receptor activation differentially modulate inputs to the premotor nucleus RA in zebra finches. Journal of neurophysiology 20080701
Partial agonism at the human alpha(2A)-autoreceptor: role of binding duration. Naunyn-Schmiedeberg's archives of pharmacology 20080701
Brimonidine-purite 0.1% versus brimonidine-purite 0.15% twice daily in glaucoma or ocular hypertension: a 12-month randomized trial. Current medical research and opinion 20080701
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha2-adrenoceptor antagonists. 2. Exploring alkyl linkers for new antidepressants. Journal of medicinal chemistry 20080612
Letter to the editor regarding Gerente, V.M., Biondi, A.C., Barbosa, C.P., et al. Effect of brimonidine tartrate 0.15% on scotopic pupil: controlled trial. J. Ocul. Pharmacol. Ther 23:476-480, 2007. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080601
Efficacy of brimonidine tartrate 0.2% ophthalmic solution in reducing halos after laser in situ keratomileusis. Journal of cataract and refractive surgery 20080601
Pharmacological characterization of alpha2D-adrenergic receptor-mediated [35S]GTPgammaS binding in rat cerebral cortical membranes. Pharmacological research 20080601
Neurodegenerative diseases of the retina and potential for protection and recovery. Current neuropharmacology 20080601
Intravitreal triamcinolone acetonide: Pattern of secondary intraocular pressure rise and possible risk factors. Clinical ophthalmology (Auckland, N.Z.) 20080601
Efficacy and tolerability of a large scale change in regimen from latanoprost to travoprost in glaucoma patients at the Manhattan Veterans Administration Hospital. Clinical ophthalmology (Auckland, N.Z.) 20080601
A study of the safety and efficacy of travoprost 0.004%/timolol 0.5% ophthalmic solution compared to latanoprost 0.005% and timolol 0.5% dosed concomitantly in patients with open-angle glaucoma or ocular hypertension. Clinical ophthalmology (Auckland, N.Z.) 20080601
Costs and persistence of alpha-2 adrenergic agonists versus carbonic anhydrase inhibitors, both associated with prostaglandin analogues, for glaucoma as recorded by The United Kingdom General Practitioner Research Database. Clinical ophthalmology (Auckland, N.Z.) 20080601
Rational use of the fixed combination of dorzolamide - timolol in the management of raised intraocular pressure and glaucoma. Clinical ophthalmology (Auckland, N.Z.) 20080601
Inhibition of opioid release in the rat spinal cord by alpha2C adrenergic receptors. Neuropharmacology 20080501
Retinal ganglion cell neuroprotection in a rat model of glaucoma following brimonidine, latanoprost or combined treatments. Experimental eye research 20080501
Brimonidine purite 0.1% versus brinzolamide 1% as adjunctive therapy to latanoprost in patients with glaucoma or ocular hypertension. Current medical research and opinion 20080501
Alpha 1-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080401
Meta-analysis of randomized controlled trials comparing timolol with brimonidine in the treatment of glaucoma. Clinical & experimental ophthalmology 20080401
Alpha 2A-adrenoceptor-specific stimulation of [35S]GTP gamma S binding to membrane preparations of rat frontal cortex. Neurochemical research 20080301
ZP120 causes relaxation by pre-junctional inhibition of noradrenergic neurotransmission in rat mesenteric resistance arteries. British journal of pharmacology 20080301
Alpha2-adrenoceptors enhance angiotensin II-induced renal vasoconstriction: role for NADPH oxidase and RhoA. Hypertension (Dallas, Tex. : 1979) 20080301
Normal-tension glaucoma. Ophthalmology 20080301
Effects of central corneal thickness on the efficacy of topical ocular hypotensive medications. Journal of glaucoma 20080301
Central alpha-2 adrenergic eye drops: case series of 3 pediatric systemic poisonings. Pediatric emergency care 20080301
Managing refractory glaucoma with a fixed combination of bimatoprost (0.03%) and timolol (0.5%). Clinical ophthalmology (Auckland, N.Z.) 20080301
Noradrenergic vasoconstriction of pig prostatic small arteries. Naunyn-Schmiedeberg's archives of pharmacology 20080201
A pilot study of topical treatment with an alpha2-agonist in patients with retinal dystrophies. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080201
Prostaglandin analogues for ophthalmic use: a cost-effectiveness analysis. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20080201
New drug information. Combigan. JAAPA : official journal of the American Academy of Physician Assistants 20080201
Cost analysis of glaucoma medications. American journal of ophthalmology 20080101
The efficacy and harm of prostaglandin analogues for IOP reduction in glaucoma patients compared to dorzolamide and brimonidine: a systematic review. The British journal of ophthalmology 20080101
Drug modification of angiogenesis in a rat cornea model. Investigative ophthalmology & visual science 20080101
Comparison of the effects of dorzolamide-timolol fixed combination and brimonidine on intraocular pressure after phacoemulsification surgery. Eye & contact lens 20080101
Acute bilateral simultaneous angle closure glaucoma after topiramate administration: a case report. Journal of medical case reports 20080101
Reversible cicatricial ectropion precipitated by topical brimonidine eye drops. Ophthalmic plastic and reconstructive surgery 20080101
Brimonidine-induced anterior uveitis and conjunctivitis: clinical and histologic features. Journal of glaucoma 20080101
Good functional recovery following intervention for delayed suprachoroidal haemorrhage post bleb needling: a case report. Journal of medical case reports 20080101
Transconjunctival penetration of mitomycin C. Indian journal of ophthalmology 20080101
Practical approach to medical management of glaucoma. Indian journal of ophthalmology 20080101
Post-penetrating keratoplasty glaucoma. Indian journal of ophthalmology 20080101
Corneal edema following diode laser cyclophotocoagulation in an eye with secondary glaucoma. Indian journal of ophthalmology 20080101
Plasminogen activator inhibitor-1 4G/5G gene polymorphism and primary open-angle glaucoma. Molecular vision 20080101
Yohimbine-induced alterations in alpha(2)-adrenoceptors in kidney regions of the spontaneously hypertensive rats: an autoradiographic analysis. Pharmacological reports : PR 20080101
Apoptosis in the trabecular meshwork of glaucomatous patients. Molecular vision 20080101
Alpha-2 adrenergic-induced changes in rectal temperature in adult and 13-day old rats following acute and repeated desipramine administration. BMC pharmacology 20080101
A European perspective on costs and cost effectiveness of ophthalmic combinations in the treatment of open-angle glaucoma. European journal of ophthalmology 20080101
Absorption of brimonidine 0.1% and 0.15% ophthalmic solutions in the aqueous humor of cataract patients. Journal of glaucoma 20080101
Ocular parasitosis: a rare cause of hypertensive uveitis. Indian journal of ophthalmology 20080101
[Efficacy of topic ocular hipotensive agents after posterior capsulotomy]. Arquivos brasileiros de oftalmologia 20080101
Reporting of noninferiority and equivalence randomized trials for major prostaglandins: a systematic survey of the ophthalmology literature. Trials 20080101
Glaucoma alters the circadian timing system. PloS one 20080101
Phosphorylated neurofilament heavy chain is a marker of neurodegeneration in Leber hereditary optic neuropathy (LHON). Molecular vision 20080101
[Fixed combinations of glaucoma medications]. Oftalmologia (Bucharest, Romania : 1990) 20080101
Costs and persistence of brimonidine versus brinzolamide in everyday glaucoma care: an analysis conducted on the UK General Practitioner Research Database. Journal of medical economics 20080101
Medical management of primary open-angle glaucoma: Best practices associated with enhanced patient compliance and persistency. Patient preference and adherence 20080101
Efficacy and safety of brimonidine and dorzolamide for intraocular pressure lowering in glaucoma and ocular hypertension. Current medical research and opinion 20071201
Cystoid macular edema in a pseudophakic patient after switching from latanoprost to BAK-free travoprost. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20071201
Noradrenergic control of odor recognition in a nonassociative olfactory learning task in the mouse. Learning & memory (Cold Spring Harbor, N.Y.) 20071201
EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing. European journal of pharmacology 20071128
Alpha2-adrenergic receptors activate cyclic AMP-response element-binding protein through arachidonic acid metabolism and protein kinase A in a subtype-specific manner. Journal of neurochemistry 20071101
Effect of antiglaucoma agents on postoperative intraocular pressure after cataract surgery with Viscoat. Journal of cataract and refractive surgery 20071101
Medical interventions for primary open angle glaucoma and ocular hypertension. The Cochrane database of systematic reviews 20071017
The alpha2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats. American journal of physiology. Cell physiology 20071001
Brimonidine 0.2% versus brimonidine Purite 0.15% in Asian ocular hypertension. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20071001
Effect of brimonidine tartrate 0.15% on scotopic pupil: controlled trial. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20071001
The use of dorzolamide versus other hypotensive agents to prevent glaucomatous progression. Therapeutics and clinical risk management 20071001
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha(2)-adrenoceptor antagonists, 1: toward new antidepressants with heteroatomic linkers. Journal of medicinal chemistry 20070906
Effects of topical clonidine versus brimonidine on choroidal blood flow and intraocular pressure during squatting. Investigative ophthalmology & visual science 20070901
Effect of prophylactic brimonidine instillation on bleeding during strabismus surgery in adults. American journal of ophthalmology 20070901
Unintentional ingestion of brimonidine antiglaucoma drops: a case report and review of the literature. Pediatric emergency care 20070901
Intravitreal bevacizumab: an analysis of the evidence. Clinical ophthalmology (Auckland, N.Z.) 20070901
Cooling augments vasoconstriction mediated by 5-HT1 and alpha2-adrenoceptors in the isolated equine digital vein: involvement of Rho kinase. European journal of pharmacology 20070827
Neuroprotective effect of topically applied brimonidine tartrate 0.2% in endothelin-1-induced optic nerve ischaemia model. Clinical & experimental ophthalmology 20070801
Ocular comfort of combination glaucoma therapies: brimonidine 0.2%/timolol 0.5% compared with dorzolamide 2%/timolol 0.5%. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070801
Brimonidine for anisocoria. Ophthalmology 20070701
Comparison of the ocular hypotensive efficacy of adjunctive brimonidine 0.15% or brinzolamide 1% in combination with travoprost 0.004%. Ophthalmology 20070701
[Depression of respiration via toxic effects on the central nervous system following use of topical brimonidine in an infant with congenital glaucoma]. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20070601
Alpha2A adrenergic receptor activation inhibits epileptiform activity in the rat hippocampal CA3 region. Molecular pharmacology 20070601
Special considerations in low-tension glaucoma. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20070601
Bilateral spontaneous anterior lens dislocation in a retinitis pigmentosa patient. Korean journal of ophthalmology : KJO 20070601
Expression of adrenergic receptors in mouse preimplantation embryos and ovulated oocytes. Reproduction (Cambridge, England) 20070601
Presynaptic modulation of 5-HT release in the rat septal region. Neuroscience 20070511
Presynaptic alpha-adrenoceptors in median preoptic nucleus modulate inhibitory neurotransmission from subfornical organ and organum vasculosum lamina terminalis. American journal of physiology. Regulatory, integrative and comparative physiology 20070501
Characterization of the postjunctional alpha 2C-adrenoceptor mediating vasoconstriction to UK14304 in porcine pulmonary veins. British journal of pharmacology 20070501
Reduced ocular allergy with fixed-combination 0.2% brimonidine-0.5% timolol. Archives of ophthalmology (Chicago, Ill. : 1960) 20070501
Fixed-combination and emerging glaucoma therapies. Expert opinion on emerging drugs 20070501
Effects of brimonidine ingestion on cardiovascular responses and renal function in conscious dogs. Veterinary research communications 20070401
Comparing the fixed combination brimonidine-timolol versus fixed combination dorzolamide-timolol in patients with elevated intraocular pressure. Current medical research and opinion 20070401
Visual field and intraocular pressure asymmetry in the low-pressure glaucoma treatment study. Ophthalmology 20070301
Cathine, an amphetamine-related compound, acts on mammalian spermatozoa via beta1- and alpha2A-adrenergic receptors in a capacitation state-dependent manner. Human reproduction (Oxford, England) 20070301
Alpha2 adrenergic receptor-mediated modulation of cytosolic Ca++ signals at the inner plexiform layer of the rat retina. Investigative ophthalmology & visual science 20070301
Cellular cytotoxicity of antiglaucoma drugs in cultured corneal endothelial cells. The Kaohsiung journal of medical sciences 20070301
Travoprost in the management of open-angle glaucoma and ocular hypertension. Clinical ophthalmology (Auckland, N.Z.) 20070301
Electrophysiological properties of catecholaminergic neurons in the norepinephrine-deficient mouse. Neuroscience 20070209
Antinociception mediated by alpha(2)-adrenergic activation involves increasing tumor necrosis factor alpha (TNFalpha) expression and restoring TNFalpha and alpha(2)-adrenergic inhibition of norepinephrine release. Neuropharmacology 20070201
Neuroprotective effects of brimonidine treatment in a rodent model of ischemic optic neuropathy. Experimental eye research 20070201
Drug-induced ectropion: what is best practice? Ophthalmology 20070201
Characterization of benzimidazole and other oxidative and conjugative metabolites of brimonidine in vitro and in rats in vivo using on-line HID exchange LC-MS/MS and stable-isotope tracer techniques. Xenobiotica; the fate of foreign compounds in biological systems 20070201
Measurement of inflammatory cytokines by multicytokine assay in tears of patients with glaucoma topically treated with chronic drugs. The British journal of ophthalmology 20070101
Meta-analysis of randomised controlled trials comparing latanoprost with brimonidine in the treatment of open-angle glaucoma, ocular hypertension or normal-tension glaucoma. The British journal of ophthalmology 20070101
Grand rounds: could occupational exposure to n-hexane and other solvents precipitate visual failure in leber hereditary optic neuropathy? Environmental health perspectives 20070101
Pharmacologic management of glaucoma in childhood. Paediatric drugs 20070101
Inhibition by brimonidine of forskolin-induced nitric oxide synthase expression in human ciliary bodies in vitro. Molecular vision 20070101
Ocular hypotensive efficacy of brimonidine 0.15% as adjunctive therapy with latanoprost 0.005% in patients with open-angle glaucoma or ocular hypertension. Advances in therapy 20070101
Unilateral dysphotopsia after bilateral intraocular lens implantation using the AR40e IOL model: case report. Arquivos brasileiros de oftalmologia 20070101
Alteration of retinal intrinsic survival signal and effect of alpha2-adrenergic receptor agonist in the retina of the chronic ocular hypertension rat. Visual neuroscience 20070101
Changes in medical and surgical treatments of glaucoma between 1997 and 2003 in France. European journal of ophthalmology 20070101
Agmatine protects retinal ganglion cells from hypoxia-induced apoptosis in transformed rat retinal ganglion cell line. BMC neuroscience 20070101
Interpretation of uniocular and binocular trials of glaucoma medications: an observational case series. BMC ophthalmology 20070101
Estrogen is not neuroprotective in a rodent model of optic nerve stroke. Molecular vision 20070101
Daily cost of glaucoma medications in China. Journal of glaucoma 20070101
The presence of beta2-adrenoceptors sensitizes alpha2A-adrenoceptors to desensitization after chronic epinephrine treatment. BMC pharmacology 20070101
[Neuroprotection in glaucoma]. Annales Academiae Medicae Stetinensis 20070101
Functional interaction between alpha2-adrenoceptors, mu- and kappa-opioid receptors in the guinea pig myenteric plexus: effect of chronic desipramine treatment. European journal of pharmacology 20061228
The growth factor response in ischemic rat retina and superior colliculus after brimonidine pre-treatment. Brain research bulletin 20061211
Mechanisms underlying lysophosphatidylcholine-induced potentiation of vascular contractions in the Otsuka Long-Evans Tokushima Fatty (OLETF) rat aorta. British journal of pharmacology 20061201
Non-systemic delivery of topical brimonidine to the brain: a neuro-ocular tissue distribution study. Journal of drug targeting 20061201
Editorial foreword. Therapeutics and clinical risk management 20061201
Brimonidine in the treatment of glaucoma and ocular hypertension. Therapeutics and clinical risk management 20061201
Effect of Proview self-tonometry on pharmaceutical compliance. Clinical & experimental optometry 20061101
Enaminones and norepinephrine employ convergent mechanisms to depress excitatory synaptic transmission in the rat nucleus accumbens in vitro. The European journal of neuroscience 20061101
Allergic contact dermatitis caused by topical eye drops. American journal of ophthalmology 20061001
Alpha2C-adrenergic receptors exhibit enhanced surface expression and signaling upon association with beta2-adrenergic receptors. The Journal of pharmacology and experimental therapeutics 20060901
Successful management of orbital cellulitis and temporary visual loss after blepharoplasty. Plastic and reconstructive surgery 20060901
Twice-daily 0.2% brimonidine-0.5% timolol fixed-combination therapy vs monotherapy with timolol or brimonidine in patients with glaucoma or ocular hypertension: a 12-month randomized trial. Archives of ophthalmology (Chicago, Ill. : 1960) 20060901
Evidence against alpha-adrenoceptors mediating relaxation in rat thoracic aortae: alpha-agonists relaxation depends on interaction with alpha-adrenoceptors. Fundamental & clinical pharmacology 20060801
The safety and intraocular pressure-lowering efficacy of brimonidine tartrate 0.15% preserved with polyquaternium-1. Ophthalmology 20060801
Vitreous concentration of topically applied brimonidine-purite 0.15%. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20060801
Receptors involved in moxonidine-stimulated atrial natriuretic peptide release from isolated normotensive rat hearts. European journal of pharmacology 20060710
Brimonidine evokes heterogeneous vasomotor response of retinal arterioles: diminished nitric oxide-mediated vasodilation when size goes small. American journal of physiology. Heart and circulatory physiology 20060701
Effects of topical hypotensive drugs on circadian IOP, blood pressure, and calculated diastolic ocular perfusion pressure in patients with glaucoma. Investigative ophthalmology & visual science 20060701
K(+)-evoked [(3)H]-norepinephrine release in human brain slices from epileptic and non-epileptic patients is differentially modulated by gabapentin and pinacidil. Neuroscience research 20060601
Progression of visual field defects in leber hereditary optic neuropathy: experience of the LHON treatment trial. American journal of ophthalmology 20060601
A rat model for acute rise in intraocular pressure: immune modulation as a therapeutic strategy. American journal of ophthalmology 20060601
An evaluation of the rate of nonresponders to latanoprost therapy. Journal of glaucoma 20060601
Is brimonidine ophthalmic a safe therapy for infants? Journal of clinical pharmacy and therapeutics 20060601
Brimonidine 0.2% versus brimonidine Purite 0.15%: prophylactic effect on iop elevation after Nd:YAG laser posterior capsulotomy. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20060601
Triamcinolone-induced intraocular pressure elevation: intravitreal injection for macular edema and posterior subtenon injection for uveitis. Korean journal of ophthalmology : KJO 20060601
The management of glaucoma and intraocular hypertension: current approaches and recent advances. Therapeutics and clinical risk management 20060601
Efficacy and tolerability of 0.2% brimonidine tartrate for the treatment of acute non-arteritic anterior ischemic optic neuropathy (NAION): a 3-month, double-masked, randomised, placebo-controlled trial. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20060501
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Acute vibration increases alpha2C-adrenergic smooth muscle constriction and alters thermosensitivity of cutaneous arteries. Journal of applied physiology (Bethesda, Md. : 1985) 20060401
Severe photic phenomenon. Journal of cataract and refractive surgery 20060401
Comparative analysis of the effects of brimonidine and dorzolamide on ocular blood flow velocity in patients with newly diagnosed primary open-angle glaucoma. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20060401
A randomized, investigator-masked, 4-week study comparing timolol maleate 0.5%, brinzolamide 1%, and brimonidine tartrate 0.2% as adjunctive therapies to travoprost 0.004% in adults with primary open-angle glaucoma or ocular hypertension. Clinical therapeutics 20060401
Effects of a topical alpha2 adrenergic agonist on ciliary blood flow and aqueous production in rabbits. Experimental eye research 20060301
Acute and long-term administration of citalopram desensitizes alpha2-adrenoceptors in the rat vas deferens. The Journal of pharmacy and pharmacology 20060301
[Ocular hypertension in children treated with brimonidine 0.2%. A clinical study]. Archivos de la Sociedad Espanola de Oftalmologia 20060301
Argon laser trabeculoplasty and reduction of ocular hypotensive medication used by glaucoma patients. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20060201
Impairment of presynaptic alpha2-adrenoceptor-regulated norepinephrine overflow in failing hearts from Zucker diabetic fatty rats. Journal of cardiovascular pharmacology 20060201
Effects of antiglaucoma drugs on calcium mobility in cultured corneal endothelial cells. The Kaohsiung journal of medical sciences 20060201
Characterization of brimonidine transport in retinal pigment epithelium. Investigative ophthalmology & visual science 20060101
Insertion of a foldable hydrophobic IOL through the trabeculectomy fistula in cases with microincision cataract surgery combined with trabeculectomy. BMC ophthalmology 20060101
Bilateral acute angle closure glaucoma as a presentation of isolated microspherophakia in an adult: case report. BMC ophthalmology 20060101
[Intraocular pressure after ND: YAG laser capsulotomy in pseudophakic patients with glaucoma]. Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti 20060101
[Use of antiglaucoma therapy to reduce acute intraocular pressure rise following neodymium: YAG laser iridotomy in angle-closure glaucoma patients]. Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti 20060101
Topical brimonidine 0.2%/timolol 0.5% ophthalmic solution: in glaucoma and ocular hypertension. Drugs & aging 20060101
Brimonidine/Timolol: a viewpoint by Richard Fiscella. Drugs & aging 20060101
Brimonidine/Timolol: a viewpoint by Robert M. Feldman. Drugs & aging 20060101
Brimonidine/Timolol: a viewpoint by Francisco J. Goñi. Drugs & aging 20060101
Imidazoline receptors in relaxation of acetylcholine-constricted isolated rat jejunum. Pharmacological reports : PR 20060101
Side-effect profile of brimonidine tartrate in children. Ophthalmology 20051201
Comparison of the effects of brimonidine 0.2% and timolol 0.5% on retinal nerve fiber layer thickness in ocular hypertensive patients: a prospective, unmasked study. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20051201
The effects of anesthetics and ethanol on alpha2 adrenoceptor subtypes expressed with G protein-coupled inwardly rectifying potassium channels in Xenopus oocytes. Anesthesia and analgesia 20051101
[Late endophthalmitis following Ahmed valve]. Archivos de la Sociedad Espanola de Oftalmologia 20051101
Loss of association between activated Galpha q and Gbetagamma disrupts receptor-dependent and receptor-independent signaling. Cellular signalling 20051001
Ischemia results 3 months later in altered ERG, degeneration of inner layers, and deafferented tectum: neuroprotection with brimonidine. Investigative ophthalmology & visual science 20051001
[The effect of brimonidine on the pupillary reflex. A pupillographic study in healthy volunteers]. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20050901
Topical brimonidine reduces collateral damage caused by laser photocoagulation for choroidal neovascularization. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20050901
Mechanism of the vascular angiotensin II/alpha2-adrenoceptor interaction. The Journal of pharmacology and experimental therapeutics 20050901
Prophylaxis for second eye involvement in leber hereditary optic neuropathy: an open-labeled, nonrandomized multicenter trial of topical brimonidine purite. American journal of ophthalmology 20050901
Minimally invasive, direct, real time measurement of drug concentration in the anterior eye. The British journal of ophthalmology 20050901
Effect of brimonidine on pupil diameter. Journal of cataract and refractive surgery 20050901
Brimonidine 0.15% versus apraclonidine 0.5% for prevention of intraocular pressure elevation after anterior segment laser surgery. Journal of cataract and refractive surgery 20050901
Two 'knockout' mouse models demonstrate that aortic vasodilatation is mediated via alpha2a-adrenoceptors located on the endothelium. The Journal of pharmacology and experimental therapeutics 20050801
Proteomic exploration of pancreatic islets in mice null for the alpha2A adrenergic receptor. Journal of molecular endocrinology 20050801
Brimonidine and timolol fixed-combination therapy versus monotherapy: a 3-month randomized trial in patients with glaucoma or ocular hypertension. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20050801
Oxytocin increases the density of high affinity alpha(2)-adrenoceptors within the hypothalamus, the amygdala and the nucleus of the solitary tract in ovariectomized rats. Brain research 20050712
alpha(2)-Adrenoceptor involvement in the in vitro inhibitory effect of citalopram on a subpopulation of rat locus coeruleus neurons. European journal of pharmacology 20050704
Bilateral retinal venous occlusion in pigmentary glaucoma. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20050701
Influence of the membrane lipid structure on signal processing via G protein-coupled receptors. Molecular pharmacology 20050701
Intraocular pressure-lowering effects of all commonly used glaucoma drugs: a meta-analysis of randomized clinical trials. Ophthalmology 20050701
Brimonidine versus dapiprazole: Influence on pupil size at various illumination levels. Journal of cataract and refractive surgery 20050701
Cost considerations of the new fixed combinations for glaucoma medical therapy. Journal of clinical pharmacy and therapeutics 20050601
Prediction of genotoxicity of chemical compounds by statistical learning methods. Chemical research in toxicology 20050601
Water-drinking test in patients with primary open-angle glaucoma while treated with different topical medications. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20050601
Prospective survey of adverse reactions to topical antiglaucoma medications in a hospital population. Eye (London, England) 20050401
Phenylpropanolamine constricts mouse and human blood vessels by preferentially activating alpha2-adrenoceptors. The Journal of pharmacology and experimental therapeutics 20050401
Involvement of G i/o proteins in nerve growth factor-stimulated phosphorylation and degradation of tuberin in PC-12 cells and cortical neurons. Molecular pharmacology 20050401
The effect of combination pharmacotherapy on the prescription trends of glaucoma medications. Journal of glaucoma 20050401
Latanoprost or brimonidine as treatment for elevated intraocular pressure: multicenter trial in the United States. Journal of glaucoma 20050401
24-hour intraocular pressures with brimonidine purite versus dorzolamide added to latanoprost in primary open-angle glaucoma subjects. Ophthalmology 20050401
Effect of tumor necrosis factor-alpha on the reciprocal G-protein-induced regulation of norepinephrine release by the alpha2-adrenergic receptor. Journal of neuroscience research 20050315
An unusual appearance of limbal conjunctival follicles in a patient on brimonidine and dorzolamide. Eye (London, England) 20050301
The Low-pressure Glaucoma Treatment Study (LoGTS) study design and baseline characteristics of enrolled patients. Ophthalmology 20050301
[Drug induced uveitis]. Archivos de la Sociedad Espanola de Oftalmologia 20050301
Comparison of additional intraocular pressure-lowering effects of latanoprost vs brimonidine in primary open-angle glaucoma patients with intraocular pressure uncontrolled by timolol-dorzolamide combination. Eye (London, England) 20050201
Alphagan allergy may increase the propensity for multiple eye-drop allergy. Eye (London, England) 20050201
Comparison of the efficacy and safety of dorzolamide 2% when added to brimonidine 0.2% or timolol maleate 0.5% in patients with primary open-angle glaucoma. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20050201
Brimonidine 0.2% vs unoprostone 0.15% both added to timolol maleate 0.5% given twice daily to patients with primary open-angle glaucoma or ocular hypertension. Eye (London, England) 20050101
Heterologous desensitization of insulin secretion by GIP (glucose-dependent insulinotropic peptide) in INS-1 cells: the significance of Galphai2 and investigations on the mechanism involved. Cell biochemistry and function 20050101
Effects of glaucoma drugs on ocular hemodynamics in normal tension glaucoma: a randomized trial comparing bimatoprost and latanoprost with dorzolamide [ISRCTN18873428]. BMC ophthalmology 20050101
Effect of prophylactic brimonidine on bleeding complications after cataract surgery. European journal of ophthalmology 20050101
Comparing brimonidine 0.2% to apraclonidine 1.0% in the prevention of intraocular pressure elevation and their pupillary effects following laser peripheral iridotomy. Japanese journal of ophthalmology 20050101
An antidepressant mechanism of desipramine is to decrease tumor necrosis factor-alpha production culminating in increases in noradrenergic neurotransmission. Neuroscience 20050101
12-week study comparing the fixed combination of brimonidine and timolol with concomitant use of the individual components in patients with glaucoma and ocular hypertension. European journal of ophthalmology 20050101
Differential gene expression in anatomical compartments of the human eye. Genome biology 20050101
[Contemporary possibilities and perspectives in the treatment of glaucoma]. Annales Academiae Medicae Stetinensis 20050101
[Anterior uveitis and topical brimonidine: a case report]. Journal francais d'ophtalmologie 20041201
Intravitreal triamcinolone injection for diabetic macular edema: a clinical and fluorescein angiographic case series. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20041201
Polycarboxylic acid nanoparticles for ophthalmic drug delivery: an ex vivo evaluation with human cornea. Journal of microencapsulation 20041201
The efficacy of topical administration of brimonidine to reduce ischaemia in the very early stage of diabetic retinopathy in good controlled type-2 diabetes mellitus. Journal of the Indian Medical Association 20041201
Regulation of cAMP levels in area CA1 of hippocampus by Gi/o-coupled receptors is stimulus dependent in mice. Neuroscience letters 20041103
The role of Rho kinase and extracellular regulated kinase-mitogen-activated protein kinase in alpha2-adrenoceptor-mediated vasoconstriction in the porcine palmar lateral vein. The Journal of pharmacology and experimental therapeutics 20041101
Efficacy and safety of the latanoprost/timolol maleate fixed combination vs concomitant brimonidine and latanoprost therapy. Eye (London, England) 20041001
Lys-[Leu8,des-Arg9]-bradykinin blocks lipopolysaccharide-induced SHR aorta hyperpolarization by inhibition of Ca(++)- and ATP-dependent K+ channels. European journal of pharmacology 20040913
Loss of endothelial KATP channel-dependent, NO-mediated dilation of endocardial resistance coronary arteries in pigs with left ventricular hypertrophy. British journal of pharmacology 20040901
Chronic morphine treatment reduces recovery from opioid desensitization. The Journal of neuroscience : the official journal of the Society for Neuroscience 20040901
Diurnal intraocular pressure and blood pressure with two dosing regimens of brimonidine in normal tension glaucoma. Journal of the Chinese Medical Association : JCMA 20040901
Ligand-induced alpha2-adrenoceptor endocytosis: relationship to Gi protein activation. Biochemical and biophysical research communications 20040813
[Cost-effectivity analysis of the most used antiglaucoma drugs]. Archivos de la Sociedad Espanola de Oftalmologia 20040801
Miotic effect of brimonidine tartrate 0.15% ophthalmic solution in normal eyes. Journal of cataract and refractive surgery 20040801
Effect of brimonidine tartrate 0.2% ophthalmic solution on pupil size. Journal of cataract and refractive surgery 20040801
Effect of topical brinzolamide 1% and brimonidine 0.2% on intraocular pressure after phacoemulsification. Journal of cataract and refractive surgery 20040801
Effects of the preservative purite on the bioavailability of brimonidine in the aqueous humor of rabbits. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040801
The comparative cardiovascular, pulmonary, ocular blood flow, and ocular hypotensive effects of topical travoprost, bimatoprost, brimonidine, and betaxolol. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040801
[Neuroprotection and regeneration after traumatic lesion of the optic nerve]. Klinische Monatsblatter fur Augenheilkunde 20040801
alpha2-Adrenergic receptor-mediated modulation of calcium current in neocortical pyramidal neurons. Brain research 20040716
A comparison of the fixed combination of latanoprost and timolol with the unfixed combination of brimonidine and timolol in patients with elevated intraocular pressure. A six month, evaluator masked, multicentre study in Europe. The British journal of ophthalmology 20040701
Brimonidine purite 0.15% versus dorzolamide 2% each given twice daily to reduce intraocular pressure in subjects with open angle glaucoma or ocular hypertension. The British journal of ophthalmology 20040701
The effect of daily use of brimonidine tartrate on the dark-adapted pupil diameter. American journal of ophthalmology 20040701
Anterior uveitis and concurrent allergic conjunctivitis associated with long-term use of topical 0.2% brimonidine tartrate. Archives of ophthalmology (Chicago, Ill. : 1960) 20040701
Trends in glaucoma surgery before and after the introduction of new topical glaucoma pharmacotherapies. Journal of glaucoma 20040601
Inhibition of endothelin-1 and KCL-induced increase of [CA2+]i by antiglaucoma drugs in cultured A7r5 vascular smooth-muscle cells. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040601
Comparative study of the effects of desipramine and reboxetine on locus coeruleus neurons in rat brain slices. Neuropharmacology 20040501
Charles Bonnet syndrome and brimonidine: comments. The British journal of ophthalmology 20040501
Adrenoceptor agonist poisoning after accidental oral ingestion of brimonidine eye drops. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20040501
Increased tyrosine phosphorylation mediates the cooling-induced contraction and increased vascular reactivity of Raynaud's disease. Arthritis and rheumatism 20040501
Glaucoma management in developing countries: medical, laser, and surgical options for glaucoma management in countries with limited resources. Current opinion in ophthalmology 20040401
Fixed combinations of topical glaucoma medications. Current opinion in ophthalmology 20040401
Management of inflammatory glaucomas. Current opinion in ophthalmology 20040401
Tonopen measurement of intraocular pressure in mice. Experimental eye research 20040401
The safety and efficacy of unoprostone 0.15% versus brimonidine 0.2%. Acta ophthalmologica Scandinavica 20040401
Dorzolamide/Timolol fixed combination versus concomitant administration of brimonidine and timolol in patients with elevated intraocular pressure: a 3-month comparison of efficacy, tolerability, and patient-reported measures. Journal of glaucoma 20040401
Demographic and clinical factors associated with development of brimonidine tartrate 0.2%-induced ocular allergy. Journal of glaucoma 20040401
Comparison of the safety and efficacy of dorzolamide 2% and brimonidine 0.2% in patients with glaucoma or ocular hypertension. Journal of glaucoma 20040401
[Efficiency of brimonidine 0.2% and dorzolamide 2% as adjunctive therapy to beta-blockers]. Archivos de la Sociedad Espanola de Oftalmologia 20040401
Noradrenaline inhibits autonomous activity in the isolated guinea pig bladder. BJU international 20040201
Aqueous humor flow in normal human eyes treated with brimonidine and dorzolamide, alone and in combination. Archives of ophthalmology (Chicago, Ill. : 1960) 20040201
Brimonidine and latanoprost as adjunctive therapy. Ophthalmology 20040201
Role of membrane potential and expression of endothelial factors in restenosis after angioplasty in SHR. Hypertension (Dallas, Tex. : 1979) 20040101
Randomised controlled trial comparing the effect of brimonidine and timolol on visual field loss after acute primary angle closure. The British journal of ophthalmology 20040101
Patient persistency with topical ocular hypotensive therapy in a managed care population. American journal of ophthalmology 20040101
Observed time between prescription refills for newer ocular hypotensive agents: the effect of bottle size. American journal of ophthalmology 20040101
Ocular and systemic side effects of brimonidine 0.2% eye drops (Alphagan) in children. Eye (London, England) 20040101
Systemic side effects of ophthalmic drops. Clinical pediatrics 20040101
[Neuroprotection and vasoprotection in glaucoma]. Oftalmologia (Bucharest, Romania : 1990) 20040101
Effect of latanoprost 0.005% and brimonidine 0.2% on intraocular pressure after phacoemulsification and intraocular lens implantation surgery. Japanese journal of ophthalmology 20040101
[Latanoprost topical ophthalmic combinations]. Oftalmologia (Bucharest, Romania : 1990) 20040101
All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons. Naunyn-Schmiedeberg's archives of pharmacology 20031201
Short posterior ciliary artery, central retinal artery, and choroidal hemodynamics in brimonidine-treated primary open-angle glaucoma patients. American journal of ophthalmology 20031201
Influence of alpha2-autoreceptor stimulation on the facilitation by angiotensin II and bradykinin of noradrenaline release. Naunyn-Schmiedeberg's archives of pharmacology 20031201
Contrast sensitivity improves after brimonidine therapy in primary open angle glaucoma: a case for neuroprotection. The British journal of ophthalmology 20031201
Efficacy of brimonidine 0.2% in controlling acute postoperative intraocular pressure elevation after phacoemulsification. Journal of cataract and refractive surgery 20031201
Efficacy and safety of brimonidine, dorzolamide and latanoprost as adjunctive therapy in primary open angle glaucoma. International journal of clinical practice 20031201
Transient ischemia of the retina results in massive degeneration of the retinotectal projection: long-term neuroprotection with brimonidine. Experimental neurology 20031201
Role of alpha2-adrenergic receptors and cyclic adenosine monophosphate-dependent protein kinase in the regulation of norepinephrine release in the central nervous system of spontaneously hypertensive rats. Journal of cardiovascular pharmacology 20031201
No evidence for activation of alpha(2)-adrenoceptors by methanolic extracts of bovine brain and lung containing clonidine-displacing substance. Annals of the New York Academy of Sciences 20031201
Moxonidine displays a presynaptic alpha-2-adrenoceptor-dependent synergistic sympathoinhibitory action at imidazoline-1 receptors. Annals of the New York Academy of Sciences 20031201
Norepinephrine activates extracellular-regulated kinase in cortical neurons. Biological psychiatry 20031115
Bilateral simultaneous anterior ischemic optic neuropathy in a young, healthy man. Archives of ophthalmology (Chicago, Ill. : 1960) 20031101
Bilateral nongranulomatous anterior uveitis associated with bimatoprost. Journal of cataract and refractive surgery 20031101
Effect of puberty on coronary arteries from female pigs. Journal of applied physiology (Bethesda, Md. : 1985) 20031001
Metipranolol attenuates lipid peroxidation in rat brain: a comparative study with other antiglaucoma drugs. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20031001
Prescription of topical antiglaucoma agents for patients with contraindications to beta-blockers. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20031001
(+)-Nantenine isolated from Nandina domestica Thunb. inhibits adrenergic pressor responses in pithed rats. European journal of pharmacology 20030905
Endothelium-dependent responses in coronary arteries are changed with puberty in male pigs. American journal of physiology. Heart and circulatory physiology 20030901
Does topical brimonidine tartrate help NAION? The British journal of ophthalmology 20030901
Molecular mechanisms of ligand-receptor interactions in transmembrane domain V of the alpha2A-adrenoceptor. British journal of pharmacology 20030901
Evaluation of an immortalized retinal endothelial cell line as an in vitro model for drug transport studies across the blood-retinal barrier. Pharmaceutical research 20030901
Dermatological side effects of brimonidine: a report of three cases. The Journal of dermatology 20030901
Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypes. Molecular endocrinology (Baltimore, Md.) 20030801
Evaluation of neuroprotective qualities of brimonidine during LASIK. Ophthalmology 20030801
Exercise restores beta-adrenergic vasorelaxation in aged rat carotid arteries. American journal of physiology. Heart and circulatory physiology 20030701
Role of the alpha2-adrenoceptors on the pulmonary circulation in the ovine fetus. Pediatric research 20030701
Charles Bonnet syndrome precipitated by brimonidine tartrate eye drops. The British journal of ophthalmology 20030701
Medical therapy cost considerations for glaucoma. American journal of ophthalmology 20030701
DPDPE-UK14,304 synergy is retained in mu opioid receptor knockout mice. Pain 20030701
Granulomatous anterior uveitis associated with 0.2% topical brimonidine. Eye (London, England) 20030701
Patient persistency with pharmacotherapy in the management of glaucoma. European journal of ophthalmology 20030701
Changes in medical and surgical treatments of glaucoma between 1997 and 2000 in France. European journal of ophthalmology 20030701
Calcium-dependent inhibition of synaptosomal serotonin transport by the alpha 2-adrenoceptor agonist 5-bromo-N-[4,5-dihydro-1H-imidazol-2-yl]-6-quinoxalinamine (UK14304). The Journal of pharmacology and experimental therapeutics 20030601
Dissimilar pharmacological responses by a new series of imidazoline derivatives at precoupled and ligand-activated alpha 2A-adrenoceptor states: evidence for effector pathway-dependent differential antagonism. The Journal of pharmacology and experimental therapeutics 20030601
Efficacy and safety of timolol maleate/latanoprost fixed combination versus timolol maleate and brimonidine given twice daily. Acta ophthalmologica Scandinavica 20030601
Effects of commercial antiglaucoma drugs to glutamate-induced [Ca2+)]i increase in cultured neuroblastoma cells. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030601
Comparison between latanoprost and brimonidine efficacy and safety in Indian eyes. Indian journal of ophthalmology 20030601
A novel D2-dopaminergic and alpha2-adrenoceptor receptor agonist induces substantial and prolonged IOP decrease in normotensive rabbits. The Journal of pharmacy and pharmacology 20030601
Pregnancy-associated changes in responsiveness of the porcine myometrium to bioactive substances. European journal of pharmacology 20030523
Presynaptic modulation of acetylcholine, noradrenaline, and serotonin release in the hippocampus of aged rats with various levels of memory impairments. Brain research bulletin 20030515
alpha 2-Adrenoceptors potentiate angiotensin II- and vasopressin-induced renal vasoconstriction in spontaneously hypertensive rats. The Journal of pharmacology and experimental therapeutics 20030501
Unoprostone as adjunctive therapy to timolol: a double masked randomised study versus brimonidine and dorzolamide. The British journal of ophthalmology 20030501
Enhancement of alpha2-adrenoceptor-mediated vasoconstriction by the thromboxane-mimetic U46619 in the porcine isolated ear artery: role of the ERK-MAP kinase signal transduction cascade. British journal of pharmacology 20030501
Altered prejunctional modulation of intestinal cholinergic and noradrenergic pathways by alpha2-adrenoceptors in the presence of experimental colitis. British journal of pharmacology 20030501
The efficacy and safety of brimonidine 0.2% compared with timolol 0.5% in glaucoma: a randomized clinical trial on Taiwanese patients. Journal of the Chinese Medical Association : JCMA 20030501
Regulation of Cl- secretion by alpha2-adrenergic receptors in mouse colonic epithelium. The Journal of physiology 20030415
A 24-day old with episodic lethargy, hypotonia, and apnea: the eyes have it. Current opinion in pediatrics 20030401
Cystoid macular oedema associated with brimonidine therapy. Clinical & experimental ophthalmology 20030401
Piribedil enhances frontocortical and hippocampal release of acetylcholine in freely moving rats by blockade of alpha 2A-adrenoceptors: a dialysis comparison to talipexole and quinelorane in the absence of acetylcholinesterase inhibitors. The Journal of pharmacology and experimental therapeutics 20030401
The effect of latanoprost, brimonidine, and a fixed combination of timolol and dorzolamide on circadian intraocular pressure in patients with glaucoma or ocular hypertension. Archives of ophthalmology (Chicago, Ill. : 1960) 20030401
The effects of latanoprost and brimonidine on blood flow velocity of the retrobulbar vessels: a 3-month clinical trial. Acta ophthalmologica Scandinavica 20030401
Presynaptic regulation of neurotransmitter release in the cortex of aged rats with differential memory impairments. Pharmacology, biochemistry, and behavior 20030401
[The effect of brimonidine on postoperative hypertonia after an extracapsular cataract extraction]. Journal francais d'ophtalmologie 20030401
Role of alpha-2 agonists in neuroprotection. Survey of ophthalmology 20030401
Dorzolamide/timolol combination versus concomitant administration of brimonidine and timolol: six-month comparison of efficacy and tolerability. Ophthalmology 20030301
Desensitization of alpha 2A-adrenoceptor signalling by modest levels of adrenaline is facilitated by beta 2-adrenoceptor-dependent GRK3 up-regulation. British journal of pharmacology 20030301
Miotic effect of alphagan P. Journal of cataract and refractive surgery 20030301
Four years later: a clinical update on latanoprost. European journal of ophthalmology 20030301
alpha2C-Adrenoceptor blockade by clozapine and other antipsychotic drugs. European journal of pharmacology 20030221
Readability of ocular medication inserts. Journal of glaucoma 20030201
New topical drugs for open-angle glaucoma. Drug and therapeutics bulletin 20030201
Characterization of alpha2-adrenoceptors in smooth muscles of the spontaneously hypertensive rat aorta. Vascular pharmacology 20030201
A 3-month comparison of efficacy and safety of brimonidine-purite 0.15% and brimonidine 0.2% in patients with glaucoma or ocular hypertension. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030201
Hypotension and bradycardia in infants after the use of topical brimonidine and beta-blockers. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 20030201
Neurotransmitter release and its presynaptic modulation in the rat hippocampus after selective damage to cholinergic or/and serotonergic afferents. Brain research bulletin 20030130
Mechanism of enhanced calcium sensitivity and alpha 2-AR vasoreactivity in chronic NOS inhibition hypertension. American journal of physiology. Heart and circulatory physiology 20030101
A paradoxical ocular effect of brimonidine. American journal of ophthalmology 20030101
Brimonidine and latanoprost as adjunctive therapy. Ophthalmology 20030101
Regulation of leptin release by insulin, glucocorticoids, G(i)-coupled receptor agonists, and pertussis toxin in adipocytes and adipose tissue explants from obese humans in primary culture. Metabolism: clinical and experimental 20030101
Consultation section. Refractive surgical problem: 3 issues to be discussed: the clinical indications, the surgical procedure, the postoperative findings. Journal of cataract and refractive surgery 20030101
Ocular perfusion pressure and visual field indice modifications induced by alpha-agonist compound (clonidine 0.125%, apraclonidine 1.0% and brimonidine 0.2%) topical administration. An acute study on primary open-angle glaucoma patients. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20030101
Nurse prescribing in glaucoma. Eye (London, England) 20030101
[Increased myopia and metaporphosia in a 59-year old patient. Serous retinal detachment of the posterior pol after latanoprost administration]. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20030101
Brimonidine Purite and bimatoprost compared with timolol and latanoprost in patients with glaucoma and ocular hypertension. Advances in therapy 20030101
Latanoprost : an update of its use in glaucoma and ocular hypertension. Drugs & aging 20030101
Comparison of brimonidine/latanoprost and timolol/dorzolamide: two randomized, double-masked, parallel clinical trials. Advances in therapy 20030101
Brimonidine formulation in polyacrylic acid nanoparticles for ophthalmic delivery. Journal of microencapsulation 20030101
A short-term study of the additive effect of latanoprost 0.005% and brimonidine 0.2%. Japanese journal of ophthalmology 20030101
Prophylactic brimonidine before LASIK. Journal of refractive surgery (Thorofare, N.J. : 1995) 20030101
Effect of brimonidine on intraocular pressure in normal tension glaucoma: a short term clinical trial. European journal of ophthalmology 20030101
A new measure of patient satisfaction with ocular hypotensive medications: the Treatment Satisfaction Survey for Intraocular Pressure (TSS-IOP). Health and quality of life outcomes 20030101
Vision related quality of life and topical glaucoma treatment side effects. Health and quality of life outcomes 20030101
Evaluation of the comfort of Alphagan P compared with Alphagan in irritated eyes. Advances in therapy 20030101
Alpha 2-Adrenergic stimulation is protective against ischemia-reperfusion-induced ventricular arrhythmias in vivo. American journal of physiology. Heart and circulatory physiology 20021201
Presynaptic effects of moxonidine in isolated buffer perfused rat hearts: role of imidazoline-1 receptors and alpha2-adrenoceptors. The Journal of pharmacology and experimental therapeutics 20021201
Effect of single and multiple doses of 0.2% brimonidine tartrate in the glaucomatous Beagle. Veterinary ophthalmology 20021201
Changes in intraocular pressure and ocular perfusion pressure after latanoprost 0.005% or brimonidine tartrate 0.2% in normal-tension glaucoma patients. Ophthalmology 20021201
The short-term IOP-lowering effect of brimonidine 0.2% and dorzolomide 2% combination in primary open-angle glaucoma. Acta ophthalmologica Scandinavica 20021201
Transient ischemia of the retina results in altered retrograde axoplasmic transport: neuroprotection with brimonidine. Experimental neurology 20021201
Nitric oxide discriminates the sites and mechanisms of action of centrally acting anti-hypertensive drugs in rabbits. Neuropharmacology 20021201
Evaluation of the intraocular pressure-reducing effect of latanoprost as monotherapy in open-angle glaucoma. Collegium antropologicum 20021201
Effect of latanoprost 0.005% and brimonidine tartrate 0.2% on pulsatile ocular blood flow in normal tension glaucoma. The British journal of ophthalmology 20021101
Effects of the imidazoline ligands efaroxan and KU14R on blood glucose homeostasis in the mouse. European journal of pharmacology 20021101
Pharmacological evidence of a role for prejunctional imidazoline (I(1)) receptors in ocular function. Current eye research 20021101
Acute and chronic NOS inhibition enhances alpha(2)- adrenoreceptor-stimulated RhoA and Rho kinase in rat aorta. American journal of physiology. Heart and circulatory physiology 20021001
Tyrosine kinases regulate intracellular calcium during alpha(2)-adrenergic contraction in rat aorta. American journal of physiology. Heart and circulatory physiology 20021001
Effect of a long-duration physical exercise on fat cell lipolytic responsiveness to adrenergic agents and insulin in obese men. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 20021001
Different contractile effects of alpha1- and alpha2-adrenergic agonists on horse isolated common digital artery smooth muscle ring preparations in vitro. Pharmacological research 20021001
Iatrogenic ring scotoma after laser in situ keratomileusis. Journal of cataract and refractive surgery 20021001
Beta-adrenoceptor-induced inhibition of rat splenocyte proliferation: cytokine gene transcription as the target of action. Immunobiology 20021001
Sympathetic denervation-induced changes in G protein expression in enteric neurons of the guinea pig colon. Life sciences 20020913
Beta 3-adrenoceptor in rat aorta: molecular and biochemical characterization and signalling pathway. British journal of pharmacology 20020901
Effects of catecholamines on kinase activation in lung neutrophils after hemorrhage or endotoxemia. Journal of leukocyte biology 20020901
Effect of treatment by medicine or surgery on intraocular pressure and pulsatile ocular blood flow in normal-pressure glaucoma. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20020901
Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse model. Vision research 20020901
Reappraising first-line treatment in glaucoma management. Hospital medicine (London, England : 1998) 20020901
Comparison of the neuroprotective effects of adrenoceptor drugs in retinal cell culture and intact retina. Investigative ophthalmology & visual science 20020801
Inhibition by brimonidine of forskolin-induced nitrite production in isolated pig ciliary processes. Investigative ophthalmology & visual science 20020801
Cost analysis of glaucoma medications: a 3-year review. Journal of glaucoma 20020801
An economic analysis of switching to latanoprost from a beta-blocker or adding brimonidine or latanoprost to a beta-blocker in open-angle glaucoma or ocular hypertension. The American journal of managed care 20020801
Rates of discontinuation and change of glaucoma therapy in a managed care setting. The American journal of managed care 20020801
Discontinuation rates of topical glaucoma medications in a managed care population. The American journal of managed care 20020801
Medical treatment of normal tension glaucoma. Survey of ophthalmology 20020801
Formulation effects on ocular absorption of brimonidine in rabbit eyes. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20020801
Efficacy of brimonidine 0.2 per cent as adjunctive therapy to beta-blockers: a comparative study between POAG and CACG in Asian eyes. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20020801
Alpha2-adrenoceptor ligands inhibit alpha1-adrenoceptor-mediated contraction of isolated rat arteries. Fundamental & clinical pharmacology 20020801
Role of mu-opioid receptors in insulin release in the presence of inhibitory and excitatory secretagogues. European journal of pharmacology 20020712
Naphazoline-induced neuroendocrine changes: increases in ANP and cGMP levels, but suppression of NE, 3H-NE, and cAMP levels in rabbit eyes. Pharmacology 20020701
Effect of hyaluronic acid on intraocular pressure in rats. Investigative ophthalmology & visual science 20020701
[Clinical efficacy of 0.2% brimonidine in patients with open-angle glaucoma or ocular hypertension]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 20020628
Pre- and postjunctional alpha(2)-adrenergic receptors in fetal and adult ovine cerebral arteries. American journal of physiology. Regulatory, integrative and comparative physiology 20020601
Stimulation of alpha2-adrenergic receptor inhibits cholangiocarcinoma growth through modulation of Raf-1 and B-Raf activities. Hepatology (Baltimore, Md.) 20020601
Additive intraocular pressure lowering effect of various medications with latanoprost. American journal of ophthalmology 20020601
Scleritis as the initial clinical manifestation of graft-versus-host disease after allogenic bone marrow transplantation. American journal of ophthalmology 20020601
Up-regulation of brain-derived neurotrophic factor expression by brimonidine in rat retinal ganglion cells. Archives of ophthalmology (Chicago, Ill. : 1960) 20020601
Cardiovascular effects of timolol maleate, brimonidine or brimonidine/timolol maleate in concomitant therapy. Acta ophthalmologica Scandinavica 20020601
[Use of brimonidine 0.2% in treatment of glaucoma or ocular hypertony after poorly tolerated beta-blocker treatment]. Journal francais d'ophtalmologie 20020601
alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation. The Journal of biological chemistry 20020531
Mutagenesis and peptide analysis of the DRY motif in the alpha2A adrenergic receptor: evidence for alternate mechanisms in G protein-coupled receptors. Biochemical and biophysical research communications 20020517
ATP release in human kidney cortex and its mitogenic effects in visceral glomerular epithelial cells. Kidney international 20020501
The effects of new topical treatments on management of glaucoma in Scotland: an examination of ophthalmological health care. The British journal of ophthalmology 20020501
Brimonidine 0.2% to prevent post laser IOP elevation. Ophthalmology 20020501
Release inhibitory receptors activation favours the A2A-adenosine receptor-mediated facilitation of noradrenaline release in isolated rat tail artery. British journal of pharmacology 20020501
New glaucoma medications in the geriatric population: efficacy and safety. Journal of the American Geriatrics Society 20020501
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Distribution of brimonidine into anterior and posterior tissues of monkey, rabbit, and rat eyes. Drug metabolism and disposition: the biological fate of chemicals 20020401
Effects of acute and subchronic administration of dexefaroxan, an alpha(2)-adrenoceptor antagonist, on memory performance in young adult and aged rodents. The Journal of pharmacology and experimental therapeutics 20020401
Intraocular pressure-lowering effects of latanoprost and brimonidine therapy in patients with open-angle glaucoma or ocular hypertension: a randomized observer-masked multicenter study. Journal of glaucoma 20020401
Twelve-month evaluation of brimonidine-purite versus brimonidine in patients with glaucoma or ocular hypertension. Journal of glaucoma 20020401
The efficacy of brimonidine in preventing intraocular pressure elevation in the provocative test for primary angle-closure glaucoma. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20020401
Failure of naloxone to reverse brimonidine-induced coma in an infant. The Journal of pediatrics 20020401
Analysis of the effects of graded levels of hypoxia on noradrenaline-evoked contraction in the rat iliac artery in vitro. Experimental physiology 20020301
Delayed hypersensitivity to brimonidine tartrate 0.2% associated with high intraocular pressure. Eye (London, England) 20020301
Oral toxicity of topical preparations. The Veterinary clinics of North America. Small animal practice 20020301
Clinical effects of brimonidine ophthalmic drops ingestion in 52 dogs. Veterinary and human toxicology 20020201
Three-month comparison of brimonidine and latanoprost as adjunctive therapy in glaucoma and ocular hypertension patients uncontrolled on beta-blockers: tolerance and peak intraocular pressure lowering. Ophthalmology 20020201
Substance P, insulinlike growth factor 1, and surface healing. Archives of ophthalmology (Chicago, Ill. : 1960) 20020201
Lysophosphatidylcholine potentiates vascular contractile responses in rat aorta via activation of tyrosine kinase. British journal of pharmacology 20020201
Allergic reactions to brimonidine in patients treated for glaucoma. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20020201
Neuroprotective effects of brimonidine against transient ischemia-induced retinal ganglion cell death: a dose response in vivo study. Experimental eye research 20020201
Modification of serotonin neuron properties in mice lacking 5-HT1A receptors. European journal of pharmacology 20020125
Tumor necrosis factor expressed by primary hippocampal neurons and SH-SY5Y cells is regulated by alpha(2)-adrenergic receptor activation. Journal of neuroscience research 20020115
alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy. The Journal of pharmacology and experimental therapeutics 20020101
Latanoprost and brimonidine: therapeutic and physiologic assessment before and after oral nonsteroidal anti-inflammatory therapy. American journal of ophthalmology 20020101
Presynaptic modulation of cholinergic neurotransmission in the human proximal stomach. British journal of pharmacology 20020101
Minimally invasive spectroscopic system for intraocular drug detection. Journal of biomedical optics 20020101
A comparison of the short-term hypotensive effects and side effects of unilateral brimonidine and apraclonidine in patients with elevated intraocular pressure. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20020101
A short term study of the additive effect of timolol and brimonidine on intraocular pressure. Eye (London, England) 20020101
Brimonidine .2% as a replacement for beta blockers in geriatric patients with glaucoma. Advances in therapy 20020101
Effect of prophylactic brimonidine on bleeding complications and flap adherence after laser in situ keratomileusis. Journal of refractive surgery (Thorofare, N.J. : 1995) 20020101
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20020101
Alpha-2 adrenoceptor agonist protects retinal function after acute retinal ischemic injury in the rat. Visual neuroscience 20020101
Effects of acute topical administration of clonidine 0.125%, apraclonidine 1.0% and brimonidine 0.2% on visual field parameters and ocular perfusion pressure in patients with primary open-angle glaucoma. Acta ophthalmologica Scandinavica. Supplement 20020101
Effect of brimonidine on patients undergoing uncontrolled IOP with beta-blockers. Acta ophthalmologica Scandinavica. Supplement 20020101
Comparison of latanoprost, brimonidine and a fixed combination of timolol and dorzolamide on circadian intraocular pressure in patients with primary open-angle glaucoma and ocular hypertension. Acta ophthalmologica Scandinavica. Supplement 20020101
Endothelial inhibitory modulation on the contractile responses to alpha 2-adrenergic agonists. Proceedings of the Western Pharmacology Society 20020101
Vasocontractile effects of alpha 2-adrenergic agonists associated with intracellular calcium release. Proceedings of the Western Pharmacology Society 20020101
Changes of the excitability of rat trigeminal root ganglion neurons evoked by alpha(2)-adrenoreceptors. Neuroscience 20020101
The impact of new drugs on management of glaucoma in Scotland: observational study. BMJ (Clinical research ed.) 20011215
Noradrenaline stimulates 5-hydroxytryptamine release from mouse ileal tissues via alpha(2)-adrenoceptors. European journal of pharmacology 20011207
A comparison of the efficacy and tolerability of brimonidine and latanoprost in adults with open-angle glaucoma or ocular hypertension: a three-month, multicenter, randomized, double-masked, parallel-group trial. Clinical therapeutics 20011201
[New medical treatments of glaucoma. New strategies?]. Journal francais d'ophtalmologie 20011201
[The ocular hypotensive effect and safety of 0.2% brimonidine]. Yan ke xue bao = Eye science 20011201
Functional characterization of alpha1-adrenoceptor subtypes in human subcutaneous resistance arteries. The Journal of pharmacology and experimental therapeutics 20011101
Ca2+ influx mediates enhanced alpha2-adrenergic contraction in aortas from rats treated with NOS inhibitor. American journal of physiology. Heart and circulatory physiology 20011101
Neuroprotection of retinal ganglion cells by brimonidine in rats with laser-induced chronic ocular hypertension. Investigative ophthalmology & visual science 20011101
alpha(2)-adrenoceptor antagonist properties of OPC-28326, a novel selective peripheral vasodilator. British journal of pharmacology 20011001
Safety and efficacy of brimonidine in children with glaucoma. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 20011001
[Brimonidine absorption and release from 1. Day acuvue disposable contact lenses]. Archivos de la Sociedad Espanola de Oftalmologia 20011001
[Prospects for neuroprotective glaucoma therapy]. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20011001
[Prevention of early postoperative increase in intraocular pressure after phacoemulsification. Comparison of different antiglaucoma drugs]. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20011001
Circadian change of adenylate cyclase activity in rabbit ciliary processes. Current eye research 20011001
Neuroprotective effect of alpha(2) agonist (brimonidine) on adult rat retinal ganglion cells after increased intraocular pressure. Brain research 20010921
Effects of central imidazolinergic and alpha2-adrenergic activation on water intake. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20010901
Enhanced interaction between renovascular alpha(2)-adrenoceptors and angiotensin II receptors in genetic hypertension. Hypertension (Dallas, Tex. : 1979) 20010901
Acute and chronic effects of brimonidine 0.2% on intraocular pressure and pulsatile ocular blood flow in patients with primary open-angle glaucoma: an open-label, uncontrolled, prospective study. Clinical therapeutics 20010901
[Experience with topical brimonidine in the treatment of glaucomas]. Journal francais d'ophtalmologie 20010901
Systemic beta-blocker therapy and brimonidine and timolol. Ophthalmology 20010801
The adverse effect of perioperative brimonidine tartrate 0.2% on flap adherence and enhancement rates in laser in situ keratomileusis patients. Ophthalmology 20010801
Potent alpha(2A)-adrenoceptor-mediated vasoconstriction by brimonidine in porcine ciliary arteries. Investigative ophthalmology & visual science 20010801
Neuroprotective effects of alpha(2)-selective adrenergic agonists against ischemia-induced retinal ganglion cell death. Investigative ophthalmology & visual science 20010801
Effect of topical brimonidine on intraocular pressure after small incision cataract surgery. Journal of cataract and refractive surgery 20010801
Clinical and economic impact of new trends in glaucoma treatment. MedGenMed : Medscape general medicine 20010726
Role of alpha(2)-adrenoceptors in the sympathetic inhibition of motility reflexes of guinea-pig ileum. The Journal of physiology 20010715
The effect of adrenergic compounds on neurogenic dural vasodilatation. European journal of pharmacology 20010713
Disturbance of the prejunctional modulation of cholinergic neurotransmission during chronic granulomatous inflammation of the mouse ileum. British journal of pharmacology 20010701
Role of the extracellular signal-regulated kinase (Erk) signal transduction cascade in alpha(2) adrenoceptor-mediated vasoconstriction in porcine palmar lateral vein. British journal of pharmacology 20010701
Comparison of the clinical success and quality-of-life impact of brimonidine 0.2% and betaxolol 0.25 % suspension in patients with elevated intraocular pressure. Clinical therapeutics 20010701
Comparative effects of antiglaucoma drugs on voltage-dependent calcium channels. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20010701
The alpha(1A)-adrenoceptor subtype mediates contraction in rat femoral resistance arteries. European journal of pharmacology 20010622
Topically applied clonidine protects the rat retina from ischaemia/reperfusion by stimulating alpha(2)-adrenoceptors and not by an action on imidazoline receptors. Brain research 20010615
Brimonidine 0.2% versus apraclonidine 0.5% for prevention of intraocular pressure elevations after anterior segment laser surgery. Ophthalmology 20010601
Brimonidine 0.2% given two or three times daily versus timolol maleate 0.5% in primary open-angle glaucoma. American journal of ophthalmology 20010601
Washout periods for brimonidine 0.2% and latanoprost 0.005%. American journal of ophthalmology 20010601
Effect of brimonidine tartrate on ocular hemodynamics in healthy volunteers. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20010601
Differential effects of alpha-adrenoceptor agonists on human retinal microvessel diameter. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20010601
Effectiveness and safety of brimonidine as adjunctive therapy for patients with elevated intraocular pressure in a large, open-label community trial. Journal of glaucoma 20010601
Quantitation of mitomycin C in human ocular tissues by high-performance liquid chromatography-photo-diode array detection. Journal of chromatography. B, Biomedical sciences and applications 20010505
The efficacy and safety of latanoprost 0.005% once daily versus brimonidine 0.2% twice daily in open-angle glaucoma or ocular hypertension. American journal of ophthalmology 20010501
Retinal ganglion cell death induced by retinal ischemia. neuroprotective effects of two alpha-2 agonists. Survey of ophthalmology 20010501
Maintaining mitochondrial membrane impermeability. an opportunity for new therapy in glaucoma? Survey of ophthalmology 20010501
Role of alpha-2 adrenergic receptors in neuroprotection and glaucoma. Survey of ophthalmology 20010501
Brimonidine and inhibition of nitrite production in isolated porcine ciliary processes. Klinische Monatsblatter fur Augenheilkunde 20010501
Evidence for a non-adrenoceptor, imidazoline-mediated contractile response to oxymetazoline in the porcine isolated rectal artery. British journal of pharmacology 20010401
Brain alpha(2)-adrenoceptors in monoamine-depleted rats: increased receptor density, G coupling proteins, receptor turnover and receptor mRNA. British journal of pharmacology 20010401
Aqueous humor flow in normal human eyes treated with brimonidine and timolol, alone and in combination. Archives of ophthalmology (Chicago, Ill. : 1960) 20010401
Effects of dietary L-arginine on structure and function of flow-restricted vein grafts. Journal of vascular surgery 20010401
Vitreous concentration of topically applied brimonidine tartrate 0.2%. Ophthalmology 20010401
Effect of brimonidine tartrate ophthalmic solution 0.2% on pupil size in normal eyes under different luminance conditions. Journal of cataract and refractive surgery 20010401
Efficacy of brimonidine 0.2% and dorzolamide 2% as adjunctive therapy to beta-blockers in adult patients with glaucoma or ocular hypertension. Clinical therapeutics 20010401
Effects of verapamil and elgodipine on isoprenaline-induced metabolic responses in rabbits. European journal of pharmacology 20010309
Adenosine inhibits norepinephrine release in the postischemic rat heart: the mechanism of neuronal stunning. Cardiovascular research 20010301
Ophthalmic drops causing coma in an infant. The Journal of pediatrics 20010301
[Neuroprotection. Bases and possibilities of a future clinical use]. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20010301
Effect of 0.2% brimonidine on retinal blood flow. Yan ke xue bao = Eye science 20010301
Postjunctional alpha(2C)-adrenoceptor contractility in human saphenous vein. European journal of pharmacology 20010216
A robust GTP-induced shift in alpha(2)-adrenoceptor agonist affinity in tissue sections from rat brain. Journal of neuroscience methods 20010215
Heat, but not mechanical hyperalgesia, following adrenergic injections in normal human skin. Pain 20010201
Receptor reserve analysis of the human alpha(2C)-adrenoceptor using. European journal of pharmacology 20010112
Influence of nitric oxide donors and of the alpha(2)-agonist UK-14,304 on acetylcholine release in the pig gastric fundus. Neuropharmacology 20010101
Increased alpha(1)- and alpha(2)-adrenoceptor-mediated contractile responses of human skeletal muscle resistance arteries in chronic limb ischemia. Cardiovascular research 20010101
alpha(2)-Adrenoceptor agonists inhibit vitreal glutamate and aspartate accumulation and preserve retinal function after transient ischemia. The Journal of pharmacology and experimental therapeutics 20010101
Alpha2-adrenoceptor-mediated inhibition of cultured sympathetic neurons: changes in alpha2A/D-adrenoceptor-deficient mice. Naunyn-Schmiedeberg's archives of pharmacology 20010101
Effects of acute and chronic ethanol administration on the response of mouse adipose tissue hormone-sensitive lipase to alpha(2)-adrenoceptor activation bu UK 14304. Alcohol and alcoholism (Oxford, Oxfordshire) 20010101
Apoptosis and anti-apoptosis signalling in glaucomatous retinopathy. European journal of ophthalmology 20010101
Alpha-2 adrenergic receptor agonists are neuroprotective in experimental models of glaucoma. European journal of ophthalmology 20010101
Brimonidine's neuroprotective effects against transient ischaemia-induced retinal ganglion cell death. European journal of ophthalmology 20010101
Influence of topical brimonidine on visual field in glaucoma. European journal of ophthalmology 20010101
Brimonidine (Alphagan): a clinical profile four years after launch. European journal of ophthalmology 20010101
Switching patients with glaucoma or ocular hypertension from dual therapy to monotherapy: evaluation of brimonidine as a model. Advances in therapy 20010101
Antiglaucomatous drugs effects on optic nerve head flow: design, baseline and preliminary report. International ophthalmology 20010101
Does glaucoma medication influence the diameter of the retinal arteriole in the human eye? (A pilot study using the retinal vessel analyser). Acta physiologica Hungarica 20010101
Incidence of brimonidine allergy in patients previously allergic to apraclonidine. Journal of glaucoma 20000601
Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using intracellular Ca(2+) changes: evidence for cross-talk between recombinant alpha(2A)- and native alpha(1)-adrenoceptors. British journal of pharmacology 20000401
Platelet alpha2-adrenoceptor alterations in patients with essential hypertension are normalized after treatment with doxazosin but not propranolol. Journal of hypertension 20000201
Mechanisms of action of OPC-28326, a selective hindlimb vasodilator. The Journal of pharmacology and experimental therapeutics 19991101
Modulation of agonist binding to recombinant human alpha2-adrenoceptors by sodium ions. Biochimica et biophysica acta 19981119
Subtype-specific stimulation of [35S]GTPgammaS binding by recombinant alpha2-adrenoceptors. European journal of pharmacology 19980821
Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding. Biochemical pharmacology 19980401
Gene targeting--homing in on alpha 2-adrenoceptor-subtype function. Trends in pharmacological sciences 19970601
The inhibitory effects of alpha(2)-adrenoceptor agonists on gastrointestinal transit during croton oil-induced intestinal inflammation. British journal of pharmacology 19961201
Clinical experience with brimonidine 0.2% and timolol 0.5% in glaucoma and ocular hypertension. Survey of ophthalmology 19961101
The mu-opioid receptor antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) [but not D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP)] produces a nonopioid receptor-mediated increase in K+ conductance of rat locus ceruleus neurons. Molecular pharmacology 19960901
Naloxone-induced potentiation of cardiac alpha-2 adrenoceptor-mediated depression of neurogenic tachycardia. The Journal of pharmacology and experimental therapeutics 19930701
Presynaptic alpha 2-autoreceptors in brain cortex: alpha 2D in the rat and alpha 2A in the rabbit. Naunyn-Schmiedeberg's archives of pharmacology 19930701
In vivo pharmacological profile of SL 84.0418, a new selective, peripherally active alpha 2-adrenoceptor antagonist. European journal of pharmacology 19930406
Naloxone-induced bradycardia in pithed rats: evidence for an interaction with the peripheral sympathetic nervous system and alpha-2 adrenoceptors. The Journal of pharmacology and experimental therapeutics 19921201
Single potassium channels opened by opioids in rat locus ceruleus neurons. Proceedings of the National Academy of Sciences of the United States of America 19890501
Noradrenergic influences on sound-induced seizures. The Journal of pharmacology and experimental therapeutics 19800801
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