Home Other Building Blocks 2',3',5'-Triacetyluridine

2',3',5'-Triacetyluridine

CAS No.:
4105-38-8
Catalog Number:
AG003FFK
Molecular Formula:
C15H18N2O9
Molecular Weight:
370.3114
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
98%
In Stock USA
United States
$13
- +
5g
98%
In Stock USA
United States
$19
- +
25g
98%
In Stock USA
United States
$38
- +
100g
98%
In Stock USA
United States
$113
- +
500g
98%
In Stock USA
United States
$525
- +
Product Description
Catalog Number:
AG003FFK
Chemical Name:
2',3',5'-Triacetyluridine
CAS Number:
4105-38-8
Molecular Formula:
C15H18N2O9
Molecular Weight:
370.3114
MDL Number:
MFCD00023795
IUPAC Name:
[(2R,3R,4R,5R)-3,4-diacetyloxy-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl acetate
InChI:
InChI=1S/C15H18N2O9/c1-7(18)23-6-10-12(24-8(2)19)13(25-9(3)20)14(26-10)17-5-4-11(21)16-15(17)22/h4-5,10,12-14H,6H2,1-3H3,(H,16,21,22)/t10-,12-,13-,14-/m1/s1
InChI Key:
AUFUWRKPQLGTGF-FMKGYKFTSA-N
SMILES:
CC(=O)O[C@@H]1[C@H](OC(=O)C)[C@H](O[C@H]1n1ccc(=O)[nH]c1=O)COC(=O)C
EC Number:
223-881-5
UNII:
2WP61F175M
Properties
Complexity:
660  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0
Exact Mass:
370.101g/mol
Formal Charge:
0
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
370.314g/mol
Monoisotopic Mass:
370.101g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
138A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.5  
Literature
Title Journal
A rational approach to the regioselective deacetylation of 2',3',5'-tri-O-acetyluridine by Novozym 435 catalysed alcoholysis. Biochimica et biophysica acta 20120401
Use of uridine triacetate for the management of fluorouracil overdose. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20111001
Enhanced uridine bioavailability following administration of a triacetyluridine-rich nutritional supplement. PloS one 20110101
Triacetyluridine (TAU) decreases depressive symptoms and increases brain pH in bipolar patients. Experimental and clinical psychopharmacology 20080601
Phthalocyanine-based molecularly imprinted polymers as nucleoside receptors. Metal-based drugs 20080101
Oral uridine pro-drug PN401 is neuroprotective in the R6/2 and N171-82Q mouse models of Huntington's disease. Neurobiology of disease 20061201
Phase II trial of PN401, 5-FU, and leucovorin in unresectable or metastatic adenocarcinoma of the stomach: a Southwest Oncology Group study. Investigational new drugs 20061101
5-Fluorouracil dose escalation enabled with PN401 (triacetyluridine): toxicity reduction and increased antitumor activity in mice. Cancer chemotherapy and pharmacology 20060701
Continued survival of more than ten years, without resection of metastatic disease, in patients with metastatic colorectal cancer treated with biomodulated fluorouracil: report of two cases. Diseases of the colon and rectum 20060301
Severe cytochrome c oxidase inhibition in vivo does not induce a pyrimidine deficiency; neuroprotective action of oral uridine prodrug PN401 requires supraphysiological levels of uridine. Brain research 20051220
Neuroprotective effects of oral administration of triacetyluridine against MPTP neurotoxicity. Neuromolecular medicine 20040101
Oral uridine pro-drug PN401 decreases neurodegeneration, behavioral impairment, weight loss and mortality in the 3-nitropropionic acid mitochondrial toxin model of Huntington's disease. Brain research 20031219
Synthesis and hypnotic activities of 4-thio analogues of N3-substituted uridines. Chemical & pharmaceutical bulletin 20010901
Properties