9α,13α,14α-Morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, hydrochloride
| Title | Journal |
|---|---|
| Effects of sinomenine on the expression of microRNA-155 in 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice. | PloS one 20130101 |
| Design, synthesis and molecular docking studies of sinomenine derivatives. | Bioorganic & medicinal chemistry letters 20120915 |
| Anti-inflammatory effect of sinomenine by inhibition of pro-inflammatory mediators in PMA plus A23187-stimulated HMC-1 Cells. | European review for medical and pharmacological sciences 20120901 |
| Sinomenium acutum: a review of chemistry, pharmacology, pharmacokinetics, and clinical use. | Pharmaceutical biology 20120801 |
| Effects of alkaloid sinomenine on levels of IFN-γ, IL-1β, TNF-α and IL-6 in a rat renal allograft model. | Immunotherapy 20120801 |
| Sinomenine can prolong high-risk corneal graft survival in a rat model. | Immunotherapy 20120601 |
| Activation of PI3K/Akt and ERK signaling pathways antagonized sinomenine-induced lung cancer cell apoptosis. | Molecular medicine reports 20120501 |
| Synthesis and biological evaluation of novel sinomenine derivatives as anti-inflammatory agents. | European journal of medicinal chemistry 20120401 |
| Determination of sinomenine sustained-release capsules in healthy Chinese volunteers by liquid chromatography-tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120315 |
| Six alkaloids inhibit secretion of IL-1α, TXB(2), ET-1 and E-selectin in LPS-induced endothelial cells. | Immunological investigations 20120101 |
| Protective effects of sinomenine against doxorubicin-induced nephrosis in rats. | Journal of Asian natural products research 20120101 |
| Sinomenine reduces invasion and migration ability in fibroblast-like synoviocytes cells co-cultured with activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, CD147. | Rheumatology international 20111101 |
| Sinomenine protects against ischaemic brain injury: involvement of co-inhibition of acid-sensing ion channel 1a and L-type calcium channels. | British journal of pharmacology 20111101 |
| Anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on tumor necrosis factor-α-activated human fibroblast-like synoviocytes in rheumatoid arthritis. | Journal of ethnopharmacology 20110901 |
| Anti-allergic effects of sinomenine by inhibition of prostaglandin D₂ and leukotriene C₄ in mouse bone marrow-derived mast cells. | Immunopharmacology and immunotoxicology 20110601 |
| Two new morphinane alkaloids from Sinomenium acutum. | Journal of Asian natural products research 20110601 |
| Synthesis and biological evaluation of unique stereodimers of sinomenine analogues as potential inhibitors of NO production. | Bioorganic & medicinal chemistry 20110515 |
| Immunosuppressive and anti-inflammatory activities of sinomenine. | International immunopharmacology 20110301 |
| Sinomenine inhibits microglial activation by Aβ and confers neuroprotection. | Journal of neuroinflammation 20110101 |
| HPLC and LC-MS analysis of sinomenine and its application in pharmacokinetic studies in rats. | Acta pharmacologica Sinica 20101101 |
| [Rat in vitro plasma-binding percentage determination of sinomenine hydrochloride by using microdialysis method and ultrafiltration]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101001 |
| [Study on the alkaloids in the stems and leaves of Stephania cepharantha (II)]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20101001 |
| Protective effect of sinomenine on cartilage degradation and chondrocytes apoptosis. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20100801 |
| [Effect of sinomenine on tumor necrosis factor-alpha and nuclear factor-kappaB in the heterotopic tissue in rats with endometriosis]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100801 |
| Genetic and chemical comparison of Boi (Sinomeni Caulis et Rhizoma) and Seifuto (Caulis Sinomenii). | Journal of natural medicines 20100701 |
| Sinomenine pretreatment attenuates cold ischemia/reperfusion injury in rats: the role of heme oxygenase-1. | International immunopharmacology 20100601 |
| [The pharmacokinetics study on Sinomenine transdermal patch on anaesthetized Beagle dogs]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100601 |
| Development of patch and spray formulations for enhancing topical delivery of sinomenine hydrochloride. | Journal of pharmaceutical sciences 20100401 |
| Preparation and characterization of novel sinomenine microcapsules for oral controlled drug delivery. | Drug development and industrial pharmacy 20100401 |
| Sinomenine, theophylline, cysteine, and levamisole: Comparisons of their kinetic effects on mineral formation induced by matrix vesicles. | Journal of inorganic biochemistry 20100401 |
| [Preparation of sinomenine hydrochloride delayed-onset sustained-release tablets]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100301 |
| Effect of sinomenine on the in vitro intestinal epithelial transport of selected compounds. | Phytotherapy research : PTR 20100201 |
| [Research progress on immunosuppressive activity of monomers extracted from Chinese medicine]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100201 |
| Novel sinomenine derivative 1032 improves immune suppression in experimental autoimmune encephalomyelitis. | Biochemical and biophysical research communications 20100101 |
| [Study on the detoxification of alcohol extracts from orientvine and its effective component on withdrawal syndromes of morphine]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090901 |
| [Research advances of mechanism of sinomenine in treating rheumatoid arthritis]. | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20090801 |
| Immunoregulatory effects of sinomenine on the T-bet/GATA-3 ratio and Th1/Th2 cytokine balance in the treatment of mesangial proliferative nephritis. | International immunopharmacology 20090701 |
| [Effects of sinomenine on the cultured smooth muscle cell MAPK PKC activities and intracellular free Ca2+]. | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20090501 |
| Sinomenine influences capacity for invasion and migration in activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, and CD147. | Acta pharmacologica Sinica 20090401 |
| [Effect of sinomenine on the expression of chemokines and chemokine receptors in dendritic cells from patients with rheumatoid arthritis]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20090401 |
| [Preparation of gastric retenting and chronopharmacologic drug delivery tablets of sinomenine hydrochloride]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090301 |
| Fast screening and structural elucidation of G-quadruplex ligands from a mixture via G-quadruplex recognition and NMR methods. | Biochimie 20090201 |
| Separation and detection of isoquinoline alkaloids using MEEKC coupled with field-amplified sample injection induced by ACN. | Electrophoresis 20090201 |
| [Study on optimization of formulation and preparation process of sinomenine liposomes]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090201 |
| [Study on pharmacokinetics and absolute bioavailability of sinomenine in beagle dogs]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090201 |
| [Effects of sinomenine on synovial fluid and serum content of interleukin-1beta in rabbits with osteoarthritis]. | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20081201 |
| Sinomenine ameliorates arthritis via MMPs, TIMPs, and cytokines in rats. | Biochemical and biophysical research communications 20081114 |
| [Bioequivalence study of sinomenine patch by microdialysis]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081101 |
| Activation of opioid mu-receptor by sinomenine in cell and mice. | Neuroscience letters 20081010 |
| Sinomenine versus NSAIDs for the treatment of rheumatoid arthritis: a systematic review and meta-analysis. | Planta medica 20081001 |
| Development and evaluation of the Sinomenine transdermal patch. | Pakistan journal of pharmaceutical sciences 20081001 |
| pH-dependent, stereoselective dimerization of sinomenine. | Organic letters 20080904 |
| [Dynamic determination of sinomenine in skin by microdialysis]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080701 |
| [Inhibitory effect of sinomenine on H2O2-induced apoptosis in neonatal rat cardiomyocytes]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080401 |
| Biocatalyzed cross-coupling of sinomenine and guaiacol by Antrodiella semisupina. | Organic letters 20080320 |
| Inhibition of the antigen-induced activation of RBL-2H3 cells by sinomenine. | International immunopharmacology 20080301 |
| [Role of alkaloid sinomenine in chronic rejection in the rat heart transplantation model]. | Zhonghua xin xue guan bing za zhi 20080201 |
| Morphinane alkaloid dimers from Sinomenium acutum. | Journal of natural products 20080101 |
| Sinomenine inhibits activation of rat retinal microglia induced by advanced glycation end products. | International immunopharmacology 20071205 |
| Sinomenine suppresses TNF-alpha-induced VCAM-1 expression in human umbilical vein endothelial cells. | Journal of ethnopharmacology 20071101 |
| Effect of sinomenine on collagen-induced arthritis in mice. | Autoimmunity 20071101 |
| Vasodilatation induced by sinomenine lowers blood pressure in spontaneously hypertensive rats. | Clinical and experimental pharmacology & physiology 20071001 |
| [Preparation of sinomenine microemulsion and its transdermal absorption]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071001 |
| [Studies on preparation of sinomenine hydrochloride-loaded bovine serum albumin microspheres]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071001 |
| Sinomenine inhibits primary CD4+ T-cell proliferation via apoptosis. | Cell biology international 20070801 |
| Sinomenine promotes differentiation but impedes maturation and co-stimulatory molecule expression of human monocyte-derived dendritic cells. | International immunopharmacology 20070801 |
| Assessment of in vitro and in vivo recovery of sinomenine using microdialysis. | Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 20070801 |
| Preparative isolation and purification of sinomenine from Sinomenium acutum by centrifugal partition chromatography. | Journal of separation science 20070801 |
| Sinomenine, an antirheumatic alkaloid, ameliorates clinical signs of disease in the Lewis rat model of acute experimental autoimmune encephalolmyelitis. | Biological & pharmaceutical bulletin 20070801 |
| Voltammetric determination of sinomenine in biological fluid using a glassy carbon electrode modified by a composite film of polycysteic acid and carbon nanotubes. | Combinatorial chemistry & high throughput screening 20070801 |
| [The effect of sinomenine on nNOS activity of brain tissues in morphine dependent and withdrawal mice]. | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070801 |
| [Effects of sinomenine on NO/nNOS system in cerebellum and spinal cord of morphine-dependent and withdrawal mice]. | Sheng li xue bao : [Acta physiologica Sinica] 20070625 |
| Sinomenine attenuates 2, 4, 6-trinitrobenzene sulfonic acid-induced colitis in mice. | International immunopharmacology 20070501 |
| Sinomenine inhibits maturation of monocyte-derived dendritic cells through blocking activation of NF-kappa B. | International immunopharmacology 20070501 |
| [Effects of sinomenine on intracellular free calcium concentration and the activity of protein kinase in cultured rabbit aortic smooth muscle cells]. | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070501 |
| Effect of sinomenine on human cytochrome P450 activity. | Clinica chimica acta; international journal of clinical chemistry 20070401 |
| Determination of sinomenine in Sinomenium acutum by capillary electrophoresis with electrochemiluminescence detection. | Analytica chimica acta 20070321 |
| A spectroscopic and molecular modeling study of sinomenine binding to transferrin. | Bioorganic & medicinal chemistry letters 20070315 |
| [The effects of sinomenine on the expresssion of ICAM-1 and IL-2 during the rejection of rat cardiac allograft]. | Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20070301 |
| Pharmacokinetic study of free-form sinomenine in rat skin by microdialysis coupled with liquid chromatography-electrospray mass spectrometry. | Biomedical chromatography : BMC 20070101 |
| Three major urinary metabolites of sinomenine in rats. | Journal of Asian natural products research 20070101 |
| Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. | Journal of neuroinflammation 20070101 |
| Mechanisms responsible for poor oral bioavailability of paeoniflorin: Role of intestinal disposition and interactions with sinomenine. | Pharmaceutical research 20061201 |
| Suppression of Th1 and Th2 immune responses in mice by Sinomenine, an alkaloid extracted from the chinese medicinal plant Sinomenium acutum. | Planta medica 20061201 |
| [Effects of Caulis Sinomenii and sinomenine on morphine-induced place preference and brain histamine level in mice]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20061201 |
| Synthesis and anti-inflammatory activities investigation of sinomenine derivatives on ring C. | Natural product research 20060901 |
| [Determination in vitro of rat plasma protein binding rate of sinomenine by using microdialysis method]. | Yao xue xue bao = Acta pharmaceutica Sinica 20060901 |
| In vitro pharmacological actions of sinomenine on the smooth muscle and the endothelial cell activity in rat aorta. | Life sciences 20060815 |
| Effect of sinomenine on gene expression of the IL-1 beta-activated human synovial sarcoma. | Life sciences 20060710 |
| [Study on determination of entrapment efficiency of sinomenine liposomes]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060501 |
| [Effects of the alkaloid sinomenine on COX-2 activity and acute rejection in heart allografts: an experiment with rats]. | Zhonghua yi xue za zhi 20060404 |
| The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model. | Journal of ethnopharmacology 20060220 |
| Behavioral effects of sinomenine in murine models of anxiety. | Life sciences 20051205 |
| Pharmacokinetic interaction of paeoniflorin and sinomenine: pharmacokinetic parameters and tissue distribution characteristics in rats and protein binding ability in vitro. | Journal of pharmacological sciences 20051201 |
| [Study of the relative recovery of sinomenine microdialysis system and it's influential factor]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20051201 |
| The pharmacokinetics and tissue distribution of sinomenine in rats and its protein binding ability in vitro. | Life sciences 20051104 |
| [New study progress of sinomenine]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051001 |
| [Changes in cAMP and cGMP levels in neonatal rat histaminergic neurons of tuberomammillary nucleus following 48-hour morphine exposure and effects of sinomenine intervention]. | Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20050901 |
| [Effect of sinomenine on adjuvant arthritis and its mechanisms]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050901 |
| Impact of release characteristics of sinomenine hydrochloride dosage forms on its pharmacokinetics in beagle dogs. | World journal of gastroenterology 20050807 |
| Sinomenine inhibits B7-H1 and B7-DC expression on human renal tubular epithelial cells. | International immunopharmacology 20050801 |
| [Effect of penetration enhancers on the transdermal penetration of sinomenine liposome patch]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050701 |
| Determination of sinomenine in human plasma by HPLC/ESI/ion trap mass spectrum. | Clinica chimica acta; international journal of clinical chemistry 20050601 |
| [Research on extracting process for Fengshitongbi capsules]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050601 |
| Supercritical fluid extraction of sinomenine from Sinomenium acutum (Thumb) Rehd et Wils. | Journal of chromatography. A 20050520 |
| Influence of co-administrated sinomenine on pharmacokinetic fate of paeoniflorin in unrestrained conscious rats. | Journal of ethnopharmacology 20050513 |
| Requirement for ERK activation in sinomenine-induced apoptosis of macrophages. | Immunology letters 20050415 |
| Effect of sinomenine on cytokine expression of macrophages and synoviocytes in adjuvant arthritis rats. | Journal of ethnopharmacology 20050408 |
| [Immunopharmacological action of sinomenine, an alkaloid isolated from Sinomenium acutum, and its mechanism of action in treating rheumatoid arthritis]. | Yao xue xue bao = Acta pharmaceutica Sinica 20050201 |
| Quantification of sinomenine in caulis sinomenii collected from different growing regions and wholesale herbal markets by a modified HPLC method. | Biological & pharmaceutical bulletin 20050101 |
| The anti-angiogenic effect of sinomenine. | Angiogenesis 20050101 |
| Electropharmacological actions of the constituents of Sinomeni Caulis et Rhizome and Mokuboi-to in guinea pig heart. | The American journal of Chinese medicine 20050101 |
| N-inversion-associated conformational dynamics is unusually rapid in morphine alkaloids. | Journal of natural products 20041101 |
| [Inhibitory effect of sinomenine on expression of cyclooxygenase-2 in lipopolysaccharide-induced PC-12 cells]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040901 |
| [Synthesis and anti-inflammatory analgesic activities of sinomenine derivatives]. | Yao xue xue bao = Acta pharmaceutica Sinica 20040301 |
| Sinomenine blocks tissue remodeling in a rat model of chronic cardiac allograft rejection. | Transplantation 20030415 |
| Regulation of hepatobiliary excretion of sinomenine by P-glycoprotein in Sprague-Dawley rats. | Life sciences 20030411 |
| Effect of sinomenine on morphine dependence in isolated guinea pig ileum. | Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030401 |
| [The effect of sinomenine on cyclooxygenase activity and the expression of COX-1 and COX-2 mRNA in human peripheral monocytes]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030401 |
| [Study on the permeability of 125I-sinomenine via the transdermal delivery way in rats]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020601 |
| [Effect of sinamine on withdrawal symptom and neurotransmitter of morphine-dependent rats]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020501 |
| [Study progress in Sinomenium acutum (Thunb.) Rehd. et Wils]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020301 |
| [Advances in the study on transdermal permeation of active elements of natural drugs in vitro]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020101 |
| The alkaloid sinomenine in rat transplant models: and yet it does move. | Transplant international : official journal of the European Society for Organ Transplantation 20010101 |