In vitro glutathione peroxidase mimicry of ebselen is linked to its oxidation of critical thiols on key cerebral suphydryl proteins - A novel component of its GPx-mimic antioxidant mechanism emerging from its thiol-modulated toxicology and pharmacology.

Chemico-biological interactions 20131025

Interrogating a hexokinase-selected small-molecule library for inhibitors of Plasmodium falciparum hexokinase.

Antimicrobial agents and chemotherapy 20130801

Ebselen reduces the toxicity of mechlorethamine in A-431 cells via inhibition of apoptosis.

Journal of biochemical and molecular toxicology 20130601

Development of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries.

Analytical biochemistry 20130301

Mitochondrial electron transfer chain complexes inhibition by different organochalcogens.

Toxicology in vitro : an international journal published in association with BIBRA 20130201

Glutathione and glutaredoxin act as a backup of human thioredoxin reductase 1 to reduce thioredoxin 1 preventing cell death by aurothioglucose.

The Journal of biological chemistry 20121102

A hydrogen peroxide electrode assay to measure thiol peroxidase activity for organoselenium and organotellurium drugs.

Analytical biochemistry 20121015

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system.

Free radical biology & medicine 20120815

Ebselen inhibits iron-induced tau phosphorylation by attenuating DMT1 up-regulation and cellular iron uptake.

Neurochemistry international 20120801

The H2O2 scavenger ebselen decreases ethanol-induced locomotor stimulation in mice.

Drug and alcohol dependence 20120701

Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits.

Chemistry & biology 20120622

T-type calcium channel blockade improves survival and cardiovascular function in thalassemic mice.

European journal of haematology 20120601

Ebselen reduces hyperglycemia temporarily-induced by diazinon: a compound with insulin-mimetic properties.

Chemico-biological interactions 20120530

The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates.

Antimicrobial agents and chemotherapy 20120301

Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence.

The American journal of pathology 20120301

Protective effects of ebselen (Ebs) and para-aminosalicylic acid (PAS) against manganese (Mn)-induced neurotoxicity.

Toxicology and applied pharmacology 20120201

Synthesis and biological activity of novel organoselenium derivatives targeting multiple kinases and capable of inhibiting cancer progression to metastases.

European journal of medicinal chemistry 20120201

Multifunctional Ebselen drug functions through the activation of DNA damage response and alterations in nuclear proteins.

Biochemical pharmacology 20120115

The combination of organoselenium compounds and guanosine prevents glutamate-induced oxidative stress in different regions of rat brains.

Brain research 20120109

Ebselen is a new skin depigmenting agent that inhibits melanin biosynthesis and melanosomal transfer.

Experimental dermatology 20120101

Production of prostaglandins, isoprostanes and thromboxane by Aspergillus fumigatus: identification by gas chromatography-tandem mass spectrometry and quantification by enzyme immunoassay.

Molecular immunology 20120101

Role of reactive oxygen species in transforming growth factor beta1-induced alpha smooth-muscle actin and collagen production in nasal polyp-derived fibroblasts.

International archives of allergy and immunology 20120101

The protective effect of ebselen on radiocontrast-induced nephrotoxicity.

Renal failure 20120101

Neuroprotection for stroke: current status and future perspectives.

International journal of molecular sciences 20120101

A superoxide anion-scavenger, 1,3-selenazolidin-4-one suppresses serum deprivation-induced apoptosis in PC12 cells by activating MAP kinase.

Toxicology and applied pharmacology 20111215

Modeling the mechanism of the glutathione peroxidase mimic ebselen.

Inorganic chemistry 20111205

3-(2,6-dimethylphenyl)-2-selenoxo-1,3-thiazolidin-4-one suppresses hydrogen peroxide-induced cytotoxicity on PC12 cells via activation of MAPK.

International journal of toxicology 20111201

Synthesis, structure, and glutathione peroxidase-like activity of amino acid containing ebselen analogues and diaryl diselenides.

Chemistry (Weinheim an der Bergstrasse, Germany) 20111104

Carboxyl-ebselen-based layer-by-layer films as potential antithrombotic and antimicrobial coatings.

Biomaterials 20111101

Diphenyl diselenide and analogs are substrates of cerebral rat thioredoxin reductase: a pathway for their neuroprotective effects.

Neuroscience letters 20110926

Peroxiredoxin 2 deficiency exacerbates atherosclerosis in apolipoprotein E-deficient mice.

Circulation research 20110916

Reactive oxygen species formation during tetanic contractions in single isolated Xenopus myofibers.

Journal of applied physiology (Bethesda, Md. : 1985) 20110901

Tandem MS analysis of selenamide-derivatized peptide ions.

Journal of the American Society for Mass Spectrometry 20110901

Selenoprotein-dependent up-regulation of hematopoietic prostaglandin D2 synthase in macrophages is mediated through the activation of peroxisome proliferator-activated receptor (PPAR) gamma.

The Journal of biological chemistry 20110805

The influence of low oxygen on macrophage response to Leishmania infection.

Scandinavian journal of immunology 20110801

Mechanistic investigations on the efficient catalytic decomposition of peroxynitrite by ebselen analogues.

Organic & biomolecular chemistry 20110721

Reactive oxygen species (ROS) from NADPH and xanthine oxidase modulate the cutaneous local heating response in healthy humans.

Journal of applied physiology (Bethesda, Md. : 1985) 20110701

Methylmercury-induced alterations in astrocyte functions are attenuated by ebselen.

Neurotoxicology 20110601

Preventing metal-mediated oxidative DNA damage with selenium compounds.

Metallomics : integrated biometal science 20110501

Acute hypoxia stimulates intracellular peroxynitrite formation associated with pulmonary artery smooth muscle cell proliferation.

Journal of cardiovascular pharmacology 20110501

Synthesis and antioxidant activity of peptide-based ebselen analogues.

Chemistry (Weinheim an der Bergstrasse, Germany) 20110418

Post-transcriptional defects of antioxidant selenoenzymes cause oxidative stress under methylmercury exposure.

The Journal of biological chemistry 20110225

TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells.

American journal of physiology. Lung cellular and molecular physiology 20110201

Antioxidants induce apoptosis of rat ovarian theca-interstitial cells.

Biology of reproduction 20110101

Inhibitory effect of ebselen on lactate dehydrogenase activity from mammals: a comparative study with diphenyl diselenide and diphenyl ditelluride.

Drug and chemical toxicology 20110101

Targeted antioxidant therapies in hyperglycemia-mediated endothelial dysfunction.

Frontiers in bioscience (Scholar edition) 20110101

Effects of prevention of oxidative and nitro-oxidative stress on experimental rat colon anastomosis using acetylcysteine, Ebselen and 1400w.

Acta chirurgica Belgica 20110101

Beneficial effects of N-acetylcysteine and ebselen on renal ischemia/reperfusion injury.

Renal failure 20110101

Neuroprotective effects of ebselen following forebrain ischemia: involvement of glutamate and nitric oxide.

Neurologia medico-chirurgica 20110101

Dose-dependent protection on cisplatin-induced ototoxicity - an electrophysiological study on the effect of three antioxidants in the Sprague-Dawley rat animal model.

Medical science monitor : international medical journal of experimental and clinical research 20110101

Cu-catalyzed efficient synthetic methodology for ebselen and related Se-N heterocycles.

Organic letters 20101203

Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E/GPx1-double knockout mouse.

Diabetes 20101201

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Bioorganic & medicinal chemistry letters 20101101

2,3-diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: a structure-activity relationship study.

Bioorganic & medicinal chemistry 20100915

Glutathione peroxidase-1 protects against cigarette smoke-induced lung inflammation in mice.

American journal of physiology. Lung cellular and molecular physiology 20100901

Reactive oxygen species, Ki-Ras, and mitochondrial superoxide dismutase cooperate in nerve growth factor-induced differentiation of PC12 cells.

The Journal of biological chemistry 20100730

Diphenyl diselenide behaves differently than ebselen under different pH media in rat's liver preparations.

Pathology, research and practice 20100615

Roles for Nox4 in the contractile response of bovine pulmonary arteries to hypoxia.

American journal of physiology. Heart and circulatory physiology 20100601

Effects of ebselen versus nimodipine on cerebral vasospasm subsequent to experimental subarachnoid hemorrhage in rats.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20100501

Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytes.

Cardiovascular research 20100401

Ebselen reduces inflammation and microvascular perfusion failure after blunt skeletal muscle injury of the rat.

The Journal of trauma 20100401

A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle.

Proceedings of the National Academy of Sciences of the United States of America 20100223

5-Selenization of salicylic acid derivatives yielded isoform-specific 5-lipoxygenase inhibitors.

Organic & biomolecular chemistry 20100221

Synthesis and biological evaluation of amidine, guanidine, and thiourea derivatives of 2-amino(6-trifluoromethoxy)benzothiazole as neuroprotective agents potentially useful in brain diseases.

Journal of medicinal chemistry 20100128

The selenazal drug ebselen potently inhibits indoleamine 2,3-dioxygenase by targeting enzyme cysteine residues.

Biochemistry 20100126

Opposing regulation of histamine-induced calcium signaling by sodium selenite and ebselen via alterations of thiol redox status.

European journal of pharmacology 20100125

Comparative mechanisms of zearalenone and ochratoxin A toxicities on cultured HepG2 cells: is oxidative stress a common process?

Environmental toxicology 20091201

Inhibitory mechanism of novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferase from Haemophilus influenzae.

Journal of microbiology and biotechnology 20091201

Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II).

Chemical communications (Cambridge, England) 20091114

Towards the mechanism and comparative effect of diphenyl diselenide, diphenyl ditelluride and ebselen under various pathophysiological conditions in rat's kidney preparation.

Chemico-biological interactions 20091110

Neuroprotection of ebselen against ischemia/reperfusion injury involves GABA shunt enzymes.

Journal of the neurological sciences 20091015

Synthesis and antioxidant properties of new chromone derivatives.

Bioorganic & medicinal chemistry 20091015

Heme oxygenase-1 induction modulates hypoxic pulmonary vasoconstriction through upregulation of ecSOD.

American journal of physiology. Heart and circulatory physiology 20091001

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nature chemical biology 20091001

Erdosteine and ebselen as useful agents in intestinal ischemia/reperfusion injury.

The Journal of surgical research 20090801

Discrete generations of intracellular hydrogen peroxide and superoxide in antigen-stimulated mast cells: reciprocal regulation of store-operated Ca2+ channel activity.

Molecular immunology 20090701

Site-specific antiatherogenic effect of the antioxidant ebselen in the diabetic apolipoprotein E-deficient mouse.

Arteriosclerosis, thrombosis, and vascular biology 20090601

Growth inhibitory action of ebselen on fluconazole-resistant Candida albicans: role of the plasma membrane H+-ATPase.

Microbial drug resistance (Larchmont, N.Y.) 20090601

Modeling the oxidation of ebselen and other organoselenium compounds using explicit solvent networks.

The journal of physical chemistry. A 20090514

Ebselen attenuates cisplatin-induced ROS generation through Nrf2 activation in auditory cells.

Hearing research 20090501

Dependence of leukemic cell proliferation and survival on H2O2 and L-arginine.

Free radical biology & medicine 20090415

Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells.

The Journal of pharmacology and experimental therapeutics 20090401

Overexpression of manganese superoxide dismutase in human dermal fibroblasts enhances the contraction of free floating collagen lattice: implications for ageing and hyperplastic scar formation.

Archives of dermatological research 20090401

The redox state of glutathione regulates the hypoxic induction of HIF-1.

European journal of pharmacology 20090315

Enhancement of iron-catalyzed lipid peroxidation by acidosis in brain homogenate: comparative effect of diphenyl diselenide and ebselen.

Brain research 20090303

Redox modulation at the peripheral site alters nociceptive transmission in vivo.

Clinical and experimental pharmacology & physiology 20090301

Guanosine and synthetic organoselenium compounds modulate methylmercury-induced oxidative stress in rat brain cortical slices: involvement of oxidative stress and glutamatergic system.

Toxicology in vitro : an international journal published in association with BIBRA 20090301

Pre-treatment with ebselen and vitamin E modulate acetylcholinesterase activity: interaction with demyelinating agents.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20090201

Adoptive transfer of syngeneic bone marrow-derived cells in mice with obesity-induced diabetes: selenoorganic antioxidant ebselen restores stem cell competence.

The American journal of pathology 20090201

Threshold to N-methyl-D-aspartate-induced seizures in mice undergoing chronic nutritional magnesium deprivation is lowered in a way partly responsive to acute magnesium and antioxidant administrations.

The British journal of nutrition 20090201

Synthesis of telluroamino acid derivatives with remarkable GPx like activity.

Organic & biomolecular chemistry 20090107

Antidepressant-like effect of the organoselenium compound ebselen in mice: evidence for the involvement of the monoaminergic system.

European journal of pharmacology 20090105

Ebselen improves ischemia-reperfusion injury after rat lung transplantation.

Lung 20090101

Effects of N-acetylcysteine and ebselen on arachidonic acid release from astrocytes and neurons cultured in normoxic or simulated ischemic conditions.

Pharmacological reports : PR 20090101

Ebselen attenuates cyclophosphamide-induced oxidative stress and DNA damage in mice.

Free radical research 20081101

Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion.

Journal of neurochemistry 20081001

The requirement of reactive oxygen intermediates for lymphocytic choriomeningitis virus binding and growth.

Virology 20080930

Selenium compounds counteract the stimulation of ecto-nucleotidase activities in rat cultured cerebellar granule cells: putative correlation with neuroprotective effects.

Brain research 20080724

The protective mechanism of antioxidants in cadmium-induced ototoxicity in vitro and in vivo.

Environmental health perspectives 20080701

Protective effects of ebselen, a seleno-organic antioxidant on neurodegeneration induced by hypoxia and reperfusion in stroke-prone spontaneously hypertensive rat.

Neuroscience 20080502

Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoprotein.

The Journal of biological chemistry 20080418

Ebselen attenuates cadmium-induced testicular damage in mice.

Journal of applied toxicology : JAT 20080401

Involvement of peroxynitrite in pollen-induced nasal blockage in guinea pigs.

European journal of pharmacology 20080317

Antioxidant and anti-mutagenic effects of ebselen in yeast and in cultured mammalian V79 cells.

Mutagenesis 20080301

Effects of poly(ADP-ribose) polymerase inhibition in bladder damage caused by cyclophosphamide in rats.

Experimental biology and medicine (Maywood, N.J.) 20080301

Ebselen increases cytosolic free Ca2+ concentration, stimulates glutamate release and increases GFAP content in rat hippocampal astrocytes.

Toxicology 20080227

Ebselen, a redox regulator containing a selenium atom, induces neurofilament M expression in cultured rat pheochromocytoma PC12 cells via activation of mitogen-activated protein kinase.

Journal of neuroscience research 20080215

Effect of substituents on the GPx-like activity of ebselen: steric versus electronic.

The journal of physical chemistry. A 20080207

Antioxidant activity of the anti-inflammatory compound ebselen: a reversible cyclization pathway via selenenic and seleninic acid intermediates.

Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

Alpha-lipoic acid and ebselen prevent ischemia/reperfusion injury in the rat intestine.

Surgery today 20080101

Reduction of vesicant toxicity by butylated hydroxyanisole in A-431 skin cells.

Cutaneous and ocular toxicology 20080101

[Chronic ethanol feeding induces oxidative stress in the rat retina: treatment with the antioxidant ebselen].

Archivos de la Sociedad Espanola de Oftalmologia 20071201

Ebselen attenuates oxidative DNA damage and enhances its repair activity in the thalamus after focal cortical infarction in hypertensive rats.

Brain research 20071121

(45)Ca(2+) influx in rat brain: effect of diorganylchalcogenides compounds.

Toxicological sciences : an official journal of the Society of Toxicology 20071001

Ebselen reduces nitration and restores voltage-gated potassium channel function in small coronary arteries of diabetic rats.

American journal of physiology. Heart and circulatory physiology 20071001

Carbon monoxide stimulates the Ca2(+)-activated big conductance k channels in cultured human endothelial cells.

Hypertension (Dallas, Tex. : 1979) 20071001

3,3'-diselenodipropionic acid, an efficient peroxyl radical scavenger and a GPx mimic, protects erythrocytes (RBCs) from AAPH-induced hemolysis.

Chemical research in toxicology 20071001

2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species.

Bioorganic & medicinal chemistry 20070915

Lung toxicity of nitrogen mustard may be mediated by nitric oxide and peroxynitrite in rats.

Research in veterinary science 20070801

Previous treatment with ebselen and vitamin E alters adenine nucleotide hydrolysis in platelets from adult rats experimentally demyelinated with ethidium bromide.

Life sciences 20070627

Ebselen and diorganylchalcogenides decrease in vitro glutamate uptake by rat brain slices: prevention by DTT and GSH.

Toxicology in vitro : an international journal published in association with BIBRA 20070601

Deficient peroxide detoxification underlies the susceptibility of oligodendrocyte progenitors to dopamine toxicity.

Neuropharmacology 20070501

Ebselen protects brain, skin, lung and blood cells from mechlorethamine toxicity.

Toxicology and industrial health 20070501

Density functional theory study of the reaction mechanism and energetics of the reduction of hydrogen peroxide by ebselen, ebselen diselenide, and ebselen selenol.

The journal of physical chemistry. A 20070426

Ebselen treatment reduces noise induced hearing loss via the mimicry and induction of glutathione peroxidase.

Hearing research 20070401

Role of endogenous hydrogen peroxide in the development of nitrate tolerance.

Vascular pharmacology 20070401

Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20070401

Ebselen prevents chronic alcohol-induced rat hippocampal stress and functional impairment.

Alcoholism, clinical and experimental research 20070301

N-Acetylcysteine and ebselen but not nifedipine protected cerebellar granule neurons against 4-hydroxynonenal-induced neuronal death.

Neuroscience research 20070201

Synthesis, characterization, and antioxidant activity of some ebselen analogues.

Chemistry (Weinheim an der Bergstrasse, Germany) 20070101

Evaluation of the antimicrobial activity of ebselen: role of the yeast plasma membrane H+-ATPase.

Journal of biochemical and molecular toxicology 20070101

Effects of ebselen on glutathione level in neurons exposed to arachidonic acid and 4-hydroxynonenal during simulated ischemia in vitro.

Pharmacological reports : PR 20070101

Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects.

The Journal of pharmacology and experimental therapeutics 20061201

Cardioprotective effects of subcutaneous ebselen against daunorubicin-induced cardiomyopathy in rats.

Basic & clinical pharmacology & toxicology 20061201

Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness.

Bioorganic & medicinal chemistry letters 20061115

Diphenyl diselenide reduces temporarily hyperglycemia: possible relationship with oxidative stress.

Chemico-biological interactions 20061107

Ebselen effects on MPTP-induced neurotoxicity.

Brain research 20061106

Oral pretreatment with ebselen enhances heat shock protein 72 expression and reduces myocardial infarct size.

Hypertension research : official journal of the Japanese Society of Hypertension 20061101

Horseradish peroxidase inhibition and antioxidant activity of ebselen and related organoselenium compounds.

Bioorganic & medicinal chemistry letters 20061015

Oxidative stress induces ADAM9 protein expression in human prostate cancer cells.

Cancer research 20061001

Role of enteral nutrition supplemented with ebselen and EHEC in pancreatitis-associated multiple organ dysfunction in rats.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20061001

Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis.

Apoptosis : an international journal on programmed cell death 20060901

Protective effect of ebselen, a selenoorganic drug, against gentamicin-induced renal damage in rats.

Basic & clinical pharmacology & toxicology 20060901

Ebselen, a seleno-organic antioxidant, as an electrophile.

Chemical research in toxicology 20060901

Small-molecule screening identifies the selanazal drug ebselen as a potent inhibitor of DMT1-mediated iron uptake.

Chemistry & biology 20060901

Effect of selenium compounds on the damage induced by oxysterol on rat arterial walls.

Biological trace element research 20060901

Reactive oxygen species mediate phorbol ester-stimulated cAMP response in human eosinophils.

European journal of pharmacology 20060814

Modeling the reduction of hydrogen peroxide by glutathione peroxidase mimics.

The journal of physical chemistry. A 20060720

Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen.

Brain : a journal of neurology 20060701

Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species.

Journal of cell science 20060701

Neuroprotective effects of ebselen are associated with the regulation of Bcl-2 and Bax proteins in cultured mouse cortical neurons.

Neuroscience letters 20060522

Nitric oxide inhibits HIF-1alpha protein accumulation under hypoxic conditions: implication of 2-oxoglutarate and iron.

Biochimie 20060501

Diphenyl ditelluride- and methylmercury-induced hyperphosphorilation of the high molecular weight neurofilament subunit is prevented by organoselenium compounds in cerebral cortex of young rats.

Toxicology 20060501

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Ebselen induced C6 glioma cell death in oxygen and glucose deprivation.

Chemical research in toxicology 20060501

Protective effect of ebselen on cytotoxicity induced by cholestane-3 beta, 5 alpha, 6 beta-triol in ECV-304 cells.

Biochimica et biophysica acta 20060301

Immobilization stress induces cell death through production of reactive oxygen species in the mouse cerebral cortex.

Neuroscience letters 20060109

Beneficial effects of Ebselen on corrosive esophageal burns of rats.

International journal of pediatric otorhinolaryngology 20060101

Peroxynitrite reduces the endothelium-derived hyperpolarizing factor component of coronary flow-mediated dilation in PECAM-1-knockout mice.

American journal of physiology. Regulatory, integrative and comparative physiology 20060101

Ebselen attenuates oxidative stress in ischemic astrocytes depleted of glutathione. Comparison with glutathione precursors.

Pharmacological reports : PR 20060101

The protective effects of selenoorganic compounds against peroxynitrite-induced changes in plasma proteins and lipids.

Cellular & molecular biology letters 20060101

Design and biological evaluation of photo-switchable inhibitors.

Genome informatics. International Conference on Genome Informatics 20060101

Endothelin mediates superoxide production and vasoconstriction through activation of NADPH oxidase and uncoupled nitric-oxide synthase in the rat aorta.

The Journal of pharmacology and experimental therapeutics 20051201

Effect of diphenyl diselenide, diphenyl ditelluride and ebselen on cerebral Na(+), K(+)-ATPase activity in rats.

Toxicology 20051115

Peroxynitrite hyperpolarizes smooth muscle and relaxes internal carotid artery in rabbit via ATP-sensitive K+ channels.

American journal of physiology. Heart and circulatory physiology 20051101

Ebselen protects glutamate uptake inhibition caused by methyl mercury but does not by Hg2+.

Toxicology 20051015

Compounds for the prevention and treatment of noise-induced hearing loss.

Drug discovery today 20051001

Ebselen: a thioredoxin reductase-dependent catalyst for alpha-tocopherol quinone reduction.

Toxicology and applied pharmacology 20050901

Glutathione peroxidase (GPx)-like antioxidant activity of the organoselenium drug ebselen: unexpected complications with thiol exchange reactions.

Journal of the American Chemical Society 20050817

Ebselen attenuates haloperidol-induced orofacial dyskinesia and oxidative stress in rat brain.

Pharmacology, biochemistry, and behavior 20050701

NADPH oxidase is required for NMDA receptor-dependent activation of ERK in hippocampal area CA1.

Journal of neurochemistry 20050701

Synthesis and characterization of a triphenylphosphonium-conjugated peroxidase mimetic. Insights into the interaction of ebselen with mitochondria.

The Journal of biological chemistry 20050624

Ebselen prevents noise-induced excitotoxicity and temporary threshold shift.

Neuroscience letters 20050603

Organoselenium compounds prevent hyperphosphorylation of cytoskeletal proteins induced by the neurotoxic agent diphenyl ditelluride in cerebral cortex of young rats.

Toxicology 20050601

Combined oral delivery of ebselen and allopurinol reduces multiple cisplatin toxicities in rat breast and ovarian cancer models while enhancing anti-tumor activity.

Anti-cancer drugs 20050601

Selenium compounds prevent the effects of methylmercury on the in vitro phosphorylation of cytoskeletal proteins in cerebral cortex of young rats.

Toxicological sciences : an official journal of the Society of Toxicology 20050501

Peroxynitrite may be involved in bladder damage caused by cyclophosphamide in rats.

The Journal of urology 20050501

Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers.

Current drug targets. CNS and neurological disorders 20050401

Effect of ebselen and organochalcogenides on excitotoxicity induced by glutamate in isolated chick retina.

Brain research 20050328

Reduction of acute cisplatin ototoxicity and nephrotoxicity in rats by oral administration of allopurinol and ebselen.

Hearing research 20050301

Neuroprotective effects of ebselen on experimental spinal cord injury in rats.

Neurochemical research 20050301

Protective effect of antioxidant ebselen (PZ51) on the cerebral cortex of stroke-prone spontaneously hypertensive rats.

Hypertension research : official journal of the Japanese Society of Hypertension 20050301

Involvement of peroxynitrite in capsaicin-induced apoptosis of C6 glioma cells.

Neuroscience research 20050201

Hypoxia-induced dysfunction of rat diaphragm: role of peroxynitrite.

American journal of physiology. Lung cellular and molecular physiology 20050101

Kinetic studies of the radical-scavenging activity of ebselen, a seleno-organic compound.

Anticancer research 20050101

Effect of glutathione peroxidase mimic ebselen (PZ51) on endothelium and vascular structure of stroke-prone spontaneously hypertensive rats.

Blood pressure 20050101

Endothelial dysfunction as a modifier of angiogenic response in Zucker diabetic fat rat: amelioration with Ebselen.

Kidney international 20041201

The effects of ebselen on [3H]glutamate uptake by synaptic vesicles from rat brain.

Brain research 20041119

Protective effects on neuronal cells of mouse afforded by ebselen against oxidative stress at multiple steps.

Neuroscience letters 20041116

Ebselen augments its peroxidase activity by inducing nrf-2-dependent transcription.

Archives of biochemistry and biophysics 20041115

Potent antitumor activity of novel iron chelators derived from di-2-pyridylketone isonicotinoyl hydrazone involves fenton-derived free radical generation.

Clinical cancer research : an official journal of the American Association for Cancer Research 20041101

Azaanalogues of ebselen as antimicrobial and antiviral agents: synthesis and properties.

Farmaco (Societa chimica italiana : 1989) 20041101

Oxidant activity in skeletal muscle fibers is influenced by temperature, CO2 level, and muscle-derived nitric oxide.

American journal of physiology. Regulatory, integrative and comparative physiology 20041001

Dimethyl sulfoxide and ebselen prevent convulsions induced by 5-aminolevulinic acid.

Neurochemical research 20041001

Ebselen protects Ca2+ influx blockage but does not protect glutamate uptake inhibition caused by Hg2+.

Neurochemical research 20041001

Nitration and functional loss of voltage-gated K+ channels in rat coronary microvessels exposed to high glucose.

Diabetes 20040901

Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: prevention by chronic therapy with a peroxynitrite scavenger ebselen.

Journal of the American Society of Nephrology : JASN 20040901

The involvement of oxidative stress in bovine herpesvirus type 4-mediated apoptosis.

Frontiers in bioscience : a journal and virtual library 20040901

Protection by flavonoids against the peroxynitrite-mediated oxidation of dihydrorhodamine.

Free radical research 20040901

Interplay among platelet-activating factor, oxidative stress, and group I metabotropic glutamate receptors modulates neuronal survival.

Journal of neuroscience research 20040815

Organochalcogens affect the glutamatergic neurotransmission in human platelets.

Neurochemical research 20040801

Interaction of selenium compounds with zinc finger proteins involved in DNA repair.

European journal of biochemistry 20040801

Thiocyanate catalyzes myeloperoxidase-initiated lipid oxidation in LDL.

Free radical biology & medicine 20040715

Transforming growth factor Beta1 induction of tissue inhibitor of metalloproteinases 3 in articular chondrocytes is mediated by reactive oxygen species.

Free radical biology & medicine 20040715

Single-dose ebselen does not afford sustained neuroprotection to rats subjected to severe focal cerebral ischemia.

European journal of pharmacology 20040708

Proliferation of ovarian theca-interstitial cells is modulated by antioxidants and oxidative stress.

Human reproduction (Oxford, England) 20040701

Ebselen decreases oxygen free radical production and iron concentrations in the hearts of chronically iron-overloaded mice.

Biological research for nursing 20040701

The effect of ebselen on adenine nucleotide hydrolysis by platelets from adult rats.

Chemico-biological interactions 20040630

[Oxidative stress in a model for experimental diabetic retinopathy: treatment with antioxidants].

Archivos de la Sociedad Espanola de Oftalmologia 20040601

Phosphoinositide-dependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of platelet-derived growth factor-induced smooth muscle cell migration.

Circulation research 20040514

Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen.

Circulation research 20040220

Ebselen inhibits p38 mitogen-activated protein kinase-mediated endothelial cell death by hydrogen peroxide.

European journal of pharmacology 20040206

Vascular oxidant stress enhances progression and angiogenesis of experimental atheroma.

Circulation 20040203

Additive pro-oxidative effects of methylmercury and ebselen in liver from suckling rat pups.

Toxicology letters 20040202

Ebselen is a dehydroascorbate reductase mimic, facilitating the recycling of ascorbate via mammalian thioredoxin systems.

Antioxidants & redox signaling 20040201

Ebselen-mediated protection from single and repeated noise exposure in rat.

The Laryngoscope 20040201

(-)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors.

The Journal of pharmacy and pharmacology 20040201

Simultaneous analysis of esterase and transferase activities in cytosol proteins from the bovine retina by using microscale non-denaturing two-dimensional electrophoresis.

Biochimica et biophysica acta 20040114

Renal and hepatic ALA-D activity and selected oxidative stress parameters of rats exposed to inorganic mercury and organoselenium compounds.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040101

In vitro evaluation of glutathione peroxidase (GPx)-like activity and antioxidant properties of some Ebselen analogues.

Redox report : communications in free radical research 20040101

Functionalized alkyl and aryl diselenides as antimicrobial and antiviral agents: synthesis and properties.

Farmaco (Societa chimica italiana : 1989) 20031201

Synthesis and biological evaluation of ebselen and its acyclic derivatives.

Chemical & pharmaceutical bulletin 20031201

Ebselen inhibits NO-induced apoptosis of differentiated PC12 cells via inhibition of ASK1-p38 MAPK-p53 and JNK signaling and activation of p44/42 MAPK and Bcl-2.

Journal of neurochemistry 20031201

Selenium-containing compounds attenuate peroxynitrite-mediated NF-kappaB and AP-1 activation and interleukin-8 gene and protein expression in human leukocytes.

Free radical biology & medicine 20031101

The C2-like beta-barrel domain mediates the Ca2+-dependent resistance of 5-lipoxygenase activity against inhibition by glutathione peroxidase-1.

The Journal of biological chemistry 20031031

Ebselen protects against methylmercury-induced inhibition of glutamate uptake by cortical slices from adult mice.

Toxicology letters 20031015

Hypoxia and stretch regulate intercellular communication in vascular smooth muscle cells through reactive oxygen species formation.

Arteriosclerosis, thrombosis, and vascular biology 20031001

Organochalcogens effects on delta-aminolevulinate dehydratase activity from human erythrocytic cells in vitro.

Toxicology 20030930

Reactive oxygen species sensitivity of angiotensin II-dependent translation initiation in vascular smooth muscle cells.

The Journal of biological chemistry 20030919

Generation and function of reactive oxygen species in dendritic cells during antigen presentation.

Journal of immunology (Baltimore, Md. : 1950) 20030915

Differential modulation of hippocampal chemical-induced injury response by ebselen, pentoxifylline, and TNFalpha-, IL-1alpha-, and IL-6-neutralizing antibodies.

Journal of neuroscience research 20030815

T cell receptor-stimulated generation of hydrogen peroxide inhibits MEK-ERK activation and lck serine phosphorylation.

Free radical biology & medicine 20030815

Neuroprotective effect of ebselen on rat hippocampal slices submitted to oxygen-glucose deprivation: correlation with immunocontent of inducible nitric oxide synthase.

Neuroscience letters 20030731

Design and biological evaluation of novel antioxidants containing N-t-Butyl-N-hydroxylaminophenyl moieties.

Bioorganic & medicinal chemistry letters 20030721

Ebselen attenuates cochlear damage caused by acoustic trauma.

Hearing research 20030701

An inducible nitric oxide synthase-luciferase reporter system for in vivo testing of anti-inflammatory compounds in transgenic mice.

Journal of immunology (Baltimore, Md. : 1950) 20030615

Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and Ebselen for rats and mice.

Toxicology letters 20030605

Dual effect of ebselen on mitochondrial permeability transition.

Biochemical pharmacology 20030515

High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030501

Induction of cellular necrosis by the glutathione peroxidase mimetic ebselen.

Journal of cellular biochemistry 20030501

Methylmercury increases glutamate release from brain synaptosomes and glutamate uptake by cortical slices from suckling rat pups: modulatory effect of ebselen.

Toxicological sciences : an official journal of the Society of Toxicology 20030501

Influence of heme and heme oxygenase-1 transfection of pulmonary microvascular endothelium on oxidant generation and cGMP.

Experimental biology and medicine (Maywood, N.J.) 20030501

Can the ebselen derivatives catalyze the isomerization of peroxynitrite to nitrate?

Journal of the American Chemical Society 20030402

Inhibition by ebselen on nitric oxide mediated relaxations in the rat anococcygeus muscle.

European journal of pharmacology 20030221

Free radical scavengers can differentially modulate the genotoxicity of amsacrine in normal and cancer cells.

Mutation research 20030205

Anti-inflammatory and antinociceptive activity of diphenyl diselenide.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20030201

Redox catalysts as sensitisers towards oxidative stress.

FEBS letters 20030130

Antioxidant ebselen reduces oxidative damage in focal cerebral ischemia.

Free radical biology & medicine 20030101

Voltage-dependent ebselen and diorganochalcogenides inhibition of 45Ca2+ influx into brain synaptosomes.

Journal of biochemical and molecular toxicology 20030101

Protective effect of ebselen, a seleno-organic compound, against the progression of acute gastric mucosal lesions induced by compound 48/80, a mast cell degranulator, in rats.

Japanese journal of pharmacology 20021201

A novel antioxidant mechanism of ebselen involving ebselen diselenide, a substrate of mammalian thioredoxin and thioredoxin reductase.

The Journal of biological chemistry 20021018

The neuroprotectant ebselen inhibits oxidative DNA damage induced by dopamine in the presence of copper ions.

Neuroscience letters 20020913

Intrahippocampal infusion of ebselen impairs retention of an inhibitory avoidance task in rats.

European journal of pharmacology 20020913

Role of oxygen and nitrogen species in experimental uveitis: anti-inflammatory activity of the synthetic antioxidant ebselen.

Free radical biology & medicine 20020901

Ebselen attenuates oxidative stress-induced apoptosis via the inhibition of the c-Jun N-terminal kinase and activator protein-1 signalling pathway in PC12 cells.

British journal of pharmacology 20020801

Ebselen protects against the reduction in levels of drug-metabolizing enzymes in livers of rats with deoxycholic acid-induced liver injury.

Pharmacology & toxicology 20020801

Effects of antioxidants on surfactant peroxidation by stimulated human polymorphonuclear leukocytes.

Free radical research 20020701

Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cells.

Circulation research 20020628

Activation of matrix metalloproteinase-2 by overexpression of manganese superoxide dismutase in human breast cancer MCF-7 cells involves reactive oxygen species.

The Journal of biological chemistry 20020607

Divergent pathways account for two distinct effects of amyloid beta peptides on exocytosis and Ca(2+) currents: involvement of ROS and NF-kappaB.

Journal of neurochemistry 20020601

Nitric oxide mediates apoptosis induction selectively in transformed fibroblasts compared to nontransformed fibroblasts.

Carcinogenesis 20020601

The effects of ebselen on cisplatin and diethyldithiocarbamate (DDC) cytotoxicity in rat hippocampal astrocytes.

Toxicology letters 20020528

Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

The Journal of biological chemistry 20020419

Exposure to ebselen changes glutamate uptake and release by rat brain synaptosomes.

Neurochemical research 20020401

Antioxidant properties of new chalcogenides against lipid peroxidation in rat brain.

Neurochemical research 20020401

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway.

Science (New York, N.Y.) 20020329

Ebselen has dehydroascorbate reductase and thioltransferase-like activities.

Biochemical and biophysical research communications 20020301

Ebselen suppresses late airway responses and airway inflammation in guinea pigs.

Free radical biology & medicine 20020301

Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat.

Neuroscience letters 20020201

Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis.

The Journal of biological chemistry 20020125

Formation of active oxygen species and lipid peroxidation induced by hypochlorite.

Archives of biochemistry and biophysics 20020115

Action of peroxidases on protein hydroperoxides.

Redox report : communications in free radical research 20020101

A novel dicyclodextrinyl ditelluride compound with antioxidant activity.

FEBS letters 20011102

Oxidative and nitrosative stress in acute renal ischemia.

American journal of physiology. Renal physiology 20011101

Anti-oxidant ebselen causes the resolution of experimentally induced hepatic fibrosis in rats.

Journal of gastroenterology and hepatology 20011101

Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia.

Stroke 20010901

The neuroprotective agent ebselen modifies NMDA receptor function via the redox modulatory site.

Journal of neurochemistry 20010901

Mitochondrial membrane potential in density-separated trout erythrocytes exposed to oxidative stress in vitro.

Biochimica et biophysica acta 20010601

OxLDL induces macrophage gamma-GCS-HS protein expression: a role for oxLDL-associated lipid hydroperoxide in GSH synthesis.

Journal of lipid research 20010501

Epidermal growth factor receptor transactivation by angiotensin II requires reactive oxygen species in vascular smooth muscle cells.

Arteriosclerosis, thrombosis, and vascular biology 20010401

Enhanced vascular permeability in solid tumor involving peroxynitrite and matrix metalloproteinases.

Japanese journal of cancer research : Gann 20010401

Preventive effect of ebselen on acute gastric mucosal lesion development in rats treated with compound 48/80.

European journal of pharmacology 20010302

The selenoorganic compound ebselen suppresses liver injury induced by Propionibacterium acnes and lipopolysaccharide in rats.

International journal of molecular medicine 20010301

Ebselen prevents excitotoxicity provoked by glutamate in rat cerebellar granule neurons.

Neuroscience letters 20010223

Ebselen prevents early alcohol-induced liver injury in rats.

Free radical biology & medicine 20010215

The effects of thiol compounds and ebselen on nitric oxide activity in rat aortic vascular responses.

Journal of autonomic pharmacology 20010201

Reactive oxygen species and caspase activation mediate silica-induced apoptosis in alveolar macrophages.

American journal of physiology. Lung cellular and molecular physiology 20010101

Inhibition of ebselen on aflatoxin B(1)-induced hepatocarcinogenesis in Fischer 344 rats.

Carcinogenesis 20001201

Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide.

Circulation research 20000218

Cellular factors as alternative targets for inhibition of HIV-1.

Antiviral research 19970201

Molecular actions of ebselen--an antiinflammatory antioxidant.

General pharmacology 19951001

Interaction of ebselen with glutathione S-transferase and papain in vitro.

Biochemical pharmacology 19940315

PZ-51 (Ebselen) in vivo protection against adriamycin-induced mouse cardiac and hepatic lipid peroxidation and toxicity.

Biochemical pharmacology 19920818

Effects of the seleno-organic substance Ebselen in two different models of acute pancreatitis.

Pancreas 19910501