1-Methyl-1H-purine-2,6(3H,7H)-dione
| Title | Journal |
|---|---|
| Effect of decursin on the pharmacokinetics of theophylline and its metabolites in rats. | Journal of ethnopharmacology 20121121 |
| Comparison of N-acetyltransferase-2 enzyme genotype-phenotype and xanthine oxidase enzyme activity between Swedes and Koreans. | Journal of clinical pharmacology 20121001 |
| Effect of decursinol angelate on the pharmacokinetics of theophylline and its metabolites in rats. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20121001 |
| The methyl xanthine caffeine inhibits DNA damage signaling and reactive species and reduces atherosclerosis in ApoE(-/-) mice. | Arteriosclerosis, thrombosis, and vascular biology 20121001 |
| Microvascular blood flow responses to muscle contraction are not altered by high-fat feeding in rats. | Diabetes, obesity & metabolism 20120801 |
| The effects of xanthine oxidase inhibition by febuxostat on the pharmacokinetics of theophylline. | International journal of clinical pharmacology and therapeutics 20120501 |
| Regulation of muscle microcirculation in health and diabetes. | Diabetes & metabolism journal 20120401 |
| Development and validation of a sensitive LC-MS/MS method for the simultaneous quantitation of theophylline and its metabolites in rat plasma. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120315 |
| cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle. | American journal of physiology. Endocrinology and metabolism 20110801 |
| N-Acetyltransferase-2 (NAT2) gene polymorphisms and enzyme activity in Serbs: unprecedented high prevalence of rapid acetylators in a White population. | Journal of clinical pharmacology 20110701 |
| Disposition kinetics of caffeine and paraxanthine in Nile tilapia (Oreochromis niloticus): characterization of the main metabolites. | Archives of environmental contamination and toxicology 20110501 |
| Genistein alters caffeine exposure in healthy female volunteers. | European journal of clinical pharmacology 20110401 |
| Loss of insulin-mediated microvascular perfusion in skeletal muscle is associated with the development of insulin resistance. | Diabetes, obesity & metabolism 20100901 |
| Plant polyphenol curcumin significantly affects CYP1A2 and CYP2A6 activity in healthy, male Chinese volunteers. | The Annals of pharmacotherapy 20100601 |
| Is 1-methylxanthine an ideal model substrate for establishing the renal tubular transport of organic ions? | International journal of clinical pharmacology and therapeutics 20100201 |
| Demethylation of theophylline (1,3-dimethylxanthine) to 1-methylxanthine: the first step of an antioxidising cascade. | Redox report : communications in free radical research 20100101 |
| Simultaneous action of the flavonoid quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase and xanthine oxidase activity in healthy volunteers. | Clinical and experimental pharmacology & physiology 20090801 |
| Two distinct pathways for metabolism of theophylline and caffeine are coexpressed in Pseudomonas putida CBB5. | Journal of bacteriology 20090701 |
| Enhancement of radiotherapeutic effectiveness by temperature-sensitive liposomal 1-methylxanthine. | International journal of pharmaceutics 20090508 |
| Interleukin-6 attenuates insulin-mediated increases in endothelial cell signaling but augments skeletal muscle insulin action via differential effects on tumor necrosis factor-alpha expression. | Diabetes 20090501 |
| Caffeine metabolic ratios for the in vivo evaluation of CYP1A2, N-acetyltransferase 2, xanthine oxidase and CYP2A6 enzymatic activities. | Current drug metabolism 20090501 |
| Phenotyping of N-acetyltransferase type 2 and xanthine oxidase with caffeine: when should urine samples be collected? | European journal of clinical pharmacology 20090401 |
| 1-Methylxanthine enhances the radiosensitivity of tumor cells. | International journal of radiation biology 20090201 |
| Relaxing and contracting effects of theophylline's metabolites on the rabbit upper gastrointestinal tract. | Fundamental & clinical pharmacology 20081001 |
| Anti-inflammatory effect of theophylline in rats and its involvement of the glucocorticoid-glucocorticoid receptor system. | Journal of pharmacological sciences 20080401 |
| Point: There is capillary recruitment in active skeletal muscle during exercise. | Journal of applied physiology (Bethesda, Md. : 1985) 20080301 |
| [Recommended treatment of apnea in premature infants. A review based on literature and own experience]. | Medycyna wieku rozwojowego 20080101 |
| Inhibitory effects of caffeine and its metabolites on intracellular lipid accumulation in murine 3T3-L1 adipocytes. | BioFactors (Oxford, England) 20080101 |
| Theophylline and its metabolites produce a stimulating cholinergic effect on the small intestine and a nonadrenergic noncholinergic relaxing effect on the colon: a comparative study in the rabbit intestine. | Journal of veterinary pharmacology and therapeutics 20071201 |
| Reduction in non-glomerular renal clearance of the caffeine metabolite 1-methylxanthine by probenecid. | International journal of clinical pharmacology and therapeutics 20070801 |
| The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors. | Bioorganic & medicinal chemistry 20070515 |
| Acute effects of wortmannin on insulin's hemodynamic and metabolic actions in vivo. | American journal of physiology. Endocrinology and metabolism 20070301 |
| Concordance between the deduced acetylation status generated by high-speed: real-time PCR based NAT2 genotyping of seven single nucleotide polymorphisms and human NAT2 phenotypes determined by a caffeine assay. | Clinica chimica acta; international journal of clinical chemistry 20070201 |
| In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios. | Biomedical chromatography : BMC 20070201 |
| Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants. | Pediatric research 20061201 |
| Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls. | European journal of clinical pharmacology 20061201 |
| Caffeine metabolites are inhibitors of the nuclear enzyme poly(ADP-ribose)polymerase-1 at physiological concentrations. | Biochemical pharmacology 20060928 |
| Associations between CYP2E1 promoter polymorphisms and plasma 1,3-dimethyluric acid/theophylline ratios. | European journal of clinical pharmacology 20060801 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| [Determination of the activity of cytochrome P-450 CYP2A6 by HPLC method with caffeine as metabolizing probe]. | Yao xue xue bao = Acta pharmaceutica Sinica 20060301 |
| Kinetic analysis and modelling of the allosteric behaviour of liver and muscle glycogen phosphorylases. | Journal of molecular recognition : JMR 20060101 |
| Re-investigation of the concordance of human NAT2 phenotypes and genotypes. | Archives of toxicology 20050401 |
| Measurement of caffeine and five of the major metabolites in urine by high-performance liquid chromatography/tandem mass spectrometry. | Journal of mass spectrometry : JMS 20050301 |
| Capillary electrochromatography of caffeine and its metabolites in rat brain microdialysate. | Electrophoresis 20050201 |
| Exercise and insulin-mediated capillary recruitment in muscle. | Exercise and sport sciences reviews 20050101 |
| Local methacholine but not bradykinin potentiates insulin-mediated glucose uptake in muscle in vivo by augmenting capillary recruitment. | Diabetologia 20041201 |
| High-throughput liquid chromatography-tandem mass spectrometry assay for plasma theophylline and its metabolites. | Clinical chemistry 20041101 |
| Skeletal muscle contraction stimulates capillary recruitment and glucose uptake in insulin-resistant obese Zucker rats. | American journal of physiology. Endocrinology and metabolism 20041001 |
| Separation, pre-concentration, and HPLC analysis of methylxanthines in urine samples. | Journal of separation science 20041001 |
| Inhibition of the human organic anion transporter 1 by the caffeine metabolite 1-methylxanthine. | Biochemical and biophysical research communications 20040716 |
| Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure. | European journal of clinical pharmacology 20040301 |
| Insulin sensitivity of muscle capillary recruitment in vivo. | Diabetes 20040201 |
| Cytochrome P450 1A2 (CYP1A2) activity, mammographic density, and oxidative stress: a cross-sectional study. | Breast cancer research : BCR 20040101 |
| Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study. | Breast cancer research : BCR 20040101 |
| Acetylator phenotyping in patients with malignant lymphomas, using caffeine as the metabolic probe. | Polish journal of pharmacology 20040101 |
| T-1032, a cyclic GMP phosphodiesterase-5 inhibitor, acutely blocks physiologic insulin-mediated muscle haemodynamic effects and glucose uptake in vivo. | British journal of pharmacology 20031201 |
| TNF-alpha acutely inhibits vascular effects of physiological but not high insulin or contraction. | American journal of physiology. Endocrinology and metabolism 20030901 |
| Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin. | American journal of physiology. Endocrinology and metabolism 20030701 |
| Preventive effect of zaprinast and 3-isobutyl, 1-methylxanthine (phosphodiesterase inhibitors) on gastric injury induced by nonsteroidal antiinflammatory drugs in rats. | Digestive diseases and sciences 20030501 |
| Nonnutritive flow impairs uptake of fatty acid by white muscles of the perfused rat hindlimb. | American journal of physiology. Endocrinology and metabolism 20030301 |
| Interaction of ibuprofen and probenecid with drug metabolizing enzyme phenotyping procedures using caffeine as the probe drug. | British journal of clinical pharmacology 20030201 |
| Pharmacokinetics of intravenous theophylline in mutant Nagase analbuminemic rats. | Life sciences 20030131 |
| Insulin-mediated hemodynamic changes are impaired in muscle of Zucker obese rats. | Diabetes 20021201 |
| Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous theophylline in rats: the role of CYP2E1 induction in 1,3-dimethyluric acid formation. | The Journal of pharmacy and pharmacology 20021201 |
| Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction. | Clinical pharmacology and therapeutics 20020801 |
| Differences in caffeine and paraxanthine metabolism between human and murine CYP1A2. | Biochemical pharmacology 20020615 |
| Lipid infusion impairs physiologic insulin-mediated capillary recruitment and muscle glucose uptake in vivo. | Diabetes 20020401 |
| Autocrine and paracrine regulation of lymphocyte CB2 receptor expression by TGF-beta. | Biochemical and biophysical research communications 20020111 |
| Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow. | Diabetes 20020101 |
| Group I aptazymes as genetic regulatory switches. | BMC biotechnology 20020101 |
| Structural basis for the binding affinity of xanthines with the DNA intercalator acridine orange. | Journal of medicinal chemistry 20011220 |
| Exercise training improves insulin-mediated capillary recruitment in association with glucose uptake in rat hindlimb. | Diabetes 20011201 |
| Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment. | Diabetes 20011201 |
| Urinary biomarkers for assessing dietary exposure to caffeine. | Food additives and contaminants 20011201 |
| Use of novel solid-phase extraction sorbent materials for high-performance liquid chromatography quantitation of caffeine metabolism products methylxanthines and methyluric acids in samples of biological origin. | Journal of chromatography. B, Biomedical sciences and applications 20010815 |
| The effect of pregnancy on cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activities in humans. | Clinical pharmacology and therapeutics 20010801 |
| Validity of an ELISA for N-acetyltransferase-2 (NAT2) phenotyping. | Journal of immunological methods 20010501 |
| Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline. | Xenobiotica; the fate of foreign compounds in biological systems 20010301 |
| Determination of urinary methylated purine pattern by high-performance liquid chromatography. | Journal of chromatography. B, Biomedical sciences and applications 20010210 |
| Caffeine metabolism before and after liver transplantation. | International journal of clinical pharmacology and therapeutics 20010201 |
| Caffeine metabolism in a group of 67 patients with primary biliary cirrhosis. | International journal of clinical pharmacology and therapeutics 20010101 |
| Xanthine oxidase activity and blood glutathione redox ratio in infants and children with septic shock syndrome. | Intensive care medicine 20010101 |
| [The acetylator polymorphism in a Khmer population: clinical consequences]. | Therapie 20010101 |
| Neurotoxic convulsions induced by theophylline and its metabolites in mice. | Biological & pharmaceutical bulletin 19960601 |
| Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii. | Biochemical pharmacology 19951109 |
| Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists. | Journal of medicinal chemistry 19940513 |
| Enhancement of acute myocardial lesions by asthma drugs in rats. | Toxicologic pathology 19940101 |
| Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors. | Journal of medicinal chemistry 19931029 |