Home Halogens (2S,3R,4R,5S,6R)-2-[4-chloro-3-({4-[(3S)-oxolan-3-yloxy]phenyl}methyl)phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol

(2S,3R,4R,5S,6R)-2-[4-chloro-3-({4-[(3S)-oxolan-3-yloxy]phenyl}methyl)phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol

CAS No.:
864070-44-0
Catalog Number:
AG0039QH
Molecular Formula:
C23H27ClO7
Molecular Weight:
450.9093
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
98%
In Stock USA
United States
$44
- +
5g
98%
In Stock USA
United States
$113
- +
10g
98%
In Stock USA
United States
$175
- +
25g
98%
In Stock USA
United States
$350
- +
100g
98%
In Stock USA
United States
$938
- +
Product Description
Catalog Number:
AG0039QH
Chemical Name:
(2S,3R,4R,5S,6R)-2-[4-chloro-3-({4-[(3S)-oxolan-3-yloxy]phenyl}methyl)phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
CAS Number:
864070-44-0
Molecular Formula:
C23H27ClO7
Molecular Weight:
450.9093
MDL Number:
MFCD22566222
IUPAC Name:
(2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
InChI:
InChI=1S/C23H27ClO7/c24-18-6-3-14(23-22(28)21(27)20(26)19(11-25)31-23)10-15(18)9-13-1-4-16(5-2-13)30-17-7-8-29-12-17/h1-6,10,17,19-23,25-28H,7-9,11-12H2/t17-,19+,20+,21-,22+,23-/m0/s1
InChI Key:
OBWASQILIWPZMG-QZMOQZSNSA-N
SMILES:
OC[C@H]1O[C@@H](c2ccc(c(c2)Cc2ccc(cc2)O[C@@H]2COCC2)Cl)[C@@H]([C@H]([C@@H]1O)O)O
UNII:
HDC1R2M35U
Properties
Complexity:
558  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Defined Bond Stereocenter Count:
0
Exact Mass:
450.145g/mol
Formal Charge:
0
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
450.912g/mol
Monoisotopic Mass:
450.145g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
109A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2  
Literature
Title Journal
Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. The New England journal of medicine 20151126
Pharmacokinetics, Pharmacodynamics and Clinical Use of SGLT2 Inhibitors in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease. Clinical pharmacokinetics 20150701
Empagliflozin for the treatment of type 2 diabetes. Expert opinion on pharmacotherapy 20141101
Empagliflozin (Jardiance) for diabetes. The Medical letter on drugs and therapeutics 20141013
Efficacy and safety of empagliflozin for type 2 diabetes: a systematic review and meta-analysis. Diabetes, obesity & metabolism 20141001
Empagliflozin as add-on to metformin in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial. Diabetes care 20140601
Empagliflozin, a sodium glucose co-transporter 2 inhibitor, in the treatment of type 1 diabetes. Expert opinion on investigational drugs 20140601
Empagliflozin for the treatment of Type 2 diabetes. Expert review of clinical pharmacology 20140501
Empagliflozin: a new sodium-glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes. Drugs in context 20140101
Nonclinical safety of the sodium-glucose cotransporter 2 inhibitor empagliflozin. International journal of toxicology 20140101
Pharmacokinetics of empagliflozin, a sodium glucose cotransporter-2 (SGLT-2) inhibitor, coadministered with sitagliptin in healthy volunteers. Advances in therapy 20121001
Empagliflozin, a novel potent and selective SGLT-2 inhibitor, improves glycaemic control alone and in combination with insulin in streptozotocin-induced diabetic rats, a model of type 1 diabetes mellitus. Diabetes, obesity & metabolism 20120701
A novel approach to control hyperglycemia in type 2 diabetes: sodium glucose co-transport (SGLT) inhibitors: systematic review and meta-analysis of randomized trials. Annals of medicine 20120601
[New possibility in the oral glucose lowering treatment of type 2 diabetes mellitus: sodium-glucose co-transporter-2 inhibitors]. Orvosi hetilap 20120506
Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors. Diabetes, obesity & metabolism 20120101
Long-term treatment with empagliflozin, a novel, potent and selective SGLT-2 inhibitor, improves glycaemic control and features of metabolic syndrome in diabetic rats. Diabetes, obesity & metabolism 20120101
Sodium glucose cotransporter 2 inhibitors as a new treatment for diabetes mellitus. The Journal of clinical endocrinology and metabolism 20100101
From victim to ally: the kidney as an emerging target for the treatment of diabetes mellitus. Current medical research and opinion 20090301
Inhibition of renal glucose reabsorption: a novel strategy for achieving glucose control in type 2 diabetes mellitus. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20080901
Properties