Home Other Building Blocks N'-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

N'-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

CAS No.:
849217-68-1
Catalog Number:
AG003A8Q
Molecular Formula:
C28H24FN3O5
Molecular Weight:
501.5057
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$105
- +
5mg
99%
1 week
United States
$126
- +
10mg
99%
1 week
United States
$154
- +
50mg
99%
1 week
United States
$182
- +
100mg
99%
1 week
United States
$223
- +
200mg
99%
1 week
United States
$321
- +
Product Description
Catalog Number:
AG003A8Q
Chemical Name:
N'-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
CAS Number:
849217-68-1
Molecular Formula:
C28H24FN3O5
Molecular Weight:
501.5057
MDL Number:
MFCD20926324
IUPAC Name:
1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
InChI:
InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)
InChI Key:
ONIQOQHATWINJY-UHFFFAOYSA-N
SMILES:
COc1cc2c(ccnc2cc1OC)Oc1ccc(cc1)NC(=O)C1(CC1)C(=O)Nc1ccc(cc1)F
UNII:
1C39JW444G
Properties
Complexity:
795  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
501.17g/mol
Formal Charge:
0
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
501.514g/mol
Monoisotopic Mass:
501.17g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
98.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
5.4  
Literature
Title Journal
Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes. Toxicology letters 20180701
Precision Targeted Therapy with BLU-667 for RET-Driven Cancers. Cancer discovery 20180701
Cabozantinib for the treatment of progressive metastatic medullary thyroid cancer. Expert review of clinical pharmacology 20160101
Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma. The New England journal of medicine 20151105
Cabozantinib: a MET, RET, and VEGFR2 tyrosine kinase inhibitor. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20140101
Identification of potent Yes1 kinase inhibitors using a library screening approach. Bioorganic & medicinal chemistry letters 20130801
Novel molecular targeted therapies for refractory thyroid cancer. Head & neck 20120501
Novel molecular targets for the therapy of castration-resistant prostate cancer. European urology 20120501
Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors. Cancer discovery 20120301
c-Met is a marker of pancreatic cancer stem cells and therapeutic target. Gastroenterology 20111201
Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Molecular cancer therapeutics 20111201
Novel therapies for metastatic castrate-resistant prostate cancer. Journal of the National Cancer Institute 20111116
Multi-targeted tyrosine kinase inhibitors in clinical development: focus on XL-184 (cabozantinib). Drugs of today (Barcelona, Spain : 1998) 20111101
VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer research 20110715
Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110701
Activated MET is a molecular prognosticator and potential therapeutic target for malignant peripheral nerve sheath tumors. Clinical cancer research : an official journal of the American Association for Cancer Research 20110615
The effects of four different tyrosine kinase inhibitors on medullary and papillary thyroid cancer cells. The Journal of clinical endocrinology and metabolism 20110601
XL184 (cabozantinib) for medullary thyroid carcinoma. Expert opinion on investigational drugs 20110301
Current status of molecularly targeted drugs for the treatment of advanced thyroid cancer. Endocrine journal 20110101
Novel treatment of medullary thyroid cancer. Current opinion in endocrinology, diabetes, and obesity 20091001
Properties