Home Halogens 2,2',4,4'-Tetrabromodiphenyl ether

2,2',4,4'-Tetrabromodiphenyl ether

CAS No.:
5436-43-1
Catalog Number:
AG0039ZX
Molecular Formula:
C12H6Br4O
Molecular Weight:
485.7914
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Product Description
Catalog Number:
AG0039ZX
Chemical Name:
2,2',4,4'-Tetrabromodiphenyl ether
CAS Number:
5436-43-1
Molecular Formula:
C12H6Br4O
Molecular Weight:
485.7914
MDL Number:
MFCD00626457
IUPAC Name:
2,4-dibromo-1-(2,4-dibromophenoxy)benzene
InChI:
InChI=1S/C12H6Br4O/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6H
InChI Key:
XYBSIYMGXVUVGY-UHFFFAOYSA-N
SMILES:
Brc1ccc(c(c1)Br)Oc1ccc(cc1Br)Br
UNII:
0N97R5X10X
NSC Number:
21724
Properties
Complexity:
227  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
485.711g/mol
Formal Charge:
0
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
485.795g/mol
Monoisotopic Mass:
481.715g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
9.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
6.2  
Literature
Title Journal
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In utero and lactational exposure to BDE-47 promotes obesity development in mouse offspring fed a high-fat diet: impaired lipid metabolism and intestinal dysbiosis. Archives of toxicology 20180501
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Effects of 2,2',4,4'-tetrabromodiphenyl ether on neurobehavior and memory change and bcl-2, c-fos, grin1b and lingo1b gene expression in male zebrafish (Danio rerio). Toxicology and applied pharmacology 20171015
Perinatal exposure to 2,2',4'4' -Tetrabromodiphenyl ether induces testicular toxicity in adult rats. Toxicology 20170815
High-fat diet aggravates 2,2',4,4'-tetrabromodiphenyl ether-inhibited testosterone production via DAX-1 in Leydig cells in rats. Toxicology and applied pharmacology 20170515
The flame retardant 2,2',4,4'-Tetrabromodiphenyl ether enhances the expression of corticotropin-releasing hormone in the placental cell model JEG-3. Chemosphere 20170501
Activation of Peroxisome Proliferator-Activated Receptor Gamma and Disruption of Progesterone Synthesis of 2-Ethylhexyl Diphenyl Phosphate in Human Placental Choriocarcinoma Cells: Comparison with Triphenyl Phosphate. Environmental science & technology 20170404
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Assessing the identity and expression level of the cytochrome P450 20A1 (CYP20A1) gene in the BPA-, BDE-47, and WAF-exposed copepods Tigriopus japonicus and Paracyclopina nana. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20170301
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Different mechanisms of action of 2, 2', 4, 4'-tetrabromodiphenyl ether (BDE-47) and its metabolites (5-OH-BDE-47 and 6-OH-BDE-47) on cell proliferation in OVCAR-3 ovarian cancer cells and MCF-7 breast cancer cells. Journal of applied toxicology : JAT 20161201
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Organophosphate Flame Retardants Act as Endocrine-Disrupting Chemicals in MA-10 Mouse Tumor Leydig Cells. Toxicological sciences : an official journal of the Society of Toxicology 20160401
Effect of triclosan, triclocarban, 2,2',4,4'-tetrabromodiphenyl ether, and bisphenol A on the iodide uptake, thyroid peroxidase activity, and expression of genes involved in thyroid hormone synthesis. Toxicology in vitro : an international journal published in association with BIBRA 20160401
Do persistent organic pollutants interact with the stress response? Individual compounds, and their mixtures, interaction with the glucocorticoid receptor. Toxicology letters 20160122
Environmental exposure to BDE47 is associated with increased diabetes prevalence: Evidence from community-based case-control studies and an animal experiment. Scientific reports 20160101
Protective effect of (±)α-tocopherol on brominated diphenyl ether-47-stimulated prostaglandin pathways in human extravillous trophoblasts in vitro. Toxicology in vitro : an international journal published in association with BIBRA 20151001
Activation of Human Peroxisome Proliferator-Activated Nuclear Receptors (PPARγ1) by Semi-Volatile Compounds (SVOCs) and Chemical Mixtures in Indoor Dust. Environmental science & technology 20150818
Disruption of type 2 iodothyronine deiodinase activity in cultured human glial cells by polybrominated diphenyl ethers. Chemical research in toxicology 20150615
Effect of omega-3 fatty acid oxidation products on the cellular and mitochondrial toxicity of BDE 47. Toxicology in vitro : an international journal published in association with BIBRA 20150601
Steroid hormone related effects of marine persistent organic pollutants in human H295R adrenocortical carcinoma cells. Toxicology in vitro : an international journal published in association with BIBRA 20150601
Multiple biomarkers of the cytotoxicity induced by BDE-47 in human embryonic kidney cells. Chemosphere 20150501
The brominated flame retardant BDE-47 causes oxidative stress and apoptotic cell death in vitro and in vivo in mice. Neurotoxicology 20150501
Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently. Toxicology and applied pharmacology 20150401
Troxerutin inhibits 2,2',4,4'-tetrabromodiphenyl ether (BDE-47)-induced hepatocyte apoptosis by restoring proteasome function. Toxicology letters 20150318
Epigenetic effects of low perinatal doses of flame retardant BDE-47 on mitochondrial and nuclear genes in rat offspring. Toxicology 20150203
Bioaccumulation, biotransformation, and toxicity of BDE-47, 6-OH-BDE-47, and 6-MeO-BDE-47 in early life-stages of zebrafish (Danio rerio). Environmental science & technology 20150203
Characterizing the peroxisome proliferator-activated receptor (PPARγ) ligand binding potential of several major flame retardants, their metabolites, and chemical mixtures in house dust. Environmental health perspectives 20150201
In vitro immune toxicity of polybrominated diphenyl ethers on murine peritoneal macrophages: apoptosis and immune cell dysfunction. Chemosphere 20150201
Evaluation of the toxic effects of brominated compounds (BDE-47, 99, 209, TBBPA) and bisphenol A (BPA) using a zebrafish liver cell line, ZFL. Aquatic toxicology (Amsterdam, Netherlands) 20150201
High-throughput RNA sequencing reveals the effects of 2,2',4,4' -tetrabromodiphenyl ether on retina and bone development of zebrafish larvae. BMC genomics 20150101
Aberrant 5'-CpG Methylation of Cord Blood TNFα Associated with Maternal Exposure to Polybrominated Diphenyl Ethers. PloS one 20150101
Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8/SVneo human first trimester extravillous trophoblast cell line. Toxicology and applied pharmacology 20141115
Different action of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) and its hydroxylated metabolites on ERα and ERβ gene and protein expression. Toxicology letters 20140817
Biosynthesis of polybrominated aromatic organic compounds by marine bacteria. Nature chemical biology 20140801
Cross-omics gene and protein expression profiling in juvenile female mice highlights disruption of calcium and zinc signalling in the brain following dietary exposure to CB-153, BDE-47, HBCD or TCDD. Toxicology 20140703
Identification and mRNA expression of two 17β-hydroxysteroid dehydrogenase genes in the marine mussel Mytilus galloprovincialis following exposure to endocrine disrupting chemicals. Environmental toxicology and pharmacology 20140501
PBDE: structure-activity studies for the inhibition of hepatitis C virus NS3 helicase. Molecules (Basel, Switzerland) 20140402
Decabrominated diphenyl ether (BDE-209) and/or BDE-47 exposure alters protein expression in purified neural stem/progenitor cells determined by proteomics analysis. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20140401
Transcriptional and epigenetic mechanisms underlying enhanced in vitro adipocyte differentiation by the brominated flame retardant BDE-47. Environmental science & technology 20140401
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Heavy metal influence on BDE-47 uptake in the human KERTr keratinocyte cell line. Environmental toxicology 20140301
Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes. Toxicological sciences : an official journal of the Society of Toxicology 20140201
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Effects of perchlorate on BDE-47-induced alteration thyroid hormone and gene expression of in the hypothalamus-pituitary-thyroid axis in zebrafish larvae. Environmental toxicology and pharmacology 20131101
Proteomic and metabolomic analysis of earthworm Eisenia fetida exposed to different concentrations of 2,2',4,4'-tetrabromodiphenyl ether. Journal of proteomics 20131008
Mimicking of estradiol binding by flame retardants and their metabolites: a crystallographic analysis. Environmental health perspectives 20131001
Gender-specific transcriptional profiling of marine medaka (Oryzias melastigma) liver upon BDE-47 exposure. Comparative biochemistry and physiology. Part D, Genomics & proteomics 20130901
Structure-dependent activities of hydroxylated polybrominated diphenyl ethers on human estrogen receptor. Toxicology 20130705
A hydroxylated metabolite of flame-retardant PBDE-47 decreases the survival, proliferation, and neuronal differentiation of primary cultured adult neural stem cells and interferes with signaling of ERK5 MAP kinase and neurotrophin 3. Toxicological sciences : an official journal of the Society of Toxicology 20130701
Biotransformation of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) by human liver microsomes: identification of cytochrome P450 2B6 as the major enzyme involved. Chemical research in toxicology 20130520
Hydroxylated polybrominated diphenyl ethers exhibit different activities on thyroid hormone receptors depending on their degree of bromination. Toxicology and applied pharmacology 20130501
Biotransformation of BDE-47 to potentially toxic metabolites is predominantly mediated by human CYP2B6. Environmental health perspectives 20130401
Similarities in the endocrine-disrupting potencies of indoor dust and flame retardants by using human osteosarcoma (U2OS) cell-based reporter gene assays. Environmental science & technology 20130319
The 2,2',4,4'-tetrabromodiphenyl ether hydroxylated metabolites 5-OH-BDE-47 and 6-OH-BDE-47 stimulate estradiol secretion in the ovary by activating aromatase expression. Toxicology 20130308
Cultured human peripheral blood mononuclear cells alter their gene expression when challenged with endocrine-disrupting chemicals. Toxicology 20130107
2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) decreases progesterone synthesis through cAMP-PKA pathway and P450scc downregulation in mouse Leydig tumor cells. Toxicology 20121208
Accumulation and biotransformation of BDE-47 by zebrafish larvae and teratogenicity and expression of genes along the hypothalamus-pituitary-thyroid axis. Environmental science & technology 20121204
Activation of the enzymes of phase I (CYP2B1/2) and phase II (SULT1A and COMT) metabolism by 2,2',4,4'-tetrabromodiphenyl ether (BDE47) in the pig ovary. Reproductive toxicology (Elmsford, N.Y.) 20121101
New approaches to assess the transthyretin binding capacity of bioactivated thyroid hormone disruptors. Toxicological sciences : an official journal of the Society of Toxicology 20121101
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Hepatic in vitro toxicity assessment of PBDE congeners BDE47, BDE153 and BDE154 in Atlantic salmon (Salmo salar L.). Aquatic toxicology (Amsterdam, Netherlands) 20111001
Development of a monoclonal antibody-based, congener-specific and solvent-tolerable direct enzyme-linked immunosorbent assay for the detection of 2,2',4,4'-tetrabromodiphenyl ether in environmental samples. Analytical and bioanalytical chemistry 20111001
Two-stage reduction/subsequent oxidation treatment of 2,2',4,4'-tetrabromodiphenyl ether in aqueous solutions: kinetic, pathway and toxicity. Journal of hazardous materials 20110915
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Effect of brominated flame retardant BDE-47 on androgen production of adult rat Leydig cells. Toxicology letters 20110828
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Residues of PBDEs in northeastern Pacific marine fish: evidence for spatial and temporal trends. Environmental toxicology and chemistry 20110601
Interaction of PFOS and BDE-47 co-exposure on thyroid hormone levels and TH-related gene and protein expression in developing rat brains. Toxicological sciences : an official journal of the Society of Toxicology 20110601
Bioaccumulation and maternal transfer of PBDE 47 in the marine medaka (Oryzias melastigma) following dietary exposure. Aquatic toxicology (Amsterdam, Netherlands) 20110601
A dynamic multimedia environmental and bioaccumulation model for brominated flame retardants in Lake Huron and Lake Erie, USA. Environmental toxicology and chemistry 20110501
Polybrominated diphenyl ethers and sperm quality. Reproductive toxicology (Elmsford, N.Y.) 20110501
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Polybrominated diphenyl ethers in relation to autism and developmental delay: a case-control study. Environmental health : a global access science source 20110101
Bioaccumulation and behavioral effects of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in perinatally exposed mice. Neurotoxicology and teratology 20110101
In vitro profiling of endocrine disrupting potency of 2,2',4,4'-tetrabromodiphenyl ether (BDE47) and related hydroxylated analogs (HO-PBDEs). Marine pollution bulletin 20110101
Cytotoxic effects and oxidative stress response of six PBDE metabolites on human L02 cells. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 20110101
Cytogenotoxicity induced by PBDE-47 combined with PCB153 treatment in SH-SY5Y cells. Environmental toxicology 20101201
Interconversion of hydroxylated and methoxylated polybrominated diphenyl ethers in Japanese medaka. Environmental science & technology 20101115
Structure-based investigation on the binding interaction of hydroxylated polybrominated diphenyl ethers with thyroxine transport proteins. Toxicology 20101109
Partitioning of tetra- and pentabromo diphenyl ether and benzo[a]pyrene among water and dissolved and particulate organic carbon along a salinity gradient in coastal waters. Environmental toxicology and chemistry 20101101
Vibrational spectroscopic investigation and DFT studies on 2,2',4,4'-tetrabromodiphenyl ether. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20101015
Polybrominated diphenyl ethers and arylhydrocarbon receptor agonists: Different toxicity and target gene expression. Toxicology letters 20101005
Sorption kinetic characteristics of polybrominated diphenyl ethers on natural soils. Environmental pollution (Barking, Essex : 1987) 20100901
Metabolism of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in chickens. Journal of agricultural and food chemistry 20100811
Chronic exposure of 2,2',4,4'-tetrabromodiphenyl ether (PBDE-47) alters locomotion behavior in juvenile zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands) 20100715
Cytotoxicity and apoptosis induction on RTG-2 cells of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) and decabrominated diphenyl ether (BDE-209). Toxicology in vitro : an international journal published in association with BIBRA 20100601
Mechanism of polybrominated diphenyl ether uptake into the liver: PBDE congeners are substrates of human hepatic OATP transporters. Toxicological sciences : an official journal of the Society of Toxicology 20100601
Changes in mitogen-activated protein kinase in cerebellar granule neurons by polybrominated diphenyl ethers and polychlorinated biphenyls. Toxicology and applied pharmacology 20100515
Thirty year monitoring of PCBs, organochlorine pesticides and tetrabromodiphenylether in eel from The Netherlands. Environmental pollution (Barking, Essex : 1987) 20100501
Flow cytometric analysis of BDE 47 mediated injury to rainbow trout gill epithelial cells. Aquatic toxicology (Amsterdam, Netherlands) 20100401
Bromination pattern of hydroxylated metabolites of BDE-47 affects their potency to release calcium from intracellular stores in PC12 cells. Environmental health perspectives 20100401
Mixture of dominant PBDE congeners (BDE-47, -99, -100 and -209) at levels noted in human blood dramatically enhances progesterone secretion by ovarian follicles. Endocrine regulations 20100401
Growth and transcriptional effect of dietary 2,2',4,4'-tetrabromodiphenyl ether (PBDE-47) exposure in developing zebrafish (Danio rerio). Ecotoxicology and environmental safety 20100301
Low concentrations of the brominated flame retardants BDE-47 and BDE-99 induce synergistic oxidative stress-mediated neurotoxicity in human neuroblastoma cells. Toxicology in vitro : an international journal published in association with BIBRA 20100201
Global gene expression analysis in the livers of rat offspring perinatally exposed to low doses of 2,2',4,4'-tetrabromodiphenyl ether. Environmental health perspectives 20100101
Placental transfer of the polybrominated diphenyl ethers BDE-47, BDE-99 and BDE-209 in a human placenta perfusion system: an experimental study. Environmental health : a global access science source 20100101
Prenatal exposure to organohalogens, including brominated flame retardants, influences motor, cognitive, and behavioral performance at school age. Environmental health perspectives 20091201
Mechanisms underlying the developmental neurotoxic effect of PBDE-47 and the enhanced toxicity associated with its combination with PCB153 in rats. Neurotoxicology 20091101
Human liver microsome-mediated metabolism of brominated diphenyl ethers 47, 99, and 153 and identification of their major metabolites. Chemical research in toxicology 20091101
Immunoassay for monitoring environmental and human exposure to the polybrominated diphenyl ether BDE-47. Environmental science & technology 20091015
Accessibility of polybrominated diphenyl ether congeners in aging soil. Journal of environmental monitoring : JEM 20090901
[Effects of PCB153 on oxidative stress and 8-OHdG content induced by PBDE-47 in human neuroblastoma cells in vitro]. Wei sheng yan jiu = Journal of hygiene research 20090901
[Effects and toxicity mechanism of 2,2',4,4'-tetrabrominated diphenyl ethers on the homeostasis of thyroid hormone system in C57BL/6 mice]. Wei sheng yan jiu = Journal of hygiene research 20090901
Nuclear hormone receptor activity of polybrominated diphenyl ethers and their hydroxylated and methoxylated metabolites in transactivation assays using Chinese hamster ovary cells. Environmental health perspectives 20090801
Perinatal exposure to low-dose 2,2',4,4'-tetrabromodiphenyl ether affects growth in rat offspring: what is the role of IGF-1? Toxicology 20090616
In vitro hepatic metabolism of 2,2',4,4',5-pentabromodiphenyl ether (BDE 99) in Chinook salmon (Onchorhynchus tshawytscha). Aquatic toxicology (Amsterdam, Netherlands) 20090517
Examining the role of temperature and sediment-chemical contact time on desorption and bioavailability of sediment-associated tetrabromo diphenyl ether and benzo(a)pyrene. Ecotoxicology and environmental safety 20090501
Lethal and sublethal effects of simvastatin, irgarol, and PBDE-47 on the estuarine fish, Fundulus heteroclitus. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20090501
Transcriptional effects of nonylphenol, bisphenol A and PBDE-47 in liver of juvenile Atlantic cod (Gadus morhua). Chemosphere 20090401
Preliminary evidence of the in vitro effects of BDE-47 on innate immune responses in children with autism spectrum disorders. Journal of neuroimmunology 20090331
Biomagnification of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls in a highly contaminated freshwater food web from South China. Environmental pollution (Barking, Essex : 1987) 20090301
Distribution of polybrominated diphenyl ethers in breast milk from North China: implication of exposure pathways. Chemosphere 20090301
Cytotoxicity and gene expression profiling of two hydroxylated polybrominated diphenyl ethers in human H295R adrenocortical carcinoma cells. Toxicology letters 20090225
Recombinant transthyretin purification and competitive binding with organohalogen compounds in two gull species (Larus argentatus and Larus hyperboreus). Toxicological sciences : an official journal of the Society of Toxicology 20090201
Influence of PCB153 on oxidative DNA damage and DNA repair-related gene expression induced by PBDE-47 in human neuroblastoma cells in vitro. Toxicological sciences : an official journal of the Society of Toxicology 20090101
Mechanism of the neurotoxic effect of PBDE-47 and interaction of PBDE-47 and PCB153 in enhancing toxicity in SH-SY5Y cells. Neurotoxicology 20090101
Thyroid disruption by low-dose BDE-47 in prenatally exposed lambs. Neonatology 20090101
Site-specific impacts on gene expression and behavior in fathead minnows (Pimephales promelas) exposed in situ to streams adjacent to sewage treatment plants. BMC bioinformatics 20090101
Polymeric brominated flame retardants: are they a relevant source of emerging brominated aromatic compounds in the environment? Environmental science & technology 20081215
Dietary exposure to 2,2',4,4'-tetrabromodiphenyl ether (PBDE-47) alters thyroid status and thyroid hormone-regulated gene transcription in the pituitary and brain. Environmental health perspectives 20081201
Photodegradation of 2,2',4,4'-tetrabromodiphenyl ether in nonionic surfactant solutions. Chemosphere 20081101
Airborne PBDEs in specialized occupational settings, houses and outdoor urban areas in Greece. Environmental pollution (Barking, Essex : 1987) 20080901
A technical mixture of 2,2',4,4'-tetrabromo diphenyl ether (BDE47) and brominated furans triggers aryl hydrocarbon receptor (AhR) mediated gene expression and toxicity. Chemosphere 20080901
[Effects of PCB153 on DNA damage and DNA repair-related genes expressions induced by PBDE-47 in human neuroblastoma cells in vitro]. Wei sheng yan jiu = Journal of hygiene research 20080901
Concentration of polybrominated diphenyl ethers (PBDEs) in household dust from various countries. Chemosphere 20080801
Multixenobiotic resistance, acetyl-choline esterase activity and total oxyradical scavenging capacity of the Arctic spider crab, Hyasaraneus, following exposure to bisphenol A, tetra bromo diphenyl ether and diallyl phthalate. Marine pollution bulletin 20080801
Determination of polybromodiphenyl ethers (PBDEs) in milk cream by gas chromatography-mass spectrometry. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20080801
Toxicity and physiological effects of brominated flame retardant PBDE-47 on two life stages of grass shrimp, Palaemonetes pugio. The Science of the total environment 20080725
Spatial trends of polybrominated diphenyl ethers in avian species: utilization of stored samples in the Environmental Specimen Bank of Ehime University (es-Bank). Environmental pollution (Barking, Essex : 1987) 20080701
Effect of parental exposure to trenbolone and the brominated flame retardant BDE-47 on fertility in rainbow trout (Oncorhynchus mykiss). Marine environmental research 20080701
Comparative oxygen radical formation and toxicity of BDE 47 in rainbow trout cell lines. Marine environmental research 20080701
Biomonitoring of polybrominated diphenyl ether (PBDE) pollution: a field study. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20080701
Hydroxylation increases the neurotoxic potential of BDE-47 to affect exocytosis and calcium homeostasis in PC12 cells. Environmental health perspectives 20080501
Serum concentrations of neutral and phenolic organohalogens in pregnant women and some of their infants in The Netherlands. Environmental science & technology 20080501
Atmospheric concentrations and phase partitioning of polybrominated diphenyl ethers (PBDEs) in Izmir, Turkey. Chemosphere 20080401
Gene expression profiles in rainbow trout, Onchorynchus mykiss, exposed to a simple chemical mixture. Toxicological sciences : an official journal of the Society of Toxicology 20080301
In utero and lactational exposures to low doses of polybrominated diphenyl ether-47 alter the reproductive system and thyroid gland of female rat offspring. Environmental health perspectives 20080301
Microarray analysis reveals a mechanism of phenolic polybrominated diphenylether toxicity in zebrafish. Environmental science & technology 20080301
Inhibition of human placental aromatase activity by hydroxylated polybrominated diphenyl ethers (OH-PBDEs). Toxicology and applied pharmacology 20080215
Effects of 20 PBDE metabolites on steroidogenesis in the H295R cell line. Toxicology letters 20080215
Reductive debromination of polybrominated diphenyl ethers in anaerobic sediment and a biomimetic system. Environmental science & technology 20080215
Serum concentrations of polybrominated diphenyl ethers (PBDEs) and polybrominated biphenyl (PBB) in the United States population: 2003-2004. Environmental science & technology 20080215
Possible mechanisms of thyroid hormone disruption in mice by BDE 47, a major polybrominated diphenyl ether congener. Toxicology and applied pharmacology 20080201
Biotransformation of brominated flame retardants into potentially endocrine-disrupting metabolites, with special attention to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47). Molecular nutrition & food research 20080201
Probabilistic intake assessment of polybrominated diphenyl ethers and omega-3 fatty acids through fish consumption. Molecular nutrition & food research 20080201
Consumption of fish from a contaminated lake strongly affects the concentrations of polybrominated diphenyl ethers and hexabromocyclododecane in serum. Molecular nutrition & food research 20080201
Temporal trends of polybrominated diphenyl ethers and hexabromocyclododecane in milk from Stockholm mothers, 1980-2004. Molecular nutrition & food research 20080201
Dietary exposure to brominated flame retardants correlates with male blood levels in a selected group of Norwegians with a wide range of seafood consumption. Molecular nutrition & food research 20080201
Determination of brominated flame retardants and brominated dioxins in fish collected from three regions of Japan. Molecular nutrition & food research 20080201
Effects of PBDE-47 on cytotoxicity and genotoxicity in human neuroblastoma cells in vitro. Mutation research 20080108
Geographical distribution and accumulation features of PBDEs in human breast milk from Indonesia. Environmental pollution (Barking, Essex : 1987) 20080101
The role of mitochondrial and oxidative injury in BDE 47 toxicity to human fetal liver hematopoietic stem cells. Toxicological sciences : an official journal of the Society of Toxicology 20080101
PBDE-47-induced oxidative stress, DNA damage and apoptosis in primary cultured rat hippocampal neurons. Neurotoxicology 20080101
Acute postnatal exposure to brominated diphenylether 47 delays neuromotor ontogeny and alters motor activity in mice. Neurotoxicology and teratology 20080101
Lack of alterations in thyroid hormones following exposure to polybrominated diphenyl ether 47 during a period of rapid brain development in mice. Drug and chemical toxicology 20080101
A cohort study of in utero polychlorinated biphenyl (PCB) exposures in relation to secondary sex ratio. Environmental health : a global access science source 20080101
Facing the challenge of data transfer from animal models to humans: the case of persistent organohalogens. Environmental health : a global access science source 20080101
Fish as biomonitors of polybrominated diphenyl ethers and hexabromocyclododecane in Czech aquatic ecosystems: pollution of the Elbe River basin. Environmental health perspectives 20071201
Debromination of polybrominated diphenyl ether-99 (BDE-99) in carp (Cyprinus carpio) microflora and microsomes. Chemosphere 20071001
Plasma concentrations of selected organobromine compounds and polychlorinated biphenyls in postmenopausal women of Québec, Canada. Environmental health perspectives 20071001
Flame retardants in placenta and breast milk and cryptorchidism in newborn boys. Environmental health perspectives 20071001
Distribution of BDE-99 and effects on metamorphosis of BDE-99 and -47 after oral exposure in Xenopus tropicalis. Aquatic toxicology (Amsterdam, Netherlands) 20070815
Disruption of thyroid hormone binding to sea bream recombinant transthyretin by ioxinyl and polybrominated diphenyl ethers. Chemosphere 20070801
Food web-specific biomagnification of persistent organic pollutants. Science (New York, N.Y.) 20070713
Polybrominated diphenyl ethers and ortho-substituted polychlorinated biphenyls as neuroendocrine disruptors of vasopressin release: effects during physiological activation in vitro and structure-activity relationships. Toxicological sciences : an official journal of the Society of Toxicology 20070701
Measurement of polybrominated diphenyl ethers and metabolites in mouse plasma after exposure to a commercial pentabromodiphenyl ether mixture. Environmental health perspectives 20070701
Tetrabromodiphenyl ether (BDE 47) evokes estrogenicity and calbindin-D9k expression through an estrogen receptor-mediated pathway in the uterus of immature rats. Toxicological sciences : an official journal of the Society of Toxicology 20070601
Neonatal exposure to brominated flame retardant BDE-47 reduces long-term potentiation and postsynaptic protein levels in mouse hippocampus. Environmental health perspectives 20070601
Neural defects and cardiac arrhythmia in fish larvae following embryonic exposure to 2,2',4,4'-tetrabromodiphenyl ether (PBDE 47). Aquatic toxicology (Amsterdam, Netherlands) 20070531
Silica gel as a particulate carrier of poorly water-soluble substances in aquatic toxicity testing. Aquatic toxicology (Amsterdam, Netherlands) 20070531
The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators. Toxicological sciences : an official journal of the Society of Toxicology 20070501
[Effects of 2,2', 4,4' -tetrabromodiphenyl ethers on oxidative stress and DNA damage in SH-SY5Y cells]. Wei sheng yan jiu = Journal of hygiene research 20070501
Physicochemical properties of selected polybrominated diphenyl ethers and extension of the UNIFAC model to brominated aromatic compounds. Chemosphere 20070401
Plasma PBDE and thyroxine levels in rats exposed to Bromkal or BDE-47. Chemosphere 20070401
Dehalogenation of polychlorinated biphenyls and polybrominated diphenyl ethers using a hybrid bioinorganic catalyst. Journal of environmental monitoring : JEM 20070401
Congener distribution of polybrominated diphenyl ethers in feral carp (Cyprinus carpio) from the Llobregat River, Spain. Environmental pollution (Barking, Essex : 1987) 20070301
[Effects of PBDE-47 on oxidative stress and apoptosis in SH-SY5Y cell]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20070301
Indoor organophosphate and polybrominated flame retardants in Tokyo. Indoor air 20070201
Bioaccumulation and biotransformation of 61 polychlorinated biphenyl and four polybrominated diphenyl ether congeners in juvenile American kestrels (Falco sparverius). Environmental toxicology and chemistry 20070201
Bioavailability and mass balance studies of a commercial pentabromodiphenyl ether mixture in male Sprague-Dawley rats. Chemosphere 20070101
Polybrominated diphenyl ether levels in the blood of pregnant women living in an agricultural community in California. Environmental health perspectives 20070101
Toxicokinetics of polybrominated diphenyl ether congeners 47, 99, 100, and 153 in mice. Toxicological sciences : an official journal of the Society of Toxicology 20061101
In vitro effects of brominated flame retardants and metabolites on CYP17 catalytic activity: a novel mechanism of action? Toxicology and applied pharmacology 20061015
Children show highest levels of polybrominated diphenyl ethers in a California family of four: a case study. Environmental health perspectives 20061001
Effects of xenobiotics and steroids on renal and hepatic estrogen metabolism in lake trout. General and comparative endocrinology 20060901
Nonabsorbable dietary fat enhances disposal of 2,2',4,4'-tetrabromodiphenyl ether in rats through interruption of enterohepatic circulation. Journal of agricultural and food chemistry 20060823
Antagonism of TCDD-induced ethoxyresorufin-O-deethylation activity by polybrominated diphenyl ethers (PBDEs) in primary cynomolgus monkey (Macaca fascicularis) hepatocytes. Toxicology letters 20060701
In vitro profiling of the endocrine-disrupting potency of brominated flame retardants. Toxicological sciences : an official journal of the Society of Toxicology 20060701
Interactions of polybrominated diphenyl ethers with the aryl hydrocarbon receptor pathway. Toxicological sciences : an official journal of the Society of Toxicology 20060701
Identification of proteomic signatures of exposure to marine pollutants in mussels (Mytilus edulis). Molecular & cellular proteomics : MCP 20060701
Preliminary study of responses in mussel (Mytilus edilus) exposed to bisphenol A, diallyl phthalate and tetrabromodiphenyl ether. Aquatic toxicology (Amsterdam, Netherlands) 20060601
Expression of cytoskeletal proteins, cross-reacting with anti-CYP1A, in Mytilus sp. exposed to organic contaminants. Aquatic toxicology (Amsterdam, Netherlands) 20060601
Induction of micronuclei and other nuclear abnormalities in mussels exposed to bisphenol A, diallyl phthalate and tetrabromodiphenyl ether-47. Aquatic toxicology (Amsterdam, Netherlands) 20060601
The BEEP Stavanger Workshop: Mesocosm exposures. Aquatic toxicology (Amsterdam, Netherlands) 20060601
Chronic toxicity of 2,4,2',4'-tetrabromodiphenyl ether on the marine alga Skeletonema costatum and the crustacean Daphnia magna. Environmental toxicology and chemistry 20060601
Gene expression patterns in rainbow trout, Oncorhynchus mykiss, exposed to a suite of model toxicants. Aquatic toxicology (Amsterdam, Netherlands) 20060525
Determination of HBCD, PBDEs and MeO-BDEs in California sea lions (Zalophus californianus) stranded between 1993 and 2003. Marine pollution bulletin 20060501
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Identification of hydroxylated metabolites in 2,2',4,4'-tetrabromodiphenyl ether exposed rats. Chemosphere 20060401
Disposition of BDE 47 in developing mice. Toxicological sciences : an official journal of the Society of Toxicology 20060401
Impact of repeated exposure on the toxicokinetics of BDE 47 in mice. Toxicological sciences : an official journal of the Society of Toxicology 20060201
Oral exposure of PBDE-47 in fish: toxicokinetics and reproductive effects in Japanese Medaka (Oryzias latipes) and fathead minnows (Pimephales promelas). Environmental science & technology 20060115
Tissue localisation of tetra- and pentabromodiphenyl ether congeners (BDE-47, -85 and -99) in perinatal and adult C57BL mice. Chemosphere 20060101
Metabolism and disposition of 2,2',4,4'- tetrabromodiphenyl ether following administration of single or multiple doses to rats and mice. Xenobiotica; the fate of foreign compounds in biological systems 20060101
Absorption of [14C]-tetrabromodiphenyl ether (TeBDE) through human and rat skin in vitro. Drug and chemical toxicology 20060101
Concentrations of polybrominated diphenyl ethers, polychlonnated biphenyls, and polychlorobiphenylols in serum from pregnant Faroese women and their children 7 years later. Environmental science & technology 20051215
Inhibition and induction of aromatase (CYP19) activity by brominated flame retardants in H295R human adrenocortical carcinoma cells. Toxicological sciences : an official journal of the Society of Toxicology 20051201
Polybrominated diphenyl ether (PBDE) effects in rat neuronal cultures: 14C-PBDE accumulation, biological effects, and structure-activity relationships. Toxicological sciences : an official journal of the Society of Toxicology 20051101
Differential expression of CYP1A, 2B, and 3A genes in the F344 rat following exposure to a polybrominated diphenyl ether mixture or individual components. Toxicological sciences : an official journal of the Society of Toxicology 20051101
In vitro estrogenicity of polybrominated flame retardants. Aquatic toxicology (Amsterdam, Netherlands) 20050910
Brominated-chlorinated diphenyl ethers formed by thermolysis of polybrominated diphenyl ethers at low temperatures. Chemosphere 20050901
In vivo and in vitro anti-androgenic effects of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture. Toxicology and applied pharmacology 20050822
Toxicokinetics of BDE 47 in female mice: effect of dose, route of exposure, and time. Toxicological sciences : an official journal of the Society of Toxicology 20050201
Menstrual function among women exposed to polybrominated biphenyls: a follow-up prevalence study. Environmental health : a global access science source 20050101
Accumulation of PBDE-47 in primary cultures of rat neocortical cells. Toxicological sciences : an official journal of the Society of Toxicology 20041101
Debromination of polybrominated diphenyl ether congeners BDE 99 and BDE 183 in the intestinal tract of the common carp (Cyprinus carpio). Environmental science & technology 20040215
Optimization of solid-phase microextraction for the gas chromatography/mass spectrometry analysis of persistent organic pollutants. Journal of AOAC International 20040101
Brominated flame retardants and phenolic endocrine disrupters in Finnish human adipose tissue. Chemosphere 20031201
A review on human exposure to brominated flame retardants--particularly polybrominated diphenyl ethers. Environment international 20030901
Brominated dioxin-like compounds: in vitro assessment in comparison to classical dioxin-like compounds and other polyaromatic compounds. Environment international 20030901
Comparing polybrominated diphenyl ether and polychlorinated biphenyl bioaccumulation in a food web in Grand Traverse Bay, Lake Michigan. Archives of environmental contamination and toxicology 20030801
High body burdens of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in California women. Environmental health perspectives 20030701
Polybrominated dibenzo-p-dioxins, dibenzofurans, and diphenyl ethers in Japanese human adipose tissue. Environmental science & technology 20030301
Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and chlorinated paraffins (CPs) in rats-testing interactions and mechanisms for thyroid hormone effects. Toxicology 20020815
Brominated flame retardants in archived serum samples from Norway: a study on temporal trends and the role of age. Environmental science & technology 20020401
Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption. Toxicological sciences : an official journal of the Society of Toxicology 20020301
Spatial distribution of polybrominated diphenyl ethers and polybrominated biphenyls in lake trout from the Laurentian Great Lakes. Chemosphere 20020201
Brominated flame retardants in serum from U.S. blood donors. Environmental science & technology 20011001
Brominated flame retardants: a novel class of developmental neurotoxicants in our environment? Environmental health perspectives 20010901
Brominated flame retardants in plasma samples from three different occupational groups in Norway. Journal of environmental monitoring : JEM 20010801
Effects of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) on thyroid hormone and vitamin A levels in rats and mice. Archives of toxicology 20010601
Plasma levels of persistent organohalogens and hormone levels in adult male humans. Archives of environmental health 20010101
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