[Effect of 2,5-hexanedione on light-molecular-weight neurofilaments (NF-L) degradation of rat nerve tissues].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20120601

[Studying the damages of mouse retina induced by 2,5-hexanedione].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20120501

2,5-Hexanedione induces human ovarian granulosa cell apoptosis through BCL-2, BAX, and CASPASE-3 signaling pathways.

Archives of toxicology 20120201

The effects of idebenone on mitochondrial bioenergetics.

Biochimica et biophysica acta 20120201

Optimization of a filter-lysis protocol to purify rat testicular homogenates for automated spermatid counting.

Journal of andrology 20120101

Analysis of volatile organic compounds released from human lung cancer cells and from the urine of tumor-bearing mice.

Cancer cell international 20120101

Sperm mRNA transcripts are indicators of sub-chronic low dose testicular injury in the Fischer 344 rat.

PloS one 20120101

Communication: stabilization of radical anions with weakly bound electron in condensed media: a case study of diacetonyl radical anion.

The Journal of chemical physics 20110914

The high dosage of earthworm (Eisenia andrei) extract decreases cell proliferation and neuroblast differentiation in the mouse hippocampal dentate gyrus.

Anatomy & cell biology 20110901

External quality assessment scheme for biological monitoring of occupational exposure to toxic chemicals.

Safety and health at work 20110901

The effect of 2,5-hexanedione on myelin protein zero expression, and its mitigation using Ginkgo biloba extract.

Biomedical and environmental sciences : BES 20110801

E6 and E7 from beta HPV38 cooperate with ultraviolet light in the development of actinic keratosis-like lesions and squamous cell carcinoma in mice.

PLoS pathogens 20110701

[Effects of n-hexane exposure on human serum myelin basic proteins].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20110601

Carboxyl-terminus of Hsc70 interacting protein mediates 2,5-hexanedione-induced neurofilament medium chain degradation.

Biochemical pharmacology 20110315

Mitochondrial optic neuropathies - disease mechanisms and therapeutic strategies.

Progress in retinal and eye research 20110301

The chemistry of acetone at extreme conditions by density functional molecular dynamics simulations.

The Journal of chemical physics 20110214

[Effects on serum myelin proteins of n-hexane exposure].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20110201

Leber's Hereditary Optic Neuropathy-Gene Therapy: From Benchtop to Bedside.

Journal of ophthalmology 20110101

Spinal cord injury causes sustained disruption of the blood-testis barrier in the rat.

PloS one 20110101

Microwave assisted solvent free synthesis of 1,3-diphenylpropenones.

Chemistry Central journal 20110101

[Effects of garlic oil, age and sex on n-hexane metabolism in rats].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20110101

Physiologically based pharmacokinetic modeling: methodology, applications, and limitations with a focus on its role in pediatric drug development.

Journal of biomedicine & biotechnology 20110101

A case study on co-exposure to a mixture of organic solvents in a Tunisian adhesive-producing company.

Journal of occupational medicine and toxicology (London, England) 20110101

Occupational neurological disorders in Korea.

Journal of Korean medical science 20101201

Occupational diseases in Korea.

Journal of Korean medical science 20101201

Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. III. Candidate gene analysis identifies a role for fas in the attenuation of X-ray-induced apoptosis.

Toxicological sciences : an official journal of the Society of Toxicology 20101001

Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. I. Histopathological analysis reveals stage dependence of attenuated apoptosis.

Toxicological sciences : an official journal of the Society of Toxicology 20101001

Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. II. Gene array analysis reveals adaptive changes in cell cycle and cell death pathways.

Toxicological sciences : an official journal of the Society of Toxicology 20101001

Gamma-diketone axonopathy: analyses of cytoskeletal motors and highways in CNS myelinated axons.

Toxicological sciences : an official journal of the Society of Toxicology 20100901

The effect of 2,5-hexanedione on permeability of blood-nerve barrier in rats.

Human & experimental toxicology 20100601

Occupational neurologic disorders in Korea.

Journal of clinical neurology (Seoul, Korea) 20100601

[Effect of 2,5-hexanedione on myelin protein zero in sciatic nerve and its antibody in serum of rats at different time points].

Wei sheng yan jiu = Journal of hygiene research 20100501

Highly efficient and stereoselective biosynthesis of (2S,5S)-hexanediol with a dehydrogenase from Saccharomyces cerevisiae.

Organic & biomolecular chemistry 20100407

Remarkable iodine-catalyzed synthesis of novel pyrrole-bearing N-polyaromatic beta-lactams.

Molecules (Basel, Switzerland) 20100223

Degradation of hexane and other recalcitrant hydrocarbons by a novel isolate, Rhodococcus sp. EH831.

Environmental science and pollution research international 20100101

[The effect of 2,5-hexanedione on nerve growth factor in sciatic nerve of rats and VSC4.1 cell].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20100101

Engineering cofactor preference of ketone reducing biocatalysts: A mutagenesis study on a γ-diketone reductase from the yeast Saccharomyces cerevisiae serving as an example.

International journal of molecular sciences 20100101

New automated and high-throughput quantitative analysis of urinary ketones by multifiber exchange-solid phase microextraction coupled to fast gas chromatography/negative chemical-electron ionization/mass spectrometry.

Journal of automated methods & management in chemistry 20100101

Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease.

PloS one 20100101

Mitochondrial DNA sequence variation and haplogroup distribution in Chinese patients with LHON and m.14484T>C.

PloS one 20100101

Somatic point mutations in mtDNA control region are influenced by genetic background and associated with healthy aging: a GEHA study.

PloS one 20100101

New insights into mechanisms of gamma-diketone-induced axonopathy.

Neurochemical research 20091101

1,5-Bis(2,5-dimethyl-1H-pyrrol-1-yl)naphthalene.

Acta crystallographica. Section E, Structure reports online 20091101

Workplace exposures and the risk of amyotrophic lateral sclerosis.

Environmental health perspectives 20090901

The effect of workload on biological monitoring of occupational exposure to toluene and n-Hexane: contribution of physiologically based toxicokinetic modeling.

Journal of occupational and environmental hygiene 20090701

2,2',5,5'-Tetra-methyl-1,1'-(hexane-1,6-di-yl)di-1H-pyrrole.

Acta crystallographica. Section E, Structure reports online 20090701

Neurotoxic effect of 2,5-hexanedione on neural progenitor cells and hippocampal neurogenesis.

Toxicology 20090616

Determination of 2,5-hexanedione in urine by headspace solid-phase microextraction and gas chromatography.

Journal of analytical toxicology 20090501

[Effects of garlic oil on n-hexane metabolized to 2, 5-hexanedione in mice serum].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20090501

Probing mechanisms of axonopathy. Part II: Protein targets of 2,5-hexanedione, the neurotoxic metabolite of the aliphatic solvent n-hexane.

Toxicological sciences : an official journal of the Society of Toxicology 20090201

Comparative covalent protein binding of 2,5-hexanedione and 3-acetyl-2,5-hexanedione in the rat.

Journal of toxicology and environmental health. Part A 20090101

The background of mitochondrial DNA haplogroup J increases the sensitivity of Leber's hereditary optic neuropathy cells to 2,5-hexanedione toxicity.

PloS one 20090101

[Effects of garlic oil on 2, 5-HD induced lipid peroxidation damage in rat nerve tissues].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20081101

2,5-hexanedione (HD) treatment alters calmodulin, Ca2+/calmodulin-dependent protein kinase II, and protein kinase C in rats' nerve tissues.

Toxicology and applied pharmacology 20081001

[Dynamic study of neurofilament contents in rat's spinal cord induced by 2, 5-hexanedione].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20081001

Resveratrol reestablishes spermatogenesis after testicular injury in rats caused by 2, 5-hexanedione.

Chinese medical journal 20080705

Laboratory evolution of Pyrococcus furiosus alcohol dehydrogenase to improve the production of (2S,5S)-hexanediol at moderate temperatures.

Extremophiles : life under extreme conditions 20080701

Involvement of cyclin-dependent kinase 5 in 2,5-hexanedione-induced neuropathy.

Toxicology 20080603

Re-establishment of spermatogenesis by diethylstilbestrol after 2,5-hexanedione-induced irreversible testicular atrophy in rats.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20080401

Polyneuropathy induced by n-hexane intoxication in Taiwan.

Acta neurologica Taiwanica 20080301

Changes of cytoskeletal proteins in nerve tissues and serum of rats treated with 2,5-hexanedione.

Toxicology 20080227

The reversibility of neurofilaments decline induced by 2,5-hexanedione in rat nerve tissues.

Biochemical pharmacology 20080201

A comparison of the apoptotic and cytotoxic effects of hexanedione derivatives on human non-neuronal lines and the neuroblastoma line SH-SY5Y.

Basic & clinical pharmacology & toxicology 20080101

Inhalant abuse detection and evaluation in young Tunisians.

Journal of forensic sciences 20080101

Spermatid head retention as a marker of 2,5-hexanedione-induced testicular toxicity in the rat.

Toxicologic pathology 20080101

Expression of Bcl-2, Bax and Caspase-3 in nerve tissues of rats chronically exposed to 2,5-hexanedione.

Neurochemical research 20070901

Enzymatic characteristics of an aldo-keto reductase family protein (AKR1C15) and its localization in rat tissues.

Archives of biochemistry and biophysics 20070901

Time-dependent alteration of cytoskeletal proteins in cerebral cortex of rat during 2,5-hexanedione-induced neuropathy.

Neurochemical research 20070801

Dose-dependent effects of sertoli cell toxicants 2,5-hexanedione, carbendazim, and mono-(2-ethylhexyl) phthalate in adult rat testis.

Toxicologic pathology 20070801

Effect of physical exertion on the biological monitoring of exposure to various solvents following exposure by inhalation in human volunteers: II. n-Hexane.

Journal of occupational and environmental hygiene 20070701

[Resveratrol helps restore spermatogenesis after testis injury induced by 2,5-hexanedione].

Zhonghua nan ke xue = National journal of andrology 20070701

Diketone radical cations: ketonic and enolic forms as revealed by matrix EPR studies and DFT calculations.

The journal of physical chemistry. A 20070503

[Effect of nerve growth factor on mitochondrion dysfunction of motor neuron induced by 2,5-hexanedione].

Wei sheng yan jiu = Journal of hygiene research 20070501

Apoptotic and necrotic effects of hexanedione derivatives on the human neuroblastoma line SK-N-SH.

Toxicology 20070307

Two new reactive targets of 2,5-hexanedione in vitro - beta-alanine and glycine.

Amino acids 20070201

Activation of soluble guanylate cyclase by nitric oxide is increased in lymphocytes from both rats chronically exposed to 2,5-hexanedione and workers chronically exposed to n-hexane.

Toxicology 20070105

Grand rounds: could occupational exposure to n-hexane and other solvents precipitate visual failure in leber hereditary optic neuropathy?

Environmental health perspectives 20070101

Working conditions and related neuropsychiatric problems among shoemakers in Turkey: Do child workers differ from others?

Indian journal of occupational and environmental medicine 20070101

The toxicity of hexanedione isomers in neural and astrocytic cell lines.

Environmental toxicology and pharmacology 20061101

Synthesis of enantiopure (5R)-hydroxyhexane-2-one with immobilised whole cells of Lactobacillus kefiri.

Applied microbiology and biotechnology 20060701

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

[Effect of 2, 5-hexanedione on calcium homeostasis of motor neuron].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20060501

Changes in cytosolic Ca2+ levels regulate Bcl-xS and Bcl-xL expression in spermatogenic cells during apoptotic death.

The Journal of biological chemistry 20060127

Association between metabolic gene polymorphisms and susceptibility to peripheral nerve damage in workers exposed to n-hexane: a preliminary study.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20060101

Gamma-Diketone central neuropathy: quantitative analyses of cytoskeletal components in myelinated axons of the rat rubrospinal tract.

Neurotoxicology 20051201

Protein adduct formation as a molecular mechanism in neurotoxicity.

Toxicological sciences : an official journal of the Society of Toxicology 20050801

Effects of male reproductive toxicants on gene expression in rat testes.

The Journal of toxicological sciences 20050801

2,5-Hexanedione induced reduction in protein content and mRNA expression of neurofilament in rat cerebral cortex.

Environmental toxicology and pharmacology 20050701

Protein expression analysis of rat testes induced testicular toxicity with several reproductive toxicants.

The Journal of toxicological sciences 20050501

[Effects of 2,5-hexanedione on NGF expression in motor and sensory neuronal cells of rats].

Wei sheng yan jiu = Journal of hygiene research 20050501

2,5-Hexanedione-induced changes in the neurofilament subunit pools of rat peripheral nerve.

Neurotoxicology 20050301

Physiologically based modeling of n-hexane kinetics in humans following inhalation exposure at rest and under physical exertion: impact on free 2,5-hexanedione in urine and on n-hexane in alveolar air.

Journal of occupational and environmental hygiene 20050201

2,5-Hexanedione induced decrease in cytoskeletal proteins of rat sciatic-tibial nerve.

Neurochemical research 20050201

Are sperm parameters the best indicator of 2,5-hexanedione reproductive toxicity in male rats?

Reproductive toxicology (Elmsford, N.Y.) 20050101

Microwave-assisted derivatization of 2,5-hexanedione in urine: evaluation using GC-MS and GC-ECD.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041225

Some pyrrole substituted aryl pyridazinone and phthalazinone derivatives and their antihypertensive activities.

European journal of medicinal chemistry 20041201

gamma-Diketone neuropathy: axon atrophy and the role of cytoskeletal protein adduction.

Toxicology and applied pharmacology 20040815

2,5-hexanedione and carbendazim coexposure synergistically disrupts rat spermatogenesis despite opposing molecular effects on microtubules.

Toxicological sciences : an official journal of the Society of Toxicology 20040701

2,5-Hexanedione-induced changes in the monomeric neurofilament protein content of rat spinal cord fractions.

Toxicology and applied pharmacology 20040701

Nature is complex: our orchestra seats at the most wonderful show on earth.

Toxicological sciences : an official journal of the Society of Toxicology 20040701

Comparison of unchanged n-hexane in alveolar air and 2,5-hexanedione in urine for the biological monitoring of n-hexane exposure in human volunteers.

International archives of occupational and environmental health 20040501

Pyridoxamine: an extremely potent scavenger of 1,4-dicarbonyls.

Chemical research in toxicology 20040301

2,5-Hexanedione inhibits rat brain acetylcholinesterase activity in vitro.

Toxicology letters 20040202

Free and total 2,5-hexanedione in biological monitoring of workers exposed to n-hexane in the shoe industry.

Toxicology letters 20031210

gamma-diketone central neuropathy: quantitative morphometric analysis of axons in rat spinal cord white matter regions and nerve roots.

Toxicology and applied pharmacology 20031115

Protection of the amino group of adenosine and guanosine derivatives by elaboration into a 2,5-dimethylpyrrole moiety.

Organic letters 20030904

Chronic exposure to 2,5-hexanedione impairs the glutamate-nitric oxide-cyclic GMP pathway in cerebellar neurons in culture and in rat brain in vivo.

Neurochemistry international 20030601

Poor metabolization of n-hexane in Parkinson's disease.

Journal of neurology 20030501

Occupational exposure to n-hexane in Italy--analysis of a registry of biological monitoring.

International archives of occupational and environmental health 20030501

2,5-hexanedione-induced testicular injury.

Annual review of pharmacology and toxicology 20030101

Evidence of zinc protection against 2,5-hexanedione neurotoxicity: correlation of neurobehavioral testing with biomarkers of excretion.

Neurotoxicology 20021201

Behavioral and electrophysiological responses of natural enemies to synomones from tea shoots and kairomones from tea aphids, Toxoptera aurantii.

Journal of chemical ecology 20021101

Evaluation of 2,5-hexanedione in urine of workers exposed to n-hexane in Brazilian shoe factories.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021005

Finnish quality assurance programme for biological monitoring of organic solvents.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021005

Amino acid and protein targets of 1,2-diacetylbenzene, a potent aromatic gamma-diketone that induces proximal neurofilamentous axonopathy.

Toxicology and applied pharmacology 20020815

Changes in n-hexane toxicokinetics in short-term single exposure due to co-exposure to methyl ethyl ketone in volunteers.

International archives of occupational and environmental health 20020801

Selective regional alterations in the content or distribution of neuronal and glial cytoskeletal proteins in brain of rats chronically exposed to 2,5-hexanedione.

Toxicology and industrial health 20020801

Partial conduction blocks in N-hexane neuropathy.

Muscle & nerve 20020701

Neurological evaluation of toxic axonopathies in rats: acrylamide and 2,5-hexanedione.

Neurotoxicology 20020501

Diastereoselective synthesis of optically active (2 R,5 R)-hexanediol.

Applied microbiology and biotechnology 20020401

Early spatial memory deficit induced by 2,5-hexanedione in the rat.

Toxicology letters 20020310

Aromatic as well as aliphatic hydrocarbon solvent axonopathy.

International journal of hygiene and environmental health 20020301

Toxicokinetic interaction of 2,5-hexanedione and methyl ethyl ketone.

Archives of toxicology 20020101

Computerized posturography with sway frequency analysis: application in occupational and environmental health.

Industrial health 20020101

Cytogenetic analysis of buccal cells from shoe-workers and pathology and anatomy laboratory workers exposed to n-hexane, toluene, methyl ethyl ketone and formaldehyde.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20020101

Urinary 2,5 hexanedione as a biomarker of n-hexane exposure.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20020101

Spectrophotometric analysis of solubilized rat hair proteins following intraperitoneal injection of 2,5-hexanedione.

Toxicology mechanisms and methods 20020101

Overview of studies on rat sperm motion analysis using a Hamilton-Thorne Sperm Analyzer--collaborative working study.

The Journal of toxicological sciences 20011201

Biological monitoring of n-hexane exposure in Portuguese shoe manufacturing workers.

Applied occupational and environmental hygiene 20010701

Neurofilaments are nonessential to the pathogenesis of toxicant-induced axonal degeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20010401

Gamma-diketone peripheral neuropathy III. Neurofilament gene expression.

Neurotoxicology 20010401

Novel 2,5-hexanedione analogues. Substituent-induced control of the protein cross-linking potential and oxidation susceptibility of the resulting primary amine-derived pyrroles.

Chemical research in toxicology 20010301

Interaction of zinc on biomarker responses in rats exposed to 2,5-hexanedione by two routes of exposure.

Toxicology letters 20010203

Spermatogenesis by Sisyphus: proliferating stem germ cells fail to repopulate the testis after 'irreversible' injury.

Advances in experimental medicine and biology 20010101

Functional Cyp2e1 is required for substantial in vivo formation of 2,5-hexanedione from n-hexane in the mouse.

Archives of toxicology 20001201

Rat epididymal sperm motion changes induced by ethylene glycol monoethyl ether, sulfasalazine, and 2,5-hexandione.

Reproductive toxicology (Elmsford, N.Y.) 20000101

Effects of n-hexane and its metabolites on cloned voltage-operated neuronal potassium channels.

Archives of toxicology 19970101

Endpoints of spermatotoxicity in the rat after short duration exposures to fourteen reproductive toxicants.

Reproductive toxicology (Elmsford, N.Y.) 19920101

Phenylmethanesulfonyl fluoride elicits and intensifies the clinical expression of neuropathic insults.

Archives of toxicology 19920101

The same chemicals induce different neurotoxicity when administered in high doses for short term or low doses for long term to rats and dogs.

Molecular and chemical neuropathology 19920101

Dose-dependent cytotoxicity of chlorinated hydrocarbons in isolated rat hepatocytes.

Fundamental and applied toxicology : official journal of the Society of Toxicology 19900501

Ultrastructural studies of the dying-back process. VI. Examination of nerve fibers undergoing giant axonal degeneration in organotypic culture.

Journal of neuropathology and experimental neurology 19830301

The neurotoxins 2,5-hexanedione and acrylamide promote aggregation of intermediate filaments in cultured fibroblasts.

Muscle & nerve 19830101

Potentiation of chlorinated hydrocarbon toxicity by 2,5-hexanedione in primary cultures of adult rat hepatocytes.

Fundamental and applied toxicology : official journal of the Society of Toxicology 19830101

Role of biotransformation in the potentiation of halocarbon hepatotoxicity by 2,5-hexanedione.

Journal of toxicology and environmental health 19820101

Clioquinol and 2,5-hexanedione induce different types of distal axonopathy in the dog.

Acta neuropathologica 19790801

Experimental neuropathy produced by 2,5-hexanedione--a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone.

Journal of neurology, neurosurgery, and psychiatry 19750801