Piperidin-1-amine
| Title | Journal |
|---|---|
| Linagliptin: a novel methylxanthin based approved dipeptidyl peptidase-4 inhibitor. | Current drug targets 20120601 |
| Reactivity ratios and sequence structures of the copolymers prepared using photo-induced copolymerization of MMA with MTMP. | Magnetic resonance in chemistry : MRC 20120501 |
| 3-aminopiperidine-based peptide analogues as the first selective noncovalent inhibitors of the bacterial cysteine protease IdeS. | Journal of medicinal chemistry 20120322 |
| 4-Piperidin-4-ylidenemethyl-benzamides as δ-opioid receptor agonists for CNS indications: identifying clinical candidates. | Bioorganic & medicinal chemistry letters 20120115 |
| 7,8-dichloro-1-oxo-β-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes. | Journal of medicinal chemistry 20120112 |
| Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H₁-antihistamines for insomnia. | Bioorganic & medicinal chemistry letters 20120101 |
| Structural insights from binding poses of CCR2 and CCR5 with clinically important antagonists: a combined in silico study. | PloS one 20120101 |
| Spiroindolines identify the vesicular acetylcholine transporter as a novel target for insecticide action. | PloS one 20120101 |
| A comprehensive review of the pharmacodynamics, pharmacokinetics, and clinical effects of the neutral endopeptidase inhibitor racecadotril. | Frontiers in pharmacology 20120101 |
| Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases. | Bioorganic & medicinal chemistry letters 20111215 |
| 4-N-Hydroxy-4-[1-(sulfonyl)piperidin-4-yl]-butyramides as HDAC inhibitors. | Bioorganic & medicinal chemistry letters 20111115 |
| Spectroscopic properties of neuroleptics: IR and Raman spectra of Risperidone (Risperdal) and of its mono- and di-protonated forms. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111015 |
| A novel biotransformation of alkyl aminopyrrolidine to aminopiperidine ring by human CYP3A. | Drug metabolism and disposition: the biological fate of chemicals 20110901 |
| Discovery of piperidinyl aminopyrimidine derivatives as IKK-2 inhibitors. | Bioorganic & medicinal chemistry letters 20110515 |
| Exhaustive sampling of docking poses reveals binding hypotheses for propafenone type inhibitors of P-glycoprotein. | PLoS computational biology 20110501 |
| The new pyridoindole antioxidant SMe1EC2 and its intervention in hypoxia/hypoglycemia-induced impairment of longterm potentiation in rat hippocampus. | Interdisciplinary toxicology 20110301 |
| Biarylmethoxy isonipecotanilides as potent and selective inhibitors of blood coagulation factor Xa. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110214 |
| Kinetic control of protonation in electrospray ionization. | Journal of the American Society for Mass Spectrometry 20110201 |
| Racemisation dynamics of torsion angle restricted biphenyl push-pull cyclophanes. | Organic & biomolecular chemistry 20110107 |
| Azido-iodo-N-benzyl derivatives of threo-methylphenidate (Ritalin, Concerta): Rational design, synthesis, pharmacological evaluation, and dopamine transporter photoaffinity labeling. | Bioorganic & medicinal chemistry 20110101 |
| Ropivacaine: A review of its pharmacology and clinical use. | Indian journal of anaesthesia 20110101 |
| Microarray profiling reveals the integrated stress response is activated by halofuginone in mammary epithelial cells. | BMC research notes 20110101 |
| The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors. | PloS one 20110101 |
| A Guided Tour of the Structural Biology of Gaucher Disease: Acid-β-Glucosidase and Saposin C. | Enzyme research 20110101 |
| Structural requirements of N-substituted spiropiperidine analogues as agonists of nociceptin/orphanin FQ receptor. | International journal of molecular sciences 20110101 |
| N-H activation of hydrazines by iridium(I). Double N-H activation to form iridium aminonitrene complexes. | Journal of the American Chemical Society 20100825 |
| Synthesis and pharmacological activity of potential cocaine antagonists. 2. Structure-activity relationship studies of piperidine ring-substituted methylphenidate analogs. | Medicinal chemistry (Shariqah (United Arab Emirates)) 20100701 |
| Inhibition of ergosterol synthesis by novel antifungal compounds targeting C-14 reductase. | Medical mycology 20100601 |
| Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. | Bioorganic & medicinal chemistry letters 20100201 |
| Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase. | The Journal of biological chemistry 20100122 |
| In vitro and in vivo antifungal activities of aminopiperidine derivatives, novel ergosterol synthesis inhibitors. | Biological & pharmaceutical bulletin 20100101 |
| Synthesis of a novel analogue of DPP-4 inhibitor Alogliptin: Introduction of a spirocyclic moiety on the piperidine ring. | Beilstein journal of organic chemistry 20100101 |
| Inhibition requirements of the human apical sodium-dependent bile acid transporter (hASBT) using aminopiperidine conjugates of glutamyl-bile acids. | Pharmaceutical research 20090701 |
| Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: inhibitors of factor Xa and platelet aggregation. | Journal of medicinal chemistry 20090226 |
| Mutagenic mapping suggests a novel binding mode for selective agonists of M1 muscarinic acetylcholine receptors. | Molecular pharmacology 20090201 |
| In vivo evaluation of substituted 3-amino-1,4-benzodiazepines as anti-depressant, anxiolytic and anti-nociceptive agents. | Arzneimittel-Forschung 20090101 |
| Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening. | PloS one 20090101 |
| Quantitative mass spectrometric analysis of ropivacaine and bupivacaine in authentic, pharmaceutical and spiked human plasma without chromatographic separation. | Analytical chemistry insights 20090101 |
| Recognition properties and competitive assays of a dual dopamine/serotonin selective molecularly imprinted polymer. | International journal of molecular sciences 20081201 |
| Pharmacokinetic and pharmacogenetic determinants of the activity and toxicity of irinotecan in metastatic colorectal cancer patients. | British journal of cancer 20081021 |
| Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas--the effect of capping the distal basic piperidine nitrogen. | Bioorganic & medicinal chemistry letters 20081015 |
| Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer. | Journal of medicinal chemistry 20080724 |
| Facile synthesis, ex-vivo and in vitro screening of 3-sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide (SR141716) a potent CB1 receptor antagonist. | Bioorganic & medicinal chemistry letters 20080715 |
| Diastereoselective synthesis of piperidine imino sugars using aldol additions of metalated bislactim ethers to threose and erythrose acetonides. | The Journal of organic chemistry 20080321 |
| Drug interaction prediction using ontology-driven hypothetical assertion framework for pathway generation followed by numerical simulation. | BMC bioinformatics 20080101 |
| Ruthenium complexes of substituted hydrazine: new solution- and solid-state binding modes. | Chemistry (Weinheim an der Bergstrasse, Germany) 20080101 |
| The exceptional hydrogen-bond properties of neutral and protonated lobeline. | The journal of physical chemistry. A 20070719 |
| Discovery of new C3aR ligands. Part 2: amino-piperidine derivatives. | Bioorganic & medicinal chemistry letters 20070615 |
| 1,3-disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors. | Bioorganic & medicinal chemistry letters 20070601 |
| Design, synthesis and cytotoxic properties of novel 1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones and related compounds. | European journal of medicinal chemistry 20070101 |
| Fluorous and traceless synthesis of substituted indole alkaloids. | Journal of combinatorial chemistry 20070101 |
| Unusual retention behaviour of 4-substituted piperidines on polybutadiene and polystyrene coated zirconia by comparison to reverse phase silica. | Journal of chromatography. A 20061222 |
| 2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists: synthesis and selectivity. | Bioorganic & medicinal chemistry letters 20061101 |
| Site-specific acid-base properties of pholcodine and related compounds. | Analytical and bioanalytical chemistry 20061101 |
| Biarylpyrazole inverse agonists at the cannabinoid CB1 receptor: importance of the C-3 carboxamide oxygen/lysine3.28(192) interaction. | Journal of medicinal chemistry 20061005 |
| Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability. | Bioorganic & medicinal chemistry letters 20060815 |
| Synthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists. | Bioorganic & medicinal chemistry letters 20060715 |
| Privileged structure based ligands for melanocortin receptors--4,4-disubstituted piperidine derivatives. | Bioorganic & medicinal chemistry letters 20060715 |
| 3-(4-Piperidinyl)indoles and 3-(4-piperidinyl)pyrrolo-[2,3-b]pyridines as ligands for the ORL-1 receptor. | Bioorganic & medicinal chemistry letters 20060701 |
| Preparation of 3-spirocyclic indolin-2-ones as ligands for the ORL-1 receptor. | Bioorganic & medicinal chemistry letters 20051115 |
| Synthesis, structures, and DFT bonding analysis of new titanium hydrazido(2-) complexes. | Inorganic chemistry 20051114 |
| N-substituted piperidinyl alkyl imidazoles: discovery of methimepip as a potent and selective histamine H3 receptor agonist. | Journal of medicinal chemistry 20050324 |
| [Dependence of rifabutin properties and liposome entrapment on pH of the medium]. | Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20050101 |
| Identification and synthesis of norhydromorphone, and determination of antinociceptive activities in the rat formalin test. | Life sciences 20041112 |
| Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040601 |
| Characterization and metal affinity of Tirofiban, a pharmaceutical compound used in acute coronary syndromes. | Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20040401 |
| Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. | Bioorganic & medicinal chemistry letters 20040223 |
| trans-3,4-dimethyl-4-(3-carboxamidophenyl)piperidines: a novel class of micro-selective opioid antagonists. | Bioorganic & medicinal chemistry letters 20031215 |
| Enantiocontrolled synthesis of 2,6-disubstituted piperidines by desymmetrization of meso-eta-(3,4,5)-dihydropyridinylmolybdenum complexes. application to the total synthesis of (-)-dihydropinidine and (-)-andrachcinidine. | Journal of the American Chemical Society 20030312 |
| Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists. | Journal of medicinal chemistry 20030116 |
| Benzimidazole derivatives. 3. 3D-QSAR/CoMFA model and computational simulation for the recognition of 5-HT(4) receptor antagonists. | Journal of medicinal chemistry 20021024 |
| Novel piperidinyloxy oxazolidinone antibacterial agents. Diversification of the N-Substituent. | Bioorganic & medicinal chemistry 20020701 |
| Synthesis and structure-activity relationships of amide and hydrazide analogues of the cannabinoid CB(1) receptor antagonist N-(piperidinyl)- 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716). | Journal of medicinal chemistry 20020620 |
| Tandem mass spectrum of a growth hormone secretagogue: amide bond cleavage and resultant gas-phase rearrangement. | Journal of the American Society for Mass Spectrometry 20020401 |
| Structure-function relationships of the raloxifene-estrogen receptor-alpha complex for regulating transforming growth factor-alpha expression in breast cancer cells. | The Journal of biological chemistry 20020315 |
| Structure activity relationships of new inhibitors of mammalian 2,3-oxidosqualene cyclase designed from isoquinoline derivatives. | Chemical & pharmaceutical bulletin 20020301 |
| Synthesis of cyclic prodrugs of Aggrastat and its analogue with a modified phenylpropionic acid linker. | Organic letters 20020221 |
| Novel spiropiperidines as highly potent and subtype selective sigma-receptor ligands. Part 1. | Journal of medicinal chemistry 20020117 |
| Computational model of the complex between GR113808 and the 5-HT4 receptor guided by site-directed mutagenesis and the crystal structure of rhodopsin. | Journal of computer-aided molecular design 20011101 |
| Opioid peptide receptor studies. 15. Relative efficacy of 4-[(N-allyl-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide and related compounds at the cloned human delta-opioid receptor. | Synapse (New York, N.Y.) 20010615 |
| Design, synthesis, and discovery of a novel CCR1 antagonist. | Journal of medicinal chemistry 20010426 |
| A conformational and structure-activity relationship study of cytotoxic 3,5-bis(arylidene)-4-piperidones and related N-acryloyl analogues. | Journal of medicinal chemistry 20010215 |
| Opioid peptide receptor studies. 14. Stereochemistry determines agonist efficacy and intrinsic efficacy in the [(35)S]GTP-gamma-S functional binding assay. | Synapse (New York, N.Y.) 20010101 |