Home Other Building Blocks Catalpol

Catalpol

CAS No.:
2415-24-9
Catalog Number:
AG0039M9
Molecular Formula:
C15H22O10
Molecular Weight:
362.3292
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
50mg
≥98%
1 week
United States
$122
- +
100mg
≥98%
1 week
United States
$175
- +
250mg
≥98%
1 week
United States
$286
- +
1g
≥98%
1 week
United States
$710
- +
Product Description
Catalog Number:
AG0039M9
Chemical Name:
Catalpol
CAS Number:
2415-24-9
Molecular Formula:
C15H22O10
Molecular Weight:
362.3292
MDL Number:
MFCD11111524
IUPAC Name:
(2S,3R,4S,5S,6R)-2-[[(1S,2S,4S,5S,6R,10S)-5-hydroxy-2-(hydroxymethyl)-3,9-dioxatricyclo[4.4.0.02,4]dec-7-en-10-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
InChI:
InChI=1S/C15H22O10/c16-3-6-9(19)10(20)11(21)14(23-6)24-13-7-5(1-2-22-13)8(18)12-15(7,4-17)25-12/h1-2,5-14,16-21H,3-4H2/t5-,6-,7-,8+,9-,10+,11-,12+,13+,14+,15-/m1/s1
InChI Key:
LHDWRKICQLTVDL-PZYDOOQISA-N
SMILES:
OC[C@H]1O[C@@H](O[C@@H]2OC=C[C@@H]3[C@H]2[C@@]2(CO)O[C@H]2[C@H]3O)[C@@H]([C@H]([C@@H]1O)O)O
EC Number:
219-324-0
Properties
Complexity:
542  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
11  
Defined Bond Stereocenter Count:
0
Exact Mass:
362.121g/mol
Formal Charge:
0
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
6  
Isotope Atom Count:
0
Molecular Weight:
362.331g/mol
Monoisotopic Mass:
362.121g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
162A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-3.2  
Literature
Title Journal
Catalpol improves cholinergic function and reduces inflammatory cytokines in the senescent mice induced by D-galactose. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130801
Catalpol inhibits LPS plus IFN-γ-induced inflammatory response in astrocytes primary cultures. Toxicology in vitro : an international journal published in association with BIBRA 20130301
Anti-hyperglycemic effects and mechanism of traditional Chinese medicine Huanglian Wan in streptozocin-induced diabetic rats. Journal of ethnopharmacology 20121121
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. Bioorganic & medicinal chemistry 20121115
HPLC-APCI-MS/MS method for the determination of catalpol in rat plasma and cerebrospinal fluid: application to an in vivo pharmacokinetic study. Journal of pharmaceutical and biomedical analysis 20121101
In vitro and in vivo metabolism of verproside in rats. Molecules (Basel, Switzerland) 20121012
A rapid and sensitive determination of aucubin in rat plasma by liquid chromatography-tandem mass spectrometry and its pharmacokinetic application. Biomedical chromatography : BMC 20120901
[Effect of catalpol and puerarin freeze-dried powder on coagulability, hemorheology and no in rats with Qi-deficiency and blood-stasis syndrome]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120501
[Study on the HPCE fingerprint of Rehmannia glutinosa]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20120401
Memory defect induced by β-amyloid plus glutamate receptor agonist is alleviated by catalpol and donepezil through different mechanisms. Brain research 20120302
Effect of high relative humidity on dried Plantago lanceolata L. leaves during long-term storage: effects on chemical composition, colour and microbiological quality. Phytochemical analysis : PCA 20120101
In vitro cytotoxic activity and structure activity relationships of iridoid glucosides derived from Veronica species. Phytotherapy research : PTR 20120101
Traditional chinese medicine for senile dementia. Evidence-based complementary and alternative medicine : eCAM 20120101
Diet quality can play a critical role in defense efficacy against parasitoids and pathogens in the Glanville fritillary (Melitaea cinxia). Journal of chemical ecology 20120101
Anthelmintic and relaxant activities of Verbascum Thapsus Mullein. BMC complementary and alternative medicine 20120101
Antidiabetic Effect of an Active Components Group from Ilex kudingcha and Its Chemical Composition. Evidence-based complementary and alternative medicine : eCAM 20120101
Host shifts from Lamiales to Brassicaceae in the sawfly genus Athalia. PloS one 20120101
Ginkgo biloba extract EGB761 protects against aging-associated diastolic dysfunction in cardiomyocytes of D-galactose-induced aging rat. Oxidative medicine and cellular longevity 20120101
Iridoid content and biological activities of Veronica cuneifolia subsp. cuneifolia and V. cymbalaria. Pharmaceutical biology 20111101
In silico study of the inhibition of DNA polymerase by a novel catalpol derivative. Journal of molecular modeling 20111001
Chemical defense across three trophic levels: Catalpa bignonioides, the caterpillar Ceratomia catalpae, and its endoparasitoid Cotesia congregata. Journal of chemical ecology 20111001
Bioassay-guided isolation of anti-inflammatory, antinociceptive and wound healer glycosides from the flowers of Verbascum mucronatum Lam. Journal of ethnopharmacology 20110714
Differential performance of a specialist and two generalist herbivores and their parasitoids on Plantago lanceolata. Journal of chemical ecology 20110701
[Effects of Chinese herbal medicine Liuwei Dihuang Pill and its main monomer catalpol on transforming growth factor-β1/Smad pathway in HK-2 cells]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20110701
Iridoid and phenylethanoid glucosides from Veronica lavaudiana. Journal of natural products 20110624
Protective effects of catalpol on oligodendrocyte death and myelin breakdown in a rat model of chronic cerebral hypoperfusion. Neuroscience letters 20110615
A comparison of sample preparation techniques for quantifying iridoid glycosides sequestered by lepidopteran larvae. Journal of chemical ecology 20110501
Plasma glucose lowering mechanisms of catalpol, an active principle from roots of Rehmannia glutinosa, in streptozotocin-induced diabetic rats. Journal of agricultural and food chemistry 20110427
What's in a Name? Can Mullein Weed Beat TB Where Modern Drugs Are Failing? Evidence-based complementary and alternative medicine : eCAM 20110101
A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated Mitochondrial/Caspase Pathway. Evidence-based complementary and alternative medicine : eCAM 20110101
The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. International journal of molecular sciences 20110101
Discovery of molecular mechanisms of traditional Chinese medicinal formula Si-Wu-Tang using gene expression microarray and connectivity map. PloS one 20110101
Traditional processing strongly affects metabolite composition by hydrolysis in Rehmannia glutinosa roots. Chemical & pharmaceutical bulletin 20110101
Allergy-preventive effects of chlorogenic acid and iridoid derivatives from flower buds of Lonicera japonica. Biological & pharmaceutical bulletin 20110101
Plant community diversity influences allocation to direct chemical defence in Plantago lanceolata. PloS one 20110101
Inflammatory Animal Model for Parkinson's Disease: The Intranigral Injection of LPS Induced the Inflammatory Process along with the Selective Degeneration of Nigrostriatal Dopaminergic Neurons. ISRN neurology 20110101
[Bio-activity evaluation of Qinlian Siwu decoction on inhibiting mice uterine contraction in vitro and its components analysis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101201
[End point determination by HPLC chromatographic fingerprint in processing prepared Rehmannia]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101001
Chlorinated iridoid glucosides from Veronica longifolia and their antioxidant activity. Journal of natural products 20100924
Analysis of catalpol derivatives by characteristic neutral losses using liquid chromatography combined with electrospray ionization multistage and time-of-flight mass spectrometry. Rapid communications in mass spectrometry : RCM 20100915
Caterpillar chemical defense and parasitoid success: Cotesia congregata parasitism of Ceratomia catalpae. Journal of chemical ecology 20100901
Antihyperglycemic effect of catalpol in streptozotocin-induced diabetic rats. Journal of natural products 20100625
[Studies on the chemical constituents of Buddleja albiflora (II)]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100601
Catalpol attenuates MPTP induced neuronal degeneration of nigral-striatal dopaminergic pathway in mice through elevating glial cell derived neurotrophic factor in striatum. Neuroscience 20100428
Systemic administration of catalpol prevents D-galactose induced mitochondrial dysfunction in mice. Neuroscience letters 20100412
Enhancement of antiproliferative activity by molecular simplification of catalpol. Bioorganic & medicinal chemistry 20100401
Inhibitory Potencies of Several Iridoids on Cyclooxygenase-1, Cyclooxygnase-2 Enzymes Activities, Tumor Necrosis factor-α and Nitric Oxide Production In Vitro. Evidence-based complementary and alternative medicine : eCAM 20100301
Catalpol inhibits apoptosis in hydrogen peroxide-induced endothelium by activating the PI3K/Akt signaling pathway and modulating expression of Bcl-2 and Bax. European journal of pharmacology 20100225
Sequestration of glucosinolates and iridoid glucosides in sawfly species of the genus Athalia and their role in defense against ants. Journal of chemical ecology 20100201
Oral supplementation of catalpol ameliorates diabetic encephalopathy in rats. Brain research 20100111
Catalpol increases brain angiogenesis and up-regulates VEGF and EPO in the rat after permanent middle cerebral artery occlusion. International journal of biological sciences 20100101
Improved mitochondrial function in brain aging and Alzheimer disease - the new mechanism of action of the old metabolic enhancer piracetam. Frontiers in neuroscience 20100101
Cholinesterase inhibitory and antioxidant properties of Verbascum mucronatum Lam. and its secondary metabolites. Zeitschrift fur Naturforschung. C, Journal of biosciences 20100101
Screening of common Plantago species in Hungary for bioactive molecules and antioxidant activity. Acta biologica Hungarica 20100101
[The 14 plants in Issenheim's altarpiece. An updated pharmaco-chemical approach]. Histoire des sciences medicales 20100101
Catalpol protects primary cultured cortical neurons induced by Abeta(1-42) through a mitochondrial-dependent caspase pathway. Neurochemistry international 20091201
[Investigation of oxidative stress-induced alterations in the rat brain cortical cellular culture and their correction with vitamines E and C]. Georgian medical news 20091201
[Progress in studies of pharmacological action and mechanisms of catalpol on brain diease]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091201
Catalpol ameliorates beta amyloid-induced degeneration of cholinergic neurons by elevating brain-derived neurotrophic factors. Neuroscience 20091110
Quantitation of catalpol in rat plasma by liquid chromatography/electrospray ionization tandem mass spectrometry and its pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091101
Simultaneous quantification of active components in the herbs and products of Si-Wu-Tang by high performance liquid chromatography-mass spectrometry. Journal of pharmaceutical and biomedical analysis 20090908
Effects of catalpol on mitochondrial function and working memory in mice after lipopolysaccharide-induced acute systemic inflammation. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20090901
Liquid chromatography-mass spectrometry for the simultaneous determination of the catalpol-related iridoid glucosides, verproside, isovanilloylcatalpol, catalposide and 6-O-veratroyl catalpol in rat plasma. Biomedical chromatography : BMC 20090901
[Theoretical study on infrared vibration spectrum of catalpol by DFT]. Guang pu xue yu guang pu fen xi = Guang pu 20090901
Elucidation of anti-inflammatory potencies of Eucommia ulmoides bark and Plantago asiatica seeds. Journal of medicinal food 20090801
[Protective effects of catalpol against H2O2-induced oxidative damage in astrocytes]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090801
Arbuscular mycorrhizal fungal species suppress inducible plant responses and alter defensive strategies following herbivory. Oecologia 20090701
The effects of arbuscular mycorrhizal fungi on direct and indirect defense metabolites of Plantago lanceolata L. Journal of chemical ecology 20090701
[HPLC determination of catalpol in cerebrospinal fluid of rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090701
Chemical defense, mycorrhizal colonization and growth responses in Plantago lanceolata L. Oecologia 20090601
Iridoids from Spathodea campanulata P. Beauvais leaves. Natural product communications 20090601
Pharmacokinetics of verproside after intravenous and oral administration in rats. Archives of pharmacal research 20090401
Catalpol attenuates nitric oxide increase via ERK signaling pathways induced by rotenone in mesencephalic neurons. Neurochemistry international 20090101
Ambuic acid and torreyanic acid derivatives from the endolichenic fungus Pestalotiopsis sp. Journal of natural products 20090101
Iridoids from Euphrasia genargentea, a rare Sardinian endemism. Natural product research 20090101
Antihepatotoxic activity and chemical constituents of Buddleja asiatica Lour. Zeitschrift fur Naturforschung. C, Journal of biosciences 20090101
Catapol production in Chinese foxglove (Rehmannia glutinosa Libos.) hairy roots transformed with Agrobacterium rhizogenes ATCC15834. Methods in molecular biology (Clifton, N.J.) 20090101
Differential effects of iodoacetamide and iodoacetate on glycolysis and glutathione metabolism of cultured astrocytes. Frontiers in neuroenergetics 20090101
Decontamination of organochlorine pesticides residue and heavy metal in Rehmannia glutinosa Libosch by SFE. Journal of chromatographic science 20090101
Catalpol protects mesencephalic neurons against MPTP induced neurotoxicity via attenuation of mitochondrial dysfunction and MAO-B activity. Toxicology in vitro : an international journal published in association with BIBRA 20081201
Intraspecific variation in plant defense alters effects of root herbivores on leaf chemistry and aboveground herbivore damage. Journal of chemical ecology 20081001
Protective effects of catalpol against H2O2-induced oxidative stress in astrocytes primary cultures. Neuroscience letters 20080919
Oviposition cues for a specialist butterfly--plant chemistry and size. Journal of chemical ecology 20080901
[Comparative analysis of character on germplasm resources of Rehmannia glutinosa]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901
d-galactose administration induces memory loss and energy metabolism disturbance in mice: protective effects of catalpol. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080801
Phytochemistry and molecular systematics of Triaenophora rupestris and Oreosolen wattii (Scrophulariaceae). Phytochemistry 20080801
Neuroprotective activities of catalpol on MPP+/MPTP-induced neurotoxicity. Neurological research 20080701
Further pharmacological evidence of the neuroprotective effect of catalpol from Rehmannia glutinosa. Phytomedicine : international journal of phytotherapy and phytopharmacology 20080601
Catalpol protects rat pheochromocytoma cells against oxygen and glucose deprivation-induced injury. Neurological research 20080201
Catalpol attenuates the neurotoxicity induced by beta-amyloid(1-42) in cortical neuron-glia cultures. Brain research 20080110
Catalpol protects primary cultured astrocytes from in vitro ischemia-induced damage. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20080101
Catalpol ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose. Pharmacology, biochemistry, and behavior 20071101
[Study of catalpol promoting axonal growth for cultured cortical neurons from rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070901
[Hairy root induction and plant regeneration of Rehmannia glutinosa Libosch. f. hueichingensis (Chao et Schih) Hsiao transformed by Agrobacterium rhizogenes]. Fen zi xi bao sheng wu xue bao = Journal of molecular cell biology 20070801
Neuroprotective effect of catalpol against MPP(+)-induced oxidative stress in mesencephalic neurons. European journal of pharmacology 20070730
Antispasmodic activity of an extract from Plantago lanceolata L. and some isolated compounds. Phytomedicine : international journal of phytotherapy and phytopharmacology 20070601
[Advances in research on pharmacodynamics and chemical conversion of catalpol]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070601
[Effect of concentration of catalpol and 5-hydroxymethyl-2-furaldehyde from processing of Rehmanniae Radix]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070601
Phenylethanoids, iridoids and a spirostanol saponin from Veronica turrilliana. Phytochemistry 20070501
Efficacy of catalpol as protectant against oxidative stress and mitochondrial dysfunction on rotenone-induced toxicity in mice brain. Environmental toxicology and pharmacology 20070501
Bioassay-guided isolation of anti-inflammatory and antinociceptive glycoterpenoids from the flowers of Verbascum lasianthum Boiss. ex Bentham. Journal of ethnopharmacology 20070404
Occurrence of iridoid glycosides in in vitro cultures and intact plants of Scrophularia nodosa L. Plant cell reports 20070301
Novel antiproliferative analogs of the Taq DNA polymerase inhibitor catalpol. Bioorganic & medicinal chemistry letters 20070301
Catalpol protects dopaminergic neurons from LPS-induced neurotoxicity in mesencephalic neuron-glia cultures. Life sciences 20061223
Catalpol increases hippocampal neuroplasticity and up-regulates PKC and BDNF in the aged rats. Brain research 20061206
Catalpol modulates the expressions of Bcl-2 and Bax and attenuates apoptosis in gerbils after ischemic injury. Brain research 20061018
Effect on capillary permeability in rabbits of iridoids from Buddleia scordioides. Phytotherapy research : PTR 20060701
Taxonomical markers in two endemic plants of Sardinia: Verbascum conocarpum and Scrophularia trifoliata. Natural product research 20060510
Chemotaxonomy of Veroniceae and its allies in the Plantaginaceae. Phytochemistry 20060201
Catalpol prevents the loss of CA1 hippocampal neurons and reduces working errors in gerbils after ischemia-reperfusion injury. Toxicon : official journal of the International Society on Toxinology 20051215
Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots. Phytochemistry 20050201
Neuroprotective properties of catalpol in transient global cerebral ischemia in gerbils: dose-response, therapeutic time-window and long-term efficacy. Brain research 20041217
Neuroprotection of catalpol in transient global ischemia in gerbils. Neuroscience research 20041001
Patterns of iridoid glycoside production and induction in Plantago lanceolata and the importance of plant age. Journal of chemical ecology 20040901
Inhibition of Taq DNA polymerase by catalpol. Cellular and molecular biology (Noisy-le-Grand, France) 20040901
Plant chemical defense against herbivores and pathogens: generalized defense or trade-offs? Oecologia 20040801
Aliphatic alcohol and iridoid glycosides from Asystasia intrusa. Chemical & pharmaceutical bulletin 20040801
Iridoid glucosides of Paederota lutea and the relationships between Paederota and Veronica. Phytochemistry 20040701
Earthworms and litter distribution affect plant-defensive chemistry. Journal of chemical ecology 20040401
Iridoids as allelochemicals and DNA polymerase inhibitors. Journal of natural products 20040301
[Determination of catalpol in dried rehmannia root and Taohong Siwu Decoction with high performance liquid chromatography]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20040301
Determination of aucubin and catalpol in Plantago species by micellar electrokinetic chromatography. Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101
Catalpol inhibits apoptosis in hydrogen peroxide-induced PC12 cells by preventing cytochrome c release and inactivating of caspase cascade. Toxicon : official journal of the International Society on Toxinology 20040101
Hostplant suitability and defensive chemistry of the Catalpa sphinx, Ceratomia catalpae. Journal of chemical ecology 20031001
Aragoside and iridoid glucosides from Aragoa cundinamarcensis. Phytochemistry 20030901
Determination of iridoid glycosides in larvae and adults of butterfly Melitaea cinxia by partial filling micellar electrokinetic capillary chromatography-electrospray ionisation mass spectrometry. Analytical and bioanalytical chemistry 20030701
Colorimetric estimation of total iridoid content of Picrorhiza kurrooa. Journal of Asian natural products research 20030601
Total synthesis of the quinone epoxide dimer (+)-torreyanic acid: application of a biomimetic oxidation/electrocyclization/Diels-Alder dimerization cascade. Journal of the American Chemical Society 20030430
Effect of iridoid glycoside content on oviposition host plant choice and parasitism in a specialist herbivore. Journal of chemical ecology 20030401
[Study on chitosan clarification refining the decoction of jiangtangtongmai by homogenous design method]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030201
On-line identification of unstable catalpol derivatives from Jamesbrittenia fodina by LC-mS and LC-NMR. Phytochemical analysis : PCA 20030101
Iridoids from Globularia dumulosa. Zeitschrift fur Naturforschung. C, Journal of biosciences 20030101
Iridoid glucosides from Veronica pectinata var. glandulosa. Zeitschrift fur Naturforschung. C, Journal of biosciences 20030101
Systemic, genotype-specific induction of two herbivore-deterrent iridoid glycosides in Plantago lanceolata L. in response to fungal infection by Diaporthe adunca (Rob.) Niessel. Journal of chemical ecology 20021201
Changes in the concentrations of bioactive compounds in plantain leaves. Journal of agricultural and food chemistry 20020424
Iridoid patterns of genus Plantago L. and their systematic significance. Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101
[Comparison and correlative analysis on characters of Rehmannia glutinosa Libosch. Varieties]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20011201
Determination of iridoid glycosides by micellar electrokinetic capillary chromatography-mass spectrometry with use of the partial filling technique. Electrophoresis 20010801
Iridoid glycosides from Globularia trichosantha. Journal of natural products 20010101
Iridoids from Stachys grandidentata (Labiatae). Zeitschrift fur Naturforschung. C, Journal of biosciences 20010101
Properties