2-Hydroxypyrazine
| Title | Journal |
|---|---|
| Heterologous expression and structural characterisation of a pyrazinone natural product assembly line. | Chembiochem : a European journal of chemical biology 20121105 |
| 1,3-Diphenyl-4,5-dihydro-1H-pyrazol-5-one. | Acta crystallographica. Section E, Structure reports online 20120401 |
| 4-[3,4-Dimethyl-1-(4-methyl-phen-yl)-5-oxo-4,5-dihydro-1H-pyrazol-4-yl]-3,4-dimethyl-1-(4-methyl-phen-yl)-4,5-dihydro-1H-pyrazol-5-one. | Acta crystallographica. Section E, Structure reports online 20120401 |
| Concise synthesis of an enantiopure bicyclic pyrazinone as constrained peptidomimetic building block. | Organic & biomolecular chemistry 20120314 |
| Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. | Biochemistry 20111011 |
| JBIR-56 and JBIR-57, 2(1H)-pyrazinones from a marine sponge-derived Streptomyces sp. SpD081030SC-03. | Journal of natural products 20110722 |
| New taxa in Aspergillus section Usti. | Studies in mycology 20110630 |
| 2-(4-Meth-oxy-benz-yl)-4,6-diphenyl-2,5-diaza-bicyclo-[2.2.2]oct-5-en-3-one. | Acta crystallographica. Section E, Structure reports online 20110501 |
| 4-[2-(Benzyl-sulfan-yl)acet-yl]-3,4-dihydro-quinoxalin-2(1H)-one. | Acta crystallographica. Section E, Structure reports online 20110401 |
| Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. | Journal of the American Chemical Society 20110302 |
| Chiral separation of potent corticotropin-releasing factor-1 receptor antagonists by supercritical fluid chromatography. | Journal of pharmaceutical and biomedical analysis 20110220 |
| In situ maleimide bridging of disulfides and a new approach to protein PEGylation. | Bioconjugate chemistry 20110216 |
| Structural analysis of prolyl oligopeptidases using molecular docking and dynamics: insights into conformational changes and ligand binding. | PloS one 20110101 |
| Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization. | Journal of medicinal chemistry 20101111 |
| A family of pyrazinone natural products from a conserved nonribosomal peptide synthetase in Staphylococcus aureus. | Chemistry & biology 20100924 |
| Discovery of achiral inhibitors of the hepatitis C virus NS3 protease based on 2(1H)-pyrazinones. | Bioorganic & medicinal chemistry 20100901 |
| Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors. | Bioorganic & medicinal chemistry letters 20100715 |
| Intramolecular 1,6-addition to 2-pyridones. Mechanism and synthetic scope. | The Journal of organic chemistry 20100604 |
| Comparative biotransformation of pyrazinone-containing corticotropin-releasing factor receptor-1 antagonists: minimizing the reactive metabolite formation. | Drug metabolism and disposition: the biological fate of chemicals 20100101 |
| New in vitro dermal absorption database and the prediction of dermal absorption under finite conditions for risk assessment purposes. | Regulatory toxicology and pharmacology : RTP 20100101 |
| Functional characterization of the protein C A267T mutation: evidence for impaired secretion due to defective intracellular transport. | BMC cell biology 20100101 |
| 4-[(2,5-Dimethyl-anilino)acet-yl]-3,4-di-hydro-quinoxalin-2(1H)-one. | Acta crystallographica. Section E, Structure reports online 20091201 |
| [Overview in 45 years of studies on peptide chemistry]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20091001 |
| 3-Substituted pyrazinone nucleosides--a new family of D4T analogues. | Nucleosides, nucleotides & nucleic acids 20090901 |
| New cyclic somatostatin analogues containing a pyrazinone ring: importance of Tyr for antiproliferative activity. | Bioorganic & medicinal chemistry letters 20081201 |
| Synthesis of highly functionalized 2(1H)-pyrazinone 3-carboxamide scaffolds. | Organic letters 20081016 |
| Synthesis of new pyrrolo[1,2-a]quinoxaline derivatives as potential inhibitors of Akt kinase. | Journal of enzyme inhibition and medicinal chemistry 20081001 |
| Ethyl-enediammonium bis-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-pyrazol-1-ide): a hydrogen-bond-supported supra-molecular ionic assembly. | Acta crystallographica. Section E, Structure reports online 20080901 |
| Sugar-driven prebiotic synthesis of 3,5(6)-dimethylpyrazin-2-one: a possible nucleobase of a primitive replication process. | Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life 20080801 |
| Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP). | Bioorganic & medicinal chemistry letters 20080801 |
| Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery. | The AAPS journal 20080301 |
| 3-Benzyl-5-bromo-pyrazin-2(1H)-one. | Acta crystallographica. Section E, Structure reports online 20080301 |
| trans-Chlorido[6-chloro-4-(4-methoxy-benz-yl)-3-oxo-3,4-dihydro-pyrazin-2-yl]-bis-(triphenyl-phosphine)palladium(II). | Acta crystallographica. Section E, Structure reports online 20080101 |
| Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform. | Bioorganic & medicinal chemistry letters 20071101 |
| Synthesis of opioidmimetics, 3-[H-Dmt-NH(CH(2))(m)]-6-[H-Dmt-NH(CH(2))(n)]-2(1H)-pyrazinones, and studies on structure-activity relationships. | Medicinal chemistry (Shariqah (United Arab Emirates)) 20071101 |
| Unintentional organophosphate intoxication in children. | Pediatric emergency care 20071001 |
| Palladium-catalyzed copper(I)-mediated cross-coupling of arylboronic acids and 2(1H)-pyrazinones facilitated by microwave irradiation with simultaneous cooling. | Organic & biomolecular chemistry 20070921 |
| Various Molecular Species of Diacylglycerol Hydroperoxide Activate Human Neutrophils via PKC Activation. | Journal of clinical biochemistry and nutrition 20070701 |
| Azetidine-based inhibitors of dipeptidyl peptidase IV (DPP IV). | Current topics in medicinal chemistry 20070101 |
| Transition metal-catalyzed orthogonal solid-phase decoration of the 2(1H)-pyrazinone scaffold using a sulfur linker. | Journal of combinatorial chemistry 20070101 |
| Cobalt-mediated [2+2+2] cycloaddition versus C-H and N-H activation of pyridones and pyrazinones with alkynes: an experimental study. | Chemistry (Weinheim an der Bergstrasse, Germany) 20070101 |
| Bis and tris indole alkaloids from marine organisms: new leads for drug discovery. | Current medicinal chemistry 20070101 |
| Polyphasic taxonomy of Aspergillus section Usti. | Studies in mycology 20070101 |
| Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity. | Bioorganic & medicinal chemistry letters 20061115 |
| Copper(II)-mediated cross-coupling of arylboronic acids and 2(1H)-pyrazinones facilitated by microwave irradiation with simultaneous cooling. | Organic letters 20060427 |
| Removal of atrazine, lindane and diazinone from water by organo-zeolites. | Water research 20060301 |
| Application of automated mass spectrometry deconvolution and identification software for pesticide analysis in surface waters. | Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20060101 |
| Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization. | Bioorganic & medicinal chemistry letters 20051015 |
| In vitro metabolism of a thrombin inhibitor and quantitation of metabolically generated cyanide. | Journal of pharmaceutical and biomedical analysis 20051004 |
| Studies on the mechanism of 1,2-dihydropyrazin-2-one ring formation from dipeptidyl chloromethyl ketone and its chemical properties: immediate deamination during catalytic hydrogenation. | Chemical & pharmaceutical bulletin 20050901 |
| Novel pyrazinone and pyridinone thrombin inhibitors incorporating weakly basic heterobicyclic P(1)-arginine mimetics. | European journal of medicinal chemistry 20050801 |
| Synthesis of cyclic endiamino peptides. | Journal of the American Chemical Society 20050601 |
| Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity. | Journal of medicinal chemistry 20050324 |
| Solid-phase synthesis of the 2(1H)-pyrazinone scaffold: a new approach toward diversely substituted heterocycles. | Journal of combinatorial chemistry 20050101 |
| The application of 'click chemistry' for the decoration of 2(1H)-pyrazinone scaffold: generation of templates. | Journal of combinatorial chemistry 20050101 |
| N-h insertion reactions of Boc-amino acid amides: solution- and solid-phase synthesis of pyrazinones and pyrazines. | Organic letters 20041125 |
| Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation. | Bioorganic & medicinal chemistry letters 20041004 |
| Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis. | Journal of medicinal chemistry 20040506 |
| Oral bioavailability of a new class of micro-opioid receptor agonists containing 3,6-bis[Dmt-NH(CH(2))(n)]-2(1H)-pyrazinone with central-mediated analgesia. | Journal of medicinal chemistry 20040506 |
| Novel 2',6'-dimethyl-L-tyrosine-containing pyrazinone opioid mimetic mu-agonists with potent antinociceptive activity in mice. | The Journal of pharmacology and experimental therapeutics 20040401 |
| Synthesis of 3-aminopyrazinone mediated by 2-pyridylthioimidate-ZnCl2 complexes. Development of an efficient route to a thrombin inhibitor. | The Journal of organic chemistry 20031114 |
| Bioactivation of the 3-amino-6-chloropyrazinone ring in a thrombin inhibitor leads to novel dihydro-imidazole and imidazolidine derivatives: structures and mechanism using 13C-labels, mass spectrometry, and NMR. | Drug metabolism and disposition: the biological fate of chemicals 20031101 |
| Design, synthesis, and crystal structure of selective 2-pyridone tissue factor VIIa inhibitors. | Journal of medicinal chemistry 20031023 |
| Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex. | Journal of medicinal chemistry 20030911 |
| Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex. | Bioorganic & medicinal chemistry letters 20030721 |
| Non-peptide alphavbeta3 antagonists. Part 6: design and synthesis of alphavbeta3 antagonists containing a pyridone or pyrazinone central scaffold. | Bioorganic & medicinal chemistry letters 20030519 |
| Azaindoles: moderately basic P1 groups for enhancing the selectivity of thrombin inhibitors. | Bioorganic & medicinal chemistry letters 20030310 |
| Metabolic activation of a pyrazinone-containing thrombin inhibitor. Evidence for novel biotransformation involving pyrazinone ring oxidation, rearrangement, and covalent binding to proteins. | Chemical research in toxicology 20030201 |
| Dmt and opioid peptides: a potent alliance. | Biopolymers 20030101 |
| Microwave-enhanced transition metal-catalyzed decoration of 2(1H)-pyrazinone scaffolds. | Molecular diversity 20030101 |
| Immunoglobulin E binding determinants on beta-lactam drugs. | Current opinion in allergy and clinical immunology 20020801 |
| Pyrazinone conjugates as potential cephalosporin allergens. | Bioorganic & medicinal chemistry letters 20010723 |
| Enantioselective synthesis for the (-)-antipode of the pyrazinone marine alkaloid, hamacanthin A. | The Journal of organic chemistry 20010713 |
| Imidazo-thiazine, -diazinone and -diazepinone derivatives. Synthesis, structure and benzodiazepine receptor binding. | European journal of medicinal chemistry 20010501 |