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Folinic acid

CAS No.:
58-05-9
Catalog Number:
AG003A0Z
Molecular Formula:
C20H23N7O7
Molecular Weight:
473.4393
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%(HPLC)
In Stock USA
United States
$115
- +
25mg
98%(HPLC)
In Stock USA
United States
$279
- +
100mg
98%(HPLC)
In Stock USA
United States
$486
- +
Product Description
Catalog Number:
AG003A0Z
Chemical Name:
Folinic acid
CAS Number:
58-05-9
Molecular Formula:
C20H23N7O7
Molecular Weight:
473.4393
MDL Number:
MFCD00867488
IUPAC Name:
(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
InChI:
InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1
InChI Key:
VVIAGPKUTFNRDU-ABLWVSNPSA-N
SMILES:
O=CN1C(CNc2ccc(cc2)C(=O)N[C@H](C(=O)O)CCC(=O)O)CNc2c1c(=O)nc([nH]2)N
Properties
Complexity:
911  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
473.166g/mol
Formal Charge:
0
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
7  
Isotope Atom Count:
0
Molecular Weight:
473.446g/mol
Monoisotopic Mass:
473.166g/mol
Rotatable Bond Count:
9  
Topological Polar Surface Area:
216A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
-1.2  
Literature
Title Journal
Levoleucovorin as replacement for leucovorin in cancer treatment. The Annals of pharmacotherapy 20121001
Trafficking of intracellular folates. Advances in nutrition (Bethesda, Md.) 20110701
Is levoleucovorin an alternative to racemic leucovorin? A literature review. Clinical colorectal cancer 20091001
Intrathecal leucovorin after intrathecal methotrexate overdose. Journal of pediatric hematology/oncology 19960801
Pharmacokinetics and in vitro studies of l-leucovorin. Comparison with the d and d,l-leucovorin. Annals of oncology : official journal of the European Society for Medical Oncology 19930101
Effect of folinic acid on the capacity of trimethoprim-sulfamethoxazole to prevent and treat Pneumocystis carinii pneumonia in rats. Antimicrobial agents and chemotherapy 19860201
Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates. The Journal of biological chemistry 19850815
Properties