Piperazin-2-one
| Title | Journal |
|---|---|
| Discovery of dehydro-oxopiperazine acetamides as novel bradykinin B1 receptor antagonists with enhanced in vitro potency. | Bioorganic & medicinal chemistry letters 20120115 |
| Identification of novel sildenafil-analogues in an adulterated herbal food supplement. | Journal of pharmaceutical and biomedical analysis 20111205 |
| Discovery of potent, orally bioavailable phthalazinone bradykinin B1 receptor antagonists. | Journal of medicinal chemistry 20111027 |
| Discovery of DA-1229: a potent, long acting dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes. | Bioorganic & medicinal chemistry letters 20110615 |
| 3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammation. | Bioorganic & medicinal chemistry letters 20110601 |
| A submarine journey: the pyrrole-imidazole alkaloids. | Marine drugs 20091201 |
| Ligand scaffold hopping combining 3D maximal substructure search and molecular similarity. | BMC bioinformatics 20090101 |
| Ebastine in the light of CONGA recommendations for the development of third-generation antihistamines. | Journal of asthma and allergy 20090101 |
| Computer applications for prediction of protein-protein interactions and rational drug design. | Advances and applications in bioinformatics and chemistry : AABC 20090101 |
| Discovery of orally bioavailable 1,3,4-trisubstituted 2-oxopiperazine-based melanocortin-4 receptor agonists as potential antiobesity agents. | Journal of medicinal chemistry 20081009 |
| Concise synthesis of the CDE ring system of tetrahydroisoquinoline alkaloids using carbophilic Lewis acid-catalyzed hydroamidation and oxidative Friedel-Crafts cyclization. | The Journal of organic chemistry 20080704 |
| Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors. | Bioorganic & medicinal chemistry letters 20080601 |
| Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers. | Bioorganic & medicinal chemistry 20080201 |
| [Piperazines as model substrate for oxidations]. | Die Pharmazie 20061001 |
| New class of nucleophiles for palladium-catalyzed asymmetric allylic alkylation. Total synthesis of agelastatin A. | Journal of the American Chemical Society 20060510 |
| Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I. | Organic & biomolecular chemistry 20060507 |
| (13)C NMR spectral assignment of 1,4-diarylpiperazinones. | Magnetic resonance in chemistry : MRC 20060101 |
| Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as factor Xa inhibitors III. Effect of ring opening of piperazinone moiety on inhibition. | Chemical & pharmaceutical bulletin 20040401 |
| Macrocyclic piperazinones as potent dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I. | Bioorganic & medicinal chemistry letters 20040209 |
| Synthesis of a library of 3-oxopiperazinium and perhydro-3-oxo-1,4-diazepinium derivatives and identification of bioactive compounds. | Journal of combinatorial chemistry 20040101 |
| alpha-Keto amides as precursors to heterocycles--generation and cycloaddition reactions of piperazin-5-one nitrones. | Organic & biomolecular chemistry 20030407 |
| Synthesis of 1,4-diazines by ring expansion of 1,3-diazines. | The Journal of organic chemistry 20030321 |
| Molecular structures of human factor Xa complexed with ketopiperazine inhibitors: preference for a neutral group in the S1 pocket. | Journal of medicinal chemistry 20030227 |
| Potent dibasic GPIIb/IIIa antagonists with reduced prolongation of bleeding time: synthesis and pharmacological evaluation of 2-oxopiperazine derivatives. | Journal of medicinal chemistry 20010719 |
| The design of competitive, small-molecule inhibitors of coagulation factor Xa. | Current topics in medicinal chemistry 20010601 |
| 3,8-Diazabicyclo[3.2.1]octan-2-one peptide mimetics: synthesis of a conformationally restricted inhibitor of farnesyltransferase. | Organic letters 20010322 |
| Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferase. | Bioorganic & medicinal chemistry letters 20010226 |
| Potent and selective bicyclic lactam inhibitors of thrombin. Part 4: transition state inhibitors. | Bioorganic & medicinal chemistry letters 20010212 |