Home Other Building Blocks Terazosin hydrochloride dihydrate

Terazosin hydrochloride dihydrate

CAS No.:
70024-40-7
Catalog Number:
AG003CY2
Molecular Formula:
C19H30ClN5O6
Molecular Weight:
459.9244
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
25mg
98%
In Stock USA
United States
$69
- +
100mg
98%
In Stock USA
United States
$119
- +
1g
98%
In Stock USA
United States
$779
- +
Product Description
Catalog Number:
AG003CY2
Chemical Name:
Terazosin hydrochloride dihydrate
CAS Number:
70024-40-7
Molecular Formula:
C19H30ClN5O6
Molecular Weight:
459.9244
MDL Number:
MFCD00941408
IUPAC Name:
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone;dihydrate;hydrochloride
InChI:
InChI=1S/C19H25N5O4.ClH.2H2O/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;;;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H;2*1H2
InChI Key:
NZMOFYDMGFQZLS-UHFFFAOYSA-N
SMILES:
COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)C1CCCO1.Cl.O.O
Properties
Complexity:
544  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
4  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
459.188g/mol
Formal Charge:
0
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
459.928g/mol
Monoisotopic Mass:
459.188g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
105A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
Literature
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Hypertension in L-NAME-treated diabetic rats depends on an intact sympathetic nervous system. American journal of physiology. Regulatory, integrative and comparative physiology 20020401
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Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole alpha1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia. Journal of medicinal chemistry 20010607
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Initiation of nonselective alpha1-antagonist therapy and occurrence of hypotension-related adverse events among men with benign prostatic hyperplasia: a retrospective cohort study. Clinical therapeutics 20010501
The short-term effects of terazosin in Japanese men with benign prostatic hyperplasia. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 20010401
Overstimulation of the alpha1B-adrenergic receptor causes a 'seizure plus' syndrome. Nature medicine 20010201
Magnetic resonance imaging and morphometric histologic analysis of prostate tissue composition in predicting the clinical outcome of terazosin therapy in benign prostatic hyperplasia. International journal of urology : official journal of the Japanese Urological Association 20010201
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alpha-Blockade improves symptoms suggestive of bladder outlet obstruction but fails to relieve it. The Journal of urology 20010101
Targeted transurethral microwave thermotherapy versus alpha-blockade in benign prostatic hyperplasia: outcomes at 18 months. Urology 20010101
Combined effect of terazosin and finasteride on apoptosis, cell proliferation, and transforming growth factor-beta expression in benign prostatic hyperplasia. The Prostate 20010101
A quantitative analysis of antagonism and inverse agonism at wild-type and constitutively active hamster alpha1B-adrenoceptors. Naunyn-Schmiedeberg's archives of pharmacology 20010101
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Effect of terazosin on the lipid profile in patients with symptomatic benign prostatic hyperplasia. Urologia internationalis 20010101
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Use of terazosine in patients with chronic pelvic pain syndrome and evaluation by prostatitis symptom score index. International urology and nephrology 20010101
High-performance liquid chromatographic analysis and pharmacokinetics of terazosin in healthy volunteers. Research communications in molecular pathology and pharmacology 20010101
Suppression of human prostate cancer cell growth by alpha1-adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis. Cancer research 20000815
Alpha 1-adrenoceptor antagonists terazosin and doxazosin induce prostate apoptosis without affecting cell proliferation in patients with benign prostatic hyperplasia. The Journal of urology 19990601
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The efficacy and safety of terazosin for the treatment of symptomatic BPH. The Prostate 19910101
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