Home Other Building Blocks Difenidol, HCl

Difenidol, HCl

CAS No.:
3254-89-5
Catalog Number:
AG003D8Z
Molecular Formula:
C21H28ClNO
Molecular Weight:
345.9061
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
10g
≥98%
1 week
United States
$105
- +
25g
≥98%
1 week
United States
$160
- +
50g
≥98%
1 week
United States
$239
- +
100g
≥98%
1 week
United States
$373
- +
Product Description
Catalog Number:
AG003D8Z
Chemical Name:
Difenidol, HCl
CAS Number:
3254-89-5
Molecular Formula:
C21H28ClNO
Molecular Weight:
345.9061
MDL Number:
MFCD00151479
IUPAC Name:
1,1-diphenyl-4-piperidin-1-ylbutan-1-ol;hydrochloride
InChI:
InChI=1S/C21H27NO.ClH/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22;/h1-2,4-7,11-14,23H,3,8-10,15-18H2;1H
InChI Key:
AVZIYZHXZAYGJS-UHFFFAOYSA-N
SMILES:
OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1.Cl
EC Number:
221-850-0
UNII:
DG355XWQ4T
NSC Number:
23012
Properties
Complexity:
307  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
345.186g/mol
Formal Charge:
0
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
345.911g/mol
Monoisotopic Mass:
345.186g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
23.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Blockade of voltage-gated calcium channel Cav1.2 and α1-adrenoceptors increases vertebral artery blood flow induced by the antivertigo agent difenidol. European journal of pharmacology 20120815
Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol. Pharmacological reports : PR 20120101
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology 20100601
Generation of gold nanostructures at the surface of platinum electrode by electrodeposition for ECL detection for CE. Electrophoresis 20100301
Ultra-fast chromatographic micro-assay for quantification of diphenidol in plasma: application in an oral multi-dose switchability trial. Biomedical chromatography : BMC 20081001
Diphenidol-related diamines as novel muscarinic M4 receptor antagonists. Bioorganic & medicinal chemistry letters 20080501
Effects of endolymphatic sac drainage with steroids for intractable Meniere's disease: a long-term follow-up and randomized controlled study. The Laryngoscope 20080501
Synthesis and pharmacological profile of a series of 1-substituted-2-carbonyl derivatives of Diphenidol: novel M4 muscarinic receptor antagonists. Medicinal chemistry (Shariqah (United Arab Emirates)) 20080301
Enzymatic preparation of cefaclor with immobilized penicillin acylase. Preparative biochemistry & biotechnology 20080101
Capillary electrophoresis with end-column electrochemiluminescence for the analysis of chloroquine phosphate and the study on its interaction with human serum albumin. Journal of chromatography. A 20070622
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Determination of difenidol hydrochloride by capillary electrophoresis with electrochemiluminescence detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060202
Development of an HPLC method for determination of diphenidol in plasma and its application in an oral multi-dose bioequivalence study in a healthy female Mexican population. Journal of pharmaceutical and biomedical analysis 20050715
Diphenidol has no actual broad antiemetic activity in dogs and ferrets. Journal of pharmacological sciences 20041101
Synthesis and antagonistic activity at muscarinic receptor subtypes of some derivatives of diphenidol. Farmaco (Societa chimica italiana : 1989) 20030901
Properties