Home Sulfos Albendazole sulfone

Albendazole sulfone

CAS No.:
75184-71-3
Catalog Number:
AG003NP3
Molecular Formula:
C12H15N3O4S
Molecular Weight:
297.3302
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Product Description
Catalog Number:
AG003NP3
Chemical Name:
Albendazole sulfone
CAS Number:
75184-71-3
Molecular Formula:
C12H15N3O4S
Molecular Weight:
297.3302
MDL Number:
MFCD00600775
IUPAC Name:
methyl N-(6-propylsulfonyl-1H-benzimidazol-2-yl)carbamate
InChI:
InChI=1S/C12H15N3O4S/c1-3-6-20(17,18)8-4-5-9-10(7-8)14-11(13-9)15-12(16)19-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
InChI Key:
CLSJYOLYMZNKJB-UHFFFAOYSA-N
SMILES:
CCCS(=O)(=O)c1ccc2c(c1)nc([nH]2)NC(=O)OC
UNII:
1UIC88380G
Properties
Complexity:
448  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
297.078g/mol
Formal Charge:
0
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
297.329g/mol
Monoisotopic Mass:
297.078g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
110A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.6  
Literature
Title Journal
A cell-based screen reveals that the albendazole metabolite, albendazole sulfone, targets Wolbachia. PLoS pathogens 20120901
Assessment of the stereoselective fungal biotransformation of albendazole and its analysis by HPLC in polar organic mode. Journal of pharmaceutical and biomedical analysis 20120305
Pharmacokinetics and tissue residues of hydrochloric acid albendazole sulfoxide and its metabolites in crucian carp (Carassius auratus) after oral administration. Environmental toxicology and pharmacology 20120301
A simple LC-MS/MS method to determine plasma and cerebrospinal fluid levels of albendazole metabolites (albendazole sulfoxide and albendazole sulfone) in patients with neurocysticercosis. Biomedical chromatography : BMC 20120201
Application of ultra-performance columns in high-performance liquid chromatography for determination of albendazole and its metabolites in turkeys. Biomedical chromatography : BMC 20111001
Microbial transformation of albendazole. Indian journal of experimental biology 20100401
Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study). World journal of gastroenterology 20090107
Determination of albendazole metabolites by direct injection of bovine plasma and multidimensional achiral-chiral high performance liquid chromatography. Talanta 20080630
Kinetic disposition of albendazole in goats subclinically infected with gastrointestinal nematodes vis-à-vis naive animals following oral and intraruminal administration. Journal of helminthology 20080301
Determination of albendazole and its metabolites in the muscle tissue of hybrid striped and largemouth bass using liquid chromatography with fluorescence detection. Journal of AOAC International 20080101
Simultaneous determination of albendazole metabolites, praziquantel and its metabolite in plasma by high-performance liquid chromatography-electrospray mass spectrometry. Journal of pharmaceutical and biomedical analysis 20070628
Development and optimization of a rapid HPLC method for analysis of ricobendazole and albendazole sulfone in sheep plasma. Journal of pharmaceutical and biomedical analysis 20050901
Highly sensitive ion pair liquid chromatographic determination of albendazole marker residue in animal tissues. Journal of agricultural and food chemistry 20050223
Quantitative determination of albendazole metabolites in sheep spermatozoa and seminal plasma by liquid chromatographic analysis with fluorescence detection. Journal of pharmaceutical and biomedical analysis 20040903
Reversed-phase liquid chromatographic method with fluorescence detection for the simultaneous determination of albendazole sulphoxide, albendazole sulphone and albendazole 2-aminosulphone in sheep plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040615
Monitoring of drugs and metabolites in body fluids by capillary electrophoresis with XeHg lamp-based and laser-induced fluorescence detection. Electrophoresis 20040601
The effects of albendazole and its metabolites on hepatic cytochromes P450 activities in mouflon and rat. Research in veterinary science 20031201
Aspects of the pharmacokinetics of albendazole sulphoxide in sheep. Veterinary research communications 20031001
Time dependent pharmacokinetics of albendazole in human. Biopharmaceutics & drug disposition 20030701
Effect of clotrimazole on microsomal metabolism and pharmacokinetics of albendazole. The Journal of pharmacy and pharmacology 20030601
Simultaneous liquid chromatography-tandem mass spectrometric determination of albendazole sulfoxide and albendazole sulfone in plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030105
Effect of gender in the disposition of albendazole metabolites in humans. European journal of clinical pharmacology 20020901
Enantioselective distribution of albendazole metabolites in cerebrospinal fluid of patients with neurocysticercosis. British journal of clinical pharmacology 20020801
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