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Home Other Building Blocks 2-(4-(2-Hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

2-(4-(2-Hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

CAS No.:
1044870-39-4
Catalog Number:
AG003G94
Molecular Formula:
C20H22N2O5
Molecular Weight:
370.3991
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
250mg
98%
In Stock USA
United States
$150
- +
1g
98%
In Stock USA
United States
$400
- +
5g
98%
In Stock USA
United States
$1600
- +
Product Description
Catalog Number:
AG003G94
Chemical Name:
2-(4-(2-Hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one
CAS Number:
1044870-39-4
Molecular Formula:
C20H22N2O5
Molecular Weight:
370.3991
MDL Number:
MFCD18633270
IUPAC Name:
2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-3H-quinazolin-4-one
InChI:
InChI=1S/C20H22N2O5/c1-11-7-13(8-12(2)18(11)27-6-5-23)19-21-15-9-14(25-3)10-16(26-4)17(15)20(24)22-19/h7-10,23H,5-6H2,1-4H3,(H,21,22,24)
InChI Key:
NETXMUIMUZJUTB-UHFFFAOYSA-N
SMILES:
OCCOc1c(C)cc(cc1C)c1nc2cc(OC)cc(c2c(=O)[nH]1)OC
UNII:
8R4A7GDZ1D
Properties
Complexity:
543  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
370.153g/mol
Formal Charge:
0
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
370.405g/mol
Monoisotopic Mass:
370.153g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
89.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.3  
Literature
Title Journal
A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice. Atherosclerosis 20140901
RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. Proceedings of the National Academy of Sciences of the United States of America 20131203
RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist. PloS one 20130101
ApoA-I induction as a potential cardioprotective strategy: rationale for the SUSTAIN and ASSURE studies. Cardiovascular drugs and therapy 20120401
RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo. Journal of the American College of Cardiology 20100608
RVX-208, a stimulator of apolipoprotein AI gene expression for the treatment of cardiovascular diseases. Current opinion in investigational drugs (London, England : 2000) 20100301
Properties