Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress.

Neoplasia (New York, N.Y.) 20140901

Aberrant activation of M phase proteins by cell proliferation-evoking carcinogens after 28-day administration in rats.

Toxicology letters 20130607

Phenethylisothiocyanate alters site- and promoter-specific histone tail modifications in cancer cells.

PloS one 20130101

Time-related survival effects of two gluconasturtiin hydrolysis products on the terrestrial isopod Porcellio scaber.

Chemosphere 20121101

Development and application of a method for identification of isothiocyanate-targeted molecules in colon cancer cells.

Analytical biochemistry 20121015

miR-141 modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein.

The Prostate 20121001

Phenethyl isothiocyanate-induced cytoskeletal changes and cell death in lung cancer cells.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20121001

Differential induction of apoptosis in human breast cancer cell lines by phenethyl isothiocyanate, a glutathione depleting agent.

Cell stress & chaperones 20120901

Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.

Drug metabolism and disposition: the biological fate of chemicals 20120901

Isothiocyanates ameliorate the symptom of heart dysfunction and mortality in a murine AIDS model by inhibiting apoptosis in the left ventricle.

Journal of medicinal food 20120901

Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate.

Acta crystallographica. Section F, Structural biology and crystallization communications 20120901

Modulation of carcinogen metabolizing cytochromes P450 in rat liver and kidney by cabbage and sauerkraut juices: comparison with the effects of indole-3-carbinol and phenethyl isothiocyanate.

Phytotherapy research : PTR 20120801

Structural influence of isothiocyanates on expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120801

Biomarkers of phenethyl isothiocyanate-mediated mammary cancer chemoprevention in a clinically relevant mouse model.

Journal of the National Cancer Institute 20120801

Phenethyl isothiocyanate suppresses inhibitor of apoptosis family protein expression in prostate cancer cells in culture and in vivo.

The Prostate 20120701

β-Phenethyl isothiocyanate induces death receptor 5 to induce apoptosis in human oral cancer cells via p38.

Oral diseases 20120701

Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2.

Journal of natural products 20120622

Characterization of the temporal induction of hepatic xenobiotic-metabolizing enzymes by glucosinolates and isothiocyanates: requirement for at least a 6 h exposure to elicit complete induction profile.

Journal of agricultural and food chemistry 20120606

Bim contributes to phenethyl isothiocyanate-induced apoptosis in breast cancer cells.

Molecular carcinogenesis 20120601

Paclitaxel sensitivity of breast cancer cells requires efficient mitotic arrest and disruption of Bcl-xL/Bak interaction.

Breast cancer research and treatment 20120601

Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

Journal of medicinal chemistry 20120524

Molecular and life-history effects of a natural toxin on herbivorous and non-target soil arthropods.

Ecotoxicology (London, England) 20120501

First study on antimicriobial activity and synergy between isothiocyanates and antibiotics against selected Gram-negative and Gram-positive pathogenic bacteria from clinical and animal source.

Medicinal chemistry (Shariqah (United Arab Emirates)) 20120501

Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachment.

International journal of oncology 20120401

Ethanol suppresses ureagenesis in rat hepatocytes: role of acetaldehyde.

The Journal of biological chemistry 20120302

Phenethyl isothiocyanate, a naturally occurring phytochemical, is an antagonist of the aryl hydrocarbon receptor.

Molecular nutrition & food research 20120301

Five decades with glutathione and the GSTome.

The Journal of biological chemistry 20120224

Allyl isothiocyanate as a potential inducer of paraoxonase-1--studies in cultured hepatocytes and in mice.

IUBMB life 20120201

Apoptosis Induction in Primary Human Colorectal Cancer Cell Lines and Retarded Tumor Growth in SCID Mice by Sulforaphane.

Evidence-based complementary and alternative medicine : eCAM 20120101

Antimicrobial activities of phenethyl isothiocyanate isolated from horseradish.

Natural product research 20120101

The role of nutraceuticals in chemoprevention and chemotherapy and their clinical outcomes.

Journal of oncology 20120101

Automated reporter quantification in vivo: high-throughput screening method for reporter-based assays in zebrafish.

PloS one 20120101

A network flow approach to predict drug targets from microarray data, disease genes and interactome network - case study on prostate cancer.

Journal of clinical bioinformatics 20120101

Estrogen receptor-alpha 36 mediates mitogenic antiestrogen signaling in ER-negative breast cancer cells.

PloS one 20120101

Astroglial pentose phosphate pathway rates in response to high-glucose environments.

ASN neuro 20120101

Critical role of p53 upregulated modulator of apoptosis in benzyl isothiocyanate-induced apoptotic cell death.

PloS one 20120101

Arsenic trioxide enhances the radiation sensitivity of androgen-dependent and -independent human prostate cancer cells.

PloS one 20120101

Towards the understanding of microRNA and environmental factor interactions and their relationships to human diseases.

Scientific reports 20120101

Modeling effective dosages in hormetic dose-response studies.

PloS one 20120101

Demethoxycurcumin Retards Cell Growth and Induces Apoptosis in Human Brain Malignant Glioma GBM 8401 Cells.

Evidence-based complementary and alternative medicine : eCAM 20120101

Current and future options for the management of phantom-limb pain.

Journal of pain research 20120101

Cigarette smoke exposure-associated alterations to non-coding RNA.

Frontiers in genetics 20120101

Ethanol-mediated regulation of cytochrome P450 2A6 expression in monocytes: role of oxidative stress-mediated PKC/MEK/Nrf2 pathway.

PloS one 20120101

Turning the 'mustard oil bomb' into a 'cyanide bomb': aromatic glucosinolate metabolism in a specialist insect herbivore.

PloS one 20120101

Sulforaphane potentiates RNA damage induced by different xenobiotics.

PloS one 20120101

A combination of lipoic acid plus coenzyme Q10 induces PGC1α, a master switch of energy metabolism, improves stress response, and increases cellular glutathione levels in cultured C2C12 skeletal muscle cells.

Oxidative medicine and cellular longevity 20120101

Bioactive dietary supplements reactivate ER expression in ER-negative breast cancer cells by active chromatin modifications.

PloS one 20120101

Metformin and phenethyl isothiocyanate combined treatment in vitro is cytotoxic to ovarian cancer cultures.

Journal of ovarian research 20120101

Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models.

BMC medicine 20120101

Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G(0)/G(1) Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death.

Evidence-based complementary and alternative medicine : eCAM 20120101

Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse model.

PloS one 20120101

Effects of indole-3-carbinol and phenethyl isothiocyanate on bile and pancreatic juice excretion in rats.

The journal of medical investigation : JMI 20120101

Inhibition of mitochondrial respiration and rapid depletion of mitochondrial glutathione by β-phenethyl isothiocyanate: mechanisms for anti-leukemia activity.

Antioxidants & redox signaling 20111215

Interplay between histopathological alterations, cigarette smoke and chemopreventive agents in defining microRNA profiles in mouse lung.

Mutation research 20111201

Cancer chemoprevention by targeting the epigenome.

Current drug targets 20111201

Suppression of inflammation-associated factors by indole-3-carbinol in mice fed high-fat diets and in isolated, co-cultured macrophages and adipocytes.

International journal of obesity (2005) 20111201

Mitogen-activated protein kinase mediates the apoptosis of highly metastatic human non-small cell lung cancer cells induced by isothiocyanates.

The British journal of nutrition 20111201

NF-κB suppresses ROS levels in BCR-ABL(+) cells to prevent activation of JNK and cell death.

Oncogene 20111110

Sulforaphane induces antioxidative and antiproliferative responses by generating reactive oxygen species in human bronchial epithelial BEAS-2B cells.

Journal of Korean medical science 20111101

Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells.

Clinical epigenetics 20111026

Identification of potential protein targets of isothiocyanates by proteomics.

Chemical research in toxicology 20111017

Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatin.

Molecular nutrition & food research 20111001

Inorganic sulfur reduces the motility and invasion of MDA-MB-231 human breast cancer cells.

Nutrition research and practice 20111001

Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα.

The Journal of biological chemistry 20110923

The expression of the pro-apoptotic gene Air is inducible in human pancreatic adenocarcinoma cells.

Journal of cellular physiology 20110901

Effect of β-phenylethyl isothiocyanate from cruciferous vegetables on growth inhibition and apoptosis of cervical cancer cells through the induction of death receptors 4 and 5.

Journal of agricultural and food chemistry 20110810

Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: importance of side-chain substituent and chirality.

Archives of toxicology 20110801

Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase-3, mitochondria dysfunction and nitric oxide (NO) in human osteogenic sarcoma U-2 OS cells.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20110801

Synthesis and antiproliferative activity of novel α- and β-dialkoxyphosphoryl isothiocyanates.

Bioorganic & medicinal chemistry letters 20110801

Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myeloma.

Haematologica 20110801

Selective killing of cancer cells by a small molecule targeting the stress response to ROS.

Nature 20110714

In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.

Pest management science 20110701

Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates.

Biopharmaceutics & drug disposition 20110701

Phenethyl isothiocyanate (PEITC) promotes G2/M phase arrest via p53 expression and induces apoptosis through caspase- and mitochondria-dependent signaling pathways in human prostate cancer DU 145 cells.

Anticancer research 20110501

[Effect of phenethyl isothiocyanate given at different duration of gestation on the outcome of pregnancy in rats].

Wei sheng yan jiu = Journal of hygiene research 20110501

Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer.

Journal of the National Cancer Institute 20110406

Phenethyl isothiocyanate inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory responses in mouse skin.

Journal of medicinal food 20110401

Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways.

Cell death & disease 20110401

Modulation of rat hepatic and kidney phase II enzymes by cabbage juices: comparison with the effects of indole-3-carbinol and phenethyl isothiocyanate.

The British journal of nutrition 20110301

Allyl-, butyl- and phenylethyl-isothiocyanate activate Nrf2 in cultured fibroblasts.

Pharmacological research 20110301

Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships.

Journal of medicinal chemistry 20110210

Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells.

Carcinogenesis 20110201

Dietary phenethyl isothiocyanate alters gene expression in human breast cancer cells.

Evidence-based complementary and alternative medicine : eCAM 20110101

Exposure to isothiocyanates suppresses urinary mutagenicity in rats treated with heterocyclic amine IQ: lack of association with CYP1 activity.

Nutrition and cancer 20110101

[Changes on neurobehavioral development of the offspring in rats prenataly exposed by phenethyl isothiocyanate].

Wei sheng yan jiu = Journal of hygiene research 20110101

Sulforaphane blocks hypoxia-mediated resistance to TRAIL-induced tumor cell death.

Molecular medicine reports 20110101

NNK-Induced Lung Tumors: A Review of Animal Model.

Journal of oncology 20110101

Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly.

Molecular cancer 20110101

The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo.

PloS one 20110101

Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFκB survival axis downstream of Death receptor-3.

BMC cancer 20110101

Inhibition of premature death by isothiocyanates through immune restoration in LP-BM5 leukemia retrovirus-infected C57BL/6 mice.

Bioscience, biotechnology, and biochemistry 20110101

Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inhibitors.

Journal of biomedicine & biotechnology 20110101

Exploiting mitochondrial dysfunction for effective elimination of imatinib-resistant leukemic cells.

PloS one 20110101

Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy.

Chinese medicine 20110101

Notch activation by phenethyl isothiocyanate attenuates its inhibitory effect on prostate cancer cell migration.

PloS one 20110101

Mitochondrial peroxiredoxin III is a potential target for cancer therapy.

International journal of molecular sciences 20110101

Selenium and lung cancer: a systematic review and meta analysis.

PloS one 20110101

Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells.

Clinical epigenetics 20110101

Effect of orally administered phenethyl isothiocyanate on hepatic gene expression in rats.

Molecular nutrition & food research 20101201

Differential response of normal (PrEC) and cancerous human prostate cells (PC-3) to phenethyl isothiocyanate-mediated changes in expression of antioxidant defense genes.

Pharmaceutical research 20101201

Determination of new biomarkers to monitor the dietary consumption of isothiocyanates.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20101201

In vivo modulation of 4E binding protein 1 (4E-BP1) phosphorylation by watercress: a pilot study.

The British journal of nutrition 20101101

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Bioorganic & medicinal chemistry letters 20101101

Loss of ERα and FOXA1 expression in a progression model of luminal type breast cancer: insights from PyMT transgenic mouse model.

Oncology reports 20101101

Overcoming resistance to histone deacetylase inhibitors in human leukemia with the redox modulating compound β-phenylethyl isothiocyanate.

Blood 20101014

Phenethyl isocyanate is not the metabolite of phenethyl isothiocyanate responsible for mechanism-based inhibition of cytochrome P450.

Archives of toxicology 20101001

Differential response of four human livers to modulation of phase II enzyme systems by the chemopreventive phytochemical phenethyl isothiocyanate.

Molecular nutrition & food research 20101001

Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment.

PLoS medicine 20101001

Phenethyl isothiocyanate suppresses nitric oxide production via inhibition of phosphoinositide 3-kinase/Akt-induced IFN-gamma secretion in LPS-activated peritoneal macrophages.

Molecular nutrition & food research 20100901

Prostate cancer chemopreventive activity of phenethyl isothiocyanate through epigenetic regulation (review).

International journal of oncology 20100901

Identification of biologically relevant compounds in aboveground and belowground induced volatile blends.

Journal of chemical ecology 20100901

Multidirectional time-dependent effect of sinigrin and allyl isothiocyanate on metabolic parameters in rats.

Plant foods for human nutrition (Dordrecht, Netherlands) 20100901

Evaluation of antibacterial activity of 3-butenyl, 4-pentenyl, 2-phenylethyl, and benzyl isothiocyanate in Brassica vegetables.

Journal of food science 20100901

Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells.

The Journal of biological chemistry 20100820

A novel quasi-species of glutathione transferase with high activity towards naturally occurring isothiocyanates evolves from promiscuous low-activity variants.

Journal of molecular biology 20100820

Sensitization of non-small cell lung cancer cells to cisplatin by naturally occurring isothiocyanates.

Chemical research in toxicology 20100816

Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression.

Toxicological sciences : an official journal of the Society of Toxicology 20100801

Candidate dietary phytochemicals modulate expression of phase II enzymes GSTP1 and NQO1 in human lung cells.

The Journal of nutrition 20100801

Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.

Journal of medicinal chemistry 20100722

Breast cancer cell growth inhibition by phenethyl isothiocyanate is associated with down-regulation of oestrogen receptor-alpha36.

Journal of cellular and molecular medicine 20100601

Phthalate esters reveal skin-sensitizing activity of phenethyl isothiocyanate in mice.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100601

Phenethyl isothiocyanate inhibits migration and invasion of human gastric cancer AGS cells through suppressing MAPK and NF-kappaB signal pathways.

Anticancer research 20100601

Cytochrome P450 2A5 constitutive expression and induction by heavy metals is dependent on redox-sensitive transcription factor Nrf2 in liver.

Chemical research in toxicology 20100517

Differential in vivo mechanism of chemoprevention of tumor formation in azoxymethane/dextran sodium sulfate mice by PEITC and DBM.

Carcinogenesis 20100501

Modulation of microRNA expression by budesonide, phenethyl isothiocyanate and cigarette smoke in mouse liver and lung.

Carcinogenesis 20100501

Formation and distribution of NNK metabolites in an isolated perfused rat lung.

Drug metabolism and disposition: the biological fate of chemicals 20100501

Effects of phenylethyl isothiocyanate and its metabolite on cell-cycle arrest and apoptosis in LNCaP human prostate cancer cells.

International journal of food sciences and nutrition 20100501

Antimicrobial activity of phenolics and glucosinolate hydrolysis products and their synergy with streptomycin against pathogenic bacteria.

Medicinal chemistry (Shariqah (United Arab Emirates)) 20100501

New biomarkers for monitoring the levels of isothiocyanates in humans.

Chemical research in toxicology 20100419

Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane.

Bioorganic & medicinal chemistry letters 20100415

p66Shc is indispensable for phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells.

Cancer research 20100415

Phenethyl isothiocyanate sensitizes androgen-independent human prostate cancer cells to docetaxel-induced apoptosis in vitro and in vivo.

Pharmaceutical research 20100401

6-Chloro-3-phenethyl-2-thioxo-2,3-di-hydro-quinazolin-4(1H)-one.

Acta crystallographica. Section E, Structure reports online 20100401

Phytochemicals in cancer prevention and therapy: truth or dare?

Toxins 20100401

Biological profile of erucin: a new promising anticancer agent from cruciferous vegetables.

Toxins 20100401

Mitochondrial respiratory chain involvement in peroxiredoxin 3 oxidation by phenethyl isothiocyanate and auranofin.

FEBS letters 20100319

Prevention of cigarette smoke-induced lung tumors in mice by budesonide, phenethyl isothiocyanate, and N-acetylcysteine.

International journal of cancer 20100301

Repeated oral administration modulates the pharmacokinetic behavior of the chemopreventive agent phenethyl isothiocyanate in rats.

Molecular nutrition & food research 20100301

Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention.

The AAPS journal 20100301

Paradoxical roles for antioxidants in tumor prevention and eradication.

Cancer biology & therapy 20100301

Pharmacological modulation of genome and proteome alterations in mice treated with the endocrine disruptor bisphenol A.

Current cancer drug targets 20100301

Modulation of carcinogen-metabolising cytochromes P450 in human liver by the chemopreventive phytochemical phenethyl isothiocyanate, a constituent of cruciferous vegetables.

Toxicology 20100209

Chemoprevention of cigarette smoke-induced alterations of MicroRNA expression in rat lungs.

Cancer prevention research (Philadelphia, Pa.) 20100101

A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes.

Arthritis research & therapy 20100101

Immunochemical detection of food-derived isothiocyanate as a lysine conjugate.

Bioscience, biotechnology, and biochemistry 20100101

Oxidative stress in NSC-741909-induced apoptosis of cancer cells.

Journal of translational medicine 20100101

Suppression of inflammatory mediators by cruciferous vegetable-derived indole-3-carbinol and phenylethyl isothiocyanate in lipopolysaccharide-activated macrophages.

Mediators of inflammation 20100101

Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study.

BMC cancer 20100101

Dietary phenethylisothiocyanate attenuates bowel inflammation in mice.

BMC chemical biology 20100101

Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells.

BMC cancer 20100101

Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines.

PloS one 20100101

Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer.

Journal of molecular signaling 20100101

Comparative functional genomics analysis of NNK tobacco-carcinogen induced lung adenocarcinoma development in Gprc5a-knockout mice.

PloS one 20100101

Selective killing of cancer cells by Ashwagandha leaf extract and its component Withanone involves ROS signaling.

PloS one 20100101

Anti-cancer and potential chemopreventive actions of ginseng by activating Nrf2 (NFE2L2) anti-oxidative stress/anti-inflammatory pathways.

Chinese medicine 20100101

Cigarette smoke induces C/EBP-β-mediated activation of miR-31 in normal human respiratory epithelia and lung cancer cells.

PloS one 20100101

Purification of reversibly oxidized proteins (PROP) reveals a redox switch controlling p38 MAP kinase activity.

PloS one 20100101

Reactivating aberrantly hypermethylated p15 gene in leukemic T cells by a phenylhexyl isothiocyanate mediated inter-active mechanism on DNA and chromatin.

Journal of hematology & oncology 20100101

Curcumin-the paradigm of a multi-target natural compound with applications in cancer prevention and treatment.

Toxins 20100101

Modulation of detoxification enzymes by watercress: in vitro and in vivo investigations in human peripheral blood cells.

European journal of nutrition 20091201

Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates.

The Journal of biological chemistry 20091120

Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery.

Biochemical and biophysical research communications 20091016

Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells.

Molecular and cellular biochemistry 20091001

Growth-inhibiting activities of phenethyl isothiocyanate and its derivatives against intestinal bacteria.

Journal of food science 20091001

Inhibition of hypoxia inducible factor by phenethyl isothiocyanate.

Biochemical pharmacology 20090801

Phenethyl isothiocyanate inhibits STAT3 activation in prostate cancer cells.

Molecular nutrition & food research 20090701

Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes.

The Journal of biological chemistry 20090619

Potency of isothiocyanates to induce luciferase reporter gene expression via the electrophile-responsive element from murine glutathione S-transferase Ya.

Toxicology in vitro : an international journal published in association with BIBRA 20090601

Key residues controlling binding of diverse ligands to human cytochrome P450 2A enzymes.

Drug metabolism and disposition: the biological fate of chemicals 20090601

Initial in vitro evaluations of the antibacterial activities of glucosinolate enzymatic hydrolysis products against plant pathogenic bacteria.

Journal of applied microbiology 20090601

Modulation by phenethyl isothiocyanate and budesonide of molecular and histopathologic alterations induced by environmental cigarette smoke in mice.

Cancer prevention research (Philadelphia, Pa.) 20090601

Antimutagenic effect of phenethyl isothiocyanate.

Central European journal of public health 20090601

Anti-NF-kappaB and anti-inflammatory activities of synthetic isothiocyanates: effect of chemical structures and cellular signaling.

Chemico-biological interactions 20090515

Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells.

Cancer research 20090415

Comparison of the effects of phenethyl isothiocyanate and sulforaphane on gene expression in breast cancer and normal mammary epithelial cells.

Experimental biology and medicine (Maywood, N.J.) 20090301

[Natural compounds in chemoprevention of esophageal squamous cell tumors--experimental studies].

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20090201

Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation.

Pharmaceutical research 20090101

Phenethyl isothiocyanate induces cell cycle arrest and reduction of alpha- and beta-tubulin isotypes in human prostate cancer cells.

Cell biology international 20090101

Isothiocyanates repress estrogen receptor alpha expression in breast cancer cells.

Oncology reports 20090101

Isothiocyanate profile and selective antibacterial activity of root, stem, and leaf extracts derived from Raphanus sativus L.

Foodborne pathogens and disease 20090101

Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells.

BMC gastroenterology 20090101

Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response.

PloS one 20090101

Dietary agent, benzyl isothiocyanate inhibits signal transducer and activator of transcription 3 phosphorylation and collaborates with sulforaphane in the growth suppression of PANC-1 cancer cells.

Cancer cell international 20090101

Differing mechanisms of simple nitrile formation on glucosinolate degradation in Lepidium sativum and Nasturtium officinale seeds.

Phytochemistry 20090101

Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members.

PloS one 20090101

Targeting protein kinase C (PKC) and telomerase by phenethyl isothiocyanate (PEITC) sensitizes PC-3 cells towards chemotherapeutic drug-induced apoptosis.

Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20090101

Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis.

British journal of cancer 20081209

Tissue differences in the modulation of rat cytochromes P450 and phase II conjugation systems by dietary doses of phenethyl isothiocyanate.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20081201

Budesonide and phenethyl isothiocyanate attenuate DNA damage in bronchoalveolar lavage cells of mice exposed to environmental cigarette smoke.

Current cancer drug targets 20081201

Phenethyl isothiocyanate induced apoptosis via down regulation of Bcl-2/XIAP and triggering of the mitochondrial pathway in MCF-7 cells.

Archives of pharmacal research 20081201

Induction of apoptosis by phenethyl isothiocyanate in cells overexpressing Bcl-XL.

Cancer letters 20081128

Development of chitosan-SLN microparticles for chemotherapy: in vitro approach through efflux-transporter modulation.

Journal of controlled release : official journal of the Controlled Release Society 20081112

Acaricidal constituents isolated from Sinapis alba L. seeds and structure-activity relationships.

Journal of agricultural and food chemistry 20081112

Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo.

Journal of natural products 20081101

[Effect of phenethyl isothiocyanate on expression of genes during differentiation process of mouse embryonic stem cells in vitro].

Wei sheng yan jiu = Journal of hygiene research 20081101

Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease.

Diabetes 20081001

Role of reactive oxygen intermediates in cellular responses to dietary cancer chemopreventive agents.

Planta medica 20081001

Genetic networks controlling structural outcome of glucosinolate activation across development.

PLoS genetics 20081001

Murine prostate cancer inhibition by dietary phytochemicals--curcumin and phenyethylisothiocyanate.

Pharmaceutical research 20080901

Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism.

Blood 20080901

Cancer is a preventable disease that requires major lifestyle changes.

Pharmaceutical research 20080901

Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates.

Free radical biology & medicine 20080815

De-repression of the p21 promoter in prostate cancer cells by an isothiocyanate via inhibition of HDACs and c-Myc.

International journal of oncology 20080801

Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate.

Cancer research 20080801

Antigenotoxic properties of Eruca sativa (rocket plant), erucin and erysolin in human hepatoma (HepG2) cells towards benzo(a)pyrene and their mode of action.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080701

Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

Journal of medicinal chemistry 20080612

Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism.

Leukemia 20080601

PEITC induces G1 cell cycle arrest on HT-29 cells through the activation of p38 MAPK signaling pathway.

The AAPS journal 20080601

Chemoprevention of familial adenomatous polyposis in Apc(Min/+) mice by phenethyl isothiocyanate (PEITC).

Molecular carcinogenesis 20080501

Cytochrome P450 2E1 in the substantia nigra: relevance for dopaminergic neurotransmission and free radical production.

Synapse (New York, N.Y.) 20080501

Protective effects of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine or N-nitrosopiperidine-induced oxidative DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.

Journal of applied toxicology : JAT 20080301

Herbal compounds and toxins modulating TRP channels.

Current neuropharmacology 20080301

Barbarea vulgaris glucosinolate phenotypes differentially affect performance and preference of two different species of lepidopteran herbivores.

Journal of chemical ecology 20080201

Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate.

PloS one 20080101

Binding to protein by isothiocyanates: a potential mechanism for apoptosis induction in human non small lung cancer cells.

Nutrition and cancer 20080101

Antimicrobial and antioxidant activities of Cortex Magnoliae Officinalis and some other medicinal plants commonly used in South-East Asia.

Chinese medicine 20080101

Gene expression deregulation by KRAS G12D and G12V in a BRAF V600E context.

Molecular cancer 20080101

Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents.

Biological chemistry 20071001

The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells.

Cancer research 20070701

Effects of phenylethyl isothiocyanate on early molecular events in N-nitrosomethylbenzylamine-induced cytotoxicity in rat esophagus.

Cancer research 20070701

Modulating testosterone stimulated prostate growth by phenethyl isothiocyanate via Sp1 and androgen receptor down-regulation.

The Prostate 20070601

Targeting ROS: selective killing of cancer cells by a cruciferous vegetable derived pro-oxidant compound.

Cancer biology & therapy 20070501

Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1.

Cancer research 20070415

Kinetics of the stability of broccoli (Brassica oleracea Cv. Italica) myrosinase and isothiocyanates in broccoli juice during pressure/temperature treatments.

Journal of agricultural and food chemistry 20070321

Phenethyl isothiocyanate inhibits angiogenesis in vitro and ex vivo.

Cancer research 20070301

Does the consumption of green tea reduce the risk of lung cancer among smokers?

Evidence-based complementary and alternative medicine : eCAM 20070301

Dual action on promoter demethylation and chromatin by an isothiocyanate restored GSTP1 silenced in prostate cancer.

Molecular carcinogenesis 20070101

Polymeric nanoparticle-encapsulated curcumin ('nanocurcumin'): a novel strategy for human cancer therapy.

Journal of nanobiotechnology 20070101

Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by aspirin and phenethyl isothiocyanate.

BMC cancer 20070101

The isothiocyanate class of bioactive nutrients covalently inhibit the MEKK1 protein kinase.

BMC cancer 20070101

CYP 2E1 mutant mice are resistant to DDC-induced enhancement of MPTP toxicity.

Journal of neural transmission. Supplementum 20070101

Phenethyl isothiocyanate suppresses receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis by blocking activation of ERK1/2 and p38 MAPK in RAW264.7 macrophages.

BioFactors (Oxford, England) 20070101

Citrus nobiletin suppresses bone loss in ovariectomized ddY mice and collagen-induced arthritis in DBA/1J mice: possible involvement of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis regulation.

BioFactors (Oxford, England) 20070101

Phenylethyl isothiocyanate and its N-acetylcysteine conjugate suppress the metastasis of SK-Hep1 human hepatoma cells.

The Journal of nutritional biochemistry 20061201

Sensitisation for cisplatin-induced apoptosis by isothiocyanate E-4IB leads to signalling pathways alterations.

British journal of cancer 20061120

Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential.

Carcinogenesis 20061101

Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray.

Life sciences 20061012

Phenethyl isothiocyanate (PEITC) inhibits growth of ovarian cancer cells by inducing apoptosis: role of caspase and MAPK activation.

Gynecologic oncology 20061001

Repression of androgen receptor in prostate cancer cells by phenethyl isothiocyanate.

Carcinogenesis 20061001

Enzymatic mechanisms of ethanol oxidation in the brain.

Alcoholism, clinical and experimental research 20060901

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

Cancer cell 20060901

c-jun/AP-1 activation does not affect the antiproliferative activity of phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent.

Molecular carcinogenesis 20060801

Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2.

Molecular cancer therapeutics 20060801

Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae.

Mutation research 20060725

Phenethyl isothiocyanate triggers apoptosis in Jurkat cells made resistant by the overexpression of Bcl-2.

Cancer research 20060701

Raphanus sativus and its isothiocyanates inhibit vascular smooth muscle cells proliferation and induce G(1) cell cycle arrest.

International immunopharmacology 20060501

Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokers.

Carcinogenesis 20060401

In vitro and in vivo anti-inflammatory activity of a seed preparation containing phenethylisothiocyanate.

The Journal of pharmacology and experimental therapeutics 20060401

Early loss of Fhit in the respiratory tract of rodents exposed to environmental cigarette smoke.

Cancer research 20060401

Effect of isothiocyanates on nuclear accumulation of NF-kappaB, Nrf2, and thioredoxin in caco-2 cells.

Journal of agricultural and food chemistry 20060308

ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.

Carcinogenesis 20060301

Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin.

Carcinogenesis 20060301

The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells.

Anti-cancer drugs 20060301

Effects of indole-3-carbinol and phenethyl isothiocyanate on colon carcinogenesis induced by azoxymethane in rats.

Carcinogenesis 20060201

Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice.

Cancer research 20060115

Current trends and perspectives in nutrition and cancer prevention.

Neoplasma 20060101

Characterization of gastric adenocarcinoma cell lines established from CEA424/SV40 T antigen-transgenic mice with or without a human CEA transgene.

BMC cancer 20060101

Modest induction of phase 2 enzyme activity in the F-344 rat prostate.

BMC cancer 20060101

Modulation of N-nitrosomethylbenzylamine metabolism by black raspberries in the esophagus and liver of Fischer 344 rats.

Nutrition and cancer 20060101

Protective effects of isothiocyanates towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.

Journal of applied toxicology : JAT 20060101

Ethnoveterinary medicines used for horses in Trinidad and in British Columbia, Canada.

Journal of ethnobiology and ethnomedicine 20060101

Cytochrome P450 and Parkinson's disease: protective role of neuronal CYP 2E1 from MPTP toxicity.

Journal of neural transmission. Supplementum 20060101

Protective effects of isothiocyanates towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.

Journal of applied toxicology : JAT 20060101

Modulation of multigene expression and proteome profiles by chemopreventive agents.

Mutation research 20051211

Modulation of apoptosis by cancer chemopreventive agents.

Mutation research 20051211

The time-dependent effect of gluconasturtiin and phenethyl isothiocyanate on metabolic and antioxidative parameters in rats.

Journal of animal physiology and animal nutrition 20051201

Acute and subacute effects of tobacco alkaloids, tobacco-specific nitrosamines and phenethyl isothiocyanate on N'-nitrosonornicotine metabolism in rats.

Toxicology 20051115

Biofumigation: environmental impacts on the biological activity of diverse pure and plant-derived isothiocyanates.

Pest management science 20051101

Pharmacokinetics of dietary phenethyl isothiocyanate in rats.

Pharmaceutical research 20051001

Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.

Current drug metabolism 20051001

N-acetylcysteine conjugate of phenethyl isothiocyanate enhances apoptosis in growth-stimulated human lung cells.

Cancer research 20050915

Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.

Cancer research 20050915

Chemoprevention of acrylamide toxicity by antioxidative agents in rats--effective suppression of testicular toxicity by phenylethyl isothiocyanate.

Archives of toxicology 20050901

The role of c-Jun in the AP-1 activation induced by naturally occurring isothiocyanates.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050901

Effects of antioxidants and caspase-3 inhibitor on the phenylethyl isothiocyanate-induced apoptotic signaling pathways in human PLC/PRF/5 cells.

European journal of pharmacology 20050822

Transport of dietary phenethyl isothiocyanate is mediated by multidrug resistance protein 2 but not P-glycoprotein.

Biochemical pharmacology 20050815

Hydrogen sulfide protects colon cancer cells from chemopreventative agent beta-phenylethyl isothiocyanate induced apoptosis.

World journal of gastroenterology 20050714

Role of mitogen-activated protein kinases in phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells.

Molecular carcinogenesis 20050701

Induction of glutathione S-transferase and glutathione by toxic compounds and elicitors in reed canary grass.

Biotechnology letters 20050701

Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.

Oncogene 20050630

Beta-phenylethyl and 8-methylsulphinyloctyl isothiocyanates, constituents of watercress, suppress LPS induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages.

Nitric oxide : biology and chemistry 20050601

Caspase-dependent apoptosis induction by phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent, is mediated by Bak and Bax.

Clinical cancer research : an official journal of the American Association for Cancer Research 20050401

Comparison of phenethyl and 6-phenylhexyl isothiocyanate-induced toxicity in rat esophageal cell lines with and without glutathione depletion.

Toxicology letters 20050315

Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model.

Cancer letters 20050310

beta-Phenylethyl isothiocyanate mediated apoptosis: a proteomic investigation of early apoptotic protein changes.

Proteomics 20050301

Induction of phase I, II and III drug metabolism/transport by xenobiotics.

Archives of pharmacal research 20050301

Beta-phenylethyl isothiocyanate mediated apoptosis; contribution of Bax and the mitochondrial death pathway.

The international journal of biochemistry & cell biology 20050101

Animal models and analytical approaches for understanding the relationships between wine and cancer.

Drugs under experimental and clinical research 20050101

Membrane transport of dietary phenethyl isothiocyanate by ABCG2 (breast cancer resistance protein).

Molecular pharmaceutics 20050101

Effect of organic isothiocyanates on breast cancer resistance protein (ABCG2)-mediated transport.

Pharmaceutical research 20041201

Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20041001

Involvement of cytochrome P450 2E1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease.

Journal of neurochemistry 20041001

Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines.

Experimental biology and medicine (Maywood, N.J.) 20040901

Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest.

Carcinogenesis 20040801

Effects of benzyl-, phenethyl-, and alpha-naphthyl isothiocyanates on P-glycoprotein- and MRP1-mediated transport.

Journal of pharmaceutical sciences 20040701

Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes.

Xenobiotica; the fate of foreign compounds in biological systems 20040701

Potent chemopreventive agents against pancreatic cancer.

Current cancer drug targets 20040601

Intrinsic cytotoxicity and chemomodulatory actions of novel phenethylisothiocyanate sphingoid base derivatives in HL-60 human promyelocytic leukemia cells.

The Journal of pharmacology and experimental therapeutics 20040501

The chemopreventive agent phenethyl isothiocyanate sensitizes cells to Fas-mediated apoptosis.

Carcinogenesis 20040501

Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells.

Molecular cancer therapeutics 20040501

Modulation of AP-1 by natural chemopreventive compounds in human colon HT-29 cancer cell line.

Pharmaceutical research 20040401

Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway.

Pharmaceutical research 20040401

Genetic and metabolic effects of gluconasturtiin, a glucosinolate derived from cruciferae.

Mutation research 20040112

Hydrolysis of glucosinolates to isothiocyanates after ingestion of raw or microwaved cabbage by human volunteers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20040101

Effects of dietary anticarcinogens and nonsteroidal anti-inflammatory drugs on rat gastrointestinal UDP-glucuronosyltransferases.

Anticancer research 20040101

Inhibition by allyl sulfides and phenethyl isothiocyanate of methyl-n-pentylnitrosamine depentylation by rat esophageal microsomes, human and rat CYP2E1, and Rat CYP2A3.

Nutrition and cancer 20040101

Toxicological assessment of noxious inhalants.

GMS current topics in otorhinolaryngology, head and neck surgery 20040101

Phenethyl isothiocyanate inhibits nitrosamine carcinogenesis in a model for study of oral cancer chemoprevention.

Cancer letters 20031230

Induction of GADD gene expression by phenethylisothiocyanate in human colon adenocarcinoma cells.

Journal of cellular biochemistry 20031215

Determination of phenethyl isothiocyanate in human plasma and urine by ammonia derivatization and liquid chromatography-tandem mass spectrometry.

Analytical biochemistry 20031201

Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC).

Pharmaceutical research 20030901

Quantitative evaluation of isothiocyanates as substrates and inhibitors of P-glycoprotein.

The Journal of pharmacy and pharmacology 20030901

Ontogenic variations of ascorbic acid and phenethyl isothiocyanate concentrations in watercress (Nasturtium officinale R.Br.) leaves.

Journal of agricultural and food chemistry 20030827

The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells.

Carcinogenesis 20030801

[Effects of ursolic acid on liver-protection and bile secretion].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030801

beta-Phenylethyl isothiocyanate-mediated apoptosis in hepatoma HepG2 cells.

Cellular and molecular life sciences : CMLS 20030701

Naturally occurring Phe151Leu substitution near a conserved folding module lowers stability of glutathione transferase P1-1.

Biochimica et biophysica acta 20030626

Sensitivity of Meloidogyne javanica and Tylenchulus semipenetrans to Isothiocyanates in Laboratory Assays.

Phytopathology 20030601

Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats.

Carcinogenesis 20030301

Reversibility of proliferative lesions and induction of non-papillary tumors in rat urinary bladder treated with phenylethyl isothiocyanate.

Carcinogenesis 20030301

Effects of garden and water cress juices and their constituents, benzyl and phenethyl isothiocyanates, towards benzo(a)pyrene-induced DNA damage: a model study with the single cell gel electrophoresis/Hep G2 assay.

Chemico-biological interactions 20030106

Mechanism-based in vitro screening of potential cancer chemopreventive agents.

Mutation research 20030101

Modulation of cigarette smoke-related end-points in mutagenesis and carcinogenesis.

Mutation research 20030101

Involvement of toxicity as an early event in urinary bladder carcinogenesis induced by phenethyl isothiocyanate, benzyl isothiocyanate, and analogues in F344 rats.

Toxicologic pathology 20030101

An investigation of dopaminergic metabolites in the striatum and in the substantia nigra in vivo utilising radiolabelled L-DOPA and high performance liquid chromatography: a new approach in the search for transmitter metabolites.

Neuroscience 20030101

Effect of dietary constituents with chemopreventive potential on adduct formation of a low dose of the heterocyclic amines PhIP and IQ and phase II hepatic enzymes.

Nutrition and cancer 20030101

Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase.

The Journal of biological chemistry 20021018

In vitro induction of benzo(a)pyrene cell-transforming activity by the glucosinolate gluconasturtiin found in cruciferous vegetables.

Cancer letters 20021008

Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastine.

Pharmaceutical research 20021001

Effect of nicotine, cotinine and phenethyl isothiocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in the Syrian golden hamster.

Toxicology 20020930

Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung.

Carcinogenesis 20020901

Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination.

Carcinogenesis 20020901

Rapid in vivo assay for topical oral cancer chemopreventive agents.

International journal of oncology 20020701

Phenethyl isothiocyanate-induced apoptosis in p53-deficient PC-3 human prostate cancer cell line is mediated by extracellular signal-regulated kinases.

Cancer research 20020701

The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19.

Pharmaceutical research 20020701

Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3.

The Journal of biological chemistry 20020510

Expression of cyclin D1/2 in the lungs of strain A/J mice fed chemopreventive agents.

Carcinogenesis 20020201

[Determination of isothiocyanates and related compounds in mustard extract and horseradish extract used as natural food additives].

Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20020201

Differential induction of mafF, mafG and mafK expression by electrophile-response-element activators.

The Biochemical journal 20020115

Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 activity and induction of apoptosis.

Cancer research 20020101

4-(Methylthio)-3-butenyl isothiocyanate, a principal antimutagen in daikon (Raphanus sativus; Japanese white radish).

Journal of agricultural and food chemistry 20011201

Barbarea verna as a source of 2-phenylethyl glucosinolate, precursor of cancer chemopreventive phenylethyl isothiocyanate.

Fitoterapia 20011101

Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes.

Chemical research in toxicology 20010901

Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines.

Cancer research 20010815

Inhibition and inactivation of human cytochrome P450 isoforms by phenethyl isothiocyanate.

Drug metabolism and disposition: the biological fate of chemicals 20010801

Formation of DNA adducts in the aorta of smoke-exposed rats, and modulation by chemopreventive agents.

Mutation research 20010725

Differential effects of naturally occurring isothiocyanates on the activities of cytochrome P450 2E1 and the mutant P450 2E1 T303A.

Archives of biochemistry and biophysics 20010701

Inhibition of cytochrome P450 2E1 induces an increase in extracellular dopamine in rat substantia nigra: a new metabolic pathway?

Synapse (New York, N.Y.) 20010615

Cell-type specific differences in glutamate cysteine ligase transcriptional regulation demonstrate independent subunit control.

Toxicological sciences : an official journal of the Society of Toxicology 20010601

Consumption of watercress fails to alter coumarin metabolism in humans.

Drug metabolism and disposition: the biological fate of chemicals 20010601

High-performance liquid chromatography-based determination of total isothiocyanate levels in human plasma: application to studies with 2-phenethyl isothiocyanate.

Analytical biochemistry 20010415

Modulation of biomarkers by chemopreventive agents in smoke-exposed rats.

Cancer research 20010315

Signal transduction activated by the cancer chemopreventive isothiocyanates: cleavage of BID protein, tyrosine phosphorylation and activation of JNK.

British journal of cancer 20010301

Modulation of apoptosis by cigarette smoke and cancer chemopreventive agents in the respiratory tract of rats.

Carcinogenesis 20010301

Involvement of glutathione metabolism in the cytotoxicity of the phenethyl isothiocyanate and its cysteine conjugate to human leukaemia cells in vitro.

Biochemical pharmacology 20010115

Investigation of the enhancement of N-nitrosomethylbenzylamine-induced esophageal tumorigenesis by 6-phenylhexyl isothiocyanate.

Cancer letters 20010110

Inhibition of CYP2E1 with natural agents may be a feasible strategy for minimizing the hepatotoxicity of ethanol.

Medical hypotheses 20010101

Inhibition of carcinogenesis and toxicity by dietary constituents.

Advances in experimental medicine and biology 20010101

Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE).

Drug metabolism reviews 20010101

Comparative tissue-specific toxicities of 20 cancer preventive agents using cultured cells from 8 different normal human epithelia.

In vitro & molecular toxicology 20010101

Dose-dependent promotion by phenylethyl isothiocyanate, a known chemopreventer, of two-stage rat urinary bladder and liver carcinogenesis.

Nutrition and cancer 20010101

Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro.

Biochemical pharmacology 20000715

Metabolism of N-nitrosobenzylmethylamine by human cytochrome P-450 enzymes.

Journal of toxicology and environmental health. Part A 19991210

Effects of dietary anticarcinogens on rat gastrointestinal glutathione S-transferase theta 1-1 levels.

Carcinogenesis 19981101

Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity.

Cancer research 19980201

Mechanism of action of dietary chemoprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism.

Carcinogenesis 19970901

Chemopreventive efficacy of anethole trithione, N-acetyl-L-cysteine, miconazole and phenethylisothiocyanate in the DMBA-induced rat mammary cancer model.

International journal of cancer 19970703

Inhibitory effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), green tea catechins and other antioxidants on 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1)-induced rat hepatocarcinogenesis and dose-dependent inhibition by HTHQ of lesion induction by Glu-P-1 or 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).

Carcinogenesis 19951201

Phenethyl isothiocyanate, a new dietary liver aldehyde dehydrogenase inhibitor.

The Journal of pharmacology and experimental therapeutics 19951001

Inhibition of CYP2E1 activity does not abolish pulsatile urine alcohol concentrations during chronic alcohol infusions.

European journal of biochemistry 19950615

Reversible conjugation of isothiocyanates with glutathione catalyzed by human glutathione transferases.

Biochemical and biophysical research communications 19950117