NS-1619
| Title | Journal |
|---|---|
| Mitochondrial Channel Opener Diazoxide Attenuates Hypoxia-Induced sFlt-1 Release in Human Choriocarcinoma Cells. | Journal of menopausal medicine 20140401 |
| Role of ROS/RhoA/PI3K/PKB signaling in NS1619-mediated blood-tumor barrier permeability increase. | Journal of molecular neuroscience : MN 20120901 |
| Mitochondrial K+ channels are involved in ischemic postconditioning in rat hearts. | The journal of physiological sciences : JPS 20120701 |
| Impairment of neurovascular coupling in type 1 diabetes mellitus in rats is linked to PKC modulation of BK(Ca) and Kir channels. | American journal of physiology. Heart and circulatory physiology 20120315 |
| Mineralocorticoids participate in the reduced vascular reactivity of pregnant rats. | American journal of physiology. Heart and circulatory physiology 20120301 |
| The LRRC26 protein selectively alters the efficacy of BK channel activators. | Molecular pharmacology 20120101 |
| Microglial Ca(2+)-activated K(+) channels are possible molecular targets for the analgesic effects of S-ketamine on neuropathic pain. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20111130 |
| Large conductance Ca2+ -activated K+ channel activation with NS1619 decreases myogenic and neurogenic contractions of rat detrusor smooth muscle. | European journal of pharmacology 20111116 |
| Closure of multiple types of K+ channels is necessary to induce changes in renal vascular resistance in vivo in rats. | Pflugers Archiv : European journal of physiology 20111101 |
| CRH acts on CRH-R1 and -R2 to differentially modulate the expression of large-conductance calcium-activated potassium channels in human pregnant myometrium. | Endocrinology 20111101 |
| Effects of potassium channel modulators on myogenic spontaneous phasic contractile activity in human detrusor from neurogenic patients. | BJU international 20110801 |
| Functional and molecular characterization of maxi K+ -channels (BK(Ca)) in buffalo myometrium. | Animal reproduction science 20110701 |
| Phasic activity of urinary bladder smooth muscle in the streptozotocin-induced diabetic rat: effect of potassium channel modulators. | European journal of pharmacology 20110625 |
| The mitochondrial Ca(2+)-activated K(+) channel contributes to cardioprotection by limb remote ischemic preconditioning in rat. | Life sciences 20110606 |
| High glucose alters apoptosis and proliferation in HEK293 cells by inhibition of cloned BK Ca channel. | Journal of cellular physiology 20110601 |
| Calcium-activated potassium channel activator down-regulated the expression of tight junction protein in brain tumor model in rats. | Neuroscience letters 20110415 |
| Participation of BKCa2+ and KATP potassium ion channels in the contractility of human term pregnant myometrium in in vitro conditions. | The journal of obstetrics and gynaecology research 20110301 |
| Mitochondrial BKCa channels contribute to protection of cardiomyocytes isolated from chronically hypoxic rats. | American journal of physiology. Heart and circulatory physiology 20110201 |
| Role of large-conductance Ca²+-activated K+ channels in adenosine A₁ receptor-mediated pharmacological postconditioning in H9c2 cells. | Canadian journal of physiology and pharmacology 20110101 |
| BMS-191011, an opener of large-conductance Ca2+-activated potassium channels, dilates rat retinal arterioles in vivo. | Biological & pharmaceutical bulletin 20110101 |
| Cytoprotective action of the potassium channel opener NS1619 under conditions of disrupted calcium homeostasis. | Pharmacological reports : PR 20110101 |
| N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors. | Bioorganic & medicinal chemistry letters 20101215 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Inhibition of trigeminovascular dural nociceptive afferents by Ca(2+)-activated K(+) (MaxiK/BK(Ca)) channel opening. | Pain 20101001 |
| Antecedent ethanol attenuates cerebral ischemia/reperfusion-induced leukocyte-endothelial adhesive interactions and delayed neuronal death: role of large conductance, Ca2+-activated K+ channels. | Microcirculation (New York, N.Y. : 1994) 20100801 |
| KCa channels as therapeutic targets in episodic ataxia type-2. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100526 |
| Experimental diabetes mellitus down-regulates large-conductance Ca2+-activated K+ channels in cerebral artery smooth muscle and alters functional conductance. | Current neurovascular research 20100501 |
| Mitochondrial matrix K+ flux independent of large-conductance Ca2+-activated K+ channel opening. | American journal of physiology. Cell physiology 20100301 |
| Arterial stiffness is regulated by nitric oxide and endothelium-derived hyperpolarizing factor during changes in blood flow in humans. | Hypertension (Dallas, Tex. : 1979) 20100301 |
| Expression of Ca2+ -activated K+ channels in human dermal fibroblasts and their roles in apoptosis. | Skin pharmacology and physiology 20100101 |
| Activation of endothelial BKCa channels causes pulmonary vasodilation. | Vascular pharmacology 20100101 |
| Large conductance calcium-activated potassium channels (BKCa) modulate trigeminovascular nociceptive transmission. | Cephalalgia : an international journal of headache 20091201 |
| Impaired function of coronary BK(Ca) channels in metabolic syndrome. | American journal of physiology. Heart and circulatory physiology 20091101 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model. | Cancer biology & therapy 20091001 |
| Mechanism of differential cardiovascular response to propofol in Dahl salt-sensitive, Brown Norway, and chromosome 13-substituted consomic rat strains: role of large conductance Ca2+ and voltage-activated potassium channels. | The Journal of pharmacology and experimental therapeutics 20090901 |
| Immediate neuronal preconditioning by NS1619. | Brain research 20090818 |
| Activation of the BK(Ca) channel increases outflow facility and decreases trabecular meshwork cell volume. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090801 |
| Plasticity and emerging role of BKCa channels in nociceptive control in neuropathic pain. | Journal of neurochemistry 20090701 |
| Novel oxime and oxime ether derivatives of 12,14-dichlorodehydroabietic acid: design, synthesis, and BK channel-opening activity. | Bioorganic & medicinal chemistry letters 20081215 |
| 1,2,3-Triazol-carboxanilides and 1,2,3-triazol-(N-benzyl)-carboxamides as BK-potassium channel activators. XII. | European journal of medicinal chemistry 20081101 |
| Restoration of calcium influx corrects membrane hyperexcitability in injured rat dorsal root ganglion neurons. | Anesthesia and analgesia 20080901 |
| Novel 1,4-benzothiazine derivatives as large conductance Ca2+-activated potassium channel openers. | Journal of medicinal chemistry 20080828 |
| BK channel openers inhibit ROS production of isolated rat brain mitochondria. | Experimental neurology 20080801 |
| Calcium-activated potassium channels contribute to human skeletal muscle microvascular endothelial dysfunction related to cardiopulmonary bypass. | Surgery 20080801 |
| New amido derivatives as potential BKCa potassium channel activators. XI. | European journal of medicinal chemistry 20080401 |
| The regulation of mitochondrial respiration by opening of mKCa channels is age-dependent. | European journal of pharmacology 20080114 |
| Mitochondrial big conductance KCa channel and cardioprotection in infant rabbit heart. | Journal of cardiovascular pharmacology 20071101 |
| The role of potassium ion channels in cough and other reflexes of the airways. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20071101 |
| The mitochondrial Ca2+-activated K+ channel activator, NS 1619 inhibits L-type Ca2+ channels in rat ventricular myocytes. | Biochemical and biophysical research communications 20071012 |
| Reverse electron flow-induced ROS production is attenuated by activation of mitochondrial Ca2+-sensitive K+ channels. | American journal of physiology. Heart and circulatory physiology 20070901 |
| Stimulation of Ca2+-gated Cl- currents by the calcium-dependent K+ channel modulators NS1619 [1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one] and isopimaric acid. | The Journal of pharmacology and experimental therapeutics 20070601 |
| Carbon monoxide-releasing molecules modulate leukocyte-endothelial interactions under flow. | The Journal of pharmacology and experimental therapeutics 20070501 |
| Functional contribution of the endothelial component to the vasorelaxing effect of resveratrol and NS 1619, activators of the large-conductance calcium-activated potassium channels. | Naunyn-Schmiedeberg's archives of pharmacology 20070301 |
| Pharmacological and physiological stimuli do not promote Ca(2+)-sensitive K+ channel activity in isolated heart mitochondria. | Cardiovascular research 20070301 |
| 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR. | Journal of medicinal chemistry 20070208 |
| The mitochondrial K(ATP) channel opener BMS-191095 reduces neuronal damage after transient focal cerebral ischemia in rats. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20070201 |
| [Effect of activation of mitochondrial ATP sensitive potassium channel and calcium activated potassium channel on the permeability transition of mitochondria from both normal and ischemic rat brain]. | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070201 |
| Renovascular BK(Ca) channels are not activated in vivo under resting conditions and during agonist stimulation. | American journal of physiology. Regulatory, integrative and comparative physiology 20070101 |
| Modulation by homocysteine of the iberiotoxin-sensitive, Ca2+ -activated K+ channels of porcine coronary artery smooth muscle cells. | European journal of pharmacology 20060928 |
| Antiangiogenic effect of rosiglitazone is mediated via peroxisome proliferator-activated receptor gamma-activated maxi-K channel opening in human umbilical vein endothelial cells. | The Journal of biological chemistry 20060512 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Cardiac mitochondrial preconditioning by Big Ca2+-sensitive K+ channel opening requires superoxide radical generation. | American journal of physiology. Heart and circulatory physiology 20060101 |
| Heat shock protein modulation of KATP and KCa channel cerebrovasodilation after brain injury. | American journal of physiology. Heart and circulatory physiology 20050901 |
| Doxapram stimulates the carotid body via a different mechanism than hypoxic chemotransduction. | Respiratory physiology & neurobiology 20050512 |
| Influence of diabetes mellitus, hypercholesterolemia, and their combination on EDHF-mediated responses in mice. | Journal of cardiovascular pharmacology 20050501 |
| The cannabinoid receptor agonist WIN 55212-2 inhibits neurogenic inflammations in airway tissues. | Journal of pharmacological sciences 20050501 |
| Calcium-activated potassium channel triggers cardioprotection of ischemic preconditioning. | The Journal of pharmacology and experimental therapeutics 20050201 |
| Mitochondrial Ca2+-activated K+ channels in cardiac myocytes: a mechanism of the cardioprotective effect and modulation by protein kinase A. | Circulation 20050118 |
| Nitric oxide stimulates a large-conductance Ca-activated K+ channel in human skin fibroblasts through protein kinase G pathway. | Skin pharmacology and physiology 20050101 |
| Description and role in proliferation of iberiotoxin-sensitive currents in different human mammary epithelial normal and cancerous cells. | Biochimica et biophysica acta 20041215 |
| Opening of Ca2+-activated K+ channels triggers early and delayed preconditioning against I/R injury independent of NOS in mice. | American journal of physiology. Heart and circulatory physiology 20041101 |
| Cannabinoid receptor agonists inhibit sensory nerve activation in guinea pig airways. | American journal of respiratory and critical care medicine 20041101 |
| Important role of superoxide dismutase in EDHF-mediated responses of human mesenteric arteries. | Journal of cardiovascular pharmacology 20041101 |
| A novel mechanism of regulation of cardiac contractility by mitochondrial functional state. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040801 |
| Functional characterization of large conductance calcium-activated K+ channel openers in bladder and vascular smooth muscle. | Naunyn-Schmiedeberg's archives of pharmacology 20040501 |
| Additive antinociceptive effect of the combination of diazoxide, an activator of ATP-sensitive K+ channels, and sodium nitroprusside and dibutyryl-cGMP. | European journal of pharmacology 20040405 |
| Cilostazol enhances casein kinase 2 phosphorylation and suppresses tumor necrosis factor-alpha-induced increased phosphatase and tensin homolog deleted from chromosome 10 phosphorylation and apoptotic cell death in SK-N-SH cells. | The Journal of pharmacology and experimental therapeutics 20040101 |
| In vivo properties of potassium channels in cerebral blood vessels during diabetes mellitus. | Microcirculation (New York, N.Y. : 1994) 20040101 |
| Cerebrovascular vasodilation to extraluminal acidosis occurs via combined activation of ATP-sensitive and Ca2+-activated potassium channels. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20031001 |
| Natural modulators of large-conductance calcium-activated potassium channels. | Planta medica 20031001 |
| Functional analysis of large conductance Ca2(+)-activated K(+) channels: ion flux studies by atomic absorption spectrometry. | Assay and drug development technologies 20031001 |
| Cilostazol prevents tumor necrosis factor-alpha-induced cell death by suppression of phosphatase and tensin homolog deleted from chromosome 10 phosphorylation and activation of Akt/cyclic AMP response element-binding protein phosphorylation. | The Journal of pharmacology and experimental therapeutics 20030901 |
| The K+ channel openers diazoxide and NS1619 induce depolarization of mitochondria and have differential effects on cell Ca2+ in CD34+ cell line KG-1a. | Experimental hematology 20030901 |
| Differential effects of pulsatile versus steady flow on coronary endothelial membrane potential. | American journal of physiology. Heart and circulatory physiology 20030701 |
| Differential role of PTK and ERK MAPK in superoxide impairment of K(ATP) and K(Ca) channel cerebrovasodilation. | American journal of physiology. Regulatory, integrative and comparative physiology 20030701 |
| Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells. | Biochemical pharmacology 20030601 |
| BK channel openers inhibit migration of human glioma cells. | Pflugers Archiv : European journal of physiology 20030501 |
| Coronary myogenic constriction antagonizes EDHF-mediated dilation: role of KCa channels. | Hypertension (Dallas, Tex. : 1979) 20030401 |
| Doxapram stimulates carotid body with different mechanisms from hypoxic chemotransduction. | Advances in experimental medicine and biology 20030101 |
| Modulation of action potential firing by iberiotoxin and NS1619 in rat dorsal root ganglion neurons. | Neuroscience 20030101 |
| Prolonged activation of Ca2+-activated K+ current contributes to the long-lasting refractory period of Aplysia bag cell neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20021201 |
| Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membrane. | Science (New York, N.Y.) 20021101 |
| [BK channels play an important role as a negative feedback mechanism in the regulation of spontaneous rhythmic contraction of urinary bladder smooth muscles]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20021101 |
| Protein tyrosine kinase and mitogen-activated protein kinase activation contribute to K(ATP) and K(ca) channel impairment after brain injury. | Brain research 20020712 |
| 4,5-diphenyltriazol-3-ones: openers of large-conductance Ca(2+)-activated potassium (maxi-K) channels. | Journal of medicinal chemistry 20020704 |
| Enhancement of contraction of rat mesenteric artery by acteoside: role of endothelial nitric oxide. | Journal of natural products 20020701 |
| Potassium channels and human corporeal smooth muscle cell tone: further evidence of the physiological relevance of the Maxi-K channel subtype to the regulation of human corporeal smooth muscle tone in vitro. | The Journal of urology 20020601 |
| Regulation of blood-brain tumor barrier permeability by calcium-activated potassium channels. | The Journal of pharmacology and experimental therapeutics 20020601 |
| 14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries. | Circulation research 20020517 |
| Vascular smooth muscle cell membrane depolarization after NOS inhibition hypertension. | American journal of physiology. Heart and circulatory physiology 20020501 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| [Changes in the post-ischemic glutaminic vascular reactions in newborn swine]. | Ideggyogyaszati szemle 20020120 |
| BK channel activity determines the extent of cell degeneration after oxygen and glucose deprivation: a study in organotypical hippocampal slice cultures. | Neuroscience 20020101 |
| Human myofibroblastic hepatic stellate cells express Ca(2+)-activated K(+) channels that modulate the effects of endothelin-1 and nitric oxide. | Journal of hepatology 20011201 |
| Effects of different types of K+ channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle. | Acta physiologica Scandinavica 20011101 |
| New 5-substituted-1-(2-hydroxybenzoyl)-benzotriazoles, potassium channel activators. IV. | Farmaco (Societa chimica italiana : 1989) 20011101 |
| Endothelin-Induced cyclooxygenase-dependent superoxide generation contributes to K+ channel functional impairment after brain injury. | Journal of neurotrauma 20011001 |
| Vasopressin induced cyclooxygenase dependent superoxide generation contributes to K(+) channel function impairment after brain injury. | Brain research 20010810 |
| Vasopressin-induced protein kinase C-dependent superoxide generation contributes to atp-sensitive potassium channel but not calcium-sensitive potassium channel function impairment after brain injury. | Stroke 20010601 |
| Influence of Ca(2+)-activated K(+) channels on rat renal arteriolar responses to depolarizing agonists. | American journal of physiology. Renal physiology 20010401 |
| Relaxant effects of 17-beta-estradiol in cerebral arteries through Ca(2+) entry inhibition. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010401 |
| Modulation of recombinant small-conductance Ca(2+)-activated K(+) channels by the muscle relaxant chlorzoxazone and structurally related compounds. | The Journal of pharmacology and experimental therapeutics 20010301 |
| A common mechanism for cystic fibrosis transmembrane conductance regulator protein activation by genistein and benzimidazolone analogs. | The Journal of pharmacology and experimental therapeutics 20010201 |
| BK channel activation by NS-1619 is partially mediated by intracellular Ca2+ release in smooth muscle cells of porcine coronary artery. | British journal of pharmacology 20010201 |