Home Other Building Blocks 5,5'-((3-Carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methylene)bis(2-hydroxybenzoic acid)

5,5'-((3-Carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methylene)bis(2-hydroxybenzoic acid)

CAS No.:
4431-00-9
Catalog Number:
AG003NXR
Molecular Formula:
C22H14O9
Molecular Weight:
422.3412
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
>85%powder
In Stock USA
United States
$87
- +
5g
>85%powder
In Stock USA
United States
$223
- +
Product Description
Catalog Number:
AG003NXR
Chemical Name:
5,5'-((3-Carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methylene)bis(2-hydroxybenzoic acid)
CAS Number:
4431-00-9
Molecular Formula:
C22H14O9
Molecular Weight:
422.3412
MDL Number:
MFCD00011663
IUPAC Name:
5-[(3-carboxy-4-hydroxyphenyl)-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-2-hydroxybenzoic acid
InChI:
InChI=1S/C22H14O9/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31)
InChI Key:
GIXWDMTZECRIJT-UHFFFAOYSA-N
SMILES:
OC(=O)C1=CC(=C(c2ccc(c(c2)C(=O)O)O)c2ccc(c(c2)C(=O)O)O)C=CC1=O
EC Number:
224-628-1
Properties
Complexity:
841  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
422.064g/mol
Formal Charge:
0
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0
Molecular Weight:
422.345g/mol
Monoisotopic Mass:
422.064g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
169A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.3  
Literature
Title Journal
Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1). ACS chemical biology 20151016
The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells. The Journal of biological chemistry 20150116
Aurintricarboxylic acid modulates the affinity of hepatitis C virus NS3 helicase for both nucleic acid and ATP. Biochemistry 20130910
Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic acid synthetic complex. Neurobiology of aging 20121001
Trimethylaurintricarboxylic acid inhibits human DNA methyltransferase 1: insights from enzymatic and molecular modeling studies. Journal of molecular modeling 20120401
First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G. ACS chemical biology 20120316
Anomalous inhibition of c-Met by the kinesin inhibitor aurintricarboxylic acid. International journal of cancer 20120301
Electrophoretic deposition of TiO2 nanoparticles using organic dyes. Journal of colloid and interface science 20120301
Small molecule inhibition of RISC loading. ACS chemical biology 20120217
Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase. Bioorganic & medicinal chemistry 20120115
Quantization of bovine serum albumin by fluorescence enhancement effects and corresponding binding of macrocyclic host-protein assembly. Journal of photochemistry and photobiology. B, Biology 20120105
Arabidopsis serine decarboxylase mutants implicate the roles of ethanolamine in plant growth and development. International journal of molecular sciences 20120101
Novel optical PVC probes for on-site detection/determination of fluoroquinolones in a solid/liquid interface: application to the determination of Norfloxacin in aquaculture water. Biosensors & bioelectronics 20120101
Molecular modeling of inhibitors of human DNA methyltransferase with a crystal structure: discovery of a novel DNMT1 inhibitor. Advances in protein chemistry and structural biology 20120101
Mechanisms of xenogeneic baboon platelet aggregation and phagocytosis by porcine liver sinusoidal endothelial cells. PloS one 20120101
Aurintricarboxylic acid promotes the conversion of naive CD4+CD25- T cells into Foxp3-expressing regulatory T cells. International immunology 20110901
Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex. PLoS pathogens 20110501
Aurintricarboxylic acid inhibits the nuclear factor-κB-dependent expression of intercellular cell adhesion molecule-1 and endothelial cell selectin on activated human endothelial cells. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20110301
Investigations on the interactions of aurintricarboxylic acid with bovine serum albumin: Steady state/time resolved spectroscopic and docking studies. Journal of photochemistry and photobiology. B, Biology 20110110
The next ten stories on antiviral drug discovery (part E): advents, advances, and adventures. Medicinal research reviews 20110101
Comparative functional genomic analysis of Solanum glandular trichome types. Plant physiology 20110101
Neuroprotection in glaucoma. Indian journal of ophthalmology 20110101
An immunohistochemical analysis of the neuroprotective effects of memantine, hyperbaric oxygen therapy, and brimonidine after acute ischemia reperfusion injury. Molecular vision 20110101
Identification of tissue-specific, abiotic stress-responsive gene expression patterns in wine grape (Vitis vinifera L.) based on curation and mining of large-scale EST data sets. BMC plant biology 20110101
First transcriptome of the testis-vas deferens-male accessory gland and proteome of the spermatophore from Dermacentor variabilis (Acari: Ixodidae). PloS one 20110101
Effect of five common anticonvulsant drugs on naloxone-precipitated morphine withdrawal in mice. Research in pharmaceutical sciences 20110101
Structure-based and ligand-based virtual screening of novel methyltransferase inhibitors of the dengue virus. BMC bioinformatics 20110101
Cosalane and its analogues: a unique class of anti-HIV agents. Mini reviews in medicinal chemistry 20100901
New evidences on Tau-DNA interactions and relevance to neurodegeneration. Neurochemistry international 20100801
Lack of efficacy of aurintricarboxylic acid and ethacrynic acid against vaccinia virus respiratory infections in mice. Antiviral chemistry & chemotherapy 20100414
Inhibition of enterovirus 71 replication and the viral 3D polymerase by aurintricarboxylic acid. The Journal of antimicrobial chemotherapy 20100401
N-acetylcysteine impairs survival of luteal cells through mitochondrial dysfunction. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20100401
In vitro reconstitution of SARS-coronavirus mRNA cap methylation. PLoS pathogens 20100401
Nelfinavir, an HIV-1 protease inhibitor, induces oxidative stress-mediated, caspase-independent apoptosis in Leishmania amastigotes. PLoS neglected tropical diseases 20100301
Tumors induced in mice by direct inoculation of plasmid DNA expressing both activated H-ras and c-myc. International journal of biological sciences 20100101
Interaction of aurintricarboxylic acid (ATA) with four nucleic acid binding proteins DNase I, RNase A, reverse transcriptase and Taq polymerase. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20091201
Simultaneous trace multielement determination by ICP-OES after solid phase extraction with modified octadecyl silica gel. Journal of hazardous materials 20091015
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology 20091001
Characterization of aurintricarboxylic acid as a potent hepatitis C virus replicase inhibitor. Antiviral chemistry & chemotherapy 20090925
Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis. ChemMedChem 20090803
Single-strand DNA translation initiation step analyzed by Isothermal Titration Calorimetry. Biochemical and biophysical research communications 20090731
Discovery of selective glucocorticoid receptor modulators by multiplexed reporter screening. Proceedings of the National Academy of Sciences of the United States of America 20090324
Aurintricarboxylic acid inhibits influenza virus neuraminidase. Antiviral research 20090201
Substrate specificity of the oxidoreductase ERp57 is determined primarily by its interaction with calnexin and calreticulin. The Journal of biological chemistry 20090123
Landscape changes influence the occurrence of the melioidosis bacterium Burkholderia pseudomallei in soil in northern Australia. PLoS neglected tropical diseases 20090101
Citrate-mediated release of aurintricarboxylic acid from a calcium alginate complex: implications for intravaginal HIV chemoprophylaxis and related applications. Pharmaceutical development and technology 20090101
Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PloS one 20090101
Antagonistic actions of boron against inhibitory effects of aluminum toxicity on growth, CO2 assimilation, ribulose-1,5-bisphosphate carboxylase/oxygenase, and photosynthetic electron transport probed by the JIP-test, of Citrus grandis seedlings. BMC plant biology 20090101
Optimization and comparison of different methods for RNA isolation for cDNA library construction from the reindeer lichen Cladonia rangiferina. BMC research notes 20090101
Aurintricarboxylic acid is a potent inhibitor of influenza A and B virus neuraminidases. PloS one 20090101
Aluminum granuloma after administration of the quadrivalent human papillomavirus vaccine. Report of a case. The American Journal of dermatopathology 20081201
In vitro and in vivo activity of aurintricarboxylic acid preparations against Cryptosporidium parvum. The Journal of antimicrobial chemotherapy 20081101
Selection of an effective red-pigment producing Monascus pilosus by efficient transformation with aurintricarboxylic acid. Bioscience, biotechnology, and biochemistry 20081101
Posttreatment with the Ca(2+)-Mg(2+)-dependent endonuclease inhibitor aurintricarboxylic acid abolishes genotoxic agent-induced nuclear condensation and DNA fragmentation and decreases death of astrocytes. Journal of neuroscience research 20081001
A new binding assay of von Willebrand factor and glycoprotein Ib using solid-phase biotinylated platelets. Journal of pharmacological sciences 20081001
Apoptosis of mesenchymal cells during the pseudoglandular stage of lung development affects branching morphogenesis. Experimental lung research 20081001
Aurintricarboxylic acid upregulates the thrombomodulin expression of endothelial cells and peripheral blood monocytes. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20080901
Novel quinolinonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, and biological activities. Journal of medicinal chemistry 20080814
A general method for discovering inhibitors of protein-DNA interactions using photonic crystal biosensors. ACS chemical biology 20080718
Functional circularity of legitimate Qbeta replicase templates. Journal of molecular biology 20080606
Platelet GPIb complex as a target for anti-thrombotic drug development. Thrombosis and haemostasis 20080301
Gene expression-based screening for inhibitors of PDGFR signaling. Genome biology 20080101
Tear lipocalin is the major endonuclease in tears. Molecular vision 20080101
Docking of molecules identified in bioactive medicinal plants extracts into the p50 NF-kappaB transcription factor: correlation with inhibition of NF-kappaB/DNA interactions and inhibitory effects on IL-8 gene expression. BMC structural biology 20080101
Active transport of the ubiquitin ligase MID1 along the microtubules is regulated by protein phosphatase 2A. PloS one 20080101
Aurintricarboxylic acid inhibits endothelial activation, complement activation, and von Willebrand factor secretion in vitro and attenuates hyperacute rejection in an ex vivo model of pig-to-human pulmonary xenotransplantation. Xenotransplantation 20080101
A novel bioluminescent protease assay using engineered firefly luciferase. Current chemical genomics 20080101
Identification and characterization of UK-201844, a novel inhibitor that interferes with human immunodeficiency virus type 1 gp160 processing. Antimicrobial agents and chemotherapy 20071001
Apoptosis as a therapeutic target in heart failure. American journal of physiology. Heart and circulatory physiology 20070901
A sensitive stain for aluminum in undecalcified cancellous bone. Journal of inorganic biochemistry 20070901
A new evidence for DNA nicking property of amyloid beta-peptide (1-42): relevance to Alzheimer's disease. Archives of biochemistry and biophysics 20070715
Biodegradable magnesium scaffolds: Part 1: appropriate inflammatory response. Journal of biomedical materials research. Part A 20070601
Salmonella SPI1 effector SipA persists after entry and cooperates with a SPI2 effector to regulate phagosome maturation and intracellular replication. Cell host & microbe 20070315
Rapid, high-quality and epidermal-specific isolation of RNA from human skin. Experimental dermatology 20070301
Lipopolysaccharide down-regulates the thrombomodulin expression of peripheral blood monocytes: effect of serum on thrombomodulin expression in the THP-1 monocytic cell line. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20070301
Aurintricarboxylic acid inhibits protein synthesis independent, sanguinarine-induced apoptosis and oncosis. Toxicologic pathology 20070201
Caspase-dependent and -independent induction of phosphatidylserine externalization during apoptosis in human renal carcinoma Cak(1)-1 and A-498 cells. Toxicology 20070105
Inhibition of K+ efflux prevents mitochondrial dysfunction, and suppresses caspase-3-, apoptosis-inducing factor-, and endonuclease G-mediated constitutive apoptosis in human neutrophils. Cellular signalling 20061201
Cortisol promotes survival and regeneration of axotomised retinal ganglion cells and enhances effects of aurintricarboxylic acid. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20061101
Oral gene delivery: design of polymeric carrier systems shielding toward intestinal enzymatic attack. Biopolymers 20061101
Influence of the SCGE protocol on the amount of basal DNA damage detected in the Mediterranean mussel, Mytilus galloprovincialis. Environmental and molecular mutagenesis 20061001
Sodium selenite induces apoptosis in cultured cortical neurons with special concomitant changes in expression of the apoptosis-related genes. Neurotoxicology 20060701
Fibrosarcoma with typical features of postinjection sarcoma at site of microchip implant in a dog: histologic and immunohistochemical study. Veterinary pathology 20060701
Biological evaluation, chelation, and molecular modeling studies of novel metal-chelating inhibitors of NF-kappaB-DNA binding: structure activity relationships. Journal of medicinal chemistry 20060615
Post-treatment with the Ca(2+)-Mg(2+)-endonuclease inhibitor aurintricarboxylic acid prevents peroxynitrite-induced DNA damage and death of murine astrocytes. Biochemical and biophysical research communications 20060609
Oral gene delivery: Strategies to improve stability of pDNA towards intestinal digestion. Journal of drug targeting 20060601
Potential antivirals and antiviral strategies against SARS coronavirus infections. Expert review of anti-infective therapy 20060401
Involvement of endonuclease G in nucleosomal DNA fragmentation under sustained endogenous oxidative stress. The Journal of biological chemistry 20060310
Fusion and differentiation of murine C2C12 skeletal muscle cells that express Trichinella spiralis p43 protein. Experimental parasitology 20060201
Paradoxical effects of aurintricarboxylic acid and RG-13577: acute thrombosis and in-stent stenosis in a passive-coated stent. Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists 20060201
Dendritic supermolecules--towards controllable nanomaterials. Chemical communications (Cambridge, England) 20060107
Microtubules regulate disassembly of epithelial apical junctions. BMC cell biology 20060101
Salt is necessary for nucleosomal DNA fragmentation induced by caspase. Biotechnology letters 20051201
Barriers to productive transfection of trabecular meshwork cells. Molecular vision 20051026
Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway. Biochemical pharmacology 20050715
ATR-IR spectroscopy as applied to nucleic acid films. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050701
Structural analysis of inhibition mechanisms of aurintricarboxylic acid on SARS-CoV polymerase and other proteins. Computational biology and chemistry 20050601
Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase. The Journal of biological chemistry 20050408
Use of the nuclease inhibitor aurintricarboxylic acid (ATA) for improved non-viral intratumoral in vivo gene transfer by jet-injection. The journal of gene medicine 20050401
Activation of porcine endothelium in response to xenogeneic serum causes thrombosis independently of platelet activation. Xenotransplantation 20050301
Raf/MEK/MAPK signaling stimulates the nuclear translocation and transactivating activity of FOXM1c. Journal of cell science 20050215
Differential activation of heme oxygenase-1 by chalcones and rosolic acid in endothelial cells. The Journal of pharmacology and experimental therapeutics 20050201
p66ShcA and ageing: modulation by longevity-promoting agent aurintricarboxylic acid. Mechanisms of ageing and development 20050201
Coordinate involvement of cysteine protease and nuclease in the executive phase of plant apoptosis. FEBS letters 20041217
Green tea polyphenol (-)-epigallocatechin gallate blocks epithelial barrier dysfunction provoked by IFN-gamma but not by IL-4. American journal of physiology. Gastrointestinal and liver physiology 20041101
Induction of apoptosis by benzamide and its inhibition by aurin tricarboxylic acid (ATA) in Chinese hamster V79 cells. Mutation research 20041004
Aurintricarboxylic acid translocates across the plasma membrane, inhibits protein tyrosine phosphatase and prevents apoptosis in PC12 cells. Molecules and cells 20040831
Potent and selective inhibition of SARS coronavirus replication by aurintricarboxylic acid. Biochemical and biophysical research communications 20040806
[Neuroprotection and regeneration after traumatic lesion of the optic nerve]. Klinische Monatsblatter fur Augenheilkunde 20040801
Cancer inhibition in nude mice after systemic application of U6 promoter-driven short hairpin RNAs against PLK1. Journal of the National Cancer Institute 20040602
Programmed cell death is not a necessary prerequisite for fusion of the fetal mouse palate. The International journal of developmental biology 20040201
Novel shift of Jak/Stat signalling characterizes the protective effect of aurintricarboxylic acid (ATA) from tumor necrosis factor-alpha toxicity in human B lymphocytes. International journal of immunopathology and pharmacology 20040101
Enhanced systemic transgene expression after nonviral salivary gland transfection using a novel endonuclease inhibitor/DNA formulation. Gene therapy 20031201
RNA degradation in cell extracts: real-time monitoring by fluorescence resonance energy transfer. Journal of the American Chemical Society 20031126
Mitigation of tumor necrosis factor alpha cytotoxicity by aurintricarboxylic acid in human peripheral B lymphocytes. Biochemical pharmacology 20031115
CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death. Oncogene 20031113
Qbeta replicase discriminates between legitimate and illegitimate templates by having different mechanisms of initiation. The Journal of biological chemistry 20031107
Aurintricarboxylic acid blocks in vitro and in vivo activity of YopH, an essential virulent factor of Yersinia pestis, the agent of plague. The Journal of biological chemistry 20031024
Ca(2+)-dependent and caspase-3-independent apoptosis caused by damage in Golgi apparatus due to 2,4,5,7-tetrabromorhodamine 123 bromide-induced photodynamic effects. Photochemistry and photobiology 20030901
Nuclear factor kappa B: a potential target for anti-HIV chemotherapy. Current medicinal chemistry 20030801
Fibrosarcomas at presumed sites of injection in dogs: characteristics and comparison with non-vaccination site fibrosarcomas and feline post-vaccinal fibrosarcomas. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20030801
Pharmacologic platelet anesthesia by glycoprotein IIb/IIIa complex antagonist and argatroban during in vitro extracorporeal circulation. The Journal of thoracic and cardiovascular surgery 20030801
Inhibition of myocardial apoptosis reduces infarct size and improves regional contractile dysfunction during reperfusion. Cardiovascular research 20030701
Diethyldithiocarbamate-induced cytotoxicity and apoptosis in leukemia cell lines. Biological & pharmaceutical bulletin 20030701
Transient reporter gene (GUS) expression in creeping bentgrass (Agrostis palustris) is affected by in vivo nucleolytic activity. Biotechnology letters 20030601
Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells. The Journal of biological chemistry 20030509
Hyperacute lung rejection in the pig-to-human model. III. Platelet receptor inhibitors synergistically modulate complement activation and lung injury. Transplantation 20030415
Is platelet aggregation a more important contributor than platelet adhesion to the overall platelet-related primary haemostasis measured by PFA-100? Thrombosis research 20030315
[Resonance light scattering of aurintricarboxylic acid]. Guang pu xue yu guang pu fen xi = Guang pu 20030201
Enhanced transport of a novel anti-HIV agent--cosalane and its congeners across human intestinal epithelial (Caco-2) cell monolayers. International journal of pharmaceutics 20030102
Görög Thrombosis Test: a global in-vitro test of platelet function and thrombolysis. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20030101
Spontaneous DNA fragmentation in swim-up selected human spermatozoa during long term incubation. Journal of andrology 20030101
Non-classic characteristics define prominent DNase activities from the intestine and other tissues of Haemonchus contortus. Experimental parasitology 20030101
Combined addition of glutathione and iron chelators for decrease of intracellular level of reactive oxygen species and death of Chinese hamster ovary cells. Journal of bioscience and bioengineering 20030101
Repeated addition of insulin for dynamic control of apoptosis in serum-free culture of Chinese hamster ovary cells. Journal of bioscience and bioengineering 20030101
Inhibition of cytokine-induced JAK-STAT signalling pathways by an endonuclease inhibitor aurintricarboxylic acid. British journal of pharmacology 20021201
Alteration of intrinsic biological rhythms during interferon treatment and its possible mechanism. Molecular pharmacology 20021201
Polymorphisms of glycoprotein Ib affect the inhibition by aurintricarboxylic acid of the von Willebrand factor dependent platelet aggregation. Journal of molecular medicine (Berlin, Germany) 20021201
Electroporation in combination with a plasmid vector containing SV40 enhancer elements results in increased and persistent gene expression in mouse muscle. Biochemical and biophysical research communications 20021108
CADA inhibits human immunodeficiency virus and human herpesvirus 7 replication by down-modulation of the cellular CD4 receptor. Virology 20021025
Aurintricarboxylic acid attenuates intimal thickening after balloon injury of the rabbit aorta. Thrombosis and haemostasis 20021001
Development of nonradioactive microtiter plate assays for nuclease activity. Analytical biochemistry 20021001
Aluminum deposition in the bone of patients with chronic renal failure--detection of aluminum accumulation without signs of aluminum toxicity in bone using acid solochrome azurine. Clinical nephrology 20021001
Aurintricarboxylic acid protects against cell death caused by lipopolysaccharide in macrophages by decreasing inducible nitric-oxide synthase induction via IkappaB kinase, extracellular signal-regulated kinase, and p38 mitogen-activated protein kinase inhibition. Molecular pharmacology 20020701
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
DNase I-like endonuclease in rat kidney cortex that is activated during ischemia/reperfusion injury. Journal of the American Society of Nephrology : JASN 20020401
Aurintricarboxylic acid induces a distinct activation of the IGF-I receptor signaling within MDA-231 cells. Endocrinology 20020301
Etoposide-induced apoptosis in lymphoblastoid leukaemic MOLT-4 cells: evidence that chromatin condensation, loss of phosphatidylserine asymmetry and apoptotic body formation can occur independently. Apoptosis : an international journal on programmed cell death 20020201
Modulation of apoptosis by mitochondrial uncouplers: apoptosis-delaying features despite intrinsic cytotoxicity. Biochemical pharmacology 20020201
Intestinal absorption and biodistribution of cosalane and its amino acid conjugates: novel anti-HIV agents. International journal of pharmaceutics 20020114
Stable genetic transformation of garlic plants using particle bombardment. Cellular & molecular biology letters 20020101
DNA transfection of macaque and murine respiratory tissue is greatly enhanced by use of a nuclease inhibitor. The journal of gene medicine 20020101
[RNA, unlike DNA, binds to aurintricarboxylic acid via covalent bonds: molecular-biological and spectroscopic evidence]. Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20020101
Purification and characterization of a Bacillus subtilis 168 nuclease, YokF, involved in chromosomal DNA degradation and cell death caused by thermal shock treatments. The Journal of biological chemistry 20011214
Effects of fibrinogen receptor antagonist GR144053F and aurintricarboxylic acid on platelet activation and degranulation. Biochemical pharmacology 20011115
Synthesis and anti-HIV activity of cosalane analogues incorporating two dichlorodisalicylmethane pharmacophore fragments. Bioorganic & medicinal chemistry 20011101
Verotoxin-1-induced up-regulation of adhesive molecules renders microvascular endothelial cells thrombogenic at high shear stress. Blood 20010915
Perforated microelectrode arrays implanted in the regenerating adult central nervous system. Experimental neurology 20010901
Activation of the insulin-like growth factor 1 signaling pathway by the antiapoptotic agents aurintricarboxylic acid and evans blue. Endocrinology 20010701
Binding of cosalane--a novel highly lipophilic anti-HIV agent--to albumin and glycoprotein. Journal of pharmaceutical sciences 20010501
Preparation of bacterial RNA. Current protocols in molecular biology 20010501
Alcohol enhances oxysterol-induced apoptosis in human endothelial cells by a calcium-dependent mechanism. Arteriosclerosis, thrombosis, and vascular biology 20010301
Correlation of anti-HIV activity with anion spacing in a series of cosalane analogues with extended polycarboxylate pharmacophores. Journal of medicinal chemistry 20010301
Pharmacological interventions of cyanide-induced cytotoxicity and DNA damage in isolated rat thymocytes and their protective efficacy in vivo. Toxicology letters 20010203
Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis. Biochemistry 20010109
Inhibition of RANTES/CCR1-mediated chemotaxis by cosalane and related compounds. Bioorganic & medicinal chemistry letters 20010108
Reconsidering the importance of long-term low-level aluminum exposure in renal failure patients. Seminars in dialysis 20010101
Ca2+-sensitive cytosolic nucleases prevent efficient delivery to the nucleus of injected plasmids. The journal of gene medicine 20010101
[Aluminum and uremic bone disease. Diagnostic utility of serum aluminum and the deferoxamine (DFO) test ]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20010101
Aurintricarboxylic acid decreases proliferative potential of SKOV3 and MCF7 human carcinoma cells. Anticancer research 20010101
Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8. Reviews in medical virology 20010101
Aurintricarboxylic acid exerts insulin-like growth stimulating effects on Chinese hamster ovary cells under serum-free conditions. Journal of bioscience and bioengineering 20010101
Anti-HIV activity of a series of cosalane amino acid conjugates. Bioorganic & medicinal chemistry letters 20001120
Identification of optimal anion spacing for anti-HIV activity in a series of cosalane tetracarboxylates. Bioorganic & medicinal chemistry letters 20000918
Synthesis and anti-HIV activity of cosalane analogues incorporating nitrogen in the linker chain. Bioorganic & medicinal chemistry 20000101
Selective activity of various antiviral compounds against HHV-7 infection. Antiviral research 19990801
N-Nitrosodimethylamine-mediated cytotoxicity in a cell line expressing P450 2E1: evidence for apoptotic cell death. Toxicology and applied pharmacology 19990601
The toxicity of 6-hydroxydopamine on PC12 and P19 cells. Brain research. Molecular brain research 19990521
Extension of the polyanionic cosalane pharmacophore as a strategy for increasing anti-HIV potency. Journal of medicinal chemistry 19990520
Synthesis of a cosalane analog with an extended polyanionic pharmacophore conferring enhanced potency as an anti-HIV agent. Bioorganic & medicinal chemistry letters 19980407
Exploration of the effects of linker chain modifications on anti-HIV activities in a series of cosalane analogues. Bioorganic & medicinal chemistry 19961001
Synthesis and biological evaluation of certain alkenyldiarylmethanes as anti-HIV-1 agents which act as non-nucleoside reverse transcriptase inhibitors. Journal of medicinal chemistry 19960802
Correlation of anti-HIV potency with lipophilicity in a series of cosalane analogs having normal alkenyl and phosphodiester chains as cholestane replacements. Journal of medicinal chemistry 19960119
Cosalane analogues with enhanced potencies as inhibitors of HIV-1 protease and integrase. Journal of medicinal chemistry 19950203
Design, synthesis, and biological evaluation of cosalane, a novel anti-HIV agent which inhibits multiple features of virus reproduction. Journal of medicinal chemistry 19940916
Infection by HIV-1 blocked by binding of dextrin 2-sulphate to the cell surface of activated human peripheral blood mononuclear cells and cultured T-cells. British journal of pharmacology 19940901
Three-dimensional structure-activity analysis of a series of porphyrin derivatives with anti-HIV-1 activity targeted to the V3 loop of the gp120 envelope glycoprotein of the human immunodeficiency virus type 1. Journal of medicinal chemistry 19940415
Inhibition of HIV-1 integration protein by aurintricarboxylic acid monomers, monomer analogs, and polymer fractions. Biochemical and biophysical research communications 19920529
[The anti-HIV activity of beta-glycyrrhizic acid]. Voprosy virusologii 19920101
Preparation and anti-HIV activities of aurintricarboxylic acid fractions and analogues: direct correlation of antiviral potency with molecular weight. Journal of medicinal chemistry 19910101
Synthesis and anti-HIV activities of low molecular weight aurintricarboxylic acid fragments and related compounds. Journal of medicinal chemistry 19910101
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation. Journal of medicinal chemistry 19891001
Aurintricarboxylic acid and Evans Blue represent two different classes of anionic compounds which selectively inhibit the cytopathogenicity of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus. Biochemical and biophysical research communications 19860414
Influence of twenty potentially antiviral substances on in vitro multiplication of hepatitis A virus. Antiviral research 19860301
Properties