1-Phenylpiperazine hydrochloride
Title | Journal |
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Phenylpiperazine derivatives with selectivity for dopamine D3 receptors modulate cocaine self-administration in rats. | Neuropharmacology 20121201 |
DNA-binding, spectroscopic and antimicrobial studies of palladium(II) complexes containing 2,2'-bipyridine and 1-phenylpiperazine. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20121001 |
Phenylpiperazine derivatives: a patent review (2006 - present). | Expert opinion on therapeutic patents 20121001 |
Antiarrhythmic properties of phenylpiperazine derivatives of phenytoin with α₁-adrenoceptor affinities. | Bioorganic & medicinal chemistry 20120401 |
FT-IR and Raman spectroscopic and quantum chemical investigations of some metal halide complexes of 1-phenylpiperazine. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120301 |
Bivalent molecular probes for dopamine D2-like receptors. | Bioorganic & medicinal chemistry 20120101 |
Synthesis and vibrational spectroscopic analysis of some Hofmann type clathrates. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111101 |
Synthesis and anticonvulsant activity of new 1-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]pyrrolidine-2,5-diones. | Bioorganic & medicinal chemistry letters 20111001 |
Sleep deprivation differentially affects dopamine receptor subtypes in mouse striatum. | Neuroreport 20110713 |
The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists. | Journal of medicinal chemistry 20110414 |
Antidepressant-like activity of the phenylpiperazine pyrrolidin-2-one derivatives in mice. | Pharmacological reports : PR 20110101 |
Search for influence of spatial properties on affinity at α1-adrenoceptor subtypes for phenylpiperazine derivatives of phenytoin. | Bioorganic & medicinal chemistry letters 20101015 |
Analysis of phenylpiperazine-like stimulants in human hair as trimethylsilyl derivatives by gas chromatography-mass spectrometry. | Journal of chromatography. A 20101001 |
Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabilizer 4-[3-(methylsulfonyl)phenyl]-1-propylpiperidine (huntexil, pridopidine, ACR16). | Journal of medicinal chemistry 20100325 |
Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. | Bioorganic & medicinal chemistry 20100301 |
[(18)F]-labeled 2-methoxyphenylpiperazine derivative as a potential brain positron emission tomography imaging agent. | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20091101 |
Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. | Journal of medicinal chemistry 20090813 |
Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases. | Bioorganic & medicinal chemistry 20090701 |
Discovery process and pharmacological characterization of 2-(S)-(4-fluoro-2-methylphenyl)piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethylphenyl)ethyl]methylamide (vestipitant) as a potent, selective, and orally active NK1 receptor antagonist. | Journal of medicinal chemistry 20090528 |
Application of a library of artificial receptors formed by the self-organization of N-lipidated peptides immobilized on cellulose in studying the effects of the incorporation of a fluorine atom. | Journal of combinatorial chemistry 20090101 |
FT-IR spectroscopic investigation of some Hofmann type complexes: M(1-phenylpiperazine)2Ni(CN)4 (M=Ni, Co, Cd, Pd or Mn). | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080701 |
Synthesis, alpha 1-adrenoceptor antagonist activity, and SAR study of novel arylpiperazine derivatives of phenytoin. | Bioorganic & medicinal chemistry 20080601 |
Determination of lipophilicity of alpha-(4-phenylpiperazine) derivatives of N-benzylamides using chromatographic and computational methods. | Biomedical chromatography : BMC 20080401 |
Serotonergic neurotransmission mediates hypothermia induced by the N-phenylpiperazine antipsychotic prototypes LASSBio-579 and LASSBio-581. | Pharmacology, biochemistry, and behavior 20080301 |
Two new phenylpiperazines with atypical antipsychotic potential. | Bioorganic & medicinal chemistry letters 20071101 |
FT-IR and NMR investigation of 1-phenylpiperazine: a combined experimental and theoretical study. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070701 |
Synthesis and in vitro evaluation of substituted phenyl-piperazinyl-phenyl oxazolidinones against Gram-positive bacteria. | Chemical biology & drug design 20070401 |
Identification of metabolites produced from N-phenylpiperazine by Mycobacterium spp. | Journal of industrial microbiology & biotechnology 20070301 |
Novel potent neuropeptide Y Y5 receptor antagonists: synthesis and structure-activity relationships of phenylpiperazine derivatives. | Bioorganic & medicinal chemistry 20061115 |
Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. | Journal of medicinal chemistry 20060824 |
BACE-1 inhibitory activities of new substituted phenyl-piperazine coupled to various heterocycles: chromene, coumarin and quinoline. | Bioorganic & medicinal chemistry letters 20060401 |
Binding and photocleavage of cationic porphyrin-phenylpiperazine hybrids to DNA. | Biophysical chemistry 20060201 |
In vitro metabolism studies of (18)F-labeled 1-phenylpiperazine using mouse liver S9 fraction. | Nuclear medicine and biology 20060201 |
Hepatic metabolism of two alpha-1A-adrenergic receptor antagonists, phthalimide-phenylpiperazine analogs (RWJ-69205 and RWJ-69471), in the rat, dog and human. | European journal of drug metabolism and pharmacokinetics 20060101 |
Synthesis of potent and selective serotonin 5-HT1B receptor ligands. | Bioorganic & medicinal chemistry letters 20051101 |
[A study of physicochemical properties of 2-, 3-, 4-alkoxyphenylcarbamic acid derivatives with a substituted N-phenylpiperazine moiety in the basic part]. | Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20050901 |
Electrospray ionization mass and tandem mass spectra of a series of N-pyrazolylmethyl and N-triazolylmethyl N-phenylpiperazines: new dopaminergic ligands with potential antipsychotic properties. | Journal of mass spectrometry : JMS 20050601 |
Reinforcing and discriminative stimulus effects of 1-benzylpiperazine and trifluoromethylphenylpiperazine in rhesus monkeys. | Drug and alcohol dependence 20050214 |
Fluorous reagents and scavengers versus solid-supported reagents and scavengers, a reaction rate and kinetic comparison. | Molecular diversity 20050101 |
Acute psychosis following ingestion of 'Rapture'. | Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists 20041201 |
Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry. | Therapeutic drug monitoring 20040801 |
Phenylpiperazinylmethylheterocycle derivatives: synthesis and dopamine receptor binding profiles. | Archiv der Pharmazie 20040701 |
Discovery of a potent and selective alpha v beta 3 integrin antagonist with strong inhibitory activity against neointima formation in rat balloon injury model. | Bioorganic & medicinal chemistry letters 20040517 |
Synthesis and serotonergic activity of variously substituted (3-amido)phenylpiperazine derivatives and benzothiophene-4-piperazine derivatives: novel antagonists for the vascular 5-HT1B receptor. | European journal of medicinal chemistry 20040401 |
Design, synthesis, and alpha(1)-adrenoceptor binding properties of new arylpiperazine derivatives bearing a flavone nucleus as the terminal heterocyclic molecular portion. | Bioorganic & medicinal chemistry 20040315 |
Validated HPLC method for determination of LASSBio-581, a new heterocyclic N-phenylpiperazine derivative, in rat plasma. | Journal of pharmaceutical and biomedical analysis 20031204 |
Dopaminergic profile of new heterocyclic N-phenylpiperazine derivatives. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20030501 |
Quantitative structure-activity relationship study of novel alpha1a-selective adrenoceptor antagonists. | Journal of enzyme inhibition 20011001 |
1-(Arylpiperazinylamidoalkyl)-pyrimidones: orally active inhibitors of lipoprotein-associated phospholipase A(2). | Bioorganic & medicinal chemistry letters 20010723 |