Purvalanol b
| Title | Journal |
|---|---|
| Identification of potent Yes1 kinase inhibitors using a library screening approach. | Bioorganic & medicinal chemistry letters 20130801 |
| Vimentin phosphorylation by Cdc2 in Schwann cell controls axon growth via β1-integrin activation. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120601 |
| Role of cell cycle-associated proteins in microglial proliferation in the axotomized rat facial nucleus. | Glia 20120401 |
| Silencing of the polyamine catabolic key enzyme SSAT prevents CDK inhibitor-induced apoptosis in Caco-2 colon cancer cells. | Molecular medicine reports 20120401 |
| Olomoucine II and purvalanol A inhibit ABCG2 transporter in vitro and in situ and synergistically potentiate cytostatic effect of mitoxantrone. | Pharmacological research 20120301 |
| Regulation of a Myb transcription factor by cyclin-dependent kinase 2 in Giardia lamblia. | The Journal of biological chemistry 20120203 |
| Computational design of targeted inhibitors of polo-like kinase 1 (plk1). | Bioinformatics and biology insights 20120101 |
| The biocompatibility of nanodiamonds and their application in drug delivery systems. | Theranostics 20120101 |
| An anillin-Ect2 complex stabilizes central spindle microtubules at the cortex during cytokinesis. | PloS one 20120101 |
| IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening. | PloS one 20120101 |
| Securin enhances the anti-cancer effects of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075) in human colorectal cancer cells. | PloS one 20120101 |
| Cyclin B1 interacts with the BH3-only protein Bim and mediates its phosphorylation by Cdk1 during mitosis. | Cell cycle (Georgetown, Tex.) 20111115 |
| VMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in medulloblastoma cells. | Cancer biology & therapy 20111101 |
| Cell cycle regulators are critical for maintaining the differentiation potential and immaturity in adipogenesis of adipose-derived stem cells. | Differentiation; research in biological diversity 20111001 |
| A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor. | Oncogene 20110728 |
| Fluorescent cyclin-dependent kinase inhibitors block the proliferation of human breast cancer cells. | Bioorganic & medicinal chemistry 20110415 |
| LiCl induces TNF-α and FasL production, thereby stimulating apoptosis in cancer cells. | Cell communication and signaling : CCS 20110101 |
| Alteration in superoxide dismutase 1 causes oxidative stress and p38 MAPK activation following RVFV infection. | PloS one 20110101 |
| Acute toxicity of the antifouling compound butenolide in non-target organisms. | PloS one 20110101 |
| The Cryptosporidium parvum kinome. | BMC genomics 20110101 |
| Phosphorylation of AIB1 at mitosis is regulated by CDK1/CYCLIN B. | PloS one 20110101 |
| The yeast three-hybrid system as an experimental platform to identify proteins interacting with small signaling molecules in plant cells: potential and limitations. | Frontiers in plant science 20110101 |
| Noise cancellation: viral fine tuning of the cellular environment for its own genome replication. | PLoS pathogens 20101201 |
| Cell cycle-dependent regulation of the forkhead transcription factor FOXK2 by CDK·cyclin complexes. | The Journal of biological chemistry 20101112 |
| Purvalanol A, a CDK inhibitor, effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src. | Genes to cells : devoted to molecular & cellular mechanisms 20101001 |
| VMY-1-103, a dansylated analog of purvalanol B, induces caspase-3-dependent apoptosis in LNCaP prostate cancer cells. | Cancer biology & therapy 20100815 |
| Mitotane sensitizes adrenocortical cancer cells to ionizing radiations by involvement of the cyclin B1/CDK complex in G2 arrest and mismatch repair enzymes modulation. | International journal of oncology 20100801 |
| Compounds that target host cell proteins prevent varicella-zoster virus replication in culture, ex vivo, and in SCID-Hu mice. | Antiviral research 20100601 |
| Simultaneous detection of intracellular target and off-target binding of small molecule cancer drugs at nanomolar concentrations. | British journal of pharmacology 20100601 |
| Comprehensive screening of human genes with inhibitory effects on yeast growth and validation of a yeast cell-based system for screening chemicals. | Journal of biomolecular screening 20100401 |
| Inhibition of human immunodeficiency virus type-1 by cdk inhibitors. | AIDS research and therapy 20100101 |
| Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs. | PloS one 20100101 |
| Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells. | PloS one 20100101 |
| Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis. | Advances in pharmacological sciences 20100101 |
| Nanodiamond-mediated delivery of water-insoluble therapeutics. | ACS nano 20090728 |
| Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. | PLoS biology 20090501 |
| Cellular phototoxicity evoked through the inhibition of human ABC transporter ABCG2 by cyclin-dependent kinase inhibitors in vitro. | Pharmaceutical research 20090201 |
| Structural insights into the inhibited states of the Mer receptor tyrosine kinase. | Journal of structural biology 20090201 |
| Establishment of human papillomavirus infection requires cell cycle progression. | PLoS pathogens 20090201 |
| The utilization of humanized mouse models for the study of human retroviral infections. | Retrovirology 20090101 |
| Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2. | PloS one 20090101 |
| Purvalanol A induces apoptosis and downregulation of antiapoptotic proteins through abrogation of phosphorylation of JAK2/STAT3 and RNA polymerase II. | Anti-cancer drugs 20080701 |
| Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation. | The Journal of biological chemistry 20080627 |
| Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. | Nature chemical biology 20080601 |
| Oxidative amination of cuprated pyrimidine and purine derivatives. | Organic letters 20080501 |
| Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways. | AIDS research and therapy 20080101 |
| Standardized high-throughput evaluation of cell-based compound screens. | BMC bioinformatics 20080101 |
| [Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20071001 |
| Cyclin-dependent kinase inhibitors block erythrocyte invasion and intraerythrocytic development of Babesia bovis in vitro. | Parasitology 20070901 |
| The molecular genetics of breast cancer and targeted therapy. | Biologics : targets & therapy 20070901 |
| Purvalanol A enhances cell killing by inhibiting up-regulation of CDC2 kinase activity in tumor cells irradiated with high doses of X rays. | Radiation research 20070501 |
| The mitotic manipulation of cytotrophoblast differentiation in vitro. | Placenta 20070101 |
| Effect of downregulation of survivin expression on radiosensitivity of human epidermoid carcinoma cells. | International journal of radiation oncology, biology, physics 20061101 |
| p27 small interfering RNA induces cell death through elevating cell cycle activity in cultured cortical neurons: a proof-of-concept study. | Cellular and molecular life sciences : CMLS 20061001 |
| Dependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2. | Journal of the American Society of Nephrology : JASN 20060901 |
| Cellular stress increases RGS2 mRNA and decreases RGS4 mRNA levels in SH-SY5Y cells. | Neuroscience letters 20060724 |
| Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo. | The Journal of biological chemistry 20060616 |
| p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells. | PLoS biology 20060301 |
| Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds. | Chemical biology & drug design 20060101 |
| Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner. | The Journal of biological chemistry 20051028 |
| Crystal structures of active SRC kinase domain complexes. | Journal of molecular biology 20051021 |
| Ligand binding affinity determined by temperature-dependent circular dichroism: cyclin-dependent kinase 2 inhibitors. | Analytical biochemistry 20051015 |
| Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. | Molecular cancer therapeutics 20050901 |
| Paclitaxel induces the phosphorylation of the eukaryotic translation initiation factor 4E-binding protein 1 through a Cdk1-dependent mechanism. | Oncogene 20050714 |
| Characterization of two T. gondii CK1 isoforms. | Molecular and biochemical parasitology 20050501 |
| Purvalanol A, inhibitor of cyclin-dependent kinases attenuates proliferation of cells in the dentate gyrus of the adult rat hippocampus. | Pharmacological reports : PR 20050101 |
| The tubulin-binding agent combretastatin A-4-phosphate arrests endothelial cells in mitosis and induces mitotic cell death. | The American journal of pathology 20041001 |
| Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons. | Biochemical pharmacology 20040515 |
| Down-regulation of survivin in nitric oxide-induced cell growth inhibition and apoptosis of the human lung carcinoma cells. | The Journal of biological chemistry 20040507 |
| Protein kinases as targets for anti-parasitic chemotherapy. | Biochimica et biophysica acta 20040311 |
| Viral and cellular kinases are potential antiviral targets and have a central role in varicella zoster virus pathogenesis. | Biochimica et biophysica acta 20040311 |
| Cassette dosing pharmacokinetics of a library of 2,6,9-trisubstituted purine cyclin-dependent kinase 2 inhibitors prepared by parallel synthesis. | Molecular cancer therapeutics 20040301 |
| A three-hybrid approach to scanning the proteome for targets of small molecule kinase inhibitors. | Chemistry & biology 20040201 |
| c-Myc alters the DNA damage-induced G2/M arrest in human mammary epithelial cells. | British journal of cancer 20031020 |
| The specificities of protein kinase inhibitors: an update. | The Biochemical journal 20030401 |
| Synthesis and biological activity of olomoucine II. | Bioorganic & medicinal chemistry letters 20021118 |
| p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol. | Oncogene 20020919 |
| Progress toward virtual screening for drug side effects. | Proteins 20020901 |
| Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteins. | Journal of virology 20020801 |
| Inhibition of HTLV-1 transcription by cyclin dependent kinase inhibitors. | Molecular and cellular biochemistry 20020801 |
| Structural classification of protein kinases using 3D molecular interaction field analysis of their ligand binding sites: target family landscapes. | Journal of medicinal chemistry 20020606 |
| Cellular effects of purvalanol A: a specific inhibitor of cyclin-dependent kinase activities. | International journal of cancer 20020220 |
| Characterization of a human colorectal carcinoma cell line with acquired resistance to flavopiridol. | Molecular pharmacology 20011101 |
| Cell cycle-dependent control of polarised development by a cyclin-dependent kinase-like protein in the Fucus zygote. | Development (Cambridge, England) 20011101 |
| Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum. | Biochemical pharmacology 20010801 |
| Applications of microarray technology in breast cancer research. | Breast cancer research : BCR 20010101 |
| Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. | Science (New York, N.Y.) 19980724 |