Trifluridine
Title | Journal |
---|---|
A phase 1 study of the pharmacokinetics of nucleoside analog trifluridine and thymidine phosphorylase inhibitor tipiracil (components of TAS-102) vs trifluridine alone. | Investigational new drugs 20170101 |
Effect of food on the pharmacokinetics of TAS-102 and its efficacy and safety in patients with advanced solid tumors. | Cancer science 20160501 |
Human mass balance study of TAS-102 using (14)C analyzed by accelerator mass spectrometry. | Cancer chemotherapy and pharmacology 20160301 |
TAS-102, a novel antitumor agent: a review of the mechanism of action. | Cancer treatment reviews 20151101 |
Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. | Toxicology letters 20150105 |
Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models. | Oncology reports 20141201 |
TAS-102: more than an antimetabolite. | The Lancet. Oncology 20121201 |
Pediatric herpes simplex of the anterior segment: characteristics, treatment, and outcomes. | Ophthalmology 20121001 |
TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial. | The Lancet. Oncology 20121001 |
Phase I study of TAS-102 treatment in Japanese patients with advanced solid tumours. | British journal of cancer 20120724 |
Ganciclovir ophthalmic gel 0.15%: safety and efficacy of a new treatment for herpes simplex keratitis. | Current eye research 20120701 |
Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluorothymidine, a novel antitumor nucleoside, in rats. | The Journal of pharmacology and experimental therapeutics 20120201 |
Viral infection in renal transplant recipients. | TheScientificWorldJournal 20120101 |
Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism. | PloS one 20120101 |
A systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological data. | PloS one 20120101 |
Enhancing effect of Labrasol on the intestinal absorption of ganciclovir in rats. | Drug development and industrial pharmacy 20111201 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). | PLoS computational biology 20111201 |
Highly regioselective synthesis of 3'-O-acyl-trifluridines catalyzed by Pseudomonas cepacia lipase. | Applied biochemistry and biotechnology 20111101 |
Unilateral keratitis following death of a twin as the presenting sign of herpetic infection in a neonate. | Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 20111001 |
Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes. | International journal of oncology 20110701 |
Ocular vaccinia: a consequence of unrecognized contact transmission. | Military medicine 20110601 |
Herpes keratitis in a patient undergoing treatment with topical mitomycin C. | Cornea 20110401 |
Evaluation of therapeutic interventions for vaccinia virus keratitis. | The Journal of infectious diseases 20110301 |
Treatment of viral conjunctivitis with antiviral drugs. | Drugs 20110212 |
In vitro synergism of trifluorothymidine and ganciclovir against HSV-1. | Investigative ophthalmology & visual science 20110201 |
Photographic monitoring of herpes simplex virus keratitis during anti-inflammatory treatment. | Archives of ophthalmology (Chicago, Ill. : 1960) 20110201 |
Inhibition of viral replication in vitro by antiviral-treated amniotic membrane. Possible use of amniotic membrane as drug-delivering tool. | The British journal of ophthalmology 20110101 |
Inflammatory glaucoma. | Oman journal of ophthalmology 20110101 |
Experimental bariatric surgery in rats generates a cytotoxic chemical environment in the gut contents. | Frontiers in microbiology 20110101 |
Combination therapies in ophthalmology: implications for intravitreal delivery. | Journal of ophthalmic & vision research 20110101 |
Antiviral activity of 2,3'-anhydro and related pyrimidine nucleosides against hepatitis B virus. | Bioorganic & medicinal chemistry letters 20101115 |
Antiviral activity of various 1-(2'-deoxy-β-D-lyxofuranosyl), 1-(2'-fluoro-β-D-xylofuranosyl), 1-(3'-fluoro-β-D-arabinofuranosyl), and 2'-fluoro-2',3'-didehydro-2',3'-dideoxyribose pyrimidine nucleoside analogues against duck hepatitis B virus (DHBV) and human hepatitis B virus (HBV) replication. | Journal of medicinal chemistry 20101014 |
Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs. | Aging 20101001 |
Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines. | Cancer chemotherapy and pharmacology 20100801 |
Historical perspectives in the development of antiviral agents against poxviruses. | Viruses 20100601 |
Prodrug activation by Cryptosporidium thymidine kinase. | The Journal of biological chemistry 20100521 |
Differential activation of cell death and autophagy results in an increased cytotoxic potential for trifluorothymidine compared to 5-fluorouracil in colon cancer cells. | International journal of cancer 20100515 |
Immunohistochemical characterization of pyrimidine synthetic enzymes, thymidine kinase-1 and thymidylate synthase, in various types of cancer. | Oncology reports 20100501 |
Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2. | Molecular cancer therapeutics 20100401 |
Quantitative organ time activity curve extraction from rodent PET images without anatomical prior. | Medical physics 20100401 |
Molecular mechanism underlying the synergistic interaction between trifluorothymidine and the epidermal growth factor receptor inhibitor erlotinib in human colorectal cancer cell lines. | Cancer science 20100201 |
Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3. | Current chemical genomics 20100101 |
Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells. | BMC cancer 20100101 |
Structure activity relationship of dendrimer microbicides with dual action antiviral activity. | PloS one 20100101 |
Topical ganciclovir in the treatment of acute herpetic keratitis. | Clinical ophthalmology (Auckland, N.Z.) 20100101 |
Simple and rapid enzymatic method for the synthesis of single-strand oligonucleotides containing trifluorothymidine. | Nucleosides, nucleotides & nucleic acids 20100101 |
Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis. | The Cochrane database of systematic reviews 20100101 |
Slitlamp biomicroscopy and photographic image analysis of herpes simplex virus stromal keratitis. | Archives of ophthalmology (Chicago, Ill. : 1960) 20090201 |
A human apolipoprotein E mimetic peptide effectively inhibits HSV-1 TK-positive and TK-negative acute epithelial keratitis in rabbits. | Current eye research 20090201 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. | Journal of medicinal chemistry 20081113 |
Synergistic interaction between trifluorothymidine and docetaxel is sequence dependent. | Cancer science 20081101 |
Synthesis of nucleoside-based antiviral drugs in ionic liquids. | Bioorganic & medicinal chemistry letters 20081015 |
Effective treatment of ocular HSK with a human apolipoprotein E mimetic peptide in a mouse eye model. | Investigative ophthalmology & visual science 20081001 |
Phase 1 study of TAS-102 administered once daily on a 5-day-per-week schedule in patients with solid tumors. | Investigational new drugs 20081001 |
Phase I clinical study of three times a day oral administration of TAS-102 in patients with solid tumors. | Cancer investigation 20081001 |
[18F]FDG and [18F]FLT uptake in human breast cancer cells in relation to the effects of chemotherapy: an in vitro study. | British journal of cancer 20080805 |
Ocular pharmacokinetics of acyclovir amino acid ester prodrugs in the anterior chamber: evaluation of their utility in treating ocular HSV infections. | International journal of pharmaceutics 20080709 |
Trifluorothymidine induces cell death independently of p53. | Nucleosides, nucleotides & nucleic acids 20080601 |
Efficacy of a helicase-primase inhibitor in animal models of ocular herpes simplex virus type 1 infection. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080201 |
Therapeutic interventions for herpes simplex virus epithelial keratitis. | The Cochrane database of systematic reviews 20080123 |
Is herpes simplex virus keratitis a different disease in children? | Clinical & experimental optometry 20080101 |
Novel cell death mechanisms of trifluorothymidine. | Nucleic acids symposium series (2004) 20080101 |
Progressive hypertrophic genital herpes in an HIV-infected woman despite immune recovery on antiretroviral therapy. | Infectious diseases in obstetrics and gynecology 20080101 |
Collision induced dissociation studies of alkali metal adducts of tetracyclines and antiviral agents by electrospray ionization, hydrogen/deuterium exchange and multiple stage mass spectrometry. | European journal of mass spectrometry (Chichester, England) 20080101 |
Ganciclovir ophthalmic gel, 0.15%: a valuable tool for treating ocular herpes. | Clinical ophthalmology (Auckland, N.Z.) 20071201 |
Collisionally-induced dissociation of substituted pyrimidine antiviral agents: mechanisms of ion formation using gas phase hydrogen/deuterium exchange and electrospray ionization tandem mass spectrometry. | Journal of the American Society for Mass Spectrometry 20070801 |
Evidence-based treatment of herpes simplex virus keratitis: a systematic review. | The ocular surface 20070701 |
Therapeutic potential of the dual-targeted TAS-102 formulation in the treatment of gastrointestinal malignancies. | Cancer science 20070601 |
Mechanism of trifluorothymidine potentiation of oxaliplatin-induced cytotoxicity to colorectal cancer cells. | British journal of cancer 20070129 |
Therapeutic interventions for herpes simplex virus epithelial keratitis. | The Cochrane database of systematic reviews 20070124 |
The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells. | British journal of cancer 20070115 |
A method to distinguish between the de novo induction of thymidine kinase mutants and the selection of pre-existing thymidine kinase mutants in the mouse lymphoma assay. | Mutation research 20070110 |
Irinotecan-induced cytotoxicity to colon cancer cells in vitro is stimulated by pre-incubation with trifluorothymidine. | European journal of cancer (Oxford, England : 1990) 20070101 |
Dendritic keratitis caused by an acyclovir-resistant herpes simplex virus with frameshift mutation. | Cornea 20070101 |
High level glucose increases mutagenesis in human lymphoblastoid cells. | International journal of biological sciences 20070101 |
Phase I study to determine the safety and pharmacokinetics of oral administration of TAS-102 in patients with solid tumors. | Cancer 20060915 |
American Society of Clinical Oncology--42nd annual meeting. Poster presentations on leukemia and cytotoxic chemotherapy. 2-6 June 2006, Atlanta, GA, USA. | IDrugs : the investigational drugs journal 20060801 |
Corneal ulceration associated with naturally occurring canine herpesvirus-1 infection in two adult dogs. | Journal of the American Veterinary Medical Association 20060801 |
Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
3D-QSAR studies on antitubercular thymidine monophosphate kinase inhibitors based on different alignment methods. | Bioorganic & medicinal chemistry letters 20060215 |
Imiquimod 5% cream for the treatment of recurrent, acyclovir-resistant genital herpes. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060215 |
Low folate conditions may enhance the interaction of trifluorothymidine with antifolates in colon cancer cells. | Cancer chemotherapy and pharmacology 20060101 |
Viral infections affecting the skin in organ transplant recipients: epidemiology and current management strategies. | American journal of clinical dermatology 20060101 |
Ocular vaccinia infection in laboratory worker, Philadelphia, 2004. | Emerging infectious diseases 20060101 |
In vitro comparison of antiviral drugs against feline herpesvirus 1. | BMC veterinary research 20060101 |
Microarray analysis distinguishes differential gene expression patterns from large and small colony Thymidine kinase mutants of L5178Y mouse lymphoma cells. | BMC bioinformatics 20060101 |
Dipeptide monoester ganciclovir prodrugs for treating HSV-1-induced corneal epithelial and stromal keratitis: in vitro and in vivo evaluations. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20051201 |
Herpes simplex keratitis misdiagnosed as rheumatoid arthritis-related peripheral ulcerative keratitis. | Cornea 20051101 |
Efficacy of topical aciclovir for the treatment of feline herpetic keratitis: results of a prospective clinical trial and data from in vitro investigations. | The Veterinary record 20050827 |
Potentiation of the antitumor activity of alpha, alpha, alpha-trifluorothymidine by the co-administration of an inhibitor of thymidine phosphorylase at a suitable molar ratio in vivo. | International journal of oncology 20050801 |
Determinants of trifluorothymidine sensitivity and metabolism in colon and lung cancer cells. | Anti-cancer drugs 20050301 |
Multinodular goiter management in Western Saudi Arabia. | Saudi medical journal 20050301 |
Intracellular immunity to HIV-1: newly defined retroviral battles inside infected cells. | Retrovirology 20050101 |
Ocular complications in the Department of Defense Smallpox Vaccination Program. | Ophthalmology 20041101 |
Association between ocular herpes simplex virus and topical ocular hypotensive therapy. | Journal of glaucoma 20041001 |
Role of platelet derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity and potential role of deoxyribose-1-phosphate. | Nucleosides, nucleotides & nucleic acids 20041001 |
Intracellular thymidylate synthase inhibition by trifluorothymidine in FM3A cells. | Nucleosides, nucleotides & nucleic acids 20041001 |
A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA. | International journal of oncology 20040901 |
Herpes simplex virus keratitis in children. | American journal of ophthalmology 20040901 |
Antiviral drugs in current clinical use. | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20040601 |
Pharmacokinetic modeling of species-dependent enhanced bioavailability of trifluorothymidine by thymidine phosphorylase inhibitor. | Drug metabolism and pharmacokinetics 20040601 |
The effect of fluoropyrimidines with or without thymidine phosphorylase inhibitor on the expression of thymidine phosphorylase. | European journal of pharmacology 20040503 |
[The latest in herpes simplex keratitis therapy]. | Journal francais d'ophtalmologie 20040501 |
A novel antimetabolite, TAS-102 retains its effect on FU-related resistant cancer cells. | International journal of molecular medicine 20040401 |
Arthrographis keratitis mimicking acanthamoeba keratitis. | Cornea 20040401 |
New onset of herpes simplex virus epithelial keratitis after penetrating keratoplasty. | American journal of ophthalmology 20040301 |
Ocular vaccinia following exposure to a smallpox vaccinee. | American journal of ophthalmology 20040301 |
Thymidine kinase and thymidine phosphorylase level as the main predictive parameter for sensitivity to TAS-102 in a mouse model. | Oncology reports 20040201 |
An optimal dosing schedule for a novel combination antimetabolite, TAS-102, based on its intracellular metabolism and its incorporation into DNA. | International journal of molecular medicine 20040201 |
Management of ophthalmic zoster mucous plaque keratopathy: report of three cases. | Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20040201 |
Efficacy of antiviral agents in feline herpetic keratitis: results of an in vitro study. | Current eye research 20040101 |
Herpes simplex uveitis. | Boletin de la Asociacion Medica de Puerto Rico 20040101 |
[Trifluridine therapy in herpetic in keratitis]. | Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20040101 |
Comparison of HSV-1 thymidine kinase-dependent and -independent inhibition of replication-competent adenoviral vectors by a panel of drugs. | Cancer gene therapy 20031001 |
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase. | Bioorganic & medicinal chemistry letters 20030915 |
Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans. | Chembiochem : a European journal of chemical biology 20030804 |
Ocular complications of smallpox vaccination. | American journal of ophthalmology 20030801 |
The effect of roscovitine on herpetic keratitis. | Experimental eye research 20030601 |
In vivo antiviral efficacy of a dipeptide acyclovir prodrug, val-val-acyclovir, against HSV-1 epithelial and stromal keratitis in the rabbit eye model. | Investigative ophthalmology & visual science 20030601 |
Management of acyclovir-resistant herpes simplex virus. | Dermatologic clinics 20030401 |
Role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity. | British journal of cancer 20030324 |
Detection of thymidylate synthase modulators by a novel screening assay. | Molecular pharmacology 20030101 |
Recurrence of keratitis after excimer laser keratectomy. | Journal of cataract and refractive surgery 20030101 |
In vitro activity of potential anti-poxvirus agents. | Antiviral research 20030101 |
Novel dipeptide prodrugs of acyclovir for ocular herpes infections: Bioreversion, antiviral activity and transport across rabbit cornea. | Current eye research 20030101 |
Interventions for herpes simplex virus epithelial keratitis. | The Cochrane database of systematic reviews 20030101 |
Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors. | Nucleosides, nucleotides & nucleic acids 20030101 |
Synergistic inhibition of herpesvirus replication by docosanol and antiviral nucleoside analogs. | Antiviral research 20021101 |
Drugs for non-HIV viral infections. | The Medical letter on drugs and therapeutics 20020204 |
Mutation induction in human cells after low dose X ray exposure. | Radiation protection dosimetry 20020101 |
Positive effect of PRK on Thygeson's keratitis. | Cornea 20011101 |
Atypical presentation of Acanthamoeba keratitis. | Cornea 20011001 |
Incorporation of 2'-deoxy-5-(trifluoromethyl)uridine and 5-cyano-2'-deoxyuridine into DNA. | Bioorganic & medicinal chemistry letters 20010917 |
Antiviral drugs: current state of the art. | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20010801 |
Influence of radiation sterilization on the stability of trifluorothymidine. | International journal of pharmaceutics 20010717 |
Efficacy of polyclonal antibodies for treatment of ocular herpes simplex infection. | Cornea 20010701 |
5-(Trifluoromethyl)-beta-l-2'-deoxyuridine, the L-enantiomer of trifluorothymidine: stereospecific synthesis and antiherpetic evaluations. | Bioorganic & medicinal chemistry 20010701 |
Contact dermatitis from topical antiviral drugs. | Contact dermatitis 20010501 |
Effects of topical unoprostone and latanoprost on acute and recurrent herpetic keratitis in the rabbit. | American journal of ophthalmology 20010501 |
Vaccinia virus inhibitors as a paradigm for the chemotherapy of poxvirus infections. | Clinical microbiology reviews 20010401 |
In vitro effects of antiviral agents on human keratocytes. | Cornea 20010101 |
Interventions for herpes simplex virus epithelial keratitis. | The Cochrane database of systematic reviews 20010101 |
Synthesis and in vitro activity of D- and L-enantiomers of 5-(trifluoromethyl)uracil nucleoside derivatives. | Nucleosides, nucleotides & nucleic acids 20010101 |
Efficacy of select antivirals against Cryptosporidium parvum in vitro. | FEMS microbiology letters 19981101 |
Delivery of trifluridine to human cornea and aqueous using collagen shields. | The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc 19980401 |
Therapeutic response of herpes simplex virus-induced corneal edema to trifluridine in combination with immunosuppressive agents. | Investigative ophthalmology & visual science 19910801 |
Activity of (+)-cyclaradine (Sch 31172) against herpes simplex virus in vitro and in vivo. | Antimicrobial agents and chemotherapy 19870101 |
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters. | Journal of medicinal chemistry 19860701 |
Combination chemotherapy: interaction of 5-methoxymethyldeoxyuridine with trifluorothymidine, phosphonoformate and acycloguanosine against herpes simplex viruses. | Antiviral research 19850201 |
Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogues: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine against herpes simplex virus type 1. | Journal of medicinal chemistry 19840301 |
In vitro susceptibility of varicella-zoster virus to E-5-(2-bromovinyl)-2'-deoxyuridine and related compounds. | Antimicrobial agents and chemotherapy 19820101 |
Activity of trifluorothymidine against cytomegalovirus. | Antimicrobial agents and chemotherapy 19810901 |
(E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent. | Proceedings of the National Academy of Sciences of the United States of America 19790601 |
Effect of 9-(2-hydroxyethoxymethyl)guanine on herpesvirus-induced keratitis and iritis in rabbits. | Antimicrobial agents and chemotherapy 19781201 |
9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group. | Nature 19780413 |
Improved synthesis and in vitro antiviral activities of 5-cyanouridine and 5-cyano-2'-deoxyuridine. | Journal of medicinal chemistry 19770701 |
Nucleosides. 3. Studies on 5-methylamino-2'-deoxyuridine as a specific antiherpes agent. | Journal of medicinal chemistry 19660501 |