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MK-2461

CAS No.:
917879-39-1
Catalog Number:
AG0039XN
Molecular Formula:
C24H25N5O5S
Molecular Weight:
495.5508
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
2mg
99%
1 week
United States
$182
- +
5mg
99%
1 week
United States
$307
- +
10mg
99%
1 week
United States
$501
- +
25mg
99%
1 week
United States
$960
- +
50mg
99%
1 week
United States
$1654
- +
100mg
99%
1 week
United States
$2848
- +
Product Description
Catalog Number:
AG0039XN
Chemical Name:
MK-2461
CAS Number:
917879-39-1
Molecular Formula:
C24H25N5O5S
Molecular Weight:
495.5508
MDL Number:
MFCD11977739
IUPAC Name:
14-[[[(2R)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-5-(1-methylpyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaene
InChI:
InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
InChI Key:
JGEBLDKNWBUGRZ-HXUWFJFHSA-N
SMILES:
Cn1ncc(c1)c1cnc2c(c1)c(=O)c1cc(ccc1cc2)NS(=O)(=O)N(C[C@@H]1COCCO1)C
UNII:
4200RD53XF
Properties
Complexity:
895  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
495.158g/mol
Formal Charge:
0
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
495.554g/mol
Monoisotopic Mass:
495.158g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
124A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.2  
Literature
Title Journal
Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer. Journal of medicinal chemistry 20110623
Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives. European journal of medicinal chemistry 20110601
MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer research 20100215
Properties