Home Nitriles 3-Quinolinecarbonitrile

3-Quinolinecarbonitrile

CAS No.:
34846-64-5
Catalog Number:
AG003JWG
Molecular Formula:
C10H6N2
Molecular Weight:
154.1680
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
500mg
95%
In Stock USA
United States
$63
- +
1g
95%
In Stock USA
United States
$88
- +
5g
95%
In Stock USA
United States
$263
- +
10g
95%
In Stock USA
United States
$475
- +
25g
95%
In Stock USA
United States
$950
- +
Product Description
Catalog Number:
AG003JWG
Chemical Name:
3-Quinolinecarbonitrile
CAS Number:
34846-64-5
Molecular Formula:
C10H6N2
Molecular Weight:
154.1680
MDL Number:
MFCD00006766
IUPAC Name:
quinoline-3-carbonitrile
InChI:
InChI=1S/C10H6N2/c11-6-8-5-9-3-1-2-4-10(9)12-7-8/h1-5,7H
InChI Key:
QZZYYBQGTSGDPP-UHFFFAOYSA-N
SMILES:
N#Cc1cnc2c(c1)cccc2
EC Number:
252-248-6
NSC Number:
44644
Properties
Complexity:
203  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
154.053g/mol
Formal Charge:
0
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
154.172g/mol
Monoisotopic Mass:
154.053g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
36.7A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.6  
Literature
Title Journal
Pharmacophore generation and atom-based 3D-QSAR of novel quinoline-3-carbonitrile derivatives as Tpl2 kinase inhibitors. Journal of enzyme inhibition and medicinal chemistry 20120801
Development of a new epidermal growth factor receptor positron emission tomography imaging agent based on the 3-cyanoquinoline core: synthesis and biological evaluation. Bioorganic & medicinal chemistry 20100915
4-Anilino-7-pyridyl-3-quinolinecarbonitriles as Src kinase inhibitors. Bioorganic & medicinal chemistry letters 20090901
Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment. Bioorganic & medicinal chemistry letters 20090101
AXL is a potential target for therapeutic intervention in breast cancer progression. Cancer research 20080315
Exploitation of the 3-quinolinecarbonitrile template for SRC tyrosine kinase inhibitors. Current topics in medicinal chemistry 20080101
An efficient one-pot, three-component synthesis of indeno[1,2-b]quinoline-9,11(6H,10H)-dione, acridine-1,8(2H,5H)-dione and quinoline-3-carbonitrile derivatives from enaminones. Organic & biomolecular chemistry 20061007
Synthesis and Src kinase inhibitory activity of 2-phenyl- and 2-thienyl-7-phenylaminothieno[3,2-b]pyridine-6-carbonitriles. Journal of medicinal chemistry 20050602
Identification of 7-phenylaminothieno- [3,2-b]pyridine-6-carbonitriles as a new class of Src kinase inhibitors. Journal of medicinal chemistry 20041230
Epidermal growth factor receptor tyrosine kinase inhibitors. British journal of cancer 20040614
4-anilino-3-quinolinecarbonitriles: an emerging class of kinase inhibitors. Current topics in medicinal chemistry 20020901
Cleavage of carbon-carbon bonds in aromatic nitriles using nickel(0). Journal of the American Chemical Society 20020814
Hydrogen bonding and dipolar interactions between quinolines and organic solvents. Nuclear magnetic resonance and ultraviolet-visible spectroscopic studies. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20010701
Properties