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Incb28060

CAS No.:
1029712-80-8
Catalog Number:
AG003ABZ
Molecular Formula:
C23H17FN6O
Molecular Weight:
412.4191
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
99%
1 week
United States
$126
- +
10mg
99%
1 week
United States
$154
- +
50mg
99%
1 week
United States
$210
- +
100mg
99%
1 week
United States
$265
- +
200mg
99%
1 week
United States
$321
- +
Product Description
Catalog Number:
AG003ABZ
Chemical Name:
Incb28060
CAS Number:
1029712-80-8
Molecular Formula:
C23H17FN6O
Molecular Weight:
412.4191
MDL Number:
MFCD18633285
IUPAC Name:
2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide
InChI:
InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
InChI Key:
LIOLIMKSCNQPLV-UHFFFAOYSA-N
SMILES:
CNC(=O)c1ccc(cc1F)c1cnc2n(n1)c(cn2)Cc1ccc2c(c1)cccn2
EC Number:
813-241-9
UNII:
TY34L4F9OZ
Properties
Complexity:
637  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
412.145g/mol
Formal Charge:
0
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
412.428g/mol
Monoisotopic Mass:
412.145g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
85.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.9  
Literature
Title Journal
The novel c-Met inhibitor capmatinib mitigates diethylnitrosamine acute liver injury in mice. Toxicology letters 20161102
A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3. Clinical cancer research : an official journal of the American Association for Cancer Research 20111115
Properties