In vitro and in vivo investigation of dexibuprofen derivatives for CNS delivery.

Acta pharmacologica Sinica 20120201

Using functional signatures to identify repositioned drugs for breast, myelogenous leukemia and prostate cancer.

PLoS computational biology 20120201

[UV spectroscopy coupled with partial least squares to determine the enantiomeric composition in chiral drugs].

Guang pu xue yu guang pu fen xi = Guang pu 20120201

Case series of 64 slice computed tomography-computed tomographic angiography with 3D reconstruction to diagnose symptomatic cerebral aneurysms: new standard of care?

Neurology international 20120109

Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease.

Neurobiology of aging 20120101

A novel folate-modified self-microemulsifying drug delivery system of curcumin for colon targeting.

International journal of nanomedicine 20120101

Specificity quantification of biomolecular recognition and its implication for drug discovery.

Scientific reports 20120101

Pharmacokinetics of ibuprofen enantiomers in rats after intravenous and oral administration of ibuprofen arginate.

Yao xue xue bao = Acta pharmaceutica Sinica 20120101

Improvement of the bioavailability and glycaemic metabolism of cinnamon oil in rats by liquid loadable tablets.

TheScientificWorldJournal 20120101

Efficacy of etoricoxib, celecoxib, lumiracoxib, non-selective NSAIDs, and acetaminophen in osteoarthritis: a mixed treatment comparison.

The open rheumatology journal 20120101

Pharmacokinetic-pharmacodynamic model of newly developed dexibuprofen sustained release formulations.

ISRN pharmaceutics 20120101

In vitro evaluation of (S)-ibuprofen toxicity on joint cells and explants of cartilage and synovial membrane.

Toxicology in vitro : an international journal published in association with BIBRA 20111201

Production of ibuprofen acyl glucosides by human UGT2B7.

Drug metabolism and disposition: the biological fate of chemicals 20111201

Physicochemical stability of solid dispersions of enantiomeric or racemic ibuprofen in stearic acid.

Journal of pharmaceutical sciences 20111201

Stereoselective inhibitory effect of flurbiprofen, ibuprofen and naproxen on human organic anion transporters hOAT1 and hOAT3.

Biopharmaceutics & drug disposition 20111201

Enantiospecific fate of ibuprofen, ketoprofen and naproxen in a laboratory-scale membrane bioreactor.

Water research 20111115

Synthesis, hydrolysis studies and phamacodynamic profiles of amide prodrugs of dexibuprofen with amino acids.

Journal of enzyme inhibition and medicinal chemistry 20111001

Novel imaging agents for β-amyloid plaque based on the N-benzoylindole core.

Bioorganic & medicinal chemistry letters 20110915

A dual acting compound releasing nitric oxide (NO) and ibuprofen, NCX 320, shows significant therapeutic effects in a mouse model of muscular dystrophy.

Pharmacological research 20110901

Pharmacokinetic comparison of controlled- and immediate-release formulations of dexibuprofen after single and multiple oral doses in fasting healthy male Korean volunteers.

Clinical therapeutics 20110901

Lack of enantiomeric influence on the brain cytoprotective effect of ibuprofen and flurbiprofen.

Naunyn-Schmiedeberg's archives of pharmacology 20110801

Methyl-monofluorination of ibuprofen selectively increases its inhibitory activity toward cyclooxygenase-1 leading to enhanced analgesic activity and reduced gastric damage in vivo.

Bioorganic & medicinal chemistry letters 20110615

Understanding the terahertz spectra of crystalline pharmaceuticals: terahertz spectroscopy and solid-state density functional theory study of (S)-(+)-ibuprofen and (RS)-ibuprofen.

Journal of pharmaceutical sciences 20110301

Pharmacokinetics and bioequivalence of single dose and multiple doses of immediate- and extended-release formulations of dexibuprofen in healthy Chinese subjects.

International journal of clinical pharmacology and therapeutics 20110301

Dry elixir formulations of dexibuprofen for controlled release and enhanced oral bioavailability.

International journal of pharmaceutics 20110214

Interaction between dexibuprofen and dexketoprofen in the orofacial formalin test in mice.

Pharmacology, biochemistry, and behavior 20110101

Ibuprofen inhibits activation of nuclear {beta}-catenin in human colon adenomas and induces the phosphorylation of GSK-3{beta}.

Cancer prevention research (Philadelphia, Pa.) 20110101

Solid self-nanoemulsifying cyclosporin A pellets prepared by fluid-bed coating: preparation, characterization and in vitro redispersibility.

International journal of nanomedicine 20110101

Single dose oral analgesics for acute postoperative pain in adults.

The Cochrane database of systematic reviews 20110101

Molecularly imprinted polymers: present and future prospective.

International journal of molecular sciences 20110101

Decrease in the production of β-amyloid by berberine inhibition of the expression of β-secretase in HEK293 cells.

BMC neuroscience 20110101

Preparation, characterization, and in vivo evaluation of a self-nanoemulsifying drug delivery system (SNEDDS) loaded with morin-phospholipid complex.

International journal of nanomedicine 20110101

Development and Validation of a HPLC and an UV Spectrophotometric Methods for Determination of Dexibuprofen in Pharmaceutical Preparations.

ISRN pharmaceutics 20110101

Differences in the in vitro antiplatelet effect of dexibuprofen, ibuprofen, and flurbiprofen in human blood.

Anesthesia and analgesia 20101201

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Bioorganic & medicinal chemistry letters 20101101

Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones.

Journal of medicinal chemistry 20100923

Identifying early prescribers of cycloxygenase-2 inhibitors (COX-2s) in Nova Scotia, Canada: Considerations for targeted academic detailing.

Research in social & administrative pharmacy : RSAP 20100901

Rationale and conditions for the requirement of chiral bioanalytical methods in bioequivalence studies.

European journal of clinical pharmacology 20100601

Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors.

Journal of medicinal chemistry 20100311

Effect of drug chirality on the skin permeability of ibuprofen.

International journal of pharmaceutics 20100215

Macroscopic small bowel mucosal injury caused by chronic nonsteroidal anti-inflammatory drugs (NSAID) use as assessed by capsule endoscopy.

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 20100201

Integrated HPLC-MS and (1)H-NMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides.

Xenobiotica; the fate of foreign compounds in biological systems 20100101

Are cytochrome P450 CYP2C8 and CYP2C9 polymorphisms associated with ibuprofen response in very preterm infants?

PloS one 20100101

Microencapsulation: an acclaimed novel drug-delivery system for NSAIDs in arthritis.

Critical reviews in therapeutic drug carrier systems 20100101

A prospective study of aspirin use and the risk of gastrointestinal bleeding in men.

PloS one 20100101

Determination of actarit from human plasma for bioequivalence studies.

Indian journal of pharmaceutical sciences 20100101

Novel 7-(dimethylamino)fluorene-based fluorescent probes and their binding to human serum albumin.

Organic & biomolecular chemistry 20091021

Postmarketing cohort study to assess the safety profile of oral dexketoprofen trometamol for mild to moderate acute pain treatment in primary care.

Methods and findings in experimental and clinical pharmacology 20091001

Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: inhibition by NSAIDs.

British journal of clinical pharmacology 20090901

Enhanced oral bioavailability of dexibuprofen by a novel solid self-emulsifying drug delivery system (SEDDS).

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20090801

Commercially viable resolution of ibuprofen.

Biotechnology journal 20090801

Influence of benzylamine on the resolution of ibuprofen with (+)-(R)-phenylethylamine via supercritical fluid extraction.

Chirality 20090601

Proton pump inhibitors exert anti-inflammatory effects and decrease human microglial and monocytic THP-1 cell neurotoxicity.

Experimental neurology 20090501

Assessment of the pharmaceutical active compounds removal in wastewater treatment systems at enantiomeric level. Ibuprofen and naproxen.

Chemosphere 20090401

Nicotinamide-2,2,2-trifluoro-ethanol (2/1).

Acta crystallographica. Section E, Structure reports online 20090401

Cyclic resolution of racemic ibuprofen via coupled efficient lipase and acid-base catalysis.

Chirality 20090301

A revised conformational code for the exhaustive analysis of conformers with one-to-one correspondence between conformation and code: application to the VCD analysis of (S)-ibuprofen.

The Journal of organic chemistry 20090206

ADIDAC trial: analgesia with dexibuprofen versus ibuprofen in patients suffering from primary dysmenorrhea: a crossover trial.

Gynecologic and obstetric investigation 20090101

Single dose oral dexibuprofen [S(+)-ibuprofen] for acute postoperative pain in adults.

The Cochrane database of systematic reviews 20090101

Painful red nodules in female patient with recent travel history: a case report.

Cases journal 20090101

Solid Dispersion Matrix Tablet Comprising Indomethacin-PEG-HPMC Fabricated with Fusion and Mold Technique.

Indian journal of pharmaceutical sciences 20090101

Population pharmacokinetic analysis of Ibuprofen enantiomers in preterm newborn infants.

Journal of clinical pharmacology 20081201

The effects and safety of dexibuprofen compared with ibuprofen in febrile children caused by upper respiratory tract infection.

British journal of clinical pharmacology 20081201

Formulation of a extended release tablet containing dexibuprofen.

Archives of pharmacal research 20081201

Impaired intrinsic chiral inversion activity of ibuprofen in rats with adjuvant-induced arthritis.

Xenobiotica; the fate of foreign compounds in biological systems 20081101

Necrotizing vasculitis as a complication of propylthiouracil.

The western journal of emergency medicine 20081101

Characterization of drug-protein binding process by employing equilibrium sampling through hollow-fiber supported liquid membrane and Bjerrum and Scatchard plots.

Journal of pharmaceutical and biomedical analysis 20080910

Enantioselective formation of ibuprofen-S-acyl-glutathione in vitro in incubations of ibuprofen with rat hepatocytes.

Chemical research in toxicology 20080901

Chiral non-steroidal anti-inflammatory drugs--a review.

Journal of the Indian Medical Association 20080901

Spinal nerve ligation-induced activation of nuclear factor kappaB is facilitated by prostaglandins in the affected spinal cord and is a critical step in the development of mechanical allodynia.

Neuroscience 20080826

Influence of CYP2C8 and CYP2C9 polymorphisms on pharmacokinetic and pharmacodynamic parameters of racemic and enantiomeric forms of ibuprofen in healthy volunteers.

Pharmacological research 20080701

Dexibuprofen (S(+)-isomer ibuprofen) reduces microglial activation and impairments of spatial working memory induced by chronic lipopolysaccharide infusion.

Pharmacology, biochemistry, and behavior 20080501

Postoperative ketorolac does not predispose to pseudoarthrosis following posterior spinal fusion and instrumentation for adolescent idiopathic scoliosis.

Spine 20080501

NMR evaluation of adipocyte fatty acid binding protein (aP2) with R- and S-ibuprofen.

Bioorganic & medicinal chemistry 20080415

Prescribing pattern of drugs in the treatment of osteoarthritis in Italian general practice: the effect of rofecoxib withdrawal.

Arthritis and rheumatism 20080415

Development of an affinity silica monolith containing human serum albumin for chiral separations.

Journal of pharmaceutical and biomedical analysis 20080414

Emergency department patient knowledge concerning acetaminophen (paracetamol) in over-the-counter and prescription analgesics.

Emergency medicine journal : EMJ 20080401

Analgesic synergy between topical opioids and topical non-steroidal anti-inflammatory drugs in the mouse model of thermal pain.

European journal of pharmacology 20080128

S-ibuprofen effectively inhibits thromboxane B2 levels and platelet function in an experimental model of lipopolysaccharide-stimulated and non-stimulated whole blood.

Pharmacology 20080101

A randomized, crossover study to determine bioequivalence of two brands of dexibuprofen 400 mg tablets in healthy Asian adult male subjects of Indian origin.

International journal of clinical pharmacology and therapeutics 20080101

The role of peroxisome proliferator-activated receptors in the development and physiology of gametes and preimplantation embryos.

PPAR research 20080101

Free drug metabolic clearance in elderly people.

Clinical pharmacokinetics 20080101

Nonsteroidal anti-inflammatory drugs and breast cancer risk in the National Institutes of Health-AARP Diet and Health Study.

Breast cancer research : BCR 20080101

Chiral separation of ibuprofen and chiral pharmacokinetics in healthy Chinese volunteers.

European journal of drug metabolism and pharmacokinetics 20080101

Bioequivalence study of two formulations containing 400 mg dexibuprofen in healthy Indian subjects.

Arzneimittel-Forschung 20080101

A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms.

Clinical therapeutics 20071201

NMR spectroscopic studies on the in vitro acyl glucuronide migration kinetics of Ibuprofen ((+/-)-(R,S)-2-(4-isobutylphenyl) propanoic acid), its metabolites, and analogues.

Analytical chemistry 20071115

Effect of absorption rate on pharmacokinetics of ibuprofen in relation to chiral inversion in humans.

The Journal of pharmacy and pharmacology 20071101

Stereochemical identification of (R)- and (S)-ibuprofen using residual dipolar couplings, NMR, and modeling.

Chirality 20070901

Boswellic acids and glucosamine show synergistic effect in preclinical anti-inflammatory study in rats.

Bioorganic & medicinal chemistry letters 20070701

Stereoselective interaction between the CYP2C8 inhibitor gemfibrozil and racemic ibuprofen.

European journal of clinical pharmacology 20070501

A novel method for assessing inhibition of ibuprofen chiral inversion and its application in drug discovery.

International journal of pharmaceutics 20070420

Further characterization of a rat model of varicella zoster virus-associated pain: Relationship between mechanical hypersensitivity and anxiety-related behavior, and the influence of analgesic drugs.

Neuroscience 20070223

[Pharmacokinetic interaction between phenitoin and dexibuprofen resulting in acute neurologic toxicity].

Medicina clinica 20070217

Synthesis and biological activities of novel dexibuprofen tetraacetylriboflavin conjugates.

Bioorganic & medicinal chemistry letters 20070201

Effects of dexibuprofen on platelet function in humans: comparison with low-dose aspirin.

Anesthesiology 20070201

Effects of St. John's wort supplementation on ibuprofen pharmacokinetics.

The Annals of pharmacotherapy 20070201

Design and study of some novel ibuprofen derivatives with potential nootropic and neuroprotective properties.

Bioorganic & medicinal chemistry 20070115

An internet survey of 2,596 people with fibromyalgia.

BMC musculoskeletal disorders 20070101

The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study.

BMC medicine 20070101

(S)-Ibuprofen-imprinted polymers incorporating gamma-methacryloxypropyl-trimethoxysilane for CEC separation of ibuprofen enantiomers.

Electrophoresis 20061101

A comparative study of the pharmacokinetics of ibuprofen arginate versus dexibuprofen in healthy volunteers.

European journal of clinical pharmacology 20061001

Binding studies of taxanes to human serum albumin by bioaffinity chromatography and circular dichroism.

Journal of pharmaceutical and biomedical analysis 20060911

Use of triplet excited States for the study of drug binding to human and bovine serum albumins.

ChemMedChem 20060901

Optimization of enantioselective resolution of racemic ibuprofen by native lipase from Aspergillus niger.

Journal of industrial microbiology & biotechnology 20060801

Evidence of COX-2 independent induction of apoptosis and cell cycle block in human colon carcinoma cells after S- or R-ibuprofen treatment.

European journal of pharmacology 20060701

Chamazulene carboxylic acid and matricin: a natural profen and its natural prodrug, identified through similarity to synthetic drug substances.

Journal of natural products 20060701

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Modification of pepsinogen I levels and their correlation with gastrointestinal injury after administration of dexibuprofen, ibuprofen or diclofenac: a randomized, open-label, controlled clinical trial.

International journal of clinical pharmacology and therapeutics 20060401

[Study on ion beam mutagenizing of the Trichosporon lactis T for enantioselective separation of ibuprofen].

Wei sheng wu xue bao = Acta microbiologica Sinica 20060401

Dynamic kinetic resolution: alternative approach in optimizing S-ibuprofen production.

Bioprocess and biosystems engineering 20060301

Beyond the white coat ceremony.

The Yale journal of biology and medicine 20060301

Increased expression of cyclooxygenase and nitric oxide isoforms, and exaggerated sensitivity to prostaglandin E2, in the rat lumbar spinal cord 3 days after L5-L6 spinal nerve ligation.

Anesthesiology 20060201

Chromatographic analysis of allosteric effects between ibuprofen and benzodiazepines on human serum albumin.

Chirality 20060101

An eutomer/distomer ratio near unity does not justify non-enantiospecific assay methods in bioequivalence studies.

Chirality 20051001

Similarity in structures of racemic and enantiomeric ibuprofen sodium dihydrates.

Acta crystallographica. Section C, Crystal structure communications 20050901

Perioperative pharmacokinetics of ibuprofen enantiomers after rectal administration.

Paediatric anaesthesia 20050701

2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors.

Journal of medicinal chemistry 20050630

The effect of a dexibuprofen mouth rinse on experimental gingivitis in humans.

Journal of clinical periodontology 20050601

The interaction of lipophilic drugs with intestinal fatty acid-binding protein.

The Journal of biological chemistry 20050506

Solid-phase microextraction and chiral HPLC analysis of ibuprofen in urine.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050425

A supported liquid membrane encapsulating a surfactant-lipase complex for the selective separation of organic acids.

Chemistry (Weinheim an der Bergstrasse, Germany) 20050204

Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study.

BMC geriatrics 20050101

Enantioselective pharmacokinetics of ibuprofen and involved mechanisms.

Drug metabolism reviews 20050101

Solubility of (+/-)-ibuprofen and S (+)-ibuprofen in the presence of cosolvents and cyclodextrins.

Pharmaceutical development and technology 20050101

Application of thin-layer chromatography to investigate oscillatory instability of the selected profen enantiomers in dichloromethane.

Journal of chromatographic science 20050101

Quantitative analysis of allosteric drug-protein binding by biointeraction chromatography.

Nature biotechnology 20041101

Population pharmacokinetics of ibuprofen enantiomers in very premature neonates.

Journal of clinical pharmacology 20041001

Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms.

Clinical pharmacology and therapeutics 20040801

Optical purity determination of (S)-ibuprofen in tablets by achiral gas chromatography.

Archives of pharmacal research 20040801

Highly enantioselective separation using a supported liquid membrane encapsulating surfactant-enzyme complex.

Journal of the American Chemical Society 20040721

Enantioselective immunorecognition of protein modification with optically active ibuprofen using polyclonal antibody.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040625

Synthesis and evaluation of S-4-(3-thienyl)phenyl-alpha-methylacetic acid.

Bioorganic & medicinal chemistry letters 20040223

Bioequivalence study of two Ibuprofen formulations administered intravenously in healthy male volunteers.

Clinical drug investigation 20040101

Enzyme-facilitated enantioselective transport of (S)-ibuprofen through a supported liquid membrane based on ionic liquids.

Chemical communications (Cambridge, England) 20031207

Aspirin use and lung cancer in men.

British journal of cancer 20031103

Inhibition of spinal prostaglandin synthesis early after L5/L6 nerve ligation prevents the development of prostaglandin-dependent and prostaglandin-independent allodynia in the rat.

Anesthesiology 20031101

Dexibuprofen (S+-isomer ibuprofen) reduces gastric damage and improves analgesic and antiinflammatory effects in rodents.

Anesthesia and analgesia 20030801

Regio- and enantiospecific rhodium-catalyzed arylation of unsymmetrical fluorinated acyclic allylic carbonates: inversion of absolute configuration.

Journal of the American Chemical Society 20030618

Influence of age on the enantiomeric disposition of ibuprofen in healthy volunteers.

British journal of clinical pharmacology 20030601

Comparison of the efficacy and tolerability of dexibuprofen and celecoxib in the treatment of osteoarthritis of the hip.

International journal of clinical pharmacology and therapeutics 20030401

Ask the doctors. I have arthritis and take Motrin. Is there a problem with also taking aspirin, since my doctor has told me to do this ever since my heart attack?

Heart advisor 20030401

Spinal nerve injury activates prostaglandin synthesis in the spinal cord that contributes to early maintenance of tactile allodynia.

Pain 20030101

In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl)(methyl)amino]-2-naphthyl]ethylidene)malononitrile.

Neuroscience 20030101

Bioavailability of two dermal formulations of S(+)ibuprofen in rabbit.

Arzneimittel-Forschung 20030101

Dexibuprofen: pharmacology, therapeutic uses and safety.

Inflammopharmacology 20030101

The cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK.

Journal of cancer research and clinical oncology 20021001

Enantioselective analysis of ibuprofen in human plasma by anionic cyclodextrin-modified electrokinetic chromatography.

Electrophoresis 20020901

Stereoselectivity of ibuprofen metabolism and pharmacokinetics following the administration of the racemate to healthy volunteers.

Xenobiotica; the fate of foreign compounds in biological systems 20020801

Aspirin and lung cancer in women.

British journal of cancer 20020701

Enantiospecific effects of cytochrome P450 2C9 amino acid variants on ibuprofen pharmacokinetics and on the inhibition of cyclooxygenases 1 and 2.

Clinical pharmacology and therapeutics 20020701

Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

The Journal of biological chemistry 20020419

Enantioselective release of controlled delivery granules based on molecularly imprinted polymers.

Drug delivery 20020101

Aseptic meningo-encephalitis related to dexibuprofen use in a patient with systemic lupus erythematosus: a case report with MR findings.

Lupus 20020101

Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H(2) synthases by ibuprofen, naproxen, and indomethacin.

Biochemical pharmacology 20011215

Ibuprofen interference in the determination of 3-phenoxybenzoic acid in urine.

Fresenius' journal of analytical chemistry 20011101

Overview on clinical data of dexibuprofen.