1-[(4-methoxyphenyl)carbonyl]pyrrolidin-2-one
| Title | Journal |
|---|---|
| Determination of aniracetam's main metabolite, N-anisoyl-GABA, in human plasma by LC-MS/MS and its application to a pharmacokinetic study. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120515 |
| Clinical efficacy of aniracetam, either as monotherapy or combined with cholinesterase inhibitors, in patients with cognitive impairment: a comparative open study. | CNS neuroscience & therapeutics 20120401 |
| Impulsive behaviour induced by both NMDA receptor antagonism and GABAA receptor activation in rat ventromedial prefrontal cortex. | Psychopharmacology 20120101 |
| Systematic review on the efficacy and safety of herbal medicines for vascular dementia. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
| [Effects of moxibustion on the expressions of hippocampal VEGF, flt-1, bFGF, and bFGF-r in vascular dementia rats]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20120101 |
| NMDA receptors and fear extinction: implications for cognitive behavioral therapy. | Dialogues in clinical neuroscience 20111201 |
| Development and validation of a liquid chromatographic method for the simultaneous determination of aniracetam and its related substances in the bulk drug and a tablet formulation. | Journal of pharmaceutical and biomedical analysis 20111101 |
| Role of endocannabinoid and glutamatergic systems in DOI-induced head-twitch response in mice. | Pharmacology, biochemistry, and behavior 20110701 |
| Substituted benzoxazinones as potent positive allosteric AMPA receptor modulators: part II. | Bioorganic & medicinal chemistry letters 20110701 |
| Benzoxazinones as potent positive allosteric AMPA receptor modulators: part I. | Bioorganic & medicinal chemistry letters 20110701 |
| From toxins targeting ligand gated ion channels to therapeutic molecules. | Toxins 20110301 |
| Lipid rafts control P2X3 receptor distribution and function in trigeminal sensory neurons of a transgenic migraine mouse model. | Molecular pain 20110101 |
| Subnanogram determination of aniracetam in pharmaceutical preparations and biofluids by flow injection analysis with chemiluminescence detection based on its enhancement of the myoglobin-luminol reaction. | Journal of AOAC International 20110101 |
| Acetylcholine and memory-enhancing activity of Ficus racemosa bark. | Pharmacognosy research 20110101 |
| How right is the righting reflex? The risk of false positives in neuroprotection studies using behavioral measures to certify forebrain ischemia. | Neurological research 20101101 |
| Positive allosteric modulators of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. | Journal of medicinal chemistry 20101028 |
| Retinohypothalamic tract synapses in the rat suprachiasmatic nucleus demonstrate short-term synaptic plasticity. | Journal of neurophysiology 20100501 |
| Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors. | Journal of medicinal chemistry 20100311 |
| Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders. | Drugs 20100212 |
| [Effect of modified huanglian wendan decoction in treating senile patients with mild cognitive impairment of turbid-phlegm blocking orifice syndrome]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20100101 |
| Activation of AMPA receptors in the suprachiasmatic nucleus phase-shifts the mouse circadian clock in vivo and in vitro. | PloS one 20100101 |
| Herbal therapy: a new pathway for the treatment of Alzheimer's disease. | Alzheimer's research & therapy 20100101 |
| Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors. | Bioorganic & medicinal chemistry letters 20091201 |
| [Influence of aniracetam on the learning ability, memory ability and the expression of BCL-2 of hippocampal in vascular dementia model rats]. | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20090501 |
| Aniracetam and DNQX affect the acquisition of rapid tolerance to ethanol in mice. | Pharmacology, biochemistry, and behavior 20090301 |
| Content determination of aniracetam in aniracetam inclusion complex by HPLC. | Artificial cells, blood substitutes, and immobilization biotechnology 20090101 |
| Relative roles of different mechanisms of depression at the mouse endbulb of Held. | Journal of neurophysiology 20080501 |
| Aniracetam reversed learning and memory deficits following prenatal ethanol exposure by modulating functions of synaptic AMPA receptors. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080401 |
| Participation of hippocampal ionotropic glutamate receptors in histamine H(1) antagonist-induced memory deficit in rats. | Psychopharmacology 20080301 |
| [Effects of Goutengsan on model of Alzheimer dementia in rats by AlCl3]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080301 |
| Ameliorating effects of preadolescent aniracetam treatment on prenatal ethanol-induced impairment in AMPA receptor activity. | Neurobiology of disease 20080101 |
| [A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment]. | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20080101 |
| Pharmacokinetics and bioequivalence study of aniracetam after single-dose administration in healthy Chinese male volunteers. | Arzneimittel-Forschung 20080101 |
| Sensitive and selective liquid chromatography-tandem mass spectrometry method for the quantification of aniracetam in human plasma. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071015 |
| Progress update: Pharmacological treatment of Alzheimer's disease. | Neuropsychiatric disease and treatment 20071001 |
| [Clinical study on a randomized, double-blind control of Shenwu gelatin capsule in treatment of mild cognitive impairment]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070901 |
| Identification of a putative binding site for 5-alkyl-benzothiadiazides in the AMPA receptor dimer interface. | Journal of molecular graphics & modelling 20070701 |
| Postnatal aniracetam treatment improves prenatal ethanol induced attenuation of AMPA receptor-mediated synaptic transmission. | Neurobiology of disease 20070601 |
| Pharmacology of ampakine modulators: from AMPA receptors to synapses and behavior. | Current drug targets 20070501 |
| AMPA receptor potentiators: application for depression and Parkinson's disease. | Current drug targets 20070501 |
| The ampakine CX546 restores the prepulse inhibition and latent inhibition deficits in mGluR5-deficient mice. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070401 |
| Aniracetam restores the effects of amyloid-beta protein or ageing on membrane fluidity and intracellular calcium concentration in mice synaptosomes. | Journal of neural transmission (Vienna, Austria : 1996) 20070101 |
| Enantiomeric impurity determination of levetiracetam using capillary electrochromatography. | Journal of separation science 20061201 |
| In search of novel AMPA potentiators. | Recent patents on CNS drug discovery 20061101 |
| Aniracetam attenuates H2O2-induced deficiency of neuron viability, mitochondria potential and hippocampal long-term potentiation of mice in vitro. | Neuroscience bulletin 20060901 |
| Delayed, post-injury treatment with aniracetam improves cognitive performance after traumatic brain injury in rats. | Journal of neurotrauma 20060801 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| The alkaloid alstonine: a review of its pharmacological properties. | Evidence-based complementary and alternative medicine : eCAM 20060301 |
| Brahmi rasayana improves learning and memory in mice. | Evidence-based complementary and alternative medicine : eCAM 20060301 |
| Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus. | BMC neuroscience 20060101 |
| Nardostachys jatamansi improves learning and memory in mice. | Journal of medicinal food 20060101 |
| Cognitive aging in zebrafish. | PloS one 20060101 |
| Mechanism of positive allosteric modulators acting on AMPA receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050928 |
| Nootropic agents enhance the recruitment of fast GABAA inhibition in rat neocortex. | Cerebral cortex (New York, N.Y. : 1991) 20050701 |
| Effects of propofol on recombinant AMPA receptor channels. | European journal of pharmacology 20050321 |
| Effect of aniracetam on phosphatidylinositol transfer protein alpha in cytosolic and plasma membrane fractions of astrocytes subjected to simulated ischemia in vitro. | Pharmacological reports : PR 20050101 |
| Mild cognitive impairment: animal models. | Dialogues in clinical neuroscience 20041201 |
| Interactions of allosteric modulators of AMPA/kainate receptors on spreading depression in the chicken retina. | Brain research 20041029 |
| Nootropic nefiracetam inhibits proconvulsant action of peripheral-type benzodiazepines in epileptic mutant EL mice. | Annals of the New York Academy of Sciences 20041001 |
| AMPA protects cultured neurons against glutamate excitotoxicity through a phosphatidylinositol 3-kinase-dependent activation in extracellular signal-regulated kinase to upregulate BDNF gene expression. | Journal of neurochemistry 20040801 |
| Erk1/2 and Akt kinases are involved in the protective effect of aniracetam in astrocytes subjected to simulated ischemia in vitro. | European journal of pharmacology 20040628 |
| Piracetam and TRH analogues antagonise inhibition by barbiturates, diazepam, melatonin and galanin of human erythrocyte D-glucose transport. | British journal of pharmacology 20040601 |
| AMPA receptor potentiators for the treatment of CNS disorders. | Current drug targets. CNS and neurological disorders 20040601 |
| The cognition-enhancer nefiracetam inhibits both necrosis and apoptosis in retinal ischemic models in vitro and in vivo. | The Journal of pharmacology and experimental therapeutics 20040401 |
| Multiple molecular determinants for allosteric modulation of alternatively spliced AMPA receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20031126 |
| 2-pyrrolidinone induces a long-lasting facilitation of hippocampal synaptic transmission by enhancing alpha7 ACh receptor responses via a PKC pathway. | Brain research. Molecular brain research 20030910 |
| The mechanism of action of aniracetam at synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors: indirect and direct effects on desensitization. | Molecular pharmacology 20030801 |
| Sialic acid 9-O-acetylesterase catalyzes the hydrolyzing reaction from alacepril to deacetylalacepril. | Pharmaceutical research 20030801 |
| Facilitation of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor transmission in the suprachiasmatic nucleus by aniracetam enhances photic responses of the biological clock in rodents. | Journal of neurochemistry 20030501 |
| Multiple sclerosis and glutamate. | Annals of the New York Academy of Sciences 20030501 |
| Effects of aniracetam on extracellular levels of transmitter amino acids in the hippocampus of the conscious gerbils: an intracranial microdialysis study. | Neuroscience letters 20030327 |
| Human models as tools in the development of psychotropic drugs. | Dialogues in clinical neuroscience 20021201 |
| Nonopioid and neuropathy-specific analgesic action of the nootropic drug nefiracetam in mice. | The Journal of pharmacology and experimental therapeutics 20021001 |
| Aniracetam attenuates apoptosis of astrocytes subjected to simulated ischemia in vitro. | Neurotoxicology 20020901 |
| A desensitization-selective potentiator of AMPA-type glutamate receptors. | British journal of pharmacology 20020801 |
| DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer. | Naunyn-Schmiedeberg's archives of pharmacology 20020601 |
| Cholinergic and dopaminergic mechanisms involved in the recovery of circadian anticipation by aniracetam in aged rats. | Pharmacology, biochemistry, and behavior 20020501 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Antidepressant activity of memory-enhancing drugs in the reduction of submissive behavior model. | European journal of pharmacology 20020405 |
| Aniracetam enhances glutamatergic transmission in the prefrontal cortex of stroke-prone spontaneously hypertensive rats. | Neuroscience letters 20020308 |
| The cognition-enhancer nefiracetam is protective in BDNF-independent neuronal cell death under the serum-free condition. | Neurochemistry international 20020201 |
| The aniracetam metabolite 2-pyrrolidinone induces a long-term enhancement in AMPA receptor responses via a CaMKII pathway. | Brain research. Molecular brain research 20020131 |
| Aniracetam improves contextual fear conditioning and increases hippocampal gamma-PKC activation in DBA/2J mice. | Hippocampus 20020101 |
| Aniracetam: its novel therapeutic potential in cerebral dysfunctional disorders based on recent pharmacological discoveries. | CNS drug reviews 20020101 |
| Negative allosteric modulation of AMPA-preferring receptors by the selective isomer GYKI 53784 (LY303070), a specific non-competitive AMPA antagonist. | CNS drug reviews 20020101 |
| Maturation of synaptic transmission at end-bulb synapses of the cochlear nucleus. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20011201 |
| Antidepressant-like effects of aniracetam in aged rats and its mode of action. | Psychopharmacology 20011101 |
| Aniracetam enhances cortical dopamine and serotonin release via cholinergic and glutamatergic mechanisms in SHRSP. | Brain research 20011019 |
| The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment. | Neuroreport 20010917 |
| Pharmacological effects of AMPA receptor potentiators LY392098 and LY404187 on rat neuronal AMPA receptors in vitro. | Neuropharmacology 20010601 |
| LY392098, a novel AMPA receptor potentiator: electrophysiological studies in prefrontal cortical neurons. | Neuropharmacology 20010601 |
| Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. | European journal of pharmacology 20010518 |
| Member of the Ampakine class of memory enhancers prolongs the single channel open time of reconstituted AMPA receptors. | Synapse (New York, N.Y.) 20010501 |
| Positive allosteric modulators of AMPA receptors reduce proton-induced receptor desensitization in rat hippocampal neurons. | Journal of neurophysiology 20010501 |
| Site-specific activation of dopamine and serotonin transmission by aniracetam in the mesocorticolimbic pathway of rats. | Brain research 20010406 |
| Nootropic drug modulation of neuronal nicotinic acetylcholine receptors in rat cortical neurons. | Molecular pharmacology 20010401 |
| Minimizing synaptic depression by control of release probability. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20010315 |
| Effects of intrahippocampal aniracetam treatment on Y-maze avoidance learning performance and behavioral long-term potentiation in dentate gyrus in rat. | Neuroscience letters 20010209 |
| Can nootropic drugs be effective against the impact of ethanol teratogenicity on cognitive performance? | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20010201 |
| Autonomic consequences of brainstem infarction. | Autonomic neuroscience : basic & clinical 20010114 |
| Presynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor-mediated stimulation of glutamate and GABA release in the rat striatum in vivo: a dual-label microdialysis study. | Neuroscience 20010101 |
| Aniracetam restores motivation reduced by satiation in a choice reaction task in aged rats. | Pharmacology, biochemistry, and behavior 20010101 |
| Efficacy of acetylcholinesterase inhibitors versus nootropics in Alzheimer's disease: a retrospective, longitudinal study. | The Journal of international medical research 20010101 |
| (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release from rat hippocampal and frontal cortex slices. | European journal of pharmacology 20000804 |
| Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver. | Biological & pharmaceutical bulletin 19970801 |
| Effects of D-cycloserine and aniracetam on spatial learning in rats with entorhinal cortex lesions. | Pharmacology, biochemistry, and behavior 19970101 |
| Effects of DM-9384, a pyrrolidone derivative, on alcohol- and chlordiazepoxide-induced amnesia in mice. | Pharmacology, biochemistry, and behavior 19900601 |
| Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam. | The Journal of physiology 19900501 |
| Effects of N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide (DM-9384) on learning and memory in rats. | Japanese journal of pharmacology 19890501 |
| Effects of aniracetam on one-trial passive avoidance tests and cholinergic neurons in discrete brain regions of rats. | Archives internationales de pharmacodynamie et de therapie 19890101 |
| The hyperventilation-induced ischaemia model in human neuropharmacology: neurophysiological and psychometric studies of aniracetam and 3-OH aniracetam. | European journal of clinical pharmacology 19890101 |
| Interactions between oxiracetam, aniracetam and scopolamine on behavior and brain acetylcholine. | Pharmacology, biochemistry, and behavior 19870701 |
| Effects of the novel compound aniracetam (Ro 13-5057) upon impaired learning and memory in rodents. | Psychopharmacology 19820101 |