Home Aminos 1,2-Diaminocyclohexane

1,2-Diaminocyclohexane

CAS No.:
694-83-7
Catalog Number:
AG003DDE
Molecular Formula:
C6H14N2
Molecular Weight:
114.1888
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5g
95%
In Stock USA
United States
$13
- +
25g
95%
In Stock USA
United States
$25
- +
100g
95%
In Stock USA
United States
$63
- +
500g
95%
In Stock USA
United States
$172
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Product Description
Catalog Number:
AG003DDE
Chemical Name:
1,2-Diaminocyclohexane
CAS Number:
694-83-7
Molecular Formula:
C6H14N2
Molecular Weight:
114.1888
MDL Number:
MFCD00001491
IUPAC Name:
cyclohexane-1,2-diamine
InChI:
InChI=1S/C6H14N2/c7-5-3-1-2-4-6(5)8/h5-6H,1-4,7-8H2
InChI Key:
SSJXIUAHEKJCMH-UHFFFAOYSA-N
SMILES:
NC1CCCCC1N
EC Number:
211-776-7
UN Number:
2735
Properties
Complexity:
62.9  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
114.116g/mol
Formal Charge:
0
Heavy Atom Count:
8  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
114.192g/mol
Monoisotopic Mass:
114.116g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
52A^2
Undefined Atom Stereocenter Count:
2  
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.3  
Literature
Title Journal
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Kinetic resolution of esters via metal catalyzed methanolysis reactions. Organic & biomolecular chemistry 20080807
Two-dimensional hybrid germanium zeotype formed by selective coordination of the trans-1,2-diaminocyclohexane isomer to the ge atom: heterogeneous acid-base bifunctional catalyst. Inorganic chemistry 20080804
Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics. Bioorganic & medicinal chemistry 20080801
(E,E)-N,N'-Bis-(4-methoxy-benzyl-idene)cyclo-hexane-1,2-diamine. Acta crystallographica. Section E, Structure reports online 20080801
{4,4',6,6'-Tetra-chloro-2,2'-[(spiro-[4.4]nonane-1,6-di-yl)bis-(nitrilo-methyl-idyne)]diphenolato-κO,N,N',O'}nickel(II). Acta crystallographica. Section E, Structure reports online 20080701
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Bis[N,N'-bis-[(1H-pyrrol-2-yl)methyl-ene]cyclo-hexane-1,2-diamine]titanium(IV) tetra-hydro-furan solvate. Acta crystallographica. Section E, Structure reports online 20080201
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trans-Cyclohexane-1,2-diamine is a weak director of absolute helicity in chiral nickel-salen complexes. Journal of the American Chemical Society 20070926
Optimization of (1,2-diamino-cyclohexane)platinum(II)-loaded polymeric micelles directed to improved tumor targeting and enhanced antitumor activity. Journal of controlled release : official journal of the Controlled Release Society 20070828
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Enantioselective fluorescent recognition of chiral acids by cyclohexane-1,2-diamine-based bisbinaphthyl molecules. The Journal of organic chemistry 20070622
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A glucose derivative as natural alternative to the cyclohexane-1,2-diamine ligand in the anticancer drug oxaliplatin? ChemMedChem 20070401
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Anticancer activity of a series of platinum complexes integrating demethylcantharidin with isomers of 1,2-diaminocyclohexane. Bioorganic & medicinal chemistry letters 20060315
Angular variation of linewidths in single-crystal EPR spectra. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20060313
Trianglamines--readily prepared, conformationally flexible inclusion-forming chiral hexamines. Chemistry (Weinheim an der Bergstrasse, Germany) 20060208
Determination of different classes of amines with capillary zone electrophoresis and contactless conductivity detection. Electrophoresis 20060201
Lanthanide complexes of chiral 3 + 3 macrocycles derived from (1R,2R)-1,2-diaminocyclohexane and 2,6-diformyl-4-methylphenol. Dalton transactions (Cambridge, England : 2003) 20060114
Synthesis, structure, and magnetic behavior of a series of trinuclear Schiff base complexes of 5f (UIV, ThIV) and 3d (CuII, ZnII) ions. Inorganic chemistry 20060109
Studies on the synthesis, characterization, binding with DNA and activities of two cis-planaramineplatinum(II) complexes of the form: cis-PtL(NH3)Cl2 where L = 3-hydroxypyridine and 2,3-diaminopyridine. BMC chemical biology 20060101
Chiral trimethylsilylated C2-symmetrical diamines as phosphorous derivatizing agents for the determination of the enantiomeric excess of chiral alcohols by 1H NMR. Beilstein journal of organic chemistry 20060101
Management of oxaliplatin-induced peripheral neuropathy. Therapeutics and clinical risk management 20051201
Rhombimines-cyclic tetraimines of trans-1,2-diaminocyclohexane shaped by the diaryl ether structural motif. The Journal of organic chemistry 20051125
Marked dependence on carrier-ligand bulk but not on carrier-ligand chirality of the duplex versus single-strand forms of a DNA oligonucleotide with a series of G-Pt(II)-G intrastrand cross-links modeling cisplatin-DNA adducts. Journal of the American Chemical Society 20051116
New 2+2, 3+3 and 4+4 macrocycles derived from 1,2-diaminocyclohexane and 2,6-diformylpyridine. Organic & biomolecular chemistry 20050907
Enantioselective analysis of an asymmetric reaction using a chiral fluorosensor. Organic letters 20050901
Syntheses and ligand interconversions of copper(II) derivatives of the metalloligand [Pt2(mu-S)2(PPh3)4]. Dalton transactions (Cambridge, England : 2003) 20050821
Colorimetric enantiodiscrimination of alpha-amino acids in protic media. Journal of the American Chemical Society 20050608
Exciton chirality in trans-1,2-diamidocyclohexanes: fluorescent chromophores. Chirality 20050601
Large molecular motions are tolerated in crystals of diamine double salt of trans-chlorocinnamic acids with trans-1,2-diaminocyclohexane. Organic letters 20050512
A phase II study of biweekly oxaliplatin plus infusional 5-fluorouracil and folinic acid (FOLFOX-4) as first-line treatment of advanced gastric cancer patients. British journal of cancer 20050509
Chemistry of ruthenium(II) monohydride and dihydride complexes containing pyridyl donor ligands including catalytic ketone H2-hydrogenation. Inorganic chemistry 20050404
Identification of genes associated with platinum drug sensitivity and resistance in human ovarian cancer cells. British journal of cancer 20050328
Shape-complementarity in the recognition of tricarboxylic acids by a [3+3] polyazacyclophane receptor. The Journal of organic chemistry 20050318
A cyclohexyl-1,2-diamine-derived bis(binaphthyl) macrocycle: enhanced sensitivity and enantioselectivity in the fluorescent recognition of mandelic acid. Angewandte Chemie (International ed. in English) 20050304
Oxaliplatin activity in head and neck cancer cell lines. Cancer chemotherapy and pharmacology 20050301
Chromatographic evaluation of poly (trans-1,2-cyclohexanediyl-bis acrylamide) as a chiral stationary phase for HPLC. Journal of chromatography. A 20050225
A systematic study of the interactions between chemical partners (metal, ligands, counterions, and support) involved in the design of Al2O3-supported nickel catalysts from diamine-Ni(II) chelates. The journal of physical chemistry. B 20050224
New hybrid polymeric liquid chromatography chiral stationary phase prepared by surface-initiated polymerization. Journal of chromatography. A 20050128
Preparation and biological properties of dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt)-loaded polymeric micelles. Journal of controlled release : official journal of the Controlled Release Society 20050103
Synthesis, structure, and contrasting chiroptical properties of large trianglimine macrocycles. Chirality 20050101
A Phase II study of oxaliplatin in urothelial cancer. Urologic oncology 20050101
Survey of oxaliplatin-associated neurotoxicity using an interview-based questionnaire in patients with metastatic colorectal cancer. BMC cancer 20050101
Synthesis and in vitro antitumor potency of (cyclohexane-1,2-diamine)platinum(II) complexes with aminotris(methylenephosphonic acid) as bone-seeking ligand. Bioinorganic chemistry and applications 20050101
A novel approach to biodegradable block copolymers of epsilon-caprolactone and delta-valerolactone catalyzed by new aluminum metal complexes. Macromolecular bioscience 20041215
Chemoenzymatic preparation of optically active trans-cyclohexane-1,2-diamine derivatives: an efficient synthesis of the analgesic U-(-)-50,488. Chemistry (Weinheim an der Bergstrasse, Germany) 20041105
Synthesis, crystal structure and cytotoxicity of new oxaliplatin analogues indicating that improvement of anticancer activity is still possible. European journal of medicinal chemistry 20040801
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Influence of trans-1,2-diaminocyclohexane structure and mixed carboxylic/phosphonic group combinations on samarium-153 chelation capacity and stability. European journal of medicinal chemistry 20040501
5H-oxazol-4-ones as building blocks for asymmetric synthesis of alpha-hydroxycarboxylic acid derivatives. Journal of the American Chemical Society 20040225
Planar chiral dianthranilide and dithiodianthranilide molecules: optical resolution, chiroptical spectra, and molecular self-assembly. The Journal of organic chemistry 20040220
Parallel screening of homogeneous copper catalysts for the oxidation of benzylic alcohols with molecular oxygen in aqueous solutions. Journal of combinatorial chemistry 20040101
X-ray structure and circular dichroism of pure rotamers of bis[guanosine-5'-monophosphate(-1)](N,N,N',N'-tetramethylcyclohexyl-1,2-diamine)platinum(II) complexes that have R,R and S,S configurations at the asymmetric diamine. Chemistry (Weinheim an der Bergstrasse, Germany) 20031215
Structure, modelling and dynamic behaviour of aza- and azaoxamacrocyclic ligands derived from (R,R)-1,2-diaminocyclohexane. Organic & biomolecular chemistry 20031121
Synthesis, characterization, and in vitro antitumor activity of osteotropic diam(m)ineplatinum(II) complexes bearing a N,N-bis(phosphonomethyl)glycine ligand. Journal of medicinal chemistry 20031106
Dynamic kinetic asymmetric cycloadditions of isocyanates to vinylaziridines. Journal of the American Chemical Society 20031001
Platinum-based anticancer agents: innovative design strategies and biological perspectives. Medicinal research reviews 20030901
Synthesis of amylose acetates and amylose sulfates with high structural uniformity. Carbohydrate research 20030623
A metal-centered hydrophobic pocket recognizing pyridine over piperidine. Journal of the American Chemical Society 20030618
Nitrogen lone pair interactions in organic molecules: a photoelectron spectroscopic study. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20030601
Ion-pair extraction behavior of divalent metal cations using neutral di-Schiff base ligands derived from 1,2-cyclohexanediamine and o-phenylenediamine. Talanta 20030410
Shape-controlled bridged silsesquioxanes: hollow tubes and spheres. Chemistry (Weinheim an der Bergstrasse, Germany) 20030404
Synthesis of 1,4-diazines by ring expansion of 1,3-diazines. The Journal of organic chemistry 20030321
Tumour-inhibiting platinum complexes--state of the art and future perspectives. Reviews of physiology, biochemistry and pharmacology 20030101
Synthesis, characterization and preliminary cytotoxicity assays of poly(ethylene glycol)-malonato-Pt-DACH conjugates. European journal of medicinal chemistry 20030101
Well-defined enantiopure 1,1'-binaphthyl-based oligomers: synthesis, structure, photophysical properties, and chiral sensing. The Journal of organic chemistry 20021101
The unusual role of CO transfer in molybdenum-catalyzed asymmetric alkylations. Journal of the American Chemical Society 20021030
The copper-catalyzed N-arylation of indoles. Journal of the American Chemical Society 20021002
Remarkable stability and enhanced optical activity of a chiral supramolecular bis-porphyrin tweezer in both solution and solid state. Journal of the American Chemical Society 20020925
A practical catalytic asymmetric addition of alkyl groups to ketones. Journal of the American Chemical Society 20020918
Ferromagnetism and chirality in two-dimensional cyanide-bridged bimetallic compounds. Inorganic chemistry 20020909
Total synthesis of the antiviral glycolipid cycloviracin B. Journal of the American Chemical Society 20020904
Chiral N-alkyl-2,4,6-triphenylpyridiniums as enantioselective triplet photosensitizers. laser flash photolysis and preparative studies. The Journal of organic chemistry 20020726
Preparation and self-assembly of chiral porphyrin diads on the gold electrodes of quartz crystal microbalances: a novel potential approach to the development of enantioselective chemical sensors. Chemistry (Weinheim an der Bergstrasse, Germany) 20020603
Preparation and cell growth inhibitory activity of [PtR(2)L(2)] (R=polyfluorophenyl, L(2)=diene, cyclohexane-1,2-diamine (chxn) or cis-(dimethyl sulfoxide)(2)) and the X-ray crystal structure of [Pt(C(6)F(5))(2)(cis-chxn)]. Journal of inorganic biochemistry 20020428
The influence of plasma proteins and platelets on oxygen radical production and F-actin distribution in neutrophils adhering to polymer surfaces. Biomaterials 20020401
Folding of aromatic oligoimides of trans-1,2-diaminocyclohexane. Chemical communications (Cambridge, England) 20020321
Identification of novel Ah receptor agonists using a high-throughput green fluorescent protein-based recombinant cell bioassay. Biochemistry 20020122
Application of capillary electrophoresis-mass spectrometry for the investigation of the binding behavior of oxaliplatin to 5'-GMP in the presence of the sulfur-containing amino acid L-methionine. Electrophoresis 20020101
An approach to a chiral cycloalkanone-mediated asymmetric epoxidation of stilbene with oxone. Chemical & pharmaceutical bulletin 20011201
Irinotecan plus oxaliplatin: a promising combination for advanced colorectal cancer. Clinical colorectal cancer 20011101
Occupational contact sensitization to 1,2-diaminocyclohexane. Contact dermatitis 20010801
[Oxaliplatin tolerance in the treatment of metastatic colorectal cancers]. Bulletin du cancer 20010801
Geminal dicarboxylates as carbonyl surrogates for asymmetric synthesis. Part I. Asymmetric addition of malonate nucleophiles. Journal of the American Chemical Society 20010425
Ketalization of gaseous acylium ions. Journal of the American Society for Mass Spectrometry 20010201
The in vitro antitumour profile of some 1,2-diaminocyclohexane organotin complexes. Journal of inorganic biochemistry 20010115
[Oxaliplatin: preclinical in vitro studies]. Tumori 20010101
Potent and use-dependent block of cardiac sodium channels by U-50,488H, a benzeneacetamide kappa opioid receptor agonist. Experimental and clinical cardiology 20010101
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