Morphine withdrawal activates hypothalamic-pituitary-adrenal axis and heat shock protein 27 in the left ventricle: the role of extracellular signal-regulated kinase.

The Journal of pharmacology and experimental therapeutics 20120901

The comparative efficacy of abamectin, monepantel and an abamectin/derquantel combination against fourth-stage larvae of a macrocyclic lactone-resistant Teladorsagia spp. isolate infecting sheep.

Veterinary parasitology 20120813

Efficacy of monepantel and anthelmintic combinations against multiple-resistant Haemonchus contortus in sheep, including characterisation of the nematode isolate.

Veterinary parasitology 20120525

The efficacy of monepantel against naturally acquired inhibited and developing fourth-stage larvae of Teladorsagia circumcincta in sheep in the United Kingdom.

Veterinary parasitology 20120525

Modelling the benefits of a new class of anthelmintic in combination.

Veterinary parasitology 20120504

Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome.

Journal of neurochemistry 20120501

Safety and efficacy against fourth-stage gastrointestinal nematode larvae, of monepantel in 6-week old lambs.

Veterinary parasitology 20120430

Development and validation of a highly sensitive LC-MS/MS method for quantitation of dexlansoprazole in human plasma: application to a human pharmacokinetic study.

Biomedical chromatography : BMC 20120201

Multiple strategies to prevent oxidative stress in Arabidopsis plants lacking the malate valve enzyme NADP-malate dehydrogenase.

Journal of experimental botany 20120201

The effect of mTOR inhibition alone or combined with MEK inhibitors on brain metastasis: an in vivo analysis in triple-negative breast cancer models.

Breast cancer research and treatment 20120101

Mitogen-activated protein kinase in the amygdala plays a critical role in lithium chloride-induced taste aversion learning.

Neurobiology of learning and memory 20120101

A molecular diagnostic tool to replace larval culture in conventional faecal egg count reduction testing in sheep.

PloS one 20120101

MEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis.

Stem cells (Dayton, Ohio) 20111201

Determination of the new anthelmintic monepantel and its sulfone metabolite in milk and muscle using a UHPLC-MS/MS and QuEChERS method.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111201

In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections.

PLoS neglected tropical diseases 20111201

The use of 1,2-dipiperidinoacetylene for the preparation of monometallic diaminoacetylene and homo- or heterobimetallic diaminodicarbene ruthenium(II) complexes.

Dalton transactions (Cambridge, England : 2003) 20111028

Isolation, identification, and culture optimization of a novel glycinonitrile-hydrolyzing fungus-Fusarium oxysporum H3.

Applied biochemistry and biotechnology 20111001

Differences in efficacy of monepantel, derquantel and abamectin against multi-resistant nematodes of sheep.

Parasitology research 20110701

The MEK inhibitor SL327 blocks acquisition but not expression of lithium-induced conditioned place aversion: a behavioral and immunohistochemical study.

Psychopharmacology 20110701

Naloxone-precipitated morphine withdrawal evokes phosphorylation of heat shock protein 27 in rat heart through extracellular signal-regulated kinase.

Journal of molecular and cellular cardiology 20110701

Determination of nifedipine in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110615

Potential drug development candidates for human soil-transmitted helminthiases.

PLoS neglected tropical diseases 20110601

Predicting binding to p-glycoprotein by flexible receptor docking.

PLoS computational biology 20110601

Minimising the development of anthelmintic resistance, and optimising the use of the novel anthelmintic monepantel, for the sustainable control of nematode parasites in Australian sheep grazing systems.

Australian veterinary journal 20110501

Mining a cathepsin inhibitor library for new antiparasitic drug leads.

PLoS neglected tropical diseases 20110501

Discovery and development of veterinary antiparasitic drugs: past, present and future.

Future medicinal chemistry 20110501

Rapid determination of atropine and scopolamine content in scopolia extract powder by HPLC.

Journal of natural medicines 20110401

SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutants.

PLoS pathogens 20110401

[Determination of global DNA methylation in tissues by hydrophilic interaction liquid chromatography].

Se pu = Chinese journal of chromatography 20110401

Inhibition of extracellular signal-regulated kinase (ERK) activity with SL327 does not prevent acquisition, expression, and extinction of ethanol-seeking behavior in mice.

Behavioural brain research 20110301

Activity of novel nicotinic anthelmintics in cut preparations of Caenorhabditis elegans.

International journal for parasitology 20110301

[Determination of paraquat residue in plant-derived foodstuffs by high performance liquid chromatography-tandem mass spectrometry].

Se pu = Chinese journal of chromatography 20110201

Worm control practice against gastro-intestinal parasites in Norwegian sheep and goat flocks.

Acta veterinaria Scandinavica 20110101

[New drugs for horses and production animals in 2010].

Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere 20110101

Molecular switch from L-type Ca v 1.3 to Ca v 1.2 Ca2+ channel signaling underlies long-term psychostimulant-induced behavioral and molecular plasticity.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20101215

Assessment of risk of monepantel faecal residues to dung fauna.

Australian veterinary journal 20101201

Monepantel allosterically activates DEG-3/DES-2 channels of the gastrointestinal nematode Haemonchus contortus.

Molecular pharmacology 20101101

Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells.

Stem cells (Dayton, Ohio) 20101101

European field study of the efficacy and safety of the novel anthelmintic monepantel in sheep.

The Veterinary record 20101016

Use of monepantel.

The Veterinary record 20101009

microRNAs: a role in drug resistance in parasitic nematodes?

Trends in parasitology 20100901

Phylogenomics of ligand-gated ion channels predicts monepantel effect.

PLoS pathogens 20100901

Simultaneous determination of piracetam and its four impurities by RP-HPLC with UV detection.

Journal of chromatographic science 20100801

Cyanomethanaminium tetra-fluoro-borate.

Acta crystallographica. Section E, Structure reports online 20100801

Oral supplementation with Leu-Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase.

Behavioural brain research 20100711

Intrastriatal inhibition of extracellular signal-regulated kinases impaired the consolidation phase of motor skill learning.

Neurobiology of learning and memory 20100701

Quarantine treatment of sheep with monepantel--rapidity of fecal egg count reduction.

Veterinary parasitology 20100624

Slipped capital femoral epiphysis: an ultrastructural study before and after osteosynthesis.

Acta orthopaedica 20100601

Field efficacy and safety of an oral formulation of the novel combination anthelmintic, derquantel-abamectin, in sheep in New Zealand.

New Zealand veterinary journal 20100601

The control of inhibited fourth-stage larvae of Haemonchus contortus and Teladorsagia spp. in sheep in Australia with monepantel.

Veterinary parasitology 20100511

'Manifesto' for advancing the control and elimination of neglected tropical diseases.

PLoS neglected tropical diseases 20100501

Effect of route of administration on the efficacy and pharmacokinetics of an experimental formulation of the amino-acetonitrile derivative monepantel in sheep.

The Veterinary record 20100417

Use of monepantel.

The Veterinary record 20100410

Regulation of plant glycine decarboxylase by s-nitrosylation and glutathionylation.

Plant physiology 20100301

Tholinomics--chemical analysis of nitrogen-rich polymers.

Analytical chemistry 20100215

Identification of plasticity-associated genes regulated by Pavlovian fear conditioning in the lateral amygdala.

Journal of neurochemistry 20100201

[Determination of perfluorooctane sulfonates in fire-fighting foam and other materials by high performance liquid chromatography-tandem mass spectrometry].

Se pu = Chinese journal of chromatography 20100201

The time course of unconditioned morphine-induced psychomotor sensitization mirrors the phosphorylation of FADD and MEK/ERK in rat striatum: role of PEA-15 as a FADD-ERK binding partner in striatal plasticity.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20100101

A pooled analysis of the efficacy of monepantel, an amino-acetonitrile derivative against gastrointestinal nematodes of sheep.

Parasitology research 20100101

The effect of sheep breed, age, and gender on the pharmacokinetics and efficacy of monepantel, an amino-acetonitrile derivative.

Parasitology research 20100101

Deep-space glycine formation via Strecker-type reactions activated by ice water dust mantles. A computational approach.

Physical chemistry chemical physics : PCCP 20100101

[Determination of streptomycin in honey determined by hydrophilic interaction chromatography combined with tandem mass spectrometry].

Wei sheng yan jiu = Journal of hygiene research 20100101

Fustin flavonoid attenuates beta-amyloid (1-42)-induced learning impairment.

Journal of neuroscience research 20091201

The efficacy of monepantel, an amino-acetonitrile derivative, against gastrointestinal nematodes of sheep in three countries of southern Latin America.

Parasitology research 20091201

(Z)-Amino-(2-methyl-3-oxoisoindolin-1-yl-idene)acetonitrile.

Acta crystallographica. Section E, Structure reports online 20091201

Synergistic interactions of dopamine D1 and glutamate NMDA receptors in rat hippocampus and prefrontal cortex: involvement of ERK1/2 signaling.

Neuroscience 20091110

Cyclocondensation of alpha-aminonitriles and enones: a short access to 3,4-dihydro-2H-pyrrole 2-carbonitriles and 2,3,5-trisubstituted pyrroles.

The Journal of organic chemistry 20091106

Differential involvement of D1 and D2 dopamine receptors in L-DOPA-induced angiogenic activity in a rat model of Parkinson's disease.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20091101

Clinical field study to evaluate the efficacy and safety of the amino-acetonitrile derivative, monepantel, compared with registered anthelmintics against gastrointestinal nematodes of sheep in Australia.

Australian veterinary journal 20091101

Extracellular signal-regulated kinase activation is required for consolidation and reconsolidation of memory at an early stage of ontogenesis.

The European journal of neuroscience 20091101

Extracellular signal-regulated kinase activation in the amygdala mediates elevated plus maze behavior during opioid withdrawal.

Behavioural pharmacology 20091001

Cross-talk between protein kinase A and mitogen-activated protein kinases signalling in the adaptive changes observed during morphine withdrawal in the heart.

The Journal of pharmacology and experimental therapeutics 20090901

Abstracts of the 2008 ISSOL Meeting. August 24-29, 2008. Florence, Italy.

Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life 20090801

Pharmacokinetics of monepantel and its sulfone metabolite, monepantel sulfone, after intravenous and oral administration in sheep.

Journal of veterinary pharmacology and therapeutics 20090801

Safety of an amino-acetonitrile derivative (AAD), monepantel, in ewes and their offspring following repeated oral administration.

New Zealand veterinary journal 20090801

Effect of fasting sheep for a short period on the efficacy and safety of monepantel.

The Veterinary record 20090711

The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits.

PLoS pathogens 20090701

Increased operant responding for ethanol in male C57BL/6J mice: specific regulation by the ERK1/2, but not JNK, MAP kinase pathway.

Psychopharmacology 20090501

Haemonchus contortus acetylcholine receptors of the DEG-3 subfamily and their role in sensitivity to monepantel.

PLoS pathogens 20090401

Dose confirmation studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep.

Veterinary parasitology 20090323

Determination of the effective dose rate for monepantel (AAD 1566) against adult gastro-intestinal nematodes in sheep.

International journal for parasitology 20090301

A large-scale clinical field study to evaluate the efficacy and safety of an oral formulation of the amino-acetonitrile derivative ( AAD ), monepantel , in sheep in New Zealand.

New Zealand veterinary journal 20090201

Safety of an amino-acetonitrile derivative ( AAD ), monepantel, in weaned lambs following repeated oral administration.

New Zealand veterinary journal 20090201

Reproductive safety of an amino-acetonitrile derivative (AAD), monepantel, in rams following repeated oral administration.

New Zealand veterinary journal 20090201

Efficacy of the amino-acetonitrile derivative, monepantel, against experimental and natural adult stage gastro-intestinal nematode infections in sheep.

Veterinary parasitology 20090122

Effects of the MEK inhibitor, SL-327, on rewarding, motor- and cellular-activating effects of D-amphetamine and SKF-82958, and their augmentation by food restriction in rat.

Psychopharmacology 20090101

Anthelmintic resistance in cyathostomin populations from horse yards in Italy, United Kingdom and Germany.

Parasites & vectors 20090101

Reduction of nitrogen compounds in oceanic basement and its implications for HCN formation and abiotic organic synthesis.

Geochemical transactions 20090101

ERK signalling pathway is not involved in PSA-NCAM-dependent alterations of hippocampal plasticity evoked by CB1 receptor activation.

Pharmacological reports : PR 20090101

IL-6 mediated alterations on immobile behavior of rats in the forced swim test via ERK1/2 activation in specific brain regions.

Behavioural brain research 20081121

Changes in apical dendritic structure correlate with sustained ERK1/2 phosphorylation in medial prefrontal cortex of a rat model of dopamine D1 receptor agonist sensitization.

The Journal of comparative neurology 20081110

Dose determination studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep.

Veterinary parasitology 20081020

Regulation of extracellular signal-regulated kinases (ERKs) by naloxone-induced morphine withdrawal in the brain stress system.

Naunyn-Schmiedeberg's archives of pharmacology 20081001

The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts.

British journal of pharmacology 20080901

Identification of the amino-acetonitrile derivative monepantel (AAD 1566) as a new anthelmintic drug development candidate.

Parasitology research 20080901

Estradiol-induced enhancement of object memory consolidation involves hippocampal extracellular signal-regulated kinase activation and membrane-bound estrogen receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20080827

Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds.

Bioorganic & medicinal chemistry letters 20080501

Drug discovery: fresh hope to can the worms.

Nature 20080313

A new class of anthelmintics effective against drug-resistant nematodes.

Nature 20080313

Ni(+) reactions with aminoacetonitrile, a potential prebiological precursor of glycine.

Journal of mass spectrometry : JMS 20080301

Developing novel anthelmintics from plant cysteine proteinases.

Parasites & vectors 20080101

Extracellular signal-regulated kinase (ERK) inhibition does not prevent the development or expression of tolerance to and dependence on morphine in the mouse.

Pharmacology, biochemistry, and behavior 20071101

Extracellular signal-regulated kinase 1/2 involvement in the enhancement of contextual fear conditioning by nicotine.

Behavioral neuroscience 20071001

Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20070926

Cellular mechanisms underlying the anxiolytic effect of low doses of peripheral Delta9-tetrahydrocannabinol in rats.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070901

A novel, conformation-specific allosteric inhibitor of the tachykinin NK2 receptor (NK2R) with functionally selective properties.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070701

Activation of the ERK signalling pathway contributes to the adaptive changes in rat hearts during naloxone-induced morphine withdrawal.

British journal of pharmacology 20070701

The striatal-enriched protein tyrosine phosphatase gates long-term potentiation and fear memory in the lateral amygdala.

Biological psychiatry 20070501

Pharmacokinetic study of free-form sinomenine in rat skin by microdialysis coupled with liquid chromatography-electrospray mass spectrometry.

Biomedical chromatography : BMC 20070101

Uptake and metabolism of ciclesonide and retention of desisobutyryl-ciclesonide for up to 24 hours in rabbit nasal mucosa.

BMC pharmacology 20070101

Chemical synthesis and properties of stereoregulated phosphorothioate RNAs.

Nucleic acids symposium series (2004) 20070101

A role for ERK2 in reconsolidation of fear memories in mice.

Neurobiology of learning and memory 20060901

Carbonic anhydrase inhibitors. N-cyanomethylsulfonamides--a new zinc binding group in the design of inhibitors targeting cytosolic and membrane-anchored isoforms.

Journal of enzyme inhibition and medicinal chemistry 20060801

Diastereoselective arylithium addition to an alpha-trifluoromethyl imine. Practical synthesis of a potent cathepsin K inhibitor.

The Journal of organic chemistry 20060526

Dopamine D4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation.

Neuropharmacology 20060401

Inhibition of ERK pathway or protein synthesis during reexposure to drugs of abuse erases previously learned place preference.

Proceedings of the National Academy of Sciences of the United States of America 20060221

Beta-substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K.

Journal of medicinal chemistry 20060209

Regulation of cocaine-induced activator protein 1 transcription factors by the extracellular signal-regulated kinase pathway.

Neuroscience 20060101

Extracellular signal-regulated mitogen-activated protein kinase inhibitors decrease amphetamine-induced behavior and neuropeptide gene expression in the striatum.

Neuroscience 20060101

Role of the ERK pathway in psychostimulant-induced locomotor sensitization.

BMC neuroscience 20060101

Protonation thermochemistry of aminoacetonitrile.

Rapid communications in mass spectrometry : RCM 20060101

A direct fluorometric assay for tissue transglutaminase.

Analytical biochemistry 20051215

Extracellular signal-regulated kinases (ERKs) modulate cocaine-induced gene expression in the mouse amygdala.

The European journal of neuroscience 20050801

Fully automated analysis of estrogens in environmental waters by in-tube solid-phase microextraction coupled with liquid chromatography-tandem mass spectrometry.

Journal of chromatography. A 20050722

Odorant-induced activation of extracellular signal-regulated kinase/mitogen-activated protein kinase in the olfactory bulb promotes survival of newly formed granule cells.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20050601

Ras/ERK signalling in cannabinoid tolerance: from behaviour to cellular aspects.

Journal of neurochemistry 20050501

ERK kinase inhibition stabilizes the aryl hydrocarbon receptor: implications for transcriptional activation and protein degradation.

The Journal of biological chemistry 20050211

Food restriction increases NMDA receptor-mediated calcium-calmodulin kinase II and NMDA receptor/extracellular signal-regulated kinase 1/2-mediated cyclic amp response element-binding protein phosphorylation in nucleus accumbens upon D-1 dopamine receptor stimulation in rats.

Neuroscience 20050101

Inhibition of mitogen-activated protein kinase-extracellular signal-regulated kinase disrupts latent inhibition of cued fear conditioning in C57BL/6 mice.

Behavioral neuroscience 20041201

Sustained extracellular signal-regulated kinase 1/2 phosphorylation in neonate 6-hydroxydopamine-lesioned rats after repeated D1-dopamine receptor agonist administration: implications for NMDA receptor involvement.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20040630

Evaluation of dose-response curve analysis in delineating shared or different molecular sites of action for osteolathyrogens.

Environmental toxicology and pharmacology 20040301

Dialkylaminoacetonitrile derivatives as amide synthons. A one-pot preparation of heteroaryl amides via a strategy of sequential SNAr substitution and oxidation.

The Journal of organic chemistry 20040220

Acetonitrile derivatives as carbonyl synthons. One-pot preparation of diheteroaryl ketones via a strategy of sequential SNAr substitution and oxidation.

The Journal of organic chemistry 20040220

Stereocontrolled synthesis of phosphorothioate RNA by the oxazaphospholidine approach.

Nucleic acids symposium series (2004) 20040101

Density functional study on the mechanism of bicyclic guanidine-catalyzed Strecker reaction.

The Journal of organic chemistry 20031114

The role of the extracellular signal-regulated kinase signaling pathway in mood modulation.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20030813

Preparation of (cyanomethylene)trimethylphosphorane as a new Mitsunobu-type reagent.

Chemical & pharmaceutical bulletin 20030401

Determination of ximelagatran, an oral direct thrombin inhibitor, its active metabolite melagatran, and the intermediate metabolites, in biological samples by liquid chromatography-mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030115

Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis.

The Journal of pharmacology and experimental therapeutics 20030101

A role for ERK MAP kinase in physiologic temporal integration in hippocampal area CA1.

Learning & memory (Cold Spring Harbor, N.Y.) 20030101

Chemical and biomechanical characterization of hyperhomocysteinemic bone disease in an animal model.

BMC musculoskeletal disorders 20030101

Utilization of glycine and serine as nitrogen sources in the roots of Zea mays and Chamaegigas intrepidus.

Journal of experimental botany 20021201

Biochemical and toxicological evaluation of agent-cofactor reactivity as a mechanism of action for osteolathyrism.

Toxicology 20020815

Alcohol-induced c-Fos expression in the Edinger-Westphal nucleus: pharmacological and signal transduction mechanisms.

The Journal of pharmacology and experimental therapeutics 20020801

The role of muscarinic acetylcholine receptor-mediated activation of extracellular signal-regulated kinase 1/2 in pilocarpine-induced seizures.

Journal of neurochemistry 20020701

Mitochondrial oxidative burst involved in apoptotic response in oats.

The Plant journal : for cell and molecular biology 20020601

Bidirectional changes in synapsin I phosphorylation at MAP kinase-dependent sites by acute neuronal excitation in vivo.

Journal of neurochemistry 20020301

Uncatalyzed and amine catalyzed decarboxylation of acetoacetic acid: an examination in terms of No Barrier Theory.

Bioorganic chemistry 20020201

Differential regulation of IL-1beta and TNF-alpha RNA expression by MEK1 inhibitor after focal cerebral ischemia in mice.

Biochemical and biophysical research communications 20010907

Kinetic studies of guinea pig liver transglutaminase reveal a general-base-catalyzed deacylation mechanism.

Biochemistry 20010727

Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade.

Blood 20010401

Increased alpha1-fetoprotein production in rat liver injuries induced by various hepatotoxins.

Gan 19760401