4-(N-NITROSOMETHYLAMINO)-1-(3-PYRIDYL)-1-BUTANONE
| Title | Journal |
|---|---|
| Sex hormones reduce NNK detoxification through inhibition of short-chain dehydrogenases/reductases and aldo-keto reductases in vitro. | Chemico-biological interactions 20171001 |
| Tobacco nitrosamine NNK increases ALDH-positive cells via ROS-Wnt signaling pathway in A549 human lung cancer cells. | The Journal of toxicological sciences 20170101 |
| In vitro metabolism of N'-Nitrosonornicotine catalyzed by cytochrome P450 2A13 and its inhibition by nicotine, N'-Nitrosoanatabine and N'-Nitrosoanabasine. | Chemico-biological interactions 20161225 |
| Dihydromethysticin (DHM) Blocks Tobacco Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Induced O(6)-Methylguanine in a Manner Independent of the Aryl Hydrocarbon Receptor (AhR) Pathway in C57BL/6 Female Mice. | Chemical research in toxicology 20161121 |
| Alteration of human hepatic drug transporter activity and expression by cigarette smoke condensate. | Toxicology 20160701 |
| Activation of MEK1/2-ERK1/2 signaling during NNK-induced lung carcinogenesis in female A/J mice. | Cancer medicine 20160501 |
| Stereospecific Metabolism of the Tobacco-Specific Nitrosamine, NNAL. | Chemical research in toxicology 20151116 |
| γ-H2AX is a sensitive marker of DNA damage induced by metabolically activated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. | Toxicology in vitro : an international journal published in association with BIBRA 20151001 |
| Molecular and biochemical characterisation of human short-chain dehydrogenase/reductase member 3 (DHRS3). | Chemico-biological interactions 20150605 |
| NNK-induced DNA methyltransferase 1 in lung tumorigenesis in A/J mice and inhibitory effects of (-)-epigallocatechin-3-gallate. | Nutrition and cancer 20150101 |
| Nicotine, cotinine, and b-nicotyrine inhibit NNK-induced DNA-strand break in the hepatic cell line HepaRG. | Toxicology in vitro : an international journal published in association with BIBRA 20141001 |
| In vitro exposure of tobacco specific nitrosamines decreases the rat lung phospholipids by enhanced phospholipase A2 activity. | Toxicology in vitro : an international journal published in association with BIBRA 20140901 |
| Tissue distributions of 4-(hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronide, a stable form of reactive intermediate produced from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, in the rat. | The Journal of toxicological sciences 20140401 |
| Biochemical properties of human dehydrogenase/reductase (SDR family) member 7. | Chemico-biological interactions 20140125 |
| Proteomic analysis of differentially expressed proteins in lung cancer in Wistar rats using NNK as an inducer. | Chemico-biological interactions 20130705 |
| 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism-related enzymes gene polymorphisms, NNK metabolites levels and urothelial carcinoma. | Toxicology letters 20130110 |
| Effect of the cigarette smoke component, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), on physiological and molecular parameters of thiamin uptake by pancreatic acinar cells. | PloS one 20130101 |
| The application of hepatic P450 reductase null gpt delta mice in studying the role of hepatic P450 in genotoxic carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mutagenesis. | Archives of toxicology 20121101 |
| Prevention of tobacco carcinogen-induced lung cancer in female mice using antiestrogens. | Carcinogenesis 20121101 |
| Apigenin inhibits NNK-induced focal adhesion kinase activation in pancreatic cancer cells. | Pancreas 20121101 |
| Development, validation, and application of a liquid chromatography-tandem mass spectrometry method for the determination of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human hair. | Analytical and bioanalytical chemistry 20121101 |
| Comparison of genotoxicant-modified transcriptomic responses in conventional and epigenetically stabilized primary rat hepatocytes with in vivo rat liver data. | Archives of toxicology 20121101 |
| Formation and repair of pyridyloxobutyl DNA adducts and their relationship to tumor yield in A/J mice. | Chemical research in toxicology 20121015 |
| Increased pouch sizes and resulting changes in the amounts of nicotine and tobacco-specific N-nitrosamines in single pouches of Camel Snus and Marlboro Snus. | Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20121001 |
| Selective expression of CYP2A13 in human pancreatic α-islet cells. | Drug metabolism and disposition: the biological fate of chemicals 20121001 |
| Discrimination of genotoxic and non-genotoxic hepatocarcinogens by statistical analysis based on gene expression profiling in the mouse liver as determined by quantitative real-time PCR. | Mutation research 20120918 |
| Chemoprevention of mouse lung and colon tumors by suberoylanilide hydroxamic acid and atorvastatin. | International journal of cancer 20120915 |
| Tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone initiates and enhances pancreatitis responses. | American journal of physiology. Gastrointestinal and liver physiology 20120915 |
| Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver. | Archives of toxicology 20120901 |
| Interplay between smoking-induced genotoxicity and altered signaling in pancreatic carcinogenesis. | Carcinogenesis 20120901 |
| Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone binding and access channel in human cytochrome P450 2A6 and 2A13 enzymes. | The Journal of biological chemistry 20120803 |
| O(6)-methylguanine-DNA methyltransferase (MGMT): impact on cancer risk in response to tobacco smoke. | Mutation research 20120801 |
| NNK enhances cell migration through α7-nicotinic acetylcholine receptor accompanied by increased of fibronectin expression in gastric cancer. | Annals of surgical oncology 20120701 |
| Pioglitazone prevents smoking carcinogen-induced lung tumor development in mice. | Current cancer drug targets 20120701 |
| Low fidelity bypass of O(2)-(3-pyridyl)-4-oxobutylthymine, the most persistent bulky adduct produced by the tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by model DNA polymerases. | Chemical research in toxicology 20120618 |
| The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation in laryngeal carcinoma. | Oral oncology 20120601 |
| In vivo and in vitro metabolism of tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), by the freshwater planarian, Dugesia japonica. | Chemosphere 20120601 |
| Generation and characterization of a CYP2A13/2B6/2F1-transgenic mouse model. | Drug metabolism and disposition: the biological fate of chemicals 20120601 |
| Inhibition and inactivation of cytochrome P450 2A6 and cytochrome P450 2A13 by menthofuran, β-nicotyrine and menthol. | Chemico-biological interactions 20120530 |
| NNK promotes migration and invasion of lung cancer cells through activation of c-Src/PKCι/FAK loop. | Cancer letters 20120501 |
| An investigation of the catalytic activity of CYP2A13*4 with coumarin and polymorphisms of CYP2A13 in a Chinese Han population. | Drug metabolism and disposition: the biological fate of chemicals 20120501 |
| Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs. | Toxicological sciences : an official journal of the Society of Toxicology 20120501 |
| Development of a method for the determination of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in urine of nonsmokers and smokers using liquid chromatography/tandem mass spectrometry. | Journal of pharmaceutical and biomedical analysis 20120407 |
| Quantitative proteomic analysis revealed 4-(methylnitrosamino)-1-(3-pyridinyl)-1-butanone-induced up-regulation of 20S proteasome in cultured human fibroblast cells. | Journal of proteome research 20120406 |
| Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice. | The Journal of pharmacology and experimental therapeutics 20120401 |
| Urinary levels of volatile organic carcinogen and toxicant biomarkers in relation to lung cancer development in smokers. | Carcinogenesis 20120401 |
| Exposure to and deposition of fine and ultrafine particles in smokers of menthol and nonmenthol cigarettes. | Inhalation toxicology 20120401 |
| Genetic variability in the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL). | International journal of cancer 20120315 |
| Green tea catechin extract in intervention of chronic breast cell carcinogenesis induced by environmental carcinogens. | Molecular carcinogenesis 20120301 |
| Scientific assessment of the use of sugars as cigarette tobacco ingredients: a review of published and other publicly available studies. | Critical reviews in toxicology 20120301 |
| Environmental tobacco smoke and children's health. | Korean journal of pediatrics 20120201 |
| Green tea catechin intervention of reactive oxygen species-mediated ERK pathway activation and chronically induced breast cell carcinogenesis. | Carcinogenesis 20120101 |
| 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone is correlated with 8-hydroxy-2'-deoxyguanosine in humans after exposure to environmental tobacco smoke. | The Science of the total environment 20120101 |
| Cancer chemoprevention by citrus pulp and juices containing high amounts of β-cryptoxanthin and hesperidin. | Journal of biomedicine & biotechnology 20120101 |
| Enhancement of lung tumorigenesis in a Gprc5a Knockout mouse by chronic extrinsic airway inflammation. | Molecular cancer 20120101 |
| Cooperative regulation of non-small cell lung carcinoma by nicotinic and beta-adrenergic receptors: a novel target for intervention. | PloS one 20120101 |
| Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles. | International journal of nanomedicine 20120101 |
| Impact of heat treatment on size, structure, and bioactivity of elemental selenium nanoparticles. | International journal of nanomedicine 20120101 |
| RNA-Seq quantification of the human small airway epithelium transcriptome. | BMC genomics 20120101 |
| Revealing mammalian evolutionary relationships by comparative analysis of gene clusters. | Genome biology and evolution 20120101 |
| 3,3'Diindolylmethane suppresses vascular smooth muscle cell phenotypic modulation and inhibits neointima formation after carotid injury. | PloS one 20120101 |
| Ethanol-mediated regulation of cytochrome P450 2A6 expression in monocytes: role of oxidative stress-mediated PKC/MEK/Nrf2 pathway. | PloS one 20120101 |
| Encapsulated nanoepigallocatechin-3-gallate and elemental selenium nanoparticles as paradigms for nanochemoprevention. | International journal of nanomedicine 20120101 |
| The cumulative effects of polymorphisms in the DNA mismatch repair genes and tobacco smoking in oesophageal cancer risk. | PloS one 20120101 |
| Evaluating the number of stages in development of squamous cell and adenocarcinomas across cancer sites using human population-based cancer modeling. | PloS one 20120101 |
| Functional interaction between human papillomavirus type 16 E6 and E7 oncoproteins and cigarette smoke components in lung epithelial cells. | PloS one 20120101 |
| Role of phosphatidylinositol-3-kinase pathway in head and neck squamous cell carcinoma. | Journal of oncology 20120101 |
| Immunogenicity of a promiscuous T cell epitope peptide based conjugate vaccine against benzo[a]pyrene: redirecting antibodies to the hapten. | PloS one 20120101 |
| Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus. | PloS one 20120101 |
| Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway. | The Journal of toxicological sciences 20120101 |
| 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone induces retinoic acid receptor β hypermethylation through DNA methyltransferase 1 accumulation in esophageal squamous epithelial cells. | Asian Pacific journal of cancer prevention : APJCP 20120101 |
| Estimation and correlation of cigarette smoke exposure in Canadian smokers as determined by filter analysis and biomarkers of exposure. | Regulatory toxicology and pharmacology : RTP 20111201 |
| A study to evaluate the effect on Mouth Level Exposure and biomarkers of exposure estimates of cigarette smoke exposure following a forced switch to a lower ISO tar yield cigarette. | Regulatory toxicology and pharmacology : RTP 20111201 |
| Indole-3-carbinol inhibited tobacco smoke carcinogen-induced lung adenocarcinoma in A/J mice when administered during the post-initiation or progression phase of lung tumorigenesis. | Cancer letters 20111201 |
| Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity. | Toxicological sciences : an official journal of the Society of Toxicology 20111201 |
| Mass spectrometry based approach to study the kinetics of O6-alkylguanine DNA alkyltransferase-mediated repair of O6-pyridyloxobutyl-2'-deoxyguanosine adducts in DNA. | Chemical research in toxicology 20111121 |
| Tobacco-specific nitrosamine-derived O2-alkylthymidines are potent mutagenic lesions in SOS-induced Escherichia coli. | Chemical research in toxicology 20111121 |
| Major tobacco companies have technology to reduce carcinogen levels but do not apply it to popular smokeless tobacco products. | Tobacco control 20111101 |
| Phenylbutyl isoselenocyanate modulates phase I and II enzymes and inhibits 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone-induced DNA adducts in mice. | Cancer prevention research (Philadelphia, Pa.) 20111101 |
| Tobacco-specific carcinogen nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces AKT activation in head and neck epithelia. | International journal of oncology 20111101 |
| Chronic nicotine consumption does not influence 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis. | Cancer prevention research (Philadelphia, Pa.) 20111101 |
| Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer. | Cancer prevention research (Philadelphia, Pa.) 20111101 |
| Urinary levels of cigarette smoke constituent metabolites are prospectively associated with lung cancer development in smokers. | Cancer research 20111101 |
| Long-term nicotine replacement therapy: cancer risk in context. | Cancer prevention research (Philadelphia, Pa.) 20111101 |
| How do we safely get people to stop smoking? | Cancer prevention research (Philadelphia, Pa.) 20111101 |
| STrengthening the Reporting of OBservational studies in Epidemiology--Molecular Epidemiology (STROBE-ME): an extension of the STROBE Statement. | PLoS medicine 20111001 |
| Metabolic study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone to the enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in vitro in human bronchial epithelial cells using chiral capillary electrophoresis. | Journal of chromatography. A 20110916 |
| Thirdhand tobacco smoke: emerging evidence and arguments for a multidisciplinary research agenda. | Environmental health perspectives 20110901 |
| Computational insights into the different catalytic activities of CYP2A13 and CYP2A6 on NNK. | Journal of molecular graphics & modelling 20110901 |
| Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers. | Carcinogenesis 20110901 |
| K-ras mutations in lung tumors from NNK-treated mice with lipopolysaccharide-elicited lung inflammation. | Anticancer research 20110901 |
| Spectral modification and catalytic inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2A6, and 2A13 by four chemopreventive organoselenium compounds. | Chemical research in toxicology 20110815 |
| A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice. | Carcinogenesis 20110801 |
| Addition of porphyrins to cigarette filters to reduce the levels of benzo[a]pyrene (B[a]P) and tobacco-specific N-nitrosamines (TSNAs) in mainstream cigarette smoke. | Journal of agricultural and food chemistry 20110713 |
| Thirdhand smoke: a new dimension to the effects of cigarette smoke on the developing lung. | American journal of physiology. Lung cellular and molecular physiology 20110701 |
| Comparison of exposure to selected cigarette smoke constituents in adult smokers and nonsmokers in a European, multicenter, observational study. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20110701 |
| Facile syntheses of O(2)-[4-(3-pyridyl-4-oxobut-1-yl]thymidine, the major adduct formed by tobacco specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in vivo, and its site-specifically adducted oligodeoxynucleotides. | Chemical research in toxicology 20110620 |
| Cigarette smoking habit does not reduce the benefit from first line trastuzumab-based treatment in advanced breast cancer patients. | Oncology reports 20110601 |
| Metabolites of a tobacco-specific lung carcinogen in children exposed to secondhand or thirdhand tobacco smoke in their homes. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20110601 |
| Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach. | Toxicology and applied pharmacology 20110601 |
| A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species. | International journal of cancer 20110515 |
| Global surveillance of oral tobacco products: total nicotine, unionised nicotine and tobacco-specific N-nitrosamines. | Tobacco control 20110501 |
| 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone promoted gastric cancer growth through prostaglandin E receptor (EP2 and EP4) in vivo and in vitro. | Cancer science 20110501 |
| Differential exposure biomarker levels among cigarette smokers and smokeless tobacco consumers in the National Health and Nutrition Examination Survey 1999-2008. | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20110501 |
| Direct disease-inducing effects of menthol through the eyes of tobacco companies. | Tobacco control 20110501 |
| Cigarette smoking, cyclooxygenase-2 pathway and cancer. | Biochimica et biophysica acta 20110401 |
| Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice. | Carcinogenesis 20110401 |
| Low ratio of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol-glucuronides (NNAL-Gluc)/free NNAL increases urothelial carcinoma risk. | The Science of the total environment 20110401 |
| Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways. | Cell death & disease 20110401 |
| Effect of cigarette smoke on mutagenic activation of environmental carcinogens by cytochrome P450 2A8 and inactivation by glucuronidation in hamster liver. | Mutagenesis 20110301 |
| Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in smokers in the United States: NHANES 2007-2008. | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20110301 |
| Is 24h nicotine equivalents a surrogate for smoke exposure based on its relationship with other biomarkers of exposure? | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20110301 |
| Life-long programming implications of exposure to tobacco smoking and nicotine before and soon after birth: evidence for altered lung development. | International journal of environmental research and public health 20110301 |
| Synergism between 2,3,7,8-tetrachlorodibenzo-p-dioxin and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone on lung tumor incidence in mice. | Journal of hazardous materials 20110215 |
| A new liquid chromatography/mass spectrometry method for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in urine. | Rapid communications in mass spectrometry : RCM 20110115 |
| 4-Methylnitrosamino-1-3-pyridyl-1-butanone (NNK) promotes lung cancer cell survival by stimulating thromboxane A2 and its receptor. | Oncogene 20110106 |
| Lack of promoting effects from physical pulmonary collapse in a female A/J mouse lung tumor initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) with remarkable mesothelial cell reactions in the thoracic cavity by the polymer. | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20110101 |
| The function of IGF-IR in NNK-mediated lung tumorigenesis. | Lung cancer (Amsterdam, Netherlands) 20110101 |
| Effect of oral snus and medicinal nicotine in smokers on toxicant exposure and withdrawal symptoms: a feasibility study. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20110101 |
| Lysyl oxidase, a critical intra- and extra-cellular target in the lung for cigarette smoke pathogenesis. | International journal of environmental research and public health 20110101 |
| Electronic cigarettes and thirdhand tobacco smoke: two emerging health care challenges for the primary care provider. | International journal of general medicine 20110101 |
| Nicotinic acetylcholine receptor signaling in tumor growth and metastasis. | Journal of oncology 20110101 |
| Smoking, alcohol, and betel quid and oral cancer: a prospective cohort study. | Journal of oncology 20110101 |
| How to reduce your cancer risk: mechanisms and myths. | International journal of general medicine 20110101 |
| NNK-Induced Lung Tumors: A Review of Animal Model. | Journal of oncology 20110101 |
| Epigenetic effects and molecular mechanisms of tumorigenesis induced by cigarette smoke: an overview. | Journal of oncology 20110101 |
| Claudins in lung diseases. | Respiratory research 20110101 |
| The health effects of menthol cigarettes as compared to non-menthol cigarettes. | Tobacco induced diseases 20110101 |
| Lycopene inhibits NF-kB-mediated IL-8 expression and changes redox and PPARγ signalling in cigarette smoke-stimulated macrophages. | PloS one 20110101 |
| Null genotypes of GSTM1 and GSTT1 contribute to risk of cervical neoplasia: an evidence-based meta-analysis. | PloS one 20110101 |
| Trends in smokeless tobacco use in the us workforce: 1987-2005. | Tobacco induced diseases 20110101 |
| Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice. | The American journal of Chinese medicine 20110101 |
| Vitamin A and retinoid derivatives for lung cancer: a systematic review and meta analysis. | PloS one 20110101 |
| Molecular mechanisms of cigarette smoke-induced proliferation of lung cells and prevention by vitamin C. | Journal of oncology 20110101 |
| From smoking to cancers: novel targets to neuronal nicotinic acetylcholine receptors. | Journal of oncology 20110101 |
| Polonium and lung cancer. | Journal of oncology 20110101 |
| Short-term exposure to tobacco toxins alters expression of multiple proliferation gene markers in primary human bronchial epithelial cell cultures. | Journal of oncology 20110101 |
| Smoking and COX-2 functional polymorphisms interact to increase the risk of gastric cardia adenocarcinoma in Chinese population. | PloS one 20110101 |
| Smoking and cervical cancer. | ISRN obstetrics and gynecology 20110101 |
| The scientific foundation for tobacco harm reduction, 2006-2011. | Harm reduction journal 20110101 |
| The emphysematous lung is abnormally sensitive to TRAIL-mediated apoptosis. | Respiratory research 20110101 |
| N-Nitrosamines (15 listings): 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone. | Report on carcinogens : carcinogen profiles 20110101 |
| Loss of cytoplasmic CDK1 predicts poor survival in human lung cancer and confers chemotherapeutic resistance. | PloS one 20110101 |
| Loss of glucocorticoid receptor expression by DNA methylation prevents glucocorticoid induced apoptosis in human small cell lung cancer cells. | PloS one 20110101 |
| A clinical overview of centrosome amplification in human cancers. | International journal of biological sciences 20110101 |
| Selenium and lung cancer: a systematic review and meta analysis. | PloS one 20110101 |
| The role of tobacco-derived carcinogens in pancreas cancer. | ISRN oncology 20110101 |
| β2-adrenoceptor blockage induces G1/S phase arrest and apoptosis in pancreatic cancer cells via Ras/Akt/NFκB pathway. | Molecular cancer 20110101 |
| Naturally occurring variants of human Α9 nicotinic receptor differentially affect bronchial cell proliferation and transformation. | PloS one 20110101 |
| Extremely high Tp53 mutation load in esophageal squamous cell carcinoma in Golestan Province, Iran. | PloS one 20110101 |
| Cigarette smoke and cancer. | Journal of oncology 20110101 |
| RAS Mutations and Oncogenesis: Not all RAS Mutations are Created Equally. | Frontiers in genetics 20110101 |
| Roles of peroxisome proliferator-activated receptor-alpha and -gamma in the development of non-small cell lung cancer. | American journal of respiratory cell and molecular biology 20101201 |
| Functional characterization of eight human cytochrome P450 1A2 gene variants by recombinant protein expression. | The pharmacogenomics journal 20101201 |
| Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis. | Carcinogenesis 20101201 |
| Anticancer efficacy of 5F in NNK-induced lung cancer development of A/J mice and human lung cancer cells. | Journal of molecular medicine (Berlin, Germany) 20101201 |
| Potent mutagenicity of 3-methylindole requires pulmonary cytochrome P450-mediated bioactivation: a comparison to the prototype cigarette smoke mutagens B(a)P and NNK. | Chemical research in toxicology 20101115 |
| Urine cotinine underestimates exposure to the tobacco-derived lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in passive compared with active smokers. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20101101 |
| Urine concentrations of a tobacco-specific nitrosamine carcinogen in the U.S. population from secondhand smoke exposure. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20101101 |
| Beta-adrenergic signaling, a novel target for cancer therapy? | Oncotarget 20101101 |
| On-line concentration and determination of tobacco-specific N-nitrosamines by cation-selective exhaustive injection-sweeping-micellar electrokinetic chromatography. | Talanta 20101015 |
| Determination of methyl-, 2-hydroxyethyl- and 2-cyanoethylmercapturic acids as biomarkers of exposure to alkylating agents in cigarette smoke. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101001 |
| Chinese 'low-tar' cigarettes do not deliver lower levels of nicotine and carcinogens. | Tobacco control 20101001 |
| Overexpression and activation of the alpha9-nicotinic receptor during tumorigenesis in human breast epithelial cells. | Journal of the National Cancer Institute 20100908 |
| Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination. | Carcinogenesis 20100901 |
| Metformin prevents tobacco carcinogen--induced lung tumorigenesis. | Cancer prevention research (Philadelphia, Pa.) 20100901 |
| Stability of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in urine samples stored at various temperatures. | Journal of analytical toxicology 20100901 |
| Effects of antibodies induced by a conjugate vaccine on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone absorptive transport, metabolism, and proliferation of human lung cells. | International journal of cancer 20100801 |
| Long-term consequences of fetal and neonatal nicotine exposure: a critical review. | Toxicological sciences : an official journal of the Society of Toxicology 20100801 |
| [Determination of four carcinogens in mainstream cigarette smoke by liquid chromatography-tandem mass spectrometry]. | Se pu = Chinese journal of chromatography 20100801 |
| A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs. | Oncotarget 20100801 |
| Post-puff respiration measures on smokers of different tar yield cigarettes. | Inhalation toxicology 20100701 |
| Chronic exposure to estrogen and the tobacco carcinogen NNK cooperatively modulates nicotinic receptors in small airway epithelial cells. | Lung cancer (Amsterdam, Netherlands) 20100701 |
| 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone [corrected] induces CRM1-dependent p53 nuclear accumulation in human bronchial epithelial cells. | Toxicological sciences : an official journal of the Society of Toxicology 20100701 |
| Effect of menthol on the penetration of tobacco carcinogens and nicotine across porcine oral mucosa ex vivo. | Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20100701 |
| Study of secondhand smoke levels pre and post implementation of the comprehensive smoking ban in mumbai. | Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine 20100701 |
| Tobacco carcinogen NNK transporter MRP2 regulates CFTR function in lung epithelia: implications for lung cancer. | Cancer letters 20100628 |
| Identification of long stress-induced non-coding transcripts that have altered expression in cancer. | Genomics 20100601 |
| Effect of differing levels of tobacco-specific nitrosamines in cigarette smoke on the levels of biomarkers in smokers. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20100601 |
| Induction of lacZ mutations in MutaMouse primary hepatocytes. | Environmental and molecular mutagenesis 20100501 |
| Grape seed proanthocyanidin suppression of breast cell carcinogenesis induced by chronic exposure to combined 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene. | Molecular carcinogenesis 20100501 |
| Formation and distribution of NNK metabolites in an isolated perfused rat lung. | Drug metabolism and disposition: the biological fate of chemicals 20100501 |
| A gamma-tocopherol-rich mixture of tocopherols inhibits chemically induced lung tumorigenesis in A/J mice and xenograft tumor growth. | Carcinogenesis 20100401 |
| Evaluating oral noncombustible potential-reduced exposure products for smokers. | Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20100401 |
| Immunohistochemical analysis of CYP2A13 in various types of human lung cancers. | Cancer science 20100401 |
| 15-Lipoxygenases and its metabolites 15(S)-HETE and 13(S)-HODE in the development of non-small cell lung cancer. | Thorax 20100401 |
| UDP-glucuronosyltransferase 1A10: activity against the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and a potential role for a novel UGT1A10 promoter deletion polymorphism in cancer susceptibility. | Drug metabolism and disposition: the biological fate of chemicals 20100301 |
| Arsenite promotes centrosome abnormalities under a p53 compromised status induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). | Toxicology and applied pharmacology 20100215 |
| Human cytochrome P450 oxidoreductase deficiency caused by the Y181D mutation: molecular consequences and rescue of defect. | Drug metabolism and disposition: the biological fate of chemicals 20100201 |
| Evaluation of biomarkers of exposure in adult cigarette smokers using Marlboro snus. | Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20100201 |
| The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients. | The Journal of clinical investigation 20100201 |
| Neurotransmitter receptors as central regulators of pancreatic cancer. | Future oncology (London, England) 20100201 |
| Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation. | Cancer cell 20100119 |
| Methylation induced gene silencing of HtrA3 in smoking-related lung cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20100115 |
| PPARgamma activation extinguishes smoking carcinogen by inhibiting NNK-mediated proliferation. | American journal of respiratory cell and molecular biology 20100101 |
| FOXO3a elicits a pro-apoptotic transcription program and cellular response to human lung carcinogen nicotine-derived nitrosaminoketone (NNK). | Lung cancer (Amsterdam, Netherlands) 20100101 |
| Nicotine, through upregulating pro-survival signaling, cooperates with NNK to promote transformation. | Journal of cellular biochemistry 20100101 |
| Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study. | BMC cancer 20100101 |
| Benzo[a]pyrene diol epoxide suppresses retinoic acid receptor-beta2 expression by recruiting DNA (cytosine-5-)-methyltransferase 3A. | Molecular cancer 20100101 |
| Quantitative proteomic analysis by iTRAQ(R) for the identification of candidate biomarkers in ovarian cancer serum. | Proteome science 20100101 |
| Risk analysis of environmental chemicals on lung carcinogenesis. | Asian Pacific journal of cancer prevention : APJCP 20100101 |
| Comparative functional genomics analysis of NNK tobacco-carcinogen induced lung adenocarcinoma development in Gprc5a-knockout mice. | PloS one 20100101 |
| Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma. | Molecular cancer 20100101 |
| Analysis of death receptor 5 and caspase-8 expression in primary and metastatic head and neck squamous cell carcinoma and their prognostic impact. | PloS one 20100101 |
| Formation, repair, and genotoxic properties of bulky DNA adducts formed from tobacco-specific nitrosamines. | Journal of nucleic acids 20100101 |
| Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea. | BMC genomics 20100101 |
| Formation and repair of tobacco carcinogen-derived bulky DNA adducts. | Journal of nucleic acids 20100101 |
| Molecular analysis of carcinogen-induced rodent lung tumors: Involvement of microRNA expression and Krαs or Egfr mutations. | Molecular medicine reports 20100101 |
| Different threshold levels for 2-amino-3,8 dimethylimidazo[4,5-f]quinoxaline (MelQx) initiation of lung and colon carcinogenesis and the effects of an additional initiation by 4 (methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice. | Molecular medicine reports 20100101 |
| Determination of tobacco-specific N-nitrosamines in urine of smokers and non-smokers. | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20091201 |
| Exposure to the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers from 3 populations with different risks of lung cancer. | International journal of cancer 20091115 |
| Incremental lifetime cancer risks computed for benzo[a]pyrene and two tobacco-specific N-nitrosamines in mainstream cigarette smoke compared with lung cancer risks derived from epidemiologic data. | Regulatory toxicology and pharmacology : RTP 20091101 |
| Eukaryotic initiation factor 4E binding protein family of proteins: sentinels at a translational control checkpoint in lung tumor defense. | Cancer research 20091101 |
| The relationship between smoking machine derived tar yields and biomarkers of exposure in adult cigarette smokers in the US. | Regulatory toxicology and pharmacology : RTP 20091001 |
| Bayesian derivation of an oral cancer slope factor distribution for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). | Regulatory toxicology and pharmacology : RTP 20091001 |
| A study to estimate and correlate cigarette smoke exposure in smokers in Germany as determined by filter analysis and biomarkers of exposure. | Regulatory toxicology and pharmacology : RTP 20091001 |
| The pneumotoxin 3-methylindole is a substrate and a mechanism-based inactivator of CYP2A13, a human cytochrome P450 enzyme preferentially expressed in the respiratory tract. | Drug metabolism and disposition: the biological fate of chemicals 20091001 |
| FoxO3a gene is a target of deletion in mouse lung adenocarcinoma. | Oncology reports 20091001 |
| Effect of gefitinib on N-nitrosamine-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mice. | Lung cancer (Amsterdam, Netherlands) 20090901 |
| Lack of Modifying Effects of Intratracheal Instillation of Quartz or Dextran Sulfate Sodium (DSS) in Drinking Water on Lung Tumor Development Initiated with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Female A/J Mice. | Journal of toxicologic pathology 20090901 |
| The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines. | Chemical research in toxicology 20090817 |
| Nicotinic receptor-associated modulation of stimulatory and inhibitory neurotransmitters in NNK-induced adenocarcinoma of the lungs and pancreas. | The Journal of pathology 20090801 |
| Tobacco carcinogen induces microglial activation and subsequent neuronal damage. | Journal of neurochemistry 20090801 |
| Down-regulation of 14-3-3 isoforms and annexin A5 proteins in lung adenocarcinoma induced by the tobacco-specific nitrosamine NNK in the A/J mouse revealed by proteomic analysis. | Journal of proteome research 20090801 |
| Prevention of pancreatic cancer by the beta-blocker propranolol. | Anti-cancer drugs 20090701 |
| Is nicotine the estrogen of lung cancer? | American journal of respiratory and critical care medicine 20090615 |
| Inhibition of rat hepatic CYP2E1 by quinacrine: molecular modeling investigation and effects on 4-(methyl nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced mutagenicity. | Archives of toxicology 20090601 |
| Comparative levels of O6-methylguanine, pyridyloxobutyl-, and pyridylhydroxybutyl-DNA adducts in lung and liver of rats treated chronically with the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. | Drug metabolism and disposition: the biological fate of chemicals 20090601 |
| Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in lung tissue from mouse, rat, hamster, and man. | Chemical research in toxicology 20090601 |
| Tobacco-specific carcinogen enhances colon cancer cell migration through alpha7-nicotinic acetylcholine receptor. | Annals of surgery 20090601 |
| Toxicity and carcinogenicity of ozone in combination with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and dibutyl phthalate in B6C3F1 mice for 16 and 32 weeks. | Biomedical and environmental sciences : BES 20090601 |
| CYP1A2 genetic polymorphisms and adenocarcinoma lung cancer risk in the Tunisian population. | Life sciences 20090522 |
| 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) enhances invasiveness of lung cancer cells by up-regulating contactin-1 via the alpha7 nicotinic acetylcholine receptor/ERK signaling pathway. | Chemico-biological interactions 20090515 |
| beta-Carotene promotes the development of NNK-induced small airway-derived lung adenocarcinoma. | European journal of cancer (Oxford, England : 1990) 20090501 |
| Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. | Chemical research in toxicology 20090501 |
| In vivo treatment with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces organ-specific alterations in in vitro repair of DNA pyridyloxobutylation. | Mutation research 20090426 |
| Simultaneous determination of four tobacco-specific N-nitrosamines (TSNA) in human urine. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090415 |
| The contribution of cancer incidence, stage at diagnosis and survival to racial differences in years of life expectancy. | Journal of general internal medicine 20090401 |
| Sensitivity to NNKOAc is associated with renal cancer risk. | Carcinogenesis 20090401 |
| Effects of smoking cessation on eight urinary tobacco carcinogen and toxicant biomarkers. | Chemical research in toxicology 20090401 |
| Urinary levels of tobacco-specific nitrosamine metabolites in relation to lung cancer development in two prospective cohorts of cigarette smokers. | Cancer research 20090401 |
| Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice. | The Journal of toxicological sciences 20090401 |
| Tumorigenesis in B6C3F1 mice exposed to ozone in combination with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and dietary dibutyl phthalate. | Toxicology and industrial health 20090401 |
| Effect of CYP2A13 active site mutation N297A on metabolism of coumarin and tobacco-specific nitrosamines. | Drug metabolism and disposition: the biological fate of chemicals 20090301 |
| Ultrasensitive method for the determination of 4-hydroxy-1-(3-pyridyl)-1-butanone-releasing DNA adducts by gas chromatography-high resolution mass spectrometry in mucosal biopsies of the lower esophagus. | Analytical and bioanalytical chemistry 20090301 |
| Biomarkers of induced active and passive smoking damage. | International journal of environmental research and public health 20090301 |
| Lung Carcinogenic Bioassay of CuO and TiO(2) Nanoparticles with Intratracheal Instillation Using F344 Male Rats. | Journal of toxicologic pathology 20090301 |
| Gene expression profiles in HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. | Chemico-biological interactions 20090212 |
| Genetic susceptibility of lung cancer associated with common variants in the 3' untranslated regions of the adenosine triphosphate-binding cassette B1 (ABCB1) and ABCC1 candidate transporter genes for carcinogen export. | Cancer 20090201 |
| Chemopreventive effects of fermented brown rice and rice bran against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in female A/J mice. | Oncology reports 20090201 |
| Human cyt P450 mediated metabolic toxicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) evaluated using electrochemiluminescent arrays. | Molecular bioSystems 20090201 |
| Mitochondrial DNA adducts in the lung and liver of F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and (S)-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. | Chemical research in toxicology 20090201 |
| Evaluation of the mutagenic effects of myosmine in human lymphocytes using the HPRT gene mutation assay. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090101 |
| A prospectively measured serum biomarker for a tobacco-specific carcinogen and lung cancer in smokers. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20090101 |
| Evidence for endogenous formation of N'-nitrosonornicotine in some long-term nicotine patch users. | Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20090101 |
| A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis. | PloS one 20090101 |
| Development of reverse phase protein microarrays for the validation of clusterin, a mid-abundant blood biomarker. | Proteome science 20090101 |
| Evaluation of biomarkers of exposure and potential harm in smokers, former smokers and never-smokers. | Clinical chemistry and laboratory medicine 20090101 |
| Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation. | Cell communication and signaling : CCS 20090101 |
| Inhibition of RNA recruitment and replication of an RNA virus by acridine derivatives with known anti-prion activities. | PloS one 20090101 |
| Fish oil supplementation inhibits NNK-induced lung carcinogenesis in the A/J mouse. | Nutrition and cancer 20090101 |
| Structural basis for substrate specificity in human monomeric carbonyl reductases. | PloS one 20090101 |
| Nicotine promotes tumor growth and metastasis in mouse models of lung cancer. | PloS one 20090101 |
| The impact of new research technologies on our understanding of environmental causes of disease: the concept of clinical vulnerability. | Environmental health : a global access science source 20090101 |
| 8-Methoxypsoralen, a potent human CYP2A6 inhibitor, inhibits lung adenocarcinoma development induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice. | Molecular medicine reports 20090101 |
| Differential expression of microRNAs in early-stage neoplastic transformation in the lungs of F344 rats chronically treated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. | Carcinogenesis 20081201 |
| Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induce cyclooxygenase-2 activity in human gastric cancer cells: Involvement of nicotinic acetylcholine receptor (nAChR) and beta-adrenergic receptor signaling pathways. | Toxicology and applied pharmacology 20081201 |
| Evaluation of biomarkers of exposure to selected cigarette smoke constituents in adult smokers switched to carbon-filtered cigarettes in short-term and long-term clinical studies. | Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20081201 |
| Exposure to a tobacco-specific lung carcinogen in adolescent versus adult smokers. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20081201 |
| Correlation between the urine profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolites and N7-methylguanine in urothelial carcinoma patients. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20081201 |
| Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol. | Cancer prevention research (Philadelphia, Pa.) 20081201 |
| Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine. | Cancer research 20081115 |
| Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokers. | Drug metabolism and disposition: the biological fate of chemicals 20081101 |
| Subpicogram per milliliter determination of the tobacco-specific carcinogen metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine using liquid chromatography-tandem mass spectrometry. | Analytical chemistry 20081101 |
| CYP2A6 polymorphisms and risk for tobacco-related cancers. | Pharmacogenomics 20081101 |
| Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice. | Cancer prevention research (Philadelphia, Pa.) 20081101 |
| Gamma-aminobutyric acid, a potential tumor suppressor for small airway-derived lung adenocarcinoma. | Carcinogenesis 20081001 |
| Haem oxygenase-1 plays a central role in NNK-mediated lung carcinogenesis. | The European respiratory journal 20081001 |
| Lack of modifying potential of 8-methoxypsoralen in the promotion or progression stages of lung carcinogenesis in A/J female mice. | Oncology reports 20081001 |
| Acute damage by naphthalene triggers expression of the neuroendocrine marker PGP9.5 in airway epithelial cells. | Toxicology letters 20080926 |
| Establishment of a bioassay model for lung cancer chemoprevention initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice. | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20080901 |
| Potential reduced exposure products (PREPs) for smokeless tobacco users: clinical evaluation methodology. | Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20080901 |
| Combinations of N-Acetyl-S-(N-2-Phenethylthiocarbamoyl)-L-Cysteine and myo-inositol inhibit tobacco carcinogen-induced lung adenocarcinoma in mice. | Cancer prevention research (Philadelphia, Pa.) 20080901 |
| A randomized, controlled exposure study in adult smokers of full flavor Marlboro cigarettes switching to Marlboro Lights or Marlboro Ultra Lights cigarettes. | Regulatory toxicology and pharmacology : RTP 20080801 |
| Survivin expression in normal human bronchial epithelial cells: an early and critical step in tumorigenesis induced by tobacco exposure. | Carcinogenesis 20080801 |
| Strain-specific spontaneous and NNK-mediated tumorigenesis in Pten+/- mice. | Neoplasia (New York, N.Y.) 20080801 |
| Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley-Bixler syndrome variants of cytochrome P450 oxidoreductase. | Archives of biochemistry and biophysics 20080715 |
| Targeted disruption of the galectin-3 gene results in decreased susceptibility to NNK-induced lung tumorigenesis: an oligonucleotide microarray study. | Journal of cancer research and clinical oncology 20080701 |
| The tobacco carcinogen NNK is stereoselectively reduced by human pancreatic microsomes and cytosols. | Langenbeck's archives of surgery 20080701 |
| p-dimethylaminocinnamaldehyde derivatization for colorimetric detection and HPLC-UV/vis-MS/MS identification of indoles. | Archives of biochemistry and biophysics 20080701 |
| Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. | Chemical research in toxicology 20080701 |
| Extensive metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20080701 |
| Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis. | Molecular cancer therapeutics 20080701 |
| Precancerous model of human breast epithelial cells induced by NNK for prevention. | Breast cancer research and treatment 20080601 |
| Alterations of cellular redox state during NNK-induced malignant transformation and resistance to radiation. | Antioxidants & redox signaling 20080501 |
| Protein kinase A-mediated CREB phosphorylation is an oxidant-induced survival pathway in alveolar type II cells. | Apoptosis : an international journal on programmed cell death 20080501 |
| Cytokinesis-blocked micronucleus cytome assay biomarkers identify lung cancer cases amongst smokers. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20080501 |
| Inhibiting fatty acid synthase for chemoprevention of chemically induced lung tumors. | Clinical cancer research : an official journal of the American Association for Cancer Research 20080415 |
| Bcl2 inhibits abasic site repair by down-regulating APE1 endonuclease activity. | The Journal of biological chemistry 20080411 |
| Mgmt deficiency alters the in vivo mutational spectrum of tissues exposed to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). | Carcinogenesis 20080401 |
| Exposure to nicotine and a tobacco-specific carcinogen increase with duration of use of smokeless tobacco. | Tobacco control 20080401 |
| Mandated lowering of toxicants in cigarette smoke: a description of the World Health Organization TobReg proposal. | Tobacco control 20080401 |
| Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice. | Carcinogenesis 20080301 |
| Formation of formaldehyde adducts in the reactions of DNA and deoxyribonucleosides with alpha-acetates of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), and N-nitrosodimethylamine (NDMA). | Chemical research in toxicology 20080301 |
| Human cytochrome P450 2A13 efficiently metabolizes chemicals in air pollutants: naphthalene, styrene, and toluene. | Chemical research in toxicology 20080301 |
| Metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone to its biomarker total NNAL in smokeless tobacco users. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20080301 |
| The genomics of colorectal cancer: state of the art. | Current genomics 20080301 |
| Repair of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA pyridyloxobutylation by nucleotide excision repair. | Cancer letters 20080218 |
| Enhancements of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism and carcinogenic risk via NNK/arsenic interaction. | Toxicology and applied pharmacology 20080215 |
| Enzyme-DNA biocolloids for DNA adduct and reactive metabolite detection by chromatography-mass spectrometry. | Analytical chemistry 20080215 |
| Occurrence of mutations in the epidermal growth factor receptor gene in X-ray-induced rat lung tumors. | Cancer science 20080201 |
| Basic and clinical aspects of non-neuronal acetylcholine: biological and clinical significance of non-canonical ligands of epithelial nicotinic acetylcholine receptors. | Journal of pharmacological sciences 20080201 |
| Increased inducible nitric oxide synthase in lung carcinoma of smokers. | Cancer 20080115 |
| K-ras mutations in sinonasal cancers in relation to wood dust exposure. | BMC cancer 20080101 |
| iTRAQ analysis of complex proteome alterations in 3xTgAD Alzheimer's mice: understanding the interface between physiology and disease. | PloS one 20080101 |
| Endogenous cytosine methylation and the formation of carcinogen carcinogen-DNA adducts. | Nucleic acids symposium series (2004) 20080101 |
| Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume. | Particle and fibre toxicology 20080101 |
| A tobacco-specific carcinogen, NNK, enhances AOM/DSS-induced colon carcinogenesis in male A/J mice. | In vivo (Athens, Greece) 20080101 |
| DNA damage in preserved specimens and tissue samples: a molecular assessment. | Frontiers in zoology 20080101 |
| Metabolic profiling reveals distinct variations linked to nicotine consumption in humans--first results from the KORA study. | PloS one 20080101 |
| G-Protein Inwardly Rectifying Potassium Channel 1 (GIRK1) Knockdown Decreases Beta-Adrenergic, MAP Kinase and Akt Signaling in the MDA-MB-453 Breast Cancer Cell Line. | Breast cancer : basic and clinical research 20080101 |
| Biotransformation and transport of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in bile duct-cannulated wild-type and Mrp2/Abcc2-deficient (TR ) Wistar rats. | Carcinogenesis 20071201 |
| Functional characterization of CYP2A13 polymorphisms. | Xenobiotica; the fate of foreign compounds in biological systems 20071201 |
| Update on the treatment of cutaneous T-cell lymphoma (CTCL): Focus on vorinostat. | Biologics : targets & therapy 20071201 |
| Repair kinetics of specific types of nitroso-induced DNA damage using the comet assay in human cells. | Mutation research 20071101 |
| CYP2A13: variable expression and role in human lung microsomal metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. | The Journal of pharmacology and experimental therapeutics 20071101 |
| Analysis of CYP2A contributions to metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human peripheral lung microsomes. | Drug metabolism and disposition: the biological fate of chemicals 20071101 |
| Overexpression of SLURP-1 and -2 alleviates the tumorigenic action of tobacco-derived nitrosamine on immortalized oral epithelial cells. | Biochemical pharmacology 20071015 |
| Point mutation of K-ras gene in cisplatin-induced lung tumours in A/J mice. | Lung cancer (Amsterdam, Netherlands) 20071001 |
| A monitoring technique of piezoelectric impedance analysis used in tea polyphenols (TP) antimutagenic characteristics. | Journal of microbiological methods 20070901 |
| The association of a tobacco-specific biomarker and cigarette consumption and its dependence on host characteristics. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070901 |
| A possible photosensitizer: Tobacco-specific nitrosamine, 4-(N-methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), induced mutations, DNA strand breaks and oxidative and methylative damage with UVA. | Mutation research 20070815 |
| Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice. | Cancer research 20070815 |
| Liquid chromatography/tandem mass spectrometric method for the simultaneous determination of tobacco-specific nitrosamine NNK and its five metabolites. | Talanta 20070815 |
| The impact of clean indoor air exemptions and preemption policies on the prevalence of a tobacco-specific lung carcinogen among nonsmoking bar and restaurant workers. | American journal of public health 20070801 |
| Development of liquid chromatography electrospray ionization tandem mass spectrometry methods for analysis of DNA adducts of formaldehyde and their application to rats treated with N-nitrosodimethylamine or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. | Chemical research in toxicology 20070801 |
| Concentrations of the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in sidestream cigarette smoke increase after release into indoor air: results from unpublished tobacco industry research. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070801 |
| Similar exposure to a tobacco-specific carcinogen in smokeless tobacco users and cigarette smokers. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070801 |
| Nongenomic beta estrogen receptors enhance beta1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells. | Cancer research 20070715 |
| A modified host-cell reactivation assay to measure repair of alkylating DNA damage for assessing risk of lung adenocarcinoma. | Carcinogenesis 20070701 |
| Apo-10'-lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo. | Carcinogenesis 20070701 |
| Indole-3-carbinol inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo(a)pyrene-induced lung tumorigenesis in A/J mice and modulates carcinogen-induced alterations in protein levels. | Cancer research 20070701 |
| Relationship of human toenail nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol to levels of these biomarkers in plasma and urine. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070701 |
| Effect of delivered dosage of cigarette smoke toxins on the levels of urinary biomarkers of exposure. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070701 |
| Expression of NF-kappaB parallels COX-2 expression in oral precancer and cancer: association with smokeless tobacco. | International journal of cancer 20070615 |
| Structure of the human lung cytochrome P450 2A13. | The Journal of biological chemistry 20070608 |
| Alveolar macrophage cytotoxic activity is inhibited by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a carcinogenic component of cigarette smoke. | Cancer immunology, immunotherapy : CII 20070601 |
| SLURP-1 and -2 in normal, immortalized and malignant oral keratinocytes. | Life sciences 20070530 |
| Nitrosamines as nicotinic receptor ligands. | Life sciences 20070530 |
| The effects of combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation on antioxidant capacity, DNA single-strand breaks and levels of insulin-like growth factor-1/IGF-binding protein 3 in the ferret model of lung cancer. | International journal of cancer 20070501 |
| NNK is not insoluble in water. | Inhalation toxicology 20070501 |
| Mass spectrometric analysis of 4-hydroxy-1-(3-pyridyl)-1-butanone-releasing DNA adducts in human lung. | Toxicology 20070411 |
| Inhibition of lung carcinogenesis by 1alpha,25-dihydroxyvitamin D3 and 9-cis retinoic acid in the A/J mouse model: evidence of retinoid mitigation of vitamin D toxicity. | International journal of cancer 20070401 |
| Urinary biomarkers to assess exposure of cats to environmental tobacco smoke. | American journal of veterinary research 20070401 |
| Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity, and phenotypic progression of tobacco carcinogen-induced murine lung tumors. | Clinical cancer research : an official journal of the American Association for Cancer Research 20070401 |
| The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070401 |
| An association of CYP2A6 genotype and smoking topography. | Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20070401 |
| Possible application of human c-Ha-ras proto-oncogene transgenic rats in a medium-term bioassay model for carcinogens. | Toxicologic pathology 20070401 |
| Bcl2 impedes DNA mismatch repair by directly regulating the hMSH2-hMSH6 heterodimeric complex. | The Journal of biological chemistry 20070323 |
| Overexpressed Raf-1 and phosphorylated cyclic adenosine 3'-5'-monophosphatate response element-binding protein are early markers for lung adenocarcinoma. | Cancer 20070315 |
| Relationship between machine-derived smoke yields and biomarkers in cigarette smokers in Germany. | Regulatory toxicology and pharmacology : RTP 20070301 |
| CYP2A13 metabolizes the substrates of human CYP1A2, phenacetin, and theophylline. | Drug metabolism and disposition: the biological fate of chemicals 20070301 |
| Investigation of the reaction of myosmine with sodium nitrite in vitro and in rats. | Chemical research in toxicology 20070301 |
| Gender differences relative to smoking behavior and emissions of toxins from mainstream cigarette smoke. | Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20070301 |
| Post-initiation chemopreventive effects of dietary bovine lactoferrin on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in female A/J mice. | Cancer letters 20070208 |
| High-density oligonucleotide microarrays and functional network analysis reveal extended lung carcinogenesis pathway maps and multiple interacting genes in NNK [4-(methylnitrosamino)-1-(3-pyridyle)-1-butanone] induced CD1 mouse lung tumor. | Journal of cancer research and clinical oncology 20070201 |
| A new method for estimating the retention of selected smoke constituents in the respiratory tract of smokers during cigarette smoking. | Inhalation toxicology 20070201 |
| 4-(Methylnitrosamino)-I-(3-pyridyl)-1-butanone enhances the expression of apolipoprotein A-I and Clara cell 17-kDa protein in the lung proteomes of rats fed a corn oil diet but not a fish oil diet. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070201 |
| Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. | Chemical research in toxicology 20070201 |
| Combined genotoxic effects of radiation and a tobacco-specific nitrosamine in the lung of gpt delta transgenic mice. | Mutation research 20070110 |
| Early manifestations of NNK-induced lung cancer: role of lung immunity in tumor susceptibility. | American journal of respiratory cell and molecular biology 20070101 |
| The stimulatory role of human cytochrome b5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: a new cell expression system to study cytochrome P450-mediated biotransformation (a corrigendum report on Duarte et al. (2005) Mutagenesis 20, 93-100). | Mutagenesis 20070101 |
| Passive smoking as a risk factor of anemia in young children aged 0-35 months in Jordan. | BMC pediatrics 20070101 |
| Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by aspirin and phenethyl isothiocyanate. | BMC cancer 20070101 |
| Reduced risk of human lung cancer by selective cyclooxygenase 2 (COX-2) blockade: results of a case control study. | International journal of biological sciences 20070101 |
| ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke. | BMC cell biology 20070101 |
| The isothiocyanate class of bioactive nutrients covalently inhibit the MEKK1 protein kinase. | BMC cancer 20070101 |
| Synthesis of 4-[2-aminoethyl(nitrosamino)]-1-pyridin-3-yl-butan-1-one, a new NNK hapten for the induction of N-nitrosamine-specific antibodies. | Bioconjugate chemistry 20070101 |
| [Chemoprevention of tobacco-related lung cancer by cruciferous vegetable]. | Przeglad lekarski 20070101 |
| Determination of tobacco specific hemoglobin adducts in smoking mothers and new born babies by mass spectrometry. | Biomarker insights 20070101 |
| Translesion synthesis across O6-alkylguanine DNA adducts by recombinant human DNA polymerases. | The Journal of biological chemistry 20061215 |
| Development of a commercial cigarette 'market map' comparison methodology for evaluating new or non-conventional cigarettes. | Regulatory toxicology and pharmacology : RTP 20061201 |
| Study of the metabolism on tobacco-specific N-nitrosamines in the rabbit by solid-phase extraction and liquid chromatography-tandem mass spectrometry. | Analytical and bioanalytical chemistry 20061201 |
| [How I was enticed into molecular toxicology]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20061201 |
| Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine. | Cancer research 20061201 |
| Toxicant exposure in cigarette reducers versus light smokers. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20061201 |
| Mass spectrometric quantitation of nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human toenails. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20061201 |
| 9-cis-Retinoic acid inhibition of lung carcinogenesis in the A/J mouse model is accompanied by increased expression of RAR-beta but no change in cyclooxygenase-2. | Cancer letters 20061128 |
| Curcumin down regulates smokeless tobacco-induced NF-kappaB activation and COX-2 expression in human oral premalignant and cancer cells. | Toxicology 20061110 |
| The missense genetic polymorphisms of human CYP2A13: functional significance in carcinogen activation and identification of a null allelic variant. | Toxicological sciences : an official journal of the Society of Toxicology 20061101 |
| Expression of xenobiotic metabolizing enzymes in different lung compartments of smokers and nonsmokers. | Environmental health perspectives 20061101 |
| Effects of tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on the activation of ERK1/2 MAP kinases and the proliferation of human mammary epithelial cells. | Environmental toxicology and pharmacology 20061101 |
| NNK activates ERK1/2 and CREB/ATF-1 via beta-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells. | International journal of cancer 20061001 |
| CYP2A13 in human respiratory tissues and lung cancers: an immunohistochemical study with a new peptide-specific antibody. | Drug metabolism and disposition: the biological fate of chemicals 20061001 |
| The nicotinic receptor antagonists abolish pathobiologic effects of tobacco-derived nitrosamines on BEP2D cells. | Journal of cancer research and clinical oncology 20061001 |
| Understanding tobacco smoke carcinogen NNK and lung tumorigenesis. | International journal of oncology 20061001 |
| A biomarker of exposure to environmental tobacco smoke (ETS) and Ernst Wynder's opinion about ETS and lung cancer. | Preventive medicine 20061001 |
| Formamidopyrimidine adducts are detected using the comet assay in human cells treated with reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). | Mutation research 20060830 |
| Beta-2 adrenergic receptor gene (ADRB2) polymorphism and risk for lung adenocarcinoma: a case-control study in a Chinese population. | Cancer letters 20060828 |
| Transgenic mice overexpressing hepatocyte growth factor in the airways show increased susceptibility to lung cancer. | Carcinogenesis 20060801 |
| Combined analysis of r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in smokers' plasma. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20060801 |
| Chemopreventive effect of saponins derived from roots of Platycodon grandiflorum on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice. | Archives of pharmacal research 20060801 |
| Combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation increases the levels of lung retinoic acid and inhibits the activation of mitogen-activated protein kinase in the ferret lung cancer model. | Carcinogenesis 20060701 |
| Ethanol and the tobacco-specific carcinogen, NNK, contribute to signaling in immortalized human pancreatic duct epithelial cells. | Pancreas 20060701 |
| [Detection of metabolites of tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in lung cancer smokers' urine]. | Zhongguo fei ai za zhi = Chinese journal of lung cancer 20060620 |
| Cytokinesis-blocked micronucleus assay as a novel biomarker for lung cancer risk. | Cancer research 20060615 |
| The organoselenium compound 1,4-phenylenebis(methylene)selenocyanate inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorgenesis and enhances glutathione-related antioxidant levels in A/J mouse lung. | Chemico-biological interactions 20060610 |
| Determination of tobacco-specific N-nitrosamines in rabbit serum by capillary zone electrophoresis and capillary electrophoresis-electrospray ionization-mass spectrometry with solid-phase extraction. | Electrophoresis 20060601 |
| Bcl2 suppresses DNA repair by enhancing c-Myc transcriptional activity. | The Journal of biological chemistry 20060519 |
| Prevention of mouse lung tumors by targretin. | International journal of cancer 20060501 |
| Nicotinic receptors mediate tumorigenic action of tobacco-derived nitrosamines on immortalized oral epithelial cells. | Cancer biology & therapy 20060501 |
| DNA sequence context affects repair of the tobacco-specific adduct O(6)-[4-Oxo-4-(3-pyridyl)butyl]guanine by human O(6)-alkylguanine-DNA alkyltransferases. | Cancer research 20060501 |
| Quantitation of pyridyloxobutyl DNA adducts of tobacco-specific nitrosamines in rat tissue DNA by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry. | Chemical research in toxicology 20060501 |
| 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides in the urine of infants exposed to environmental tobacco smoke. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20060501 |
| [Induction of pulmonary precancerous lesions by tobacco-specific NNK in Wistar rats]. | Zhongguo fei ai za zhi = Chinese journal of lung cancer 20060420 |
| Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokers. | Carcinogenesis 20060401 |
| Gene promoter hypermethylation in mouse lung tumors. | Molecular cancer research : MCR 20060401 |
| Dose dependent inhibitory effects of dietary 8-methoxypsoralen on NNK-induced lung tumorigenesis in female A/J mice. | Cancer letters 20060328 |
| Induction of pulmonary neoplasia in the smoke-exposed ferret by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): a model for human lung cancer. | Cancer letters 20060328 |
| 11Beta-hydroxysteroid dehydrogenase type 1: purification from human liver and characterization as carbonyl reductase of xenobiotics. | Molecular and cellular endocrinology 20060327 |
| Flavonoids suppresses the enhancing effect of beta-carotene on DNA damage induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A549 cells. | Chemico-biological interactions 20060325 |
| Array CGH analysis reveals chromosomal aberrations in mouse lung adenocarcinomas induced by the human lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. | Biochemical and biophysical research communications 20060317 |
| Effect of selenium-containing compounds on hepatic chemoprotective enzymes in mice. | Toxicology 20060315 |
| Synergistic DNA damage and lipid peroxidation in cultured human white blood cells exposed to 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone and ultraviolet A. | Environmental and molecular mutagenesis 20060301 |
| Purification and characterization of akr1b10 from human liver: role in carbonyl reduction of xenobiotics. | Drug metabolism and disposition: the biological fate of chemicals 20060301 |
| Permeation and reservoir formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo[a]pyrene (B[a]P) across porcine esophageal tissue in the presence of ethanol and menthol. | Carcinogenesis 20060101 |
| Uptake of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by Moldovan children. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20060101 |
| [Smoking as a risk factor for pancreatic cancer]. | Nihon rinsho. Japanese journal of clinical medicine 20060101 |
| Polymorphisms of XRCC1 genes and risk of nasopharyngeal carcinoma in the Cantonese population. | BMC cancer 20060101 |
| beta-carotene-induced changes in RARbeta isoform mRNA expression patterns do not influence lung adenoma multiplicity in the NNK-initiated A/J mouse model. | Nutrition and cancer 20060101 |
| Wnt and Hedgehog are critical mediators of cigarette smoke-induced lung cancer. | PloS one 20060101 |
| [Determination of 4-(methylnirosamino) -4-(3-pyridyl)-1-butanol (NNA) in urine of pregnant women by means of LC/MS/MS]. | Przeglad lekarski 20060101 |
| Genetic polymorphism of CYP2A6 as one of the potential determinants of tobacco-related cancer risk. | Biochemical and biophysical research communications 20051209 |
| Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism by cytochrome P450 2B6. | Drug metabolism and disposition: the biological fate of chemicals 20051201 |
| Relationships between cigarette consumption and biomarkers of tobacco toxin exposure. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20051201 |
| Deguelin as a chemopreventive agent in mouse lung tumorigenesis induced by tobacco smoke carcinogens. | Journal of the National Cancer Institute 20051116 |
| Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis. | Journal of the National Cancer Institute 20051116 |
| Acute and subacute effects of tobacco alkaloids, tobacco-specific nitrosamines and phenethyl isothiocyanate on N'-nitrosonornicotine metabolism in rats. | Toxicology 20051115 |
| Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas. | Carcinogenesis 20051101 |
| Analysis of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in smokers' blood. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20051101 |
| Nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary adenocarcinomas in Syrian golden hamsters contain beta 2-adrenergic receptor single-nucleotide polymorphisms. | Genes, chromosomes & cancer 20051001 |
| The tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone stimulates proliferation of immortalized human pancreatic duct epithelia through beta-adrenergic transactivation of EGF receptors. | Journal of cancer research and clinical oncology 20051001 |
| O6-pyridyloxobutylguanine adducts contribute to the mutagenic properties of pyridyloxobutylating agents. | Chemical research in toxicology 20051001 |
| Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. | Cancer research 20050915 |
| Angiotensin II type 2 receptor gene deficiency attenuates susceptibility to tobacco-specific nitrosamine-induced lung tumorigenesis: involvement of transforming growth factor-beta-dependent cell growth attenuation. | Cancer research 20050901 |
| Tobacco-specific nitrosamines in smokeless tobacco products marketed in India. | International journal of cancer 20050810 |
| Comparison of the expression profiles induced by genotoxic and nongenotoxic carcinogens in rat liver. | Mutation research 20050804 |
| The L84F and the I143V polymorphisms in the O6-methylguanine-DNA-methyltransferase (MGMT) gene increase human sensitivity to the genotoxic effects of the tobacco-specific nitrosamine carcinogen NNK. | Pharmacogenetics and genomics 20050801 |
| Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency. | Cancer research 20050801 |
| Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells. | Carcinogenesis 20050701 |
| Gender differences in genetic damage induced by the tobacco-specific nitrosamine NNK and the influence of the Thr241Met polymorphism in the XRCC3 gene. | Environmental and molecular mutagenesis 20050701 |
| NNK-induced hamster lung adenocarcinomas over-express beta2-adrenergic and EGFR signaling pathways. | Lung cancer (Amsterdam, Netherlands) 20050701 |
| 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from cigarette smoke stimulates colon cancer growth via beta-adrenoceptors. | Cancer research 20050615 |
| Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation. | Toxicology and applied pharmacology 20050601 |
| Carcinogen exposure during short-term switching from regular to 'light' cigarettes. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050601 |
| Metabolic activation of the tobacco carcinogen 4-(methylnitrosamino)-(3-pyridyl)-1-butanone by cytochrome P450 2A13 in human fetal nasal microsomes. | Chemical research in toxicology 20050601 |
| Mass spectrometric analysis of relative levels of pyridyloxobutylation adducts formed in the reaction of DNA with a chemically activated form of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. | Chemical research in toxicology 20050601 |
| Smokeless tobacco topography and toxin exposure. | Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20050601 |
| Beta-carotene interaction with NNK in the AJ-mouse model: effects on cell proliferation, tumor formation and retinoic acid responsive genes. | Biochimica et biophysica acta 20050530 |
| Escherichia coli BTC, a human cytochrome P450 competent tester strain with a high sensitivity towards alkylating agents: involvement of alkyltransferases in the repair of DNA damage induced by aromatic amines. | Mutagenesis 20050501 |
| Urinary metabolites of a tobacco-specific lung carcinogen in nonsmoking hospitality workers. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050501 |
| Charcoal cigarette filters and lung cancer risk in Aichi Prefecture, Japan. | Cancer science 20050501 |
| Survival function of protein kinase C{iota} as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase. | The Journal of biological chemistry 20050422 |
| Racial differences in exposure and glucuronidation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). | Cancer 20050401 |
| 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone, a component of tobacco smoke, modulates mediator release from human bronchial and alveolar epithelial cells. | Clinical and experimental immunology 20050401 |
| Comparison of phenethyl and 6-phenylhexyl isothiocyanate-induced toxicity in rat esophageal cell lines with and without glutathione depletion. | Toxicology letters 20050315 |
| Duodenal acidity may increase the risk of pancreatic cancer in the course of chronic pancreatitis: an etiopathogenetic hypothesis. | JOP : Journal of the pancreas 20050310 |
| Human cytochrome p450 2s1: lack of activity in the metabolic activation of several cigarette smoke carcinogens and in the metabolism of nicotine. | Drug metabolism and disposition: the biological fate of chemicals 20050301 |
| The stimulatory role of human cytochrome b5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: a new cell expression system to study cytochrome P450 mediated biotransformation. | Mutagenesis 20050301 |
| Similar uptake of lung carcinogens by smokers of regular, light, and ultralight cigarettes. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050301 |
| Stable isotope labeling-mass spectrometry analysis of methyl- and pyridyloxobutyl-guanine adducts of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in p53-derived DNA sequences. | Biochemistry 20050215 |
| Metabolism of nicotine and cotinine by human cytochrome P450 2A13. | Drug metabolism and disposition: the biological fate of chemicals 20050201 |
| Phenotypic characteristics of mouse lung adenoma induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. | Molecular carcinogenesis 20050201 |
| Cytochrome P450 enzymes as catalysts of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco specific carcinogen. | Chemical research in toxicology 20050201 |
| 4-Hydroxy-1-(3-pyridyl)-1-butanone, an indicator for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA damage, is not detected in human pancreatic tissue. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050201 |
| The chemopreventive effects of orally administered dexamethasone in Strain A/J mice following cessation of smoke exposure. | Inhalation toxicology 20050201 |
| p53 polymorphisms associated with mutations in and loss of heterozygosity of the p53 gene in male oral squamous cell carcinomas in Taiwan. | British journal of cancer 20050117 |
| Inhibition of lung tumorigenesis by tea. | Experimental lung research 20050101 |
| Expression of the alpha7 nicotinic acetylcholine receptor in human lung cells. | Respiratory research 20050101 |
| ATP-binding cassette (ABC) transporters in normal and pathological lung. | Respiratory research 20050101 |
| Qualitatively and quantitatively similar effects of active and passive maternal tobacco smoke exposure on in utero mutagenesis at the HPRT locus. | BMC pediatrics 20050101 |
| Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines. | BMC cancer 20050101 |
| Smoking and reproduction: the oviduct as a target of cigarette smoke. | Reproductive biology and endocrinology : RB&E 20050101 |
| Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione. | Respiratory research 20050101 |
| Chemopreventive activity of selenocysteine prodrugs against tobacco-derived nitrosamine (NNK) induced lung tumors in the A/J mouse. | Journal of biochemical and molecular toxicology 20050101 |
| Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion. | The Journal of biological chemistry 20041217 |
| Identification of critical amino acid residues of human CYP2A13 for the metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen. | Drug metabolism and disposition: the biological fate of chemicals 20041201 |
| Tobacco-related-compound-induced nitrosative stress injury in the hamster cheek pouch. | Journal of dental research 20041201 |
| Cap-independent protein translation is initially responsible for 4-(N-methylnitrosamino)-1-(3-pyridyl)-butanone (NNK)-induced apoptosis in normal human bronchial epithelial cells. | Journal of veterinary science 20041201 |
| Molecular analysis of hprt mutation in B6C3F1 mice exposed to ozone alone and combined treatment of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and/or dibutyl phthalate for 32 and 52 weeks. | Journal of veterinary science 20041201 |
| Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyrene. | British journal of cancer 20041004 |
| The modulating role of nuclear factor-kappaB in the action of alpha7-nicotinic acetylcholine receptor and cross-talk between 5-lipoxygenase and cyclooxygenase-2 in colon cancer growth induced by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. | The Journal of pharmacology and experimental therapeutics 20041001 |
| Cigarette smoking, metabolic activation and carcinogenesis. | Current drug metabolism 20041001 |
| Inhibitory effects of 7-hydroxy-3-methoxy-cadalene on 4-(methylinitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice. | Cancer letters 20040930 |
| Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation. | The Journal of biological chemistry 20040917 |
| Enantioselectivity of carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone by tissue fractions from human and rat and by enzymes isolated from human liver. | Drug metabolism and disposition: the biological fate of chemicals 20040901 |
| Decreased levels of tobacco-specific N-nitrosamines in moist snuff on the Swedish market. | Journal of agricultural and food chemistry 20040811 |
| Genotoxic effects of dietary and lifestyle related carcinogens in human derived hepatoma (HepG2, Hep3B) cells. | Mutation research 20040713 |
| Increased susceptibility of mice lacking Clara cell 10-kDa protein to lung tumorigenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a potent carcinogen in cigarette smoke. | The Journal of biological chemistry 20040709 |
| Stereoselective metabolism and tissue retention in rats of the individual enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), metabolites of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). | Carcinogenesis 20040701 |
| Neuroendocrine lung carcinogenesis in hamsters is inhibited by green tea or theophylline while the development of adenocarcinomas is promoted: implications for chemoprevention in smokers. | Lung cancer (Amsterdam, Netherlands) 20040701 |
| Biomarkers in maternal and newborn blood indicate heightened fetal susceptibility to procarcinogenic DNA damage. | Environmental health perspectives 20040701 |
| Mutations induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in the lacZ and cII genes of Muta Mouse. | Mutation research 20040613 |
| Evaluation of carcinogen exposure in people who used 'reduced exposure' tobacco products. | Journal of the National Cancer Institute 20040602 |
| Cytokine production by alveolar macrophages is down regulated by the alpha-methylhydroxylation pathway of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). | Carcinogenesis 20040601 |
| Aberrant promoter hypermethylation of the death-associated protein kinase gene is early and frequent in murine lung tumors induced by cigarette smoke and tobacco carcinogens. | Cancer research 20040601 |
| Effects of cruciferous vegetable consumption on urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in singapore chinese. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20040601 |
| B6C3F1 mice exposed to ozone with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and/or dibutyl phthalate showed toxicities through alterations of NF-kappaB, AP-1, Nrf2, and osteopontin. | Journal of veterinary science 20040601 |
| Molecular modelling of CYP2A enzymes: application to metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). | Xenobiotica; the fate of foreign compounds in biological systems 20040601 |
| Arg257Cys polymorphism of CYP2A13 in a Chinese population. | Clinica chimica acta; international journal of clinical chemistry 20040501 |
| Significance of reductases in the detoxification of the tobacco-specific carcinogen NNK. | Trends in pharmacological sciences 20040501 |
| Tobacco carcinogen-induced cellular transformation increases Akt activation in vitro and in vivo. | Chest 20040501 |
| Identification of O2-substituted pyrimidine adducts formed in reactions of 4-(acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone and 4-(acetoxymethylnitros- amino)-1-(3-pyridyl)-1-butanol with DNA. | Chemical research in toxicology 20040501 |
| Antioxidative effects of 7-hydroxy-3-methoxy-cadalene extracted from Zelkova serrata on 4-(methylinitros amino)-1-(3-pyridyl)-1-butanone-induced oxidative stress in A/J mice. | Phytotherapy research : PTR 20040501 |
| Carcinogen-specific targeting of chromosome 12 for loss of heterozygosity in mouse lung adenocarcinomas: implications for chromosome instability and tumor progression. | Oncogene 20040415 |
| Carcinogen exposure differentially modulates RAR-beta promoter hypermethylation, an early and frequent event in mouse lung carcinogenesis. | Carcinogenesis 20040401 |
| The effects of dietary myoinositol on lung tumor development in tobacco smoke-exposed mice. | Inhalation toxicology 20040401 |
| Carcinogen derived biomarkers: applications in studies of human exposure to secondhand tobacco smoke. | Tobacco control 20040301 |
| Children's exposure to environmental tobacco smoke: using diverse exposure metrics to document ethnic/racial differences. | Environmental health perspectives 20040301 |
| The repair of the tobacco specific nitrosamine derived adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-alkylguanine-DNA alkyltransferase variants. | Chemical research in toxicology 20040301 |
| Assessment of tobacco-specific nitrosamines in the tobacco and mainstream smoke of Bidi cigarettes. | Carcinogenesis 20040201 |
| Correlation between UDP-glucuronosyltransferase genotypes and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronidation phenotype in human liver microsomes. | Cancer research 20040201 |
| Smoking reduction and tobacco-related cancers: the more things change, the more they stay the same. | Journal of the National Cancer Institute 20040121 |
| Effects of reduced cigarette smoking on the uptake of a tobacco-specific lung carcinogen. | Journal of the National Cancer Institute 20040121 |
| Endogenous 5-methylcytosine protects neighboring guanines from N7 and O6-methylation and O6-pyridyloxobutylation by the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. | Biochemistry 20040120 |
| Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo. | Cancer research 20040115 |
| Characteristic expression profiles induced by genotoxic carcinogens in rat liver. | Toxicological sciences : an official journal of the Society of Toxicology 20040101 |
| Effect of XPD/ERCC2 polymorphisms on chromosome aberration frequencies in smokers and on sensitivity to the mutagenic tobacco-specific nitrosamine NNK. | Environmental and molecular mutagenesis 20040101 |
| Inhibition of lung carcinogenesis and effects on angiogenesis and apoptosis in A/J mice by oral administration of green tea. | Nutrition and cancer 20040101 |
| The molecular perspective: nicotine and nitrosamines. | Stem cells (Dayton, Ohio) 20040101 |
| The effect of oxythioquinox exposure on normal human mammary epithelial cell gene expression: a microarray analysis study. | Environmental health : a global access science source 20040101 |
| Expression of inwardly rectifying potassium channels (GIRKs) and beta-adrenergic regulation of breast cancer cell lines. | BMC cancer 20040101 |
| 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone. | Report on carcinogens : carcinogen profiles 20040101 |
| Toxicological assessment of noxious inhalants. | GMS current topics in otorhinolaryngology, head and neck surgery 20040101 |
| Effects of nicotine infusion on the metabolism of the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rats. | Cancer letters 20031208 |
| The effect of methoxsalen on nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in vivo. | Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20031201 |
| Pretreatment with 8-methoxypsoralen, a potent human CYP2A6 inhibitor, strongly inhibits lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice. | Cancer research 20031115 |
| Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK. | Cancer research 20031115 |
| Genotoxic effects of myosmine in human lymphocytes and upper aerodigestive tract epithelial cells. | Toxicology 20031105 |
| Analysis of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20031101 |
| Malignant transformation of human bronchial epithelial cells with the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. | International journal of cancer 20031010 |
| SPRR1B overexpression enhances entry of cells into the G0 phase of the cell cycle. | American journal of physiology. Lung cellular and molecular physiology 20031001 |
| Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13. | Drug metabolism and disposition: the biological fate of chemicals 20031001 |
| Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in peripheral human lung microsomes. | Drug metabolism and disposition: the biological fate of chemicals 20030901 |
| Analysis of tobacco-specific N-nitrosamines in snuff by ethyl acetate extraction and liquid chromatography-tandem mass spectrometry. | Journal of chromatography. A 20030808 |
| Antiproliferative and chemopreventive effects of adlay seed on lung cancer in vitro and in vivo. | Journal of agricultural and food chemistry 20030604 |
| Synthesis of stereospecifically deuterated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) iastereomers and metabolism by A/J mouse lung microsomes and cytochrome p450 2A5. | Chemical research in toxicology 20030601 |
| Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). | Chemical research in toxicology 20030601 |
| Immunomodulatory effects of the tobacco-specific carcinogen, NNK, on alveolar macrophages. | Clinical and experimental immunology 20030501 |
| Identification of adducts formed by pyridyloxobutylation of deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a chemically activated form of tobacco specific carcinogens. | Chemical research in toxicology 20030501 |
| Nucleophilic reactions between thiols and a tobacco specific nitrosamine metabolite, 4-hydroxy-1-(3-pyridyl)-1-butanone. | Chemical research in toxicology 20030501 |
| Transformation of non-cancerous human breast epithelial cell line MCF10A by the tobacco-specific carcinogen NNK. | Breast cancer research and treatment 20030501 |
| Inhibitory effects of propolis granular A P C on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice. | Cancer letters 20030425 |
| K-ras gene sequence effects on the formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-DNA adducts. | Chemical research in toxicology 20030401 |
| An analysis of the role of tobacco-specific nitrosamines in the carcinogenicity of tobacco smoke. | Nonlinearity in biology, toxicology, medicine 20030401 |
| [Cancer from snuff?]. | HNO 20030301 |
| Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats. | Carcinogenesis 20030301 |
| Parental smoking and childhood cancer: results from the United Kingdom Childhood Cancer Study. | British journal of cancer 20030210 |
| Identification of adducts produced by the reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA. | Chemical research in toxicology 20030201 |
| Purification, characterization and NNK carbonyl reductase activities of 11beta-hydroxysteroid dehydrogenase type 1 from human liver: enzyme cooperativity and significance in the detoxification of a tobacco-derived carcinogen. | Chemico-biological interactions 20030201 |
| Increased susceptibility to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in transgenic mice overexpressing c-myc and epidermal growth factor in alveolar type II cells. | Journal of cancer research and clinical oncology 20030201 |
| Lung-specific expression of mutant p53 as mouse model for lung cancer. | Methods in molecular medicine 20030101 |
| Effects of cigarette smoke and a heterocyclic amine, MeIQx on cytochrome P-450, mutagenic activation of various carcinogens and glucuronidation in rat liver. | Mutagenesis 20030101 |
| Receptor-mediated effects of nicotine and its nitrosated derivative NNK on pulmonary neuroendocrine cells. | The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 20030101 |
| Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. | The Journal of clinical investigation 20030101 |
| Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer. | Molecular cancer 20030101 |
| Chemopreventive efficacy of suberoylanilide hydroxamic acid (SAHA) against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in female A/J mice. | Anticancer research 20030101 |
| The pyridyloxobutyl DNA adduct, O6-[4-oxo-4-(3-pyridyl)butyl]guanine, is detected in tissues from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-treated A/J mice. | Chemical research in toxicology 20030101 |
| The molecular basis of lung cancer: molecular abnormalities and therapeutic implications. | Respiratory research 20030101 |
| Comparison of the chemopreventive efficacies of 1,4-phenylenebis(methylene)selenocyanate and selenium-enriched yeast on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mouse. | Nutrition and cancer 20030101 |
| Tobacco xenobiotics release nitric oxide. | Tobacco induced diseases 20030101 |
| Carcinogenic induction directs the selection of allelic losses in mouse lung tumorigenesis. | Cancer research 20021115 |
| The cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK. | Journal of cancer research and clinical oncology 20021001 |
| Investigation of the role of lipoxygenase in bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung. | Chemical research in toxicology 20021001 |
| Effect of nicotine, cotinine and phenethyl isothiocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in the Syrian golden hamster. | Toxicology 20020930 |
| Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. | Carcinogenesis 20020901 |
| Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination. | Carcinogenesis 20020901 |
| Mechanisms of chronic disease causation by nutritional factors and tobacco products and their prevention by tea polyphenols. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020801 |
| Effects of cytochrome P450 (CYP) 2A6 gene deletion and CYP2E1 genotypes on gastric adenocarcinoma. | International journal of cancer 20020801 |
| Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant. | The Journal of pharmacology and experimental therapeutics 20020801 |
| Role of human cytochrome P450 (CYP) in the metabolic activation of nitrosamine derivatives: application of genetically engineered Salmonella expressing human CYP. | Drug metabolism reviews 20020801 |
| High oleic acid oil suppresses lung tumorigenesis in mice through the modulation of extracellular signal-regulated kinase cascade. | Lipids 20020801 |
| Combined treatment with 4-(N-methyl-N-nitrosamino)-1- (3-pyridyl)-1-butanone and dibutyl phthalate enhances ozone-induced genotoxicity in B6C3F1 mice. | Mutagenesis 20020701 |
| Frequent expression of new cancer/testis gene D40/AF15q14 in lung cancers of smokers. | British journal of cancer 20020605 |
| Evidence for phosphate adducts in DNA from mice treated with 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK). | Chemical research in toxicology 20020601 |
| Human urinary carcinogen metabolites: biomarkers for investigating tobacco and cancer. | Carcinogenesis 20020601 |
| Analysis of tobacco-specific nitrosamines in Moldovan cigarette tobacco. | Journal of agricultural and food chemistry 20020508 |
| Identification of tobacco-derived compounds in human pancreatic juice. | Chemical research in toxicology 20020501 |
| The effect of subcutaneous tumour implantation in a murine lung tumour model. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20020401 |
| Automated in-tube solid-phase microextraction coupled with HPLC for the determination of N-nitrosamines in cell cultures. | Analytical chemistry 20020401 |
| Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior. | Therapeutic drug monitoring 20020201 |
| Mutagenesis by O(6)-[4-oxo-4-(3-pyridyl)butyl]guanine in Escherichia coli and human cells. | Chemical research in toxicology 20020201 |
| Effect of acerola cherry extract on cell proliferation and activation of ras signal pathway at the promotion stage of lung tumorigenesis in mice. | Journal of nutritional science and vitaminology 20020201 |
| Inhibitory effects of cinnamaldehyde on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung carcinogenesis in rasH2 mice. | Cancer letters 20020110 |
| Disposition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in bile duct-cannulated rats: stereoselective metabolism and tissue distribution. | Carcinogenesis 20020101 |
| Quantitation of metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone after cessation of smokeless tobacco use. | Cancer research 20020101 |
| Evidence for the epidermal growth factor receptor as a target for lung cancer prevention. | Clinical cancer research : an official journal of the American Association for Cancer Research 20020101 |
| Chemoprevention of oral cancer by black raspberries. | Anticancer research 20020101 |
| 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone. | Report on carcinogens : carcinogen profiles 20020101 |
| Inhibitory effect of mandarin juice rich in beta-cryptoxanthin and hesperidin on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary tumorigenesis in mice. | Cancer letters 20011228 |
| Inhibition of human cytochrome P450 2E1 by nicotine, cotinine, and aqueous cigarette tar extract in vitro. | Toxicological sciences : an official journal of the Society of Toxicology 20011201 |
| Nicotinic receptor-mediated activation by the tobacco-specific nitrosamine NNK of a Raf-1/MAP kinase pathway, resulting in phosphorylation of c-myc in human small cell lung carcinoma cells and pulmonary neuroendocrine cells. | Journal of cancer research and clinical oncology 20011201 |
| Comparison of cytochrome P450 2A6 polymorphism frequencies in Caucasians and African-Americans using a new one-step PCR-RFLP genotyping method. | Toxicology 20011130 |
| The effect of a 2-h exposure to cigarette smoke on the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice. | Chemico-biological interactions 20011128 |
| 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a nicotine derivative, induces apoptosis of endothelial cells. | American journal of physiology. Heart and circulatory physiology 20011101 |
| Metabolites of a tobacco-specific lung carcinogen in the urine of elementary school-aged children. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20011101 |
| Characterization and mapping of DNA damage induced by reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) at nucleotide resolution in human genomic DNA. | Journal of molecular biology 20011026 |
| Re: metabolites of a tobacco-specific lung carcinogen in nonsmoking women exposed to environmental tobacco smoke. | Journal of the National Cancer Institute 20011017 |
| Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis. | Cancer research 20010801 |
| Transport of the beta -O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog. | The Journal of biological chemistry 20010727 |
| The effect of tobacco smoke, nicotine, and cotinine on the mutagenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL). | Mutation research 20010725 |
| Dose-response study of myo-inositol as an inhibitor of lung tumorigenesis induced in A/J mice by benzo. | Cancer letters 20010610 |
| Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20010601 |
| Bacterial mutagenicity of some tobacco aromatic nitrogen bases and their mixtures. | Mutation research 20010531 |
| The suppression of ornithine decarboxylase expression and cell proliferation at the promotion stage of lung tumorigenesis in mice by alpha-tocopheryloxybutyric acid. | Biochemical pharmacology 20010501 |
| Preparation of pyridine-N-glucuronides of tobacco-specific nitrosamines. | Chemical research in toxicology 20010501 |
| Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk. | Drug metabolism and disposition: the biological fate of chemicals 20010401 |
| Effects of vitamins and common drugs on reduction of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rat microsomes. | Archives of physiology and biochemistry 20010401 |
| Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population. | International journal of cancer 20010320 |
| Metabolites of a tobacco-specific lung carcinogen in nonsmoking women exposed to environmental tobacco smoke. | Journal of the National Cancer Institute 20010307 |
| Tobacco industry must not dump its high nitrosamine tobacco on poor countries. | BMJ (Clinical research ed.) 20010303 |
| p16INK4a and beta-catenin alterations in rat liver tumors induced by NNK. | Carcinogenesis 20010301 |
| Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas. | Carcinogenesis 20010301 |
| Cytochrome P450 expression and related metabolism in human buccal mucosa. | Carcinogenesis 20010301 |
| 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone modulation of cytokine release in U937 human macrophages. | Cancer immunology, immunotherapy : CII 20010201 |
| Characterization of enzymes participating in carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human placenta. | Chemico-biological interactions 20010130 |
| Expression and NNK reducing activities of carbonyl reductase and 11beta-hydroxysteroid dehydrogenase type 1 in human lung. | Chemico-biological interactions 20010130 |
| Human cervical tissue metabolizes the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, via alpha-hydroxylation and carbonyl reduction pathways. | Carcinogenesis 20010101 |
| Mutagenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosonornicotine in lacZ upper aerodigestive tissue and liver and inhibition by green tea. | Carcinogenesis 20010101 |
| Chemoprevention of lung cancer by isothiocyanates and their conjugates in A/J mouse. | Experimental lung research 20010101 |
| Joint effects of citrus peel use and black tea intake on the risk of squamous cell carcinoma of the skin. | BMC dermatology 20010101 |
| Assessment of murine lung tumour development: a comparison of two techniques. | British journal of biomedical science 20010101 |
| Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mouse lung and effect of cigarette smoke exposure on in vivo metabolism to biological reactive intermediates. | Advances in experimental medicine and biology 20010101 |
| Predicting the mutagenicity of tobacco-related N-nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH-cytochrome P450 reductase. | Environmental and molecular mutagenesis 20010101 |
| Smoke yields of tobacco-specific nitrosamines in relation to FTC tar level and cigarette manufacturer: analysis of the Massachusetts Benchmark Study. | Public health reports (Washington, D.C. : 1974) 20010101 |
| Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters. | Journal of cancer research and clinical oncology 20001101 |
| Regional and cellular induction of nicotine-metabolizing CYP2B1 in rat brain by chronic nicotine treatment. | Biochemical pharmacology 20000615 |
| Preferential effects of nicotine and 4-(N-methyl-N-nitrosamine)-1-(3-pyridyl)-1-butanone on mitochondrial glutathione S-transferase A4-4 induction and increased oxidative stress in the rat brain. | Biochemical pharmacology 19981001 |
| Tea and tea polyphenols inhibit cell hyperproliferation, lung tumorigenesis, and tumor progression. | Experimental lung research 19980101 |
| Alterations in the K-ras and p53 genes in rat lung tumors. | Environmental health perspectives 19970601 |
| Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and N'- nitrosonornicotine in human hepatic microsomes. | Drug metabolism and disposition: the biological fate of chemicals 19970201 |
| Chemopreventive effects of myo-inositol and dexamethasone on benzo[a]pyrene and 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone-induced pulmonary carcinogenesis in female A/J mice. | Cancer research 19961115 |
| Glucuronidation of 4-((hydroxymethyl)nitrosamino)-1-(3-pyridyl)-1-butanone, a metabolically activated form of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, by phenobarbital-treated rats. | Chemical research in toxicology 19950101 |
| A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6. | Carcinogenesis 19910701 |
| Comparative carcinogenicity in F344 rats of the tobacco-specific nitrosamines, N'-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. | Cancer research 19800201 |