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Budipine

CAS No.:
57982-78-2
Catalog Number:
AG003A7H
Molecular Formula:
C21H27N
Molecular Weight:
293.4458
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
95%
1 week
United States
$52
- +
25mg
95%
1 week
United States
$105
- +
Product Description
Catalog Number:
AG003A7H
Chemical Name:
Budipine
CAS Number:
57982-78-2
Molecular Formula:
C21H27N
Molecular Weight:
293.4458
MDL Number:
MFCD00866585
IUPAC Name:
1-tert-butyl-4,4-diphenylpiperidine
InChI:
InChI=1S/C21H27N/c1-20(2,3)22-16-14-21(15-17-22,18-10-6-4-7-11-18)19-12-8-5-9-13-19/h4-13H,14-17H2,1-3H3
InChI Key:
QIHLUZAFSSMXHQ-UHFFFAOYSA-N
SMILES:
CC(N1CCC(CC1)(c1ccccc1)c1ccccc1)(C)C
EC Number:
261-062-4
UNII:
L9026OPI2Z
Properties
Complexity:
313  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
293.214g/mol
Formal Charge:
0
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
293.454g/mol
Monoisotopic Mass:
293.214g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
3.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
5.2  
Literature
Title Journal
Rotigotine effects on early morning motor function and sleep in Parkinson's disease: a double-blind, randomized, placebo-controlled study (RECOVER). Movement disorders : official journal of the Movement Disorder Society 20110101
[On the role of MAO B inhibitors and NMDA antagonists in the therapy of Parkinson's disease]. Fortschritte der Neurologie-Psychiatrie 20100301
A new strategy for antidepressant prescription. Frontiers in neuroscience 20100101
Paradoxical aspects of parkinsonian tremor. Movement disorders : official journal of the Movement Disorder Society 20080130
Effects of amantadine and budipine on antidepressant drug-evoked changes in extracellular dopamine in the frontal cortex of freely moving rats. Brain research 20061030
Budipine in Parkinson's tremor. Journal of the neurological sciences 20061025
[Diagnosis and therapy of idiopathic Parkinson's disease]. MMW Fortschritte der Medizin 20060515
Efficacy and safety of high-dose cabergoline in Parkinson's disease. Acta neurologica Scandinavica 20060101
Efficacy of budipine and placebo in untreated patients with Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996) 20050801
Pharmacotherapy of Parkinson's disease in Germany. Journal of neurology 20050801
Effects of amantadine and budipine on antidepressant drug-evoked changes in extracellular 5-HT in the frontal cortex of freely moving rats. British journal of pharmacology 20050701
The anti-Parkinson drug budipine is exported actively out of the brain by P-glycoprotein in mice. Neuroscience letters 20050701
Synergism between topiramate and budipine in refractory status epilepticus in the rat. Epilepsia 20041101
Antiapoptotic effects of budipine. Journal of neural transmission (Vienna, Austria : 1996) 20041001
Drug binding to aromatic residues in the HERG channel pore cavity as possible explanation for acquired Long QT syndrome by antiparkinsonian drug budipine. Naunyn-Schmiedeberg's archives of pharmacology 20031101
Evaluation of possible pro- or antioxidative properties and of the interaction capacity with the microsomal cytochrome P450 system of different NMDA-receptor ligands and of taurine in vitro. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20030601
[Diagnosis and treatment of Parkinson's syndrome. What is important for the general practitioner?]. MMW Fortschritte der Medizin 20030526
[Dopaminergic agents, COMT inhibitors or amantadine? Proper treatment for your Parkinson patient]. MMW Fortschritte der Medizin 20020506
Budipine provides additional benefit in patients with Parkinson disease receiving a stable optimum dopaminergic drug regimen. Archives of neurology 20020501
Neuroprotection by NMDA receptor antagonists in a variety of neuropathologies. Current drug targets 20010901
Cytochrome P450 2D6.1 and cytochrome P450 2D6.10 differ in catalytic activity for multiple substrates. Pharmacogenetics 20010801
Dose linearity and steady state pharmacokinetics of the new antiparkinson agent budipine after oral administration. International journal of clinical pharmacology and therapeutics 20010601
Sudden daytime sleep onset in Parkinson's disease: polysomnographic recordings. Movement disorders : official journal of the Movement Disorder Society 20010501
Non-dopaminergic drug treatment of Parkinson's disease. Expert opinion on pharmacotherapy 20010401
[Monotherapy of Parkinson's disease with budipine. A double blind comparison with amantadine]. Fortschritte der Neurologie-Psychiatrie 20010201
Workshop IV: drug treatment guidelines for the long-term management of Parkinson's disease. Journal of neurology 20000901
Deterioration of parkinsonian symptoms following treatment of dopaminergic hallucinosis with olanzapine. European psychiatry : the journal of the Association of European Psychiatrists 19991001
[Synthesis, physical-chemical properties and pharmacologically-oriented screening studies on budipine and related 4,4-diphenylpiperidines]. Arzneimittel-Forschung 19840101
Properties