Hydroxyflutamide affects connexin 43 via the activation of PI3K/Akt-dependent pathway but has no effect on the crosstalk between PI3K/Akt and ERK1/2 pathways at the Raf-1 kinase level in primary rat Sertoli cells.

Toxicology in vitro : an international journal published in association with BIBRA 20160301

The ability of the YAS and AR CALUX assays to detect the additive effects of anti-androgenic fungicide mixtures.

Toxicology letters 20160122

Low dose evaluation of the antiandrogen flutamide following a Mode of Action approach.

Toxicology and applied pharmacology 20151215

The brominated flame retardants TBP-AE and TBP-DBPE antagonize the chicken androgen receptor and act as potential endocrine disrupters in chicken LMH cells.

Toxicology in vitro : an international journal published in association with BIBRA 20151201

Identification of a group of brominated flame retardants as novel androgen receptor antagonists and potential neuronal and endocrine disrupters.

Environment international 20150101

Metabolomics-on-a-chip of hepatotoxicity induced by anticancer drug flutamide and Its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips.

Toxicological sciences : an official journal of the Society of Toxicology 20130301

Ligand-independent androgen receptor antagonism caused by the newly developed pesticide pyrifluquinazon (PFQ).

Reproductive toxicology (Elmsford, N.Y.) 20130101

Administration of flutamide alters sperm ultrastructure, sperm plasma membrane integrity and its stability, and sperm mitochondrial oxidative capability in the boar: in vivo and in vitro approach.

Reproduction in domestic animals = Zuchthygiene 20120801

Design, synthesis, and biological evaluation of nonsteroidal cycloalkane[d]isoxazole-containing androgen receptor modulators.

Journal of medicinal chemistry 20120726

Does 2-hydroxyflutamide inhibit apoptosis in porcine granulosa cells? - An in vitro study.

The Journal of reproduction and development 20120101

Androgen receptor coregulators NOCR1, TIF2, and ARA70 may account for the hydroxyflutamide insensitivity of prostate cancer cells.

Irish journal of medical science 20111201

A novel steroidal antiandrogen targeting wild type and mutant androgen receptors.

Biochemical pharmacology 20111201

Characterization of steroid hormone receptor activities in 100 hydroxylated polychlorinated biphenyls, including congeners identified in humans.

Toxicology 20111118

Development of 3-substituted-androsterone derivatives as potent inhibitors of 17β-hydroxysteroid dehydrogenase type 3.

Bioorganic & medicinal chemistry 20110801

Unexpected binding orientation of bulky-B-ring anti-androgens and implications for future drug targets.

Journal of medicinal chemistry 20110609

Androgen receptors in the posterior bed nucleus of the stria terminalis increase neuropeptide expression and the stress-induced activation of the paraventricular nucleus of the hypothalamus.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20110601

Differential effects of a complex organochlorine mixture on the proliferation of breast cancer cell lines.

Environmental research 20110401

Hydroxyflutamide enhances cellular sensitivity to 5-fluorouracil by suppressing thymidylate synthase expression in bicalutamide-resistant human prostate cancer cells.

International journal of oncology 20110301

QSAR models for anti-androgenic effect--a preliminary study.

SAR and QSAR in environmental research 20110301

Production of human metabolites of the anti-cancer drug flutamide via biotransformation in Cunninghamella species.

Biotechnology letters 20110201

Modulation of androgen receptor signaling in hormonal therapy-resistant prostate cancer cell lines.

PloS one 20110101

The medial preoptic nucleus integrates the central influences of testosterone on the paraventricular nucleus of the hypothalamus and its extended circuitries.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20100901

Cell viability and PSA secretion assays in LNCaP cells: a tiered in vitro approach to screen chemicals with a prostate-mediated effect on male reproduction within the ReProTect project.

Reproductive toxicology (Elmsford, N.Y.) 20100801

Determination of 2-hydroxyflutamide in human plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS): application to a bioequivalence study on Chinese volunteers.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100601

A mouse model of androgenetic alopecia.

Endocrinology 20100501

Is the 'comb over' dying? A mouse model for male pattern baldness (androgenic alopecia).

Endocrinology 20100501

Systematic structure-function analysis of androgen receptor Leu701 mutants explains the properties of the prostate cancer mutant L701H.

The Journal of biological chemistry 20100212

Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.

Journal of medicinal chemistry 20091210

Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators.

Journal of medicinal chemistry 20091126

The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144.

Journal of natural products 20091101

Design and synthesis of androgen receptor antagonists with bulky side chains for overcoming antiandrogen resistance.

Journal of medicinal chemistry 20090910

Nuclear hormone receptor activity of polybrominated diphenyl ethers and their hydroxylated and methoxylated metabolites in transactivation assays using Chinese hamster ovary cells.

Environmental health perspectives 20090801

Suppression of mutant androgen receptors by flutamide.

International journal of urology : official journal of the Japanese Urological Association 20090501

Functional AR signaling is evident in an in vitro mouse follicle culture bioassay that encompasses most stages of folliculogenesis.

Biology of reproduction 20090401

Steroidal lactones as inhibitors of 17beta-hydroxysteroid dehydrogenase type 5: chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities.

European journal of medicinal chemistry 20090201

Design and synthesis of carborane-containing androgen receptor (AR) antagonist bearing a pyridine ring.

Bioorganic & medicinal chemistry 20080901

Computationally identified novel diphenyl- and phenylpyridine androgen receptor antagonist structures.

Journal of chemical information and modeling 20080901

Nandrolone decreases mu opioid receptor expression in SH-SY5Y human neuroblastoma cells.

Neuroreport 20080716

4-(Anilino)pyrrole-2-carboxamides: Novel non-steroidal/non-anilide type androgen antagonists effective upon human prostate tumor LNCaP cells with mutated nuclear androgen receptor.

Bioorganic & medicinal chemistry 20080715

A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor.

International journal of cancer 20080701

Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism.

Chemical research in toxicology 20080401

Identification and optimization of a novel series of [2.2.1]-oxabicyclo imide-based androgen receptor antagonists.

Bioorganic & medicinal chemistry letters 20080315

1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) disrupts the estrogen-androgen balance regulating the growth of hormone-dependent breast cancer cells.

Breast cancer research : BCR 20080101

Testosterone directly induces progesterone production and interacts with physiological concentrations of LH to increase granulosa cell progesterone production in laying hens (Gallus domesticus).

Animal reproduction science 20071101

Discovery and structure-activity relationships of new steroidal compounds bearing a carboxy-terminal side chain as androgen receptor pure antagonists.

Bioorganic & medicinal chemistry letters 20071015

PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor.

The Journal of steroid biochemistry and molecular biology 20071001

Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites.

Chemical research in toxicology 20071001

Effects of steroidal and non-steroidal antiandrogens on wild-type and mutant androgen receptors.

The Prostate 20070601

Dihydrotestosterone inhibits tumor necrosis factor alpha induced interleukin-1alpha mRNA expression in rheumatoid fibroblast-like synovial cells.

Biological & pharmaceutical bulletin 20070601

Testosterone inhibits matrix metalloproteinase-1 production in human endometrial stromal cells in vitro.

Reproduction (Cambridge, England) 20070601

Non-steroidal antiandrogens act as AF-1 agonists under conditions of high androgen-receptor expression.

The Prostate 20070501

Chemical synthesis and biological activities of 16alpha-derivatives of 5alpha-androstane-3alpha,17beta-diol as antiandrogens.

Bioorganic & medicinal chemistry 20070415

Synthesis and biological evaluation of [18F]bicalutamide, 4-[76Br]bromobicalutamide, and 4-[76Br]bromo-thiobicalutamide as non-steroidal androgens for prostate cancer imaging.

Journal of medicinal chemistry 20070308

Ligand-specific dynamics of the androgen receptor at its response element in living cells.

Molecular and cellular biology 20070301

The androgen receptor T877A mutant recruits LXXLL and FXXLF peptides differently than wild-type androgen receptor in a time-resolved fluorescence resonance energy transfer assay.

Biochemistry 20070123

Discovery of 7alpha-substituted dihydrotestosterones as androgen receptor pure antagonists and their structure-activity relationships.

Bioorganic & medicinal chemistry 20070101

Regulation of A Disintegrin And Metalloproteinase with ThromboSpondin repeats-1 expression in human endometrial stromal cells by gonadal steroids involves progestins, androgens, and estrogens.

The Journal of clinical endocrinology and metabolism 20061201

Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal of molecular graphics & modelling 20061101

Anti-progestogenic effect of flutamide on uterine expression of calbindin-D9k mRNA and protein in immature mice.

Reproductive toxicology (Elmsford, N.Y.) 20061101

Chiral dimethylamine flutamide derivatives--modeling, synthesis, androgen receptor affinities and carbon-11 labeling.

Nuclear medicine and biology 20060801

Synthesis and biological evaluation of a nonsteroidal bromine-76-labeled androgen receptor ligand 3-[76Br]bromo-hydroxyflutamide.

Nuclear medicine and biology 20060801

Flutamide metabolism in four different species in vitro and identification of flutamide metabolites in human patient urine by high performance liquid chromatography/tandem mass spectrometry.

Drug metabolism and disposition: the biological fate of chemicals 20060601

Androgen effects on hippocampal CA1 spine synapse numbers are retained in Tfm male rats with defective androgen receptors.

Endocrinology 20060501

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Co-activator and co-repressor interplay on the human androgen receptor.

Andrologia 20051201

Prostate cancer PET bioprobes: synthesis of [18F]-radiolabeled hydroxyflutamide derivatives.

Bioorganic & medicinal chemistry 20051115

Androgens augment the mitogenic effects of oocyte-secreted factors and growth differentiation factor 9 on porcine granulosa cells.

Biology of reproduction 20051001

Antiandrogens prevent stable DNA-binding of the androgen receptor.

Journal of cell science 20050915

The structural basis of androgen receptor activation: intramolecular and intermolecular amino-carboxy interactions.

Proceedings of the National Academy of Sciences of the United States of America 20050712

5alpha-dihydrotestosterone inhibits 1alpha,25-dihydroxyvitamin D3-induced expression of CYP24 in human prostate cancer cells.

The Prostate 20050515

Castration reduces platelet thromboxane A2 receptor density and aggregability.

QJM : monthly journal of the Association of Physicians 20050501

Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists.

Bioorganic & medicinal chemistry letters 20050117

Identification of a novel class of androgen receptor antagonists based on the bicyclic-1H-isoindole-1,3(2H)-dione nucleus.

Bioorganic & medicinal chemistry letters 20050117

Dose-dependent transitions in mechanisms of toxicity: case studies.

Toxicology and applied pharmacology 20041215

Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5alpha-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia.

Endocrinology 20041201

The effects of the reported active metabolite of methoxychlor, 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane, on testosterone formation by cultured Leydig cells from young adult rats.

Reproductive toxicology (Elmsford, N.Y.) 20041101

Androgen receptor is targeted to distinct subcellular compartments in response to different therapeutic antiandrogens.

Clinical cancer research : an official journal of the American Association for Cancer Research 20041101

Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer.

The Journal of biological chemistry 20040806

Interactions between androgen and growth factors in granulosa cell subtypes of porcine antral follicles.

Biology of reproduction 20040701

Differential effect of small ubiquitin-like modifier (SUMO)-ylation of the androgen receptor in the control of cooperativity on selective versus canonical response elements.

Molecular endocrinology (Baltimore, Md.) 20040601

Evidence that inhibited prostatic epithelial bud formation in 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed C57BL/6J fetal mice is not due to interruption of androgen signaling in the urogenital sinus.

Toxicological sciences : an official journal of the Society of Toxicology 20040601

Androgen receptor blockade in the MPOA or VMN: effects on male sociosexual behaviors.

Physiology & behavior 20040601

Effect of organochlorine pesticides on human androgen receptor activation in vitro.

Toxicology and applied pharmacology 20040415

[Examination of the change in plasma concentration of OH-flutamide in low-dose flutamide (250 mg/day) monotherapy for prostate cancer patients].

Gan to kagaku ryoho. Cancer & chemotherapy 20040301

Ectopic expression of the amino-terminal peptide of androgen receptor leads to androgen receptor dysfunction and inhibition of androgen receptor-mediated prostate cancer growth.

Molecular and cellular endocrinology 20040212

Androgen inhibition of MAP kinase pathway and Elk-1 activation in proliferating osteoblasts.

Journal of molecular endocrinology 20040201

Screening of some anti-androgenic endocrine disruptors using a recombinant cell-based in vitro bioassay.

The Journal of steroid biochemistry and molecular biology 20040201

Proteasome inhibitors and their combination with antiandrogens: effects on apoptosis, cellular proliferation and viability of prostatic adenocarcinoma cell cultures.

Prostate cancer and prostatic diseases 20040101

Potential action of androstenedione on the proliferation and apoptosis of stromal endometrial cells.

Reproductive biology and endocrinology : RB&E 20040101

Androgen dependent regulation of bacillus Calmette-Guerin induced interleukin-6 expression in human transitional carcinoma cell lines.

The Journal of urology 20031101

Modulation of androgen receptor transactivation by gelsolin: a newly identified androgen receptor coregulator.

Cancer research 20030815

UV filters with antagonistic action at androgen receptors in the MDA-kb2 cell transcriptional-activation assay.

Toxicological sciences : an official journal of the Society of Toxicology 20030701

Inhibition of fatty acid synthase expression by 1alpha,25-dihydroxyvitamin D3 in prostate cancer cells.

The Journal of steroid biochemistry and molecular biology 20030501

Effects of hydroxyflutamide in the medial preoptic area or lateral septum on reproductive behaviors in male rats.

Brain research bulletin 20021130

Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells.

Cancer research 20021101

Nerve growth factor induces the re-expression of functional androgen receptors and p75(NGFR) in the androgen-insensitive prostate cancer cell line DU145.

European journal of endocrinology 20020901

[Sex-difference on flutamide metabolism in rat liver microsomal cytochrome P450 1A2].

Yao xue xue bao = Acta pharmaceutica Sinica 20020801

Pure antiandrogens disrupt the recruitment of coactivator GRIP1 to colocalize with androgen receptor in nuclei.

FEBS letters 20020717

Acquisition of agonistic properties of nonsteroidal antiandrogens after treatment with oncostatin M in prostate cancer cells.

Clinical cancer research : an official journal of the American Association for Cancer Research 20020701

Stabilization of androgen receptor protein is induced by agonist, not by antagonists.

Biochemical and biophysical research communications 20020621

Androgens protect against apolipoprotein E4-induced cognitive deficits.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20020615

Cytotoxicity of flutamide and 2-hydroxyflutamide and their effects on CYP1A2 mRNA in primary rat hepatocytes.

Acta pharmacologica Sinica 20020601

The amino terminus of the human AR is target for corepressor action and antihormone agonism.

Molecular endocrinology (Baltimore, Md.) 20020401

A novel cell line, MDA-kb2, that stably expresses an androgen- and glucocorticoid-responsive reporter for the detection of hormone receptor agonists and antagonists.

Toxicological sciences : an official journal of the Society of Toxicology 20020301

Development of two androgen receptor assays using adenoviral transduction of MMTV-luc reporter and/or hAR for endocrine screening.

Toxicological sciences : an official journal of the Society of Toxicology 20020301

Role of cadmium in the regulation of AR gene expression and activity.

Endocrinology 20020101

Use of the probasin promoter ARR2PB to express Bax in androgen receptor-positive prostate cancer cells.

Journal of the National Cancer Institute 20010905

Determination of 2-hydroxyflutamide in human plasma by high-performance liquid chromatography and its application to pharmacokinetic studies.

Journal of chromatography. B, Biomedical sciences and applications 20010805

The subnuclear three-dimensional image analysis of androgen receptor fused to green fluorescence protein.

The Journal of biological chemistry 20010727

Homology modeling using multiple molecular dynamics simulations and docking studies of the human androgen receptor ligand binding domain bound to testosterone and nonsteroidal ligands.

Journal of medicinal chemistry 20010524

Dexamethasone blocks antioestrogen- and oxidant-induced death of pituitary tumour cells.

The Journal of endocrinology 20010501

Testosterone inhibits osteoclast formation stimulated by parathyroid hormone through androgen receptor.

FEBS letters 20010223

Mutations at the boundary of the hinge and ligand binding domain of the androgen receptor confer increased transactivation function.

Molecular endocrinology (Baltimore, Md.) 20010101

Androgen-induced cell growth and c-myc expression in human non-transformed epithelial prostatic cells in primary culture.

Endocrine research 20010101

Regulation of GCDFP-15 expression in human mammary cancer cells.

International journal of molecular medicine 19990801

Rapid and sensitive reporter gene assays for detection of antiandrogenic and estrogenic effects of environmental chemicals.

Toxicology and applied pharmacology 19990301

Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells.

Toxicology and applied pharmacology 19980701

Androgen antagonistic effect of estramustine phosphate (EMP) metabolites on wild-type and mutated androgen receptor.

Biochemical pharmacology 19980501

Synthesis and biological activity of a novel series of nonsteroidal, peripherally selective androgen receptor antagonists derived from 1,2-dihydropyridono[5,6-g]quinolines.

Journal of medicinal chemistry 19980212

Comparison of in vitro effects of the pure antiandrogens OH-flutamide, Casodex, and nilutamide on androgen-sensitive parameters.

Urology 19970401

Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay.

Toxicology and applied pharmacology 19970301

Non-steroidal L-245,976 acts as a classical antiandrogen in vitro.

The Journal of steroid biochemistry and molecular biology 19970101

The pharmacokinetics of flutamide and its major metabolites after a single oral dose and during chronic treatment.

European journal of clinical pharmacology 19880101