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Nizatidine

CAS No.:
76963-41-2
Catalog Number:
AG003AX5
Molecular Formula:
C12H21N5O2S2
Molecular Weight:
331.4574
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
97%
In Stock USA
United States
$19
- +
5g
97%
In Stock USA
United States
$44
- +
10g
97%
In Stock USA
United States
$75
- +
25g
97%
In Stock USA
United States
$150
- +
100g
97%
In Stock USA
United States
$450
- +
Product Description
Catalog Number:
AG003AX5
Chemical Name:
Nizatidine
CAS Number:
76963-41-2
Molecular Formula:
C12H21N5O2S2
Molecular Weight:
331.4574
MDL Number:
MFCD00865660
IUPAC Name:
(E)-1-N'-[2-[[2-[(dimethylamino)methyl]-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine
InChI:
InChI=1S/C12H21N5O2S2/c1-13-11(6-17(18)19)14-4-5-20-8-10-9-21-12(15-10)7-16(2)3/h6,9,13-14H,4-5,7-8H2,1-3H3/b11-6+
InChI Key:
SGXXNSQHWDMGGP-IZZDOVSWSA-N
SMILES:
CN/C(=C\[N+](=O)[O-])/NCCSCc1csc(n1)CN(C)C
NSC Number:
759289
Properties
Complexity:
349  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1  
Exact Mass:
331.114g/mol
Formal Charge:
0
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
331.453g/mol
Monoisotopic Mass:
331.114g/mol
Rotatable Bond Count:
9  
Topological Polar Surface Area:
140A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.6  
Literature
Title Journal
Influence of H2-receptor antagonists and proton pump inhibitors on dasatinib pharmacokinetics in Japanese leukemia patients. Cancer chemotherapy and pharmacology 20120401
In vitro evaluation of phototoxic properties of proton pump inhibitors, H2-receptor antagonists and statins. Acta dermato-venereologica 20120301
Nizatidine improves clinical symptoms and gastric emptying in patients with functional dyspepsia accompanied by impaired gastric emptying. Digestion 20120101
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology 20111201
Determination of ranitidine, nizatidine, and cimetidine by a sensitive fluorescent probe. The Analyst 20111021
The effects of nizatidine on transient lower esophageal sphincter relaxations (TLESRs) and acid reflux in healthy subjects. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20110101
Multicenter, double-blind, placebo-controlled crossover study to assess the acute prokinetic efficacy of nizatidine-controlled release (150 and 300 mg) in patients with gastroesophageal reflux disease. The American journal of the medical sciences 20101001
Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay. Antimicrobial agents and chemotherapy 20100901
Onset of relief of symptoms of gastroesophageal reflux disease: post hoc analysis of two previously published studies comparing pantoprazole 20 mg once daily with nizatidine or ranitidine 150 mg twice daily. Clinical therapeutics 20100401
The H2 receptor antagonist nizatidine is a P-glycoprotein substrate: characterization of its intestinal epithelial cell efflux transport. The AAPS journal 20090601
Does the use of nizatidine, as a pro-kinetic agent, improve gastric emptying in patients post-oesophagectomy? Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20090301
Sjogren's syndrome: promising, new treatment options besides nizatidine. Modern rheumatology 20090101
Predictors and correlates for weight changes in patients co-treated with olanzapine and weight mitigating agents; a post-hoc analysis. BMC psychiatry 20090101
Little necessity of acid inhibition against proton pump inhibitor rebound effects and prior helicobacter pylori eradication therapy in gastric ulcer patients: a randomized prospective study. Hepato-gastroenterology 20090101
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry 20080612
Nizatidine enhances salivary secretion in patients with dry mouth. Auris, nasus, larynx 20080601
Nizatidine and gastric emptying in functional dyspepsia. Digestive diseases and sciences 20080201
Spectrophotometric determination of H(2)-receptor antagonists via their oxidation with cerium(IV). Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080101
Validated stability-indicating methods for the determination of nizatidine in the presence of its sulfoxide derivative. Journal of AOAC International 20080101
Effect of the H2 receptor antagonist nizatidine on xerostomia in patients with primary Sjögren's syndrome. Modern rheumatology 20080101
[Analytical application of phosphotungstic acid complexes. Fabrication and characterisation of membrane selective electrodes for some H2 antihistaminics]. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20080101
Simple and universal HPLC-UV method to determine cimetidine, ranitidine, famotidine and nizatidine in urine: application to the analysis of ranitidine and its metabolites in human volunteers. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071215
Comments on 'Weight gain management in patients with schizophrenia during treatment with olanzapine in association with nizatidine'. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20070301
Effect of pantoprazole in older patients with erosive esophagitis. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20070101
[Analytical application of phosphotungstic acid complexes. Synthesis and characterisation]. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20070101
Weight gain management in patients with schizophrenia during treatment with olanzapine in association with nizatidine. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20061201
[Safety of proton pump inhibitors]. Medicina clinica 20061125
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Validation of a new high-performance liquid chromatography assay for nizatidine. Therapeutic drug monitoring 20060401
Gastric inflammatory polyposis after long-term intermittent use of nonsteroidal anti-inflammatory drugs and histamine2-receptor antagonists. Endoscopy 20050701
Effects of antisecretory agents on angiogenesis during healing of gastric ulcers. Journal of gastroenterology 20050701
Prediction of genotoxicity of chemical compounds by statistical learning methods. Chemical research in toxicology 20050601
Adiabatic pulses in 1H-15N direct and long-range heteronuclear correlations. Magnetic resonance in chemistry : MRC 20050401
Bioequivalence of two oral formulations of nizatidine capsules in healthy male volunteers. Biopharmaceutics & drug disposition 20050401
Nizatidine for the treatment of pediatric gastroesophageal reflux symptoms: an open-label, multiple-dose, randomized, multicenter clinical trial in 210 children. Clinical therapeutics 20050401
Comparative study of nizatidine and famotidine for maintenance therapy of erosive esophagitis. Journal of gastroenterology and hepatology 20050201
Pharmacokinetics of ranitidine and nizatidine in very elderly patients. American journal of therapeutics 20050101
Pantoprazole provides rapid and sustained symptomatic relief in patients treated for erosive oesophagitis. Alimentary pharmacology & therapeutics 20041115
Extrapyramidal symptoms related to adjunctive nizatidine therapy in an adolescent receiving quetiapine and paroxetine. Pharmacotherapy 20040701
Spectrophotometric determination of nizatidine and ranitidine through charge transfer complex formation. Archives of pharmacal research 20040701
Aplastic anemia associated with initiation of nizatidine therapy in a hemodialysis patient. Clinical and experimental nephrology 20040601
Teprenone, but not H2-receptor blocker or sucralfate, suppresses corpus Helicobacter pylori colonization and gastritis in humans: teprenone inhibition of H. pylori-induced interleukin-8 in MKN28 gastric epithelial cell lines. Helicobacter 20040401
Developmental pharmacokinetics and pharmacodynamics of nizatidine. Journal of pediatric gastroenterology and nutrition 20040401
Nizatidine and cisapride increase salivary secretion in rats. Digestive diseases and sciences 20040301
Nizatidine for the treatment of patients with quetiapine-induced weight gain. Human psychopharmacology 20040101
Clinical study on the effects of nizatidine on gastric motility and cardiac autonomic function. Investigations using electrogastrography and spectral analysis of heart rate variability. Arzneimittel-Forschung 20040101
[Treatment of gastroesophageal reflux disease]. Orvosi hetilap 20031228
Pantoprazole rapidly improves health-related quality of life in patients with heartburn: a prospective, randomized, double blind comparative study with nizatidine. Journal of clinical gastroenterology 20030801
Effect of nizatidine on olanzapine-associated weight gain in schizophrenic patients in Korea: a pilot study. Human psychopharmacology 20030801
Nizatidine treatment and its relationship with leptin levels in patients with olanzapine-induced weight gain. Human psychopharmacology 20030801
Meta-analysis: proton pump inhibitor or H2-receptor antagonist for Helicobacter pylori eradication. Alimentary pharmacology & therapeutics 20030515
Validation of the GSFQ, a self-administered symptom frequency questionnaire for patients with gastroesophageal reflux disease. Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20030501
Spectrophotometric and titrimetric determination of nizatidine in capsules. Journal of pharmaceutical and biomedical analysis 20030401
Nizatidine for prevention of weight gain with olanzapine: a double-blind placebo-controlled trial. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20030301
The bioequivalence of nizatidine (Axid) in two extemporaneously and one commercially prepared oral liquid formulations compared with capsule. Journal of clinical pharmacology 20030201
Pharmacokinetics and pharmacodynamics of a novel nizatidine controlled-release formulation in healthy subjects. Journal of clinical pharmacology 20030101
Influence of anti-ulcer drugs used in Japan on the result of (13)C-urea breath test for the diagnosis of Helicobacter pylori infection. Journal of gastroenterology 20030101
Comparison of the efficacy of pantoprazole vs. nizatidine in the treatment of erosive oesophagitis: a randomized, active-controlled, double-blind study. Alimentary pharmacology & therapeutics 20021201
Lack of effect of nizatidine-induced elevation of gastric pH on the oral bioavailability of dapsone in healthy volunteers. Pharmacotherapy 20021101
Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide. The Journal of pharmacy and pharmacology 20021101
Single-dose pharmacokinetics of nizatidine (Axid) in children. Journal of clinical pharmacology 20021001
Nonisothermal stability tests of famotidine and nizatidine. Farmaco (Societa chimica italiana : 1989) 20020901
Effect of preoperative oral use of erythromycin and nizatidine on gastric pH and volume. Anaesthesia and intensive care 20020801
Options for pharmacological management of obesity in patients treated with atypical antipsychotics. International clinical psychopharmacology 20020701
Effect of nizatidine on paracetamol and its metabolites in human plasma. The Journal of pharmacy and pharmacology 20020601
Susceptibility of the H2-receptor antagonists cimetidine, famotidine and nizatidine, to metabolism by the gastrointestinal microflora. International journal of pharmaceutics 20020426
Nizatidine and omeprazole enhance the effect of metronidazole on Helicobacter pylori in vitro. International journal of antimicrobial agents 20020301
Nizatidine and cisapride enhance salivary secretion in humans. Alimentary pharmacology & therapeutics 20020201
Kinetic spectrophotometric determination of nizatidine and ranitidine in pharmaceutical preparations. Journal of pharmaceutical and biomedical analysis 20020101
H2 histamine receptor blockade in the treatment of Alzheimer disease: a randomized, double-blind, placebo-controlled trial of nizatidine. Alzheimer disease and associated disorders 20020101
Spectrophotometric determination of three anti-ulcer drugs through charge-transfer complexation. Journal of AOAC International 20020101
Kinetic spectrophotometric method for the determination of ranitidine and nizatidine in pharmaceuticals. Journal of AOAC International 20020101
Nizatidine enhances the gastrocolonic response and the colonic peristaltic reflex in humans. The Journal of pharmacology and experimental therapeutics 20011001
Effectiveness and safety of nizatidine, 75 mg, for the relief of episodic heartburn. Alimentary pharmacology & therapeutics 20011001
Symptom relief in gastroesophageal reflux disease: a randomized, controlled comparison of pantoprazole and nizatidine in a mixed patient population with erosive esophagitis or endoscopy-negative reflux disease. The American journal of gastroenterology 20011001
pH-Metric log K calculations of famotidine, naproxen, nizatidine, ranitidine and salicylic acid. Farmaco (Societa chimica italiana : 1989) 20010901
Head-column field-amplified sample stacking in capillary electrophoresis for the determination of cimetidine, famotidine, nizatidine, and ranitidine-HCl in plasma. Electrophoresis 20010801
Simultaneous determination of cimetidine, famotidine, nizatidine, and ranitidine in tablets by capillary zone electrophoresis. Electrophoresis 20010801
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Inhibition of drug metabolism in human liver microsomes by nizatidine, cimetidine and omeprazole. Xenobiotica; the fate of foreign compounds in biological systems 20010101
Bicarbonate stimulatory action of nizatidine, a histamine H(2)-receptor antagonist, in rat duodenums. Journal of physiology, Paris 20010101
Effects of different antisecretory drugs on gastric potential difference in the rat: comparison with sucralfate. Pharmacological research 19981201
Nizatidine-induced delirium in a nonagenarian. The Journal of clinical psychiatry 19970701
Influence of H2-receptor- and proton pump inhibitors on some functions of the oxydative and conjugative drug metabolism. Die Pharmazie 19960701
Neurotoxic convulsions induced by histamine H2 receptor antagonists in mice. Toxicology and applied pharmacology 19960201
Effect of anti-ulcer drugs on DNA synthesis in adult normal human hepatocytes in culture. Hepatology (Baltimore, Md.) 19950901
Possible nizatidine-induced subfulminant hepatic failure. Journal of clinical gastroenterology 19950301
Properties