Home Other Building Blocks (6α,11β)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-17-(1-oxobutoxy)pregna-1,4-diene-3,20-dion

(6α,11β)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-17-(1-oxobutoxy)pregna-1,4-diene-3,20-dion

CAS No.:
23674-86-4
Catalog Number:
AG0039MA
Molecular Formula:
C27H34F2O7
Molecular Weight:
508.5515
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
10mg
98%(HPLC)
In Stock USA
United States
$57
- +
25mg
98%(HPLC)
In Stock USA
United States
$98
- +
50mg
98%(HPLC)
In Stock USA
United States
$151
- +
100mg
98%(HPLC)
In Stock USA
United States
$268
- +
Product Description
Catalog Number:
AG0039MA
Chemical Name:
(6α,11β)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-17-(1-oxobutoxy)pregna-1,4-diene-3,20-dion
CAS Number:
23674-86-4
Molecular Formula:
C27H34F2O7
Molecular Weight:
508.5515
MDL Number:
MFCD00214273
IUPAC Name:
[(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate
InChI:
InChI=1S/C27H34F2O7/c1-5-6-23(34)36-26(22(33)14-35-15(2)30)10-8-17-18-12-20(28)19-11-16(31)7-9-24(19,3)27(18,29)21(32)13-25(17,26)4/h7,9,11,17-18,20-21,32H,5-6,8,10,12-14H2,1-4H3/t17-,18-,20-,21-,24-,25-,26-,27-/m0/s1
InChI Key:
WYQPLTPSGFELIB-JTQPXKBDSA-N
SMILES:
CCCC(=O)O[C@@]1(CC[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2C[C@@H](C2=CC(=O)C=C[C@]12C)F)F)C(=O)COC(=O)C
EC Number:
245-815-4
UNII:
S8A06QG2QE
Properties
Complexity:
1050  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Defined Bond Stereocenter Count:
0
Exact Mass:
508.227g/mol
Formal Charge:
0
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
508.559g/mol
Monoisotopic Mass:
508.227g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
107A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.4  
Literature
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Intraocular pressure elevation from topical difluprednate use. Optometry (St. Louis, Mo.) 20101201
Durezol (Difluprednate Ophthalmic Emulsion 0.05%) compared with Pred Forte 1% ophthalmic suspension in the treatment of endogenous anterior uveitis. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20101001
Metabolic profiles of difluprednate in rabbit ocular tissues after instillation of difluprednate ophthalmic emulsion. Xenobiotica; the fate of foreign compounds in biological systems 20100801
Steroid eye drop treatment (difluprednate ophthalmic emulsion) is effective in reducing refractory diabetic macular edema. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20100601
New drugs 09, part 2. Nursing 20090601
Difluprednate ophthalmic emulsion 0.05% for postoperative inflammation and pain. Journal of cataract and refractive surgery 20090101
The role of difluprednate ophthalmic emulsion in clinical practice. Clinical ophthalmology (Auckland, N.Z.) 20090101
New drugs: Clevidipine butyrate, difluprednate, and tetrabenazine. Journal of the American Pharmacists Association : JAPhA 20080101
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Injection site with generalized rash caused by pegylated interferon alpha 2a injection. Dermatology (Basel, Switzerland) 20060101
Formulation of an ophthalmic lipid emulsion containing an anti-inflammatory steroidal drug, difluprednate. International journal of pharmaceutics 20050914
Cutaneous reactions to imatinib mesylate treated by topical steroid. American journal of hematology 20050301
Analysis of an anti-inflammatory steroidal drug, difluprednate, in aqueous humor by combination of semi-micro HPLC and column switching method. Journal of pharmaceutical and biomedical analysis 20030115
Neuronal cell bodies in the hypothalamic paraventricular nucleus mediate stress-induced renin and corticosterone secretion. Neuroendocrinology 19890701
Properties