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Tazobactam

CAS No.:
89786-04-9
Catalog Number:
AG0039KM
Molecular Formula:
C10H12N4O5S
Molecular Weight:
300.2911
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
98%
In Stock USA
United States
$57
- +
5g
98%
In Stock USA
United States
$169
- +
10g
98%
In Stock USA
United States
$269
- +
25g
98%
In Stock USA
United States
$538
- +
Product Description
Catalog Number:
AG0039KM
Chemical Name:
Tazobactam
CAS Number:
89786-04-9
Molecular Formula:
C10H12N4O5S
Molecular Weight:
300.2911
MDL Number:
MFCD00867002
IUPAC Name:
(2S,3S,5R)-3-methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
InChI:
InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1
InChI Key:
LPQZKKCYTLCDGQ-WEDXCCLWSA-N
SMILES:
OC(=O)[C@@H]1N2C(=O)C[C@H]2S(=O)(=O)[C@@]1(C)Cn1ccnn1
EC Number:
618-303-7
UNII:
SE10G96M8W
Properties
Complexity:
573  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0
Exact Mass:
300.053g/mol
Formal Charge:
0
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
300.289g/mol
Monoisotopic Mass:
300.053g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
131A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-2  
Literature
Title Journal
Ceftolozane/tazobactam: a novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant gram-negative bacilli. Drugs 20140101
Identification of old drugs as potential inhibitors of HIV-1 integrase - human LEDGF/p75 interaction via molecular docking. Journal of molecular modeling 20121201
Spectrum and drug resistance of pathogens from patients with burns. Burns : journal of the International Society for Burn Injuries 20121201
A case of severe toxicity during coadministration of vincristine and piperacillin: are drug transporters involved in vincristine hypersensitivity and drug-drug interactions? Journal of pediatric hematology/oncology 20121101
Quantification of seven β-lactam antibiotics and two β-lactamase inhibitors in human plasma using a validated UPLC-MS/MS method. International journal of antimicrobial agents 20121101
Lung abscess due to non-tuberculous, non-Mycobacterium fortuitum in a neonate. Pediatric pulmonology 20121001
Improving known classes of antibiotics: an optimistic approach for the future. Current opinion in pharmacology 20121001
Intrapulmonary penetration of ceftolozane/tazobactam and piperacillin/tazobactam in healthy adult subjects. The Journal of antimicrobial chemotherapy 20121001
Consumption-based approach for assessing the contribution of hospitals towards the load of pharmaceutical residues in municipal wastewater. Environment international 20120915
Antibiotics as first-line therapy for acute appendicitis: evidence for a change in clinical practice. World journal of surgery 20120901
AmpC β-lactamases in nosocomial isolates of Klebsiella pneumoniae from India. The Indian journal of medical research 20120801
Pseudomonas aeruginosa septic arthritis of knee after intra-articular ozone injection. The new microbiologica 20120701
[Antibiotic susceptibility rates and beta-lactam resistance mechanisms of Pseudomonas aeruginosa strains]. Mikrobiyoloji bulteni 20120701
Anti-anaerobic activity of a new β-lactamase inhibitor NXL104 in combination with β-lactams and metronidazole. International journal of antimicrobial agents 20120601
Burkholderia cepacia septicemia in a pediatric oncology patient: a pharmacotherapy challenge. The Annals of pharmacotherapy 20120601
Current epidemiology and growing resistance of gram-negative pathogens. The Korean journal of internal medicine 20120601
Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: a multicentre pharmacokinetic study. Critical care medicine 20120501
Treating pneumonia in critical care in the United Kingdom following failure of initial antibiotic: a cost-utility analysis comparing meropenem with piperacillin/tazobactam. The European journal of health economics : HEPAC : health economics in prevention and care 20120401
Pharmacokinetics and pharmacodynamics of piperacillin-tazobactam in 42 patients treated with concomitant CRRT. Clinical journal of the American Society of Nephrology : CJASN 20120301
[The prehospital use of antibiotics in military operations]. Annales francaises d'anesthesie et de reanimation 20120301
Antimicrobial susceptibility of Stenotrophomonas maltophilia isolates from a Korean tertiary care hospital. Yonsei medical journal 20120301
Rate of isolation and trends of antimicrobial resistance of multidrug resistant pseudomonas aeruginosa from otorrhea in chronic suppurative otitis media. Clinical and experimental otorhinolaryngology 20120301
Inactivation of a class A and a class C β-lactamase by 6β-(hydroxymethyl)penicillanic acid sulfone. Biochemical pharmacology 20120215
Evaluating outcomes associated with alternative dosing strategies for piperacillin/tazobactam: a qualitative systematic review. The Annals of pharmacotherapy 20120201
Clavulanic acid does not affect convulsions in acute seizure tests in mice. Journal of neural transmission (Vienna, Austria : 1996) 20120101
ESBLs: A Clear and Present Danger? Critical care research and practice 20120101
Granulomatous hepatitis due to Bartonella henselae infection in an immunocompetent patient. BMC infectious diseases 20120101
Bubbles in the urinary bladder. The Netherlands journal of medicine 20120101
Tuberculosis in a renal allograft recipient presenting with intussusception. Indian journal of nephrology 20120101
Extraintestinal Pathogenic Escherichia coli: A Combination of Virulence with Antibiotic Resistance. Frontiers in microbiology 20120101
Clostridium perfringens infection complicating periprosthetic fracture fixation about the hip: successful treatment with early aggressive debridement. Hip international : the journal of clinical and experimental research on hip pathology and therapy 20120101
Molecular description of plasmid-mediated AmpC β-lactamases among nosocomial isolates of Escherichia coli & Klebsiella pneumoniae from six different hospitals in India. The Indian journal of medical research 20120101
Goettingen Minipigs (GMP): Comparison of Two Different Models for Inducing Diabetes. Diabetology & metabolic syndrome 20120101
Occurrence and characteristics of extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae in food producing animals, minced meat and raw milk. BMC veterinary research 20120101
Kidney failure related to broad-spectrum antibiotics in critically ill patients: secondary end point results from a 1200 patient randomised trial. BMJ open 20120101
The regulatory repertoire of Pseudomonas aeruginosa AmpC ß-lactamase regulator AmpR includes virulence genes. PloS one 20120101
CTX-M Enzymes: Origin and Diffusion. Frontiers in microbiology 20120101
The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace. Frontiers in microbiology 20120101
Interdisciplinary three-step strategy to treat aortic stenosis and coronary artery disease in a patient with end-stage chronic obstructive pulmonary disease. Therapeutics and clinical risk management 20120101
Clinical profile and outcome of conservatively managed emphysematous pyelonephritis. ISRN urology 20120101
Myasthenia gravis in pregnancy: a case report. Case reports in obstetrics and gynecology 20120101
[Determination of target compounds in cefoperazone sodium and tazobactam sodium for injection by capillary electrophoresis]. Se pu = Chinese journal of chromatography 20120101
Emerging Aeromonas species infections and their significance in public health. TheScientificWorldJournal 20120101
[Occurrence of alert pathogens in hospital environment. Part I. ESBL-producing enterobacteriaceae strains]. Medycyna doswiadczalna i mikrobiologia 20120101
[Occurrence of alert pathogens in hospital environment Part II. Multidrug-resistant non-fermenting bacilli]. Medycyna doswiadczalna i mikrobiologia 20120101
Antibiotic resistance patterns and extended-spectrum β-lactamase production among Acinetobacter spp. isolated from an intensive care Unit of a hospital in Kerman, Iran. Antimicrobial resistance and infection control 20120101
Protective effect of citropin 1.1 and tazobactam-piperacillin against oxidative damage and lethality in mice models of gram-negative sepsis. The Journal of surgical research 20111201
Development of a liquid chromatography-tandem mass spectrometry assay of six antimicrobials in plasma for pharmacokinetic studies in premature infants. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111115
Biliary tract infection caused by Vibrio fluvialis in an immunocompromised patient. Infection 20111001
Achromobacter xylosoxidans respiratory tract infection in cystic fibrosis patients. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20110801
Is conservative treatment with antibiotics the correct strategy for management of right colonic diverticulitis?: a prospective study. Journal of the Korean Society of Coloproctology 20110801
Antibiotic utilization and Pseudomonas aeruginosa resistance in intensive care units. The new microbiologica 20110701
Susceptibility pattern of extended spectrum ß-lactamase producing isolates in various clinical specimens. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20110601
Emergence of tigecycline & colistin resistant Acinetobacter baumanii in patients with complicated urinary tract infections in north India. The Indian journal of medical research 20110601
Isolation and genetic characterization of metallo-β-lactamase and carbapenamase producing strains of Acinetobacter baumannii from patients at Tehran hospitals. Iranian journal of microbiology 20110601
Strategies to overcome extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases in shigellae. International journal of antimicrobial agents 20110501
Severe human parechovirus sepsis beyond the neonatal period. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20110501
In vitro activity of CXA-101 plus tazobactam (CXA-201) against CTX-M-14- and CTX-M-15-producing Escherichia coli and Klebsiella pneumoniae. Diagnostic microbiology and infectious disease 20110501
Piperacillin/tazobactam monotherapy versus piperacillin/tazobactam plus amikacin as initial empirical therapy for febrile neutropenia in children with acute leukemia. Pediatric hematology and oncology 20110501
A case of piperacillin-induced occupational anaphylaxis: detection of serum IgE to piperacillin-HSA conjugate. Journal of Korean medical science 20110501
Identification of products of inhibition of GES-2 beta-lactamase by tazobactam by x-ray crystallography and spectrometry. The Journal of biological chemistry 20110422
Efficacy of combination use of Beta-lactamase inhibitor with penicillin and fluoroquinolones for antibiotic prophylaxis in transrectal prostate biopsy. Korean journal of urology 20110401
Drug fever due to piperacillin/tazobactam loaded into bone cement. Journal of Korean medical science 20110201
Microbiological equivalence of bacteriostatic and bactericidal activities of the sera from healthy volunteers receiving generic piperacillin/tazobactam (Pipertaz) and original piperacillin/tazobactam (Tazocin). Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20110201
Carbapenemases in enterobacteria, Hong Kong, China, 2009. Emerging infectious diseases 20110101
Transrectal drainage of a diverticular abscess using a pigtail catheter without radiological guidance: a case report. Journal of medical case reports 20110101
WSES consensus conference: Guidelines for first-line management of intra-abdominal infections. World journal of emergency surgery : WJES 20110101
Chryseobacterium indologenes infection in a newborn: a case report. Journal of medical case reports 20110101
A rare human infection of Raoultella ornithinolytica in a diabetic foot lesion. Annals of Saudi medicine 20110101
[Perioperative antibiotic prophylaxis in radical retropubic prostatectomy: a randomised pilot study of perioperative and postoperative administration]. Aktuelle Urologie 20110101
An unexpected cause of deranged liver function: pyogenic liver abscess. JRSM short reports 20110101
Impact of de-escalation therapy on clinical outcomes for intensive care unit-acquired pneumonia. Critical care (London, England) 20110101
High prevalence of extended-spectrum beta lactamases among Salmonella enterica Typhimurium isolates from pediatric patients with diarrhea in China. PloS one 20110101
Perforation and abscess formation after radiological placement of a retrievable plastic biliary stent. Journal of medical case reports 20110101
New treatment options against gram-negative organisms. Critical care (London, England) 20110101
Churg-strauss syndrome as an unusual aetiology of stroke with haemorrhagic transformation in a patient with no cardiovascular risk factors. Case reports in neurology 20110101
Impact of ureido/carboxypenicillin resistance on the prognosis of ventilator-associated pneumonia due to Pseudomonas aeruginosa. Critical care (London, England) 20110101
Rhizomucor and scedosporium infection post hematopoietic stem-cell transplant. Case reports in medicine 20110101
Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy. Critical care (London, England) 20110101
Success rate of split-thickness skin grafting of chronic venous leg ulcers depends on the presence of Pseudomonas aeruginosa: a retrospective study. PloS one 20110101
Salmonella enteritidis liver abscess. Annals of hepatology 20110101
Successful delivery by a cesarean section in a parturient with severe dilated cardiomyopathy, an implantable cardioverter defibrillator, and a repaired tetralogy of fallot. Heart views : the official journal of the Gulf Heart Association 20110101
Primary iliac venous leiomyosarcoma: a rare cause of deep vein thrombosis in a young patient. Case reports in medicine 20110101
Rectal carriage of extended-spectrum beta-lactamase-producing gram-negative bacilli in community settings in Madagascar. PloS one 20110101
Severe bronchopulmonary dysplasia improved by noninvasive positive pressure ventilation: a case report. Journal of medical case reports 20110101
Structure of apo- and monometalated forms of NDM-1--a highly potent carbapenem-hydrolyzing metallo-β-lactamase. PloS one 20110101
Significance of Gram's stain smear, potassium hydroxide mount, culture, and microscopic pathology in the diagnosis of acrodermatitis continua of Hallopeau. Skinmed 20110101
Necrotizing fasciitis of the breast: a case managed without mastectomy. Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20110101
Changing trend of antimicrobial resistance among gram-negative bacilli isolated from lower respiratory tract of ICU patients: A 5-year study. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 20110101
Diuretics induced uremia and nonrecovery of renal function in a patient with acute renal failure caused by sepsis. Indian journal of pharmacology 20110101
Piperacillin-tazobactam-induced hypokalemia and metabolic alkalosis. Indian journal of pharmacology 20110101
Fabrication and anti-microbial evaluation of drug loaded polylactide space filler intended for ridge preservation following tooth extraction. Journal of Indian Society of Periodontology 20110101
Acquired antibiotic resistance genes: an overview. Frontiers in microbiology 20110101
Impact of definitive therapy with beta-lactam monotherapy or combination with an aminoglycoside or a quinolone for Pseudomonas aeruginosa bacteremia. PloS one 20110101
Necrotizing fasciitis: literature review of contemporary strategies for diagnosing and management with three case reports: torso, abdominal wall, upper and lower limbs. World journal of emergency surgery : WJES 20110101
Extended-Spectrum Beta-Lactamases Producing E. coli in Wildlife, yet Another Form of Environmental Pollution? Frontiers in microbiology 20110101
Genomic expression analysis reveals strategies of Burkholderia cenocepacia to adapt to cystic fibrosis patients' airways and antimicrobial therapy. PloS one 20110101
A Rare Case of Pancreatic Abscess due to Candida Tropicalis. Journal of global infectious diseases 20110101
Piperacillin-induced immune hemolysis presenting with tachycardia and cardiac arrest. Case reports in medicine 20110101
[Cefepime versus piperacillin/tazobactam with or without amikacin in the treatment of febrile hematological and oncological neutropenic patients in an internal medicine ward]. Harefuah 20101201
Delayed-type hypersensitivity reaction to piperacillin/tazobactam in a patient with an infected total knee replacement. The Journal of bone and joint surgery. British volume 20101101
Tazobactam/piperacillin for moderate-to-severe pneumonia in patients with risk for aspiration: comparison with imipenem/cilastatin. Pulmonary pharmacology & therapeutics 20101001
Serious pH1N1 influenza illness and pneumonia despite inactivated vaccine: success of prompt diagnosis and treatment. Journal of the National Medical Association 20101001
β-lactamase inhibitors display anti-seizure properties in an invertebrate assay. Neuroscience 20100915
Chequerboard titration of cephalosporin CXA-101 (FR264205) and tazobactam versus beta-lactamase-producing Enterobacteriaceae. The Journal of antimicrobial chemotherapy 20100901
Metallo-beta-lactamases among imipenem-resistant Pseudomonas aeruginosa in a Brazilian university hospital. Clinics (Sao Paulo, Brazil) 20100901
Activity of tigecycline and comparators against recent clinical isolates of Finegoldia magna from Europe. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20100801
Clostridium difficile bacteremia, Taiwan. Emerging infectious diseases 20100801
QnrB9 in association with TEM-116 extended-spectrum beta-lactamase in Citrobacter freundii isolated from sewage effluent: first report from Italy. Journal of chemotherapy (Florence, Italy) 20100801
In vitro selection of ertapenem and piperacillin/tazobactam-resistant strains of Bacteroides fragilis and analysis of their virulence in gnotobiotic mice. Journal of chemotherapy (Florence, Italy) 20100801
Late onset postpneumonectomy empyema presenting 24 years after pneumonectomy. JPMA. The Journal of the Pakistan Medical Association 20100701
Child with acute lobar nephronia. Indian journal of nephrology 20100701
Susceptibility of Klebsiella spp. to tigecycline and other selected antibiotics. Medical science monitor : international medical journal of experimental and clinical research 20100601
Electrolytes imbalance: a rare side effect of piperacillin/ tazobactam therapy. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20100601
Right atrial thrombus in a six- year- old Indian boy with metabolic syndrome. Journal of pediatric endocrinology & metabolism : JPEM 20100601
Daily serum piperacillin monitoring is advisable in critically ill patients. International journal of antimicrobial agents 20100501
Proteomic analysis of Escherichia coli with experimentally induced resistance to piperacillin/tazobactam. Research in microbiology 20100501
Current challenges in antimicrobial chemotherapy: focus on ß-lactamase inhibition. Drugs 20100416
[Pseudomonas aeruginosa: antimicrobial resistance in clinical isolates. Castellón 2004-2008]. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20100301
An unusual case of septic shock in a geriatric patient. Connecticut medicine 20100301
Enhancing resistance to cephalosporins in class C beta-lactamases: impact of Gly214Glu in CMY-2. Biochemistry 20100209
Comparative assessment of inoculum effects on the antimicrobial activity of amoxycillin-clavulanate and piperacillin-tazobactam with extended-spectrum beta-lactamase-producing and extended-spectrum beta-lactamase-non-producing Escherichia coli isolates. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20100201
First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis. International journal of antimicrobial agents 20100201
Septicemic melioidosis. The Journal of the Association of Physicians of India 20100201
In-vitro efficacy of synergistic antibiotic combinations in multidrug resistant Pseudomonas aeruginosa strains. Yonsei medical journal 20100101
Characterization of ESBL (SHV-12) producing clinical isolate of Enterobacter aerogenes from a tertiary care hospital in Nigeria. Annals of clinical microbiology and antimicrobials 20100101
Comparative in vitro study of the antimicrobial activities of different commercial antibiotic products for intravenous administration. BMC clinical pharmacology 20100101
Characterization of two diesel fuel degrading microbial consortia enriched from a non acclimated, complex source of microorganisms. Microbial cell factories 20100101
Comparative in vitro activity of Meropenem, Imipenem and Piperacillin/tazobactam against 1071 clinical isolates using 2 different methods: a French multicentre study. BMC infectious diseases 20100101
A focus on intra-abdominal infections. World journal of emergency surgery : WJES 20100101
Impact of prolonged treatment with high-dose ciprofloxacin on human gut flora: a case report. Journal of medical case reports 20100101
Medical resource utilization among patients with ventilator-associated pneumonia: pooled analysis of randomized studies of doripenem versus comparators. Critical care (London, England) 20100101
Pericardiectomy for pleuropericardial effusion complicating bacterial pneumonia. Case reports in medicine 20100101
Fatal Septicaemia Following Suprapubic Cystostomy in a Paraplegic Patient: Never Do a Cystostomy without Prior Urine Culture and Appropriate Antibiogram! Case reports in medicine 20100101
Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock. Critical care (London, England) 20100101
Bench-to-bedside review: The role of beta-lactamases in antibiotic-resistant Gram-negative infections. Critical care (London, England) 20100101
High prevalence of fecal carriage of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a pediatric unit in Madagascar. BMC infectious diseases 20100101
Hypothalamic abnormalities and Parkinsonism associated with H1N1 influenza infection. Journal of neuroinflammation 20100101
[Susceptibility of Escherichia coli strains isolated from persons with urinary tract infections in 2007 - 2008 to antimicrobial agents]. Przeglad epidemiologiczny 20100101
Nosocomial transmission of Cupriavidus pauculus during extracorporeal membrane oxygenation. ASAIO journal (American Society for Artificial Internal Organs : 1992) 20100101
Presentations of perforated colonic pathology in patients with polymyalgia rheumatica: two case reports. Journal of medical case reports 20100101
Antibiotic susceptibility pattern in urinary isolates of gram negative bacilli with special reference to AmpC β-lactamase in a tertiary care hospital. Urology annals 20100101
A case report of a septic hip secondary to a psoas abscess. Journal of orthopaedic surgery and research 20100101
Antibiotic optimization in the difficult-to-treat patient with complicated intra-abdominal or complicated skin and skin structure infections: focus on tigecycline. Therapeutics and clinical risk management 20100101
Extended-spectrum β-lactamases in Gram Negative Bacteria. Journal of global infectious diseases 20100101
Multidrug resistant acinetobacter. Journal of global infectious diseases 20100101
Fatal dialysis disequilibrium syndrome: A tale of two patients. Journal of emergencies, trauma, and shock 20100101
Interaction of CTX-M-15 enzyme with cefotaxime: a molecular modelling and docking study. Bioinformation 20100101
Eosinophilic infiltrate in a patient with severe Legionella pneumonia as a levofloxacin-related complication: a case report. Journal of medical case reports 20100101
The use of chemotherapy regimens carrying a moderate or high risk of febrile neutropenia and the corresponding management of febrile neutropenia: an expert survey in breast cancer and non-Hodgkin's lymphoma. BMC cancer 20100101
Unusual presentation of peritonitis with persistent clear aspirate: a case report. Journal of medical case reports 20100101
Outbreaks of imipenem resistant Acinetobacter baumannii producing OXA-23 beta-lactamase in a tertiary care hospital in Korea. Yonsei medical journal 20091231
A groundhog, a novel Bartonella sequence, and my father's death. Emerging infectious diseases 20091201
[A study on the active efflux system in methicillin-resistant Staphylococcus aureus]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20091201
Selection of TNF-alpha binding affibody molecules using a beta-lactamase protein fragment complementation assay. New biotechnology 20091130
In vitro synergy studies based on tazobactam/piperacillin against clinical isolates of metallo-beta-lactamase-producing Pseudomonas aeruginosa. The Journal of antimicrobial chemotherapy 20091101
Comparative pharmacodynamics of intermittent and prolonged infusions of piperacillin/tazobactam using Monte Carlo simulation and steady-state pharmacokinetic data from hospitalized patients. The Annals of pharmacotherapy 20091101
Comparative pharmacodynamics of intermittent and prolonged infusions of piperacillin/tazobactam using Monte Carlo simulations and steady-state pharmacokinetic data from hospitalized patients. The Annals of pharmacotherapy 20091101
Expanded studies of piperacillin/tazobactam formulations: variations among branded product lots and assessment of 46 generic lots. Diagnostic microbiology and infectious disease 20091101
[Post antibiotic, post beta-lactamase inhibitor and post antibiotic sub-MIC effect of ceftriaxone/tazobactam on beta-lactamase-producing Escherichia coli in vitro]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20091101
In vitro activity of the {beta}-lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases. The Journal of antimicrobial chemotherapy 20090801
Epidural abscess and meningitis, a complication of spinal anesthesia in a bacteraemic patient. JPMA. The Journal of the Pakistan Medical Association 20090801
Continuous-infusion beta-lactam antibiotics during continuous venovenous hemofiltration for the treatment of resistant gram-negative bacteria. The Annals of pharmacotherapy 20090701
Treatment of Strongyloides stercoralis hyperinfection-associated septic shock and acute respiratory distress syndrome with drotrecogin alfa (activated) in a renal transplant recipient. Transplant infectious disease : an official journal of the Transplantation Society 20090601
Outcomes of extended infusion piperacillin/tazobactam for documented Gram-negative infections. Diagnostic microbiology and infectious disease 20090601
First identification of class A carbapenemase-producing Klebsiella pneumoniae in the Republic of Ireland. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20090402
[Fournier's gangrene caused by Streptococcus agalactiae in a non-pregnant woman]. Enfermedades infecciosas y microbiologia clinica 20090401
Clostridium perfringens liver abscess after pancreatic resection. Surgical infections 20090401
Effects of combined treatment with sansanmycin and macrolides on Pseudomonas aeruginosa and formation of biofilm. Biomedical and environmental sciences : BES 20090401
Piperacillin/tazobactam Induced Myelosuppression. Journal of clinical medicine research 20090401
Characterization of blaKPC-containing Klebsiella pneumoniae isolates detected in different institutions in the Eastern USA. The Journal of antimicrobial chemotherapy 20090301
New disturbing trend in antimicrobial resistance of gram-negative pathogens. PLoS pathogens 20090301
Multidrug-resistant Gram-negative bacteria in postoperative infections. Journal of the Indian Medical Association 20090301
Different intermediate populations formed by tazobactam, sulbactam, and clavulanate reacting with SHV-1 beta-lactamases: Raman crystallographic evidence. Journal of the American Chemical Society 20090218
Sporadic and outbreak cases of melioidosis in southern Taiwan: clinical features and antimicrobial susceptibility. Infection 20090201
Pylephlebitis after a duodenal ulcer in a patient with metastasised colon carcinoma treated with chemotherapy and bevacizumab: a case report. The Netherlands journal of medicine 20090201
Late-onset Enterobacter cloacae sepsis in very-low-birth-weight neonates: experience in a medical center. Pediatrics and neonatology 20090201
Strategic design of an effective beta-lactamase inhibitor: LN-1-255, a 6-alkylidene-2'-substituted penicillin sulfone. The Journal of biological chemistry 20090109
[Clinical effects and safety of piperacillin/tazobactam in treating neutropenic febrile patients with malignant hematopathy]. Zhonghua yi xue za zhi 20090106
Phosphorylcholine impairs susceptibility to biofilm formation of hydrogel contact lenses. American journal of ophthalmology 20090101
High performance liquid chromatographic determination of plasma free and total tazobactam and piperacillin. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090101
Infarction of middle third posterior cortex of kidney: a complication of extended pyelolithotomy, intra-operative electrohydraulic lithotripsy and extraction of calyceal stones under vision using stone basket and flexible cystoscope in a spinal cord injury patient - a case report. Cases journal 20090101
[Resistance by hypermutable Pseudomonas aeruginosa and beta-lactamases production]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20090101
Species distribution and antimicrobial susceptibility of gram-negative aerobic bacteria in hospitalized cancer patients. Journal of translational medicine 20090101
Efflux pump, the masked side of beta-lactam resistance in Klebsiella pneumoniae clinical isolates. PloS one 20090101
Drug-resistance in Streptococcus pneumoniae isolates among Spanish middle aged and older adults with community-acquired pneumonia. BMC infectious diseases 20090101
Acute generalized exanthematous pustulosis: a rare clinical entity with use of piperacillin/tazobactam. American journal of therapeutics 20090101
In vitro activities of piperacillin or cefoperazone alone and in combination with beta-lactamase inhibitors against gram-negative bacilli. The new microbiologica 20090101
Nosocomial blood stream infection in intensive care units at Assiut University Hospitals (Upper Egypt) with special reference to extended spectrum beta-lactamase producing organisms. BMC research notes 20090101
How beta-lactam antibiotics enter bacteria: a dialogue with the porins. PloS one 20090101
[Evaluation of occurrence of Alcaligenes faecalis in clinical samples of patients of the university hospital in Bydgoszcz]. Medycyna doswiadczalna i mikrobiologia 20090101
Actinomyces species: A danish survey on human infections and microbiological characteristics. The open microbiology journal 20090101
Drugs associated with more suicidal ideations are also associated with more suicide attempts. PloS one 20090101
Vancomycin leading to lupus flare in an elderly lady: a case report. Cases journal 20090101
A comparative study to assess the effect of amikacin sulfate bladder wash on catheter-associated urinary tract infection in neurosurgical patients. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 20090101
Pseudomonas aeruginosa population structure revisited. PloS one 20090101
Ertapenem versus piperacillin/tazobactam for the treatment of complicated infections: a meta-analysis of randomized controlled trials. BMC infectious diseases 20090101
Engineering antigen-specific T cells from genetically modified human hematopoietic stem cells in immunodeficient mice. PloS one 20090101
Molecular characterisation of Vibrio cholerae O1 strains carrying an SXT/R391-like element from cholera outbreaks in Kenya: 1994-2007. BMC microbiology 20090101
Concurrent administration of heparin and activated protein C in a patient with pulmonary embolism and severe sepsis with positive outcome. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 20090101
Haemolytic anaemia caused by piperacillin-tazobactam. Acta clinica Belgica 20090101
Treatment of a patient with shock complicating severe falciparum malaria: a case report. Cases journal 20090101
Septic shock in digestive surgery: a retrospective study of 89 patients. Hepato-gastroenterology 20090101
Fatal Postoperative Candida glabrata Septicemia in a Child with Congenital Heart Disease. Journal of global infectious diseases 20090101
Cost-effectiveness evaluation of ertapenem versus piperacillin/tazobactam in the treatment of complicated intraabdominal infections accounting for antibiotic resistance. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20090101
Nicolau syndrome: an iatrogenic cutaneous necrosis. Journal of cutaneous and aesthetic surgery 20090101
Recent changes in the epidemiology and management of extended-spectrum β-lactamase-producing Enterobacteriaceae. F1000 medicine reports 20090101
Management of infections due to KPC-producing Klebsiella pneumoniae. F1000 medicine reports 20090101
Disseminated Coccidioidomycosis with Clinically Evident Splenomegaly in an Immunocompetent Host, First Case Reported in the literature. McGill journal of medicine : MJM : an international forum for the advancement of medical sciences by students 20090101
Stability of aseptically prepared tazocin solutions in polyvinyl chloride bags. The Canadian journal of hospital pharmacy 20090101
Concentrations of piperacillin-tazobactam in human jaw and hip bone. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 20081201
Comparison of the effect of ciprofloxacin and Tazocin on the incidence of meticillin-resistant Staphylococcus aureus (MRSA) in an Intensive Care Unit. International journal of antimicrobial agents 20081201
Evaluating the ototoxicity of topical piperacillin-tazobactam. International journal of pediatric otorhinolaryngology 20081201
Pharmacokinetic/pharmacodynamic modeling to predict in vivo effectiveness of various dosing regimens of piperacillin/tazobactam and piperacillin monotherapy against gram-negative pulmonary isolates from patients managed in intensive care units in 2002. Clinical therapeutics 20081201
Multidisciplinary approach to the treatment of invasive fungal infections in adult patients. Prophylaxis, empirical, preemptive or targeted therapy, which is the best in the different hosts? Therapeutics and clinical risk management 20081201
Effects of treatment with antimicrobial agents on the human colonic microflora. Therapeutics and clinical risk management 20081201
False positivity of the Aspergillus galactomannan Platelia ELISA because of piperacillin/tazobactam treatment: does it represent a clinical problem? The Journal of antimicrobial chemotherapy 20081101
Serological studies of piperacillin antibodies. Transfusion 20081101
Dacryocystitis: an unusual form of Mucorales infection. The Journal of the Kentucky Medical Association 20081101
Antimicrobial susceptibility of well-characterised multiresistant CTX-M-producing Escherichia coli: failure of automated systems to detect resistance to piperacillin/tazobactam. International journal of antimicrobial agents 20081001
Evaluation of sensitivity of different organisms to cefepime and tazobactum (megapime XP) in comparison to cefepime and ceftazidime. Journal of the Indian Medical Association 20080901
[Sensitivity surveillance of Haemophilus influenzae isolates for several antibiotics in Gifu Prefecture (2006)]. The Japanese journal of antibiotics 20080801
Efficacy and safety of doripenem versus piperacillin/tazobactam in nosocomial pneumonia: a randomized, open-label, multicenter study. Current medical research and opinion 20080701
Suspected drug reaction with piperacillin/tazobactam, in a premature infant. British journal of clinical pharmacology 20080601
Isolation of the first metallo-beta-lactamase producing Klebsiella pneumoniae in Lebanon. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20080601
Alveolar concentrations of piperacillin/tazobactam administered in continuous infusion to patients with ventilator-associated pneumonia. Critical care medicine 20080501
Continuous infusion of beta-lactams in the intensive care unit--best way to hit the target? Critical care medicine 20080501
Why clinically used tazobactam and sulbactam are poor inhibitors of OXA-10 beta-lactamase: Raman crystallographic evidence. Biochemistry 20080401
Piperacillin/tazobactam-induced Sweet syndrome in a patient with chronic lymphocytic leukemia and autoimmune cholangitis. The American Journal of dermatopathology 20080401
Zosyn (piperacillin/tazobactam) reformulation: Expanded compatibility and coadministration with lactated Ringer's solutions and selected aminoglycosides. Therapeutics and clinical risk management 20080401
Piperacillin/tazobactam-heteroresistant Pseudomonas aeruginosa from urinary infection, successfully treated by piperacillin/tazobactam. The Journal of antimicrobial chemotherapy 20080301
First outbreak of multidrug-resistant Klebsiella pneumoniae producing both SHV-12-type extended-spectrum beta-lactamase and DHA-1-type AmpC beta-lactamase at a Korean hospital. Yonsei medical journal 20080227
5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. Bioorganic & medicinal chemistry 20080215
Meropenem activity against European isolates: report on the MYSTIC (Meropenem Yearly Susceptibility Test Information Collection) 2006 results. Diagnostic microbiology and infectious disease 20080201
False-positive Aspergillus antigen testing due to application of piperacillin/tazobactam--is it still an issue? Diagnostic microbiology and infectious disease 20080101
Irreproducible piperacillin/tazobactam minimum inhibitory concentrations in microdilution tests with Escherichia coli strains. International journal of antimicrobial agents 20080101
Tachyplesin III and granulocyte-colony stimulating factor enhance the efficacy of tazobactam/piperacillin in a neutropenic mouse model of polymicrobial peritonitis. Peptides 20080101
Efficacy of the bovine antimicrobial peptide indolicidin combined with piperacillin/tazobactam in experimental rat models of polymicrobial peritonitis. Critical care medicine 20080101
Fatal necrotizing pneumonia due to a Panton-Valentine leukocidin positive community-associated methicillin-sensitive Staphylococcus aureus and Influenza co-infection: a case report. Annals of clinical microbiology and antimicrobials 20080101
Occurrence of ESBL & Amp-C beta-lactamases & susceptibility to newer antimicrobial agents in complicated UTI. The Indian journal of medical research 20080101
Seroma and recurrence in laparoscopic ventral hernioplasty. JSLS : Journal of the Society of Laparoendoscopic Surgeons 20080101
[Betalactam antibiotics combined with bectalactamases inhibitors. Amoxicillin-sulbactam]. Medicina 20080101
In vitro interaction between mecillinam and piperacillin-tazobactam in the presence of azithromycin against members of the Enterobacteriaceae family and Pseudomonas aeruginosa. The new microbiologica 20080101
Incidence and impact on clinical outcome of infections with piperacillin/tazobactam resistant Escherichia coli in ICU: a retrospective study. BMC infectious diseases 20080101
Pharmacodynamic optimization of beta-lactams in the patient care setting. Critical care (London, England) 20080101
Incidence of metallo-beta-lactamase-producing Pseudomonas aeruginosa in diabetes and cancer patients. Indian journal of pathology & microbiology 20080101
Hemorrhage associated with hepatic artery pseudoaneurysms after regional chemotherapy with floxuridine: case report. International seminars in surgical oncology : ISSO 20080101
Primary psoas abscess in a patient affected by acquired immunodeficiency syndrome: a rare case according to the reviewed literature. La Clinica terapeutica 20080101
The role of polyclonal intravenous immunoglobulin in treating HIV-infected children with severe bacterial infections: a retrospective cohort study. BMC infectious diseases 20080101
[Antibiotic susceptibility and occurrence of ESBL, IBL and MBL in Pseudomonas aeruginosa strains]. Medycyna doswiadczalna i mikrobiologia 20080101
[Analysis of antibiotic consumption and microorganism resistance changes]. Medicina (Kaunas, Lithuania) 20080101
[Problem of increasing resistance of pseudomonas aeruginosa in patients at ENT Clinic of Poznan University of Medical Sciences in the years 2005-2007]. Otolaryngologia polska = The Polish otolaryngology 20080101
Fulminant Clostridium difficile enteritis after proctocolectomy and ileal pouch-anal anastamosis. Gastroenterology research and practice 20080101
Laparoscopic management of a retroperitoneal duodenal perforation following ERCP for periampullary cancer. JSLS : Journal of the Society of Laparoendoscopic Surgeons 20080101
[Treatment of a septic shock due to multiresistant Acinetobacter baumannii with tigecycline in combination]. Annales francaises d'anesthesie et de reanimation 20071201
Treatment of anaerobic infection. Expert review of anti-infective therapy 20071201
Stability of antibiotics in portable pumps used for bronchial superinfection: guidelines for prescribers. Pediatrics 20071201
Irreversible inhibition of the Mycobacterium tuberculosis beta-lactamase by clavulanate. Biochemistry 20071030
Management of invasive pulmonary aspergillosis in non-neutropenic critically ill patients. Intensive care medicine 20071001
Serum piperacillin/tazobactam pharmacokinetics in a morbidly obese individual. The Annals of pharmacotherapy 20071001
Respiratory hyperinfection with Strongyloides stercoralis in a patient with renal failure. Nature clinical practice. Nephrology 20071001
Extension of the hydrolysis spectrum of AmpC beta-lactamase of Escherichia coli due to amino acid insertion in the H-10 helix. The Journal of antimicrobial chemotherapy 20070901
Class A carbapenemases. The Journal of antimicrobial chemotherapy 20070901
Lemierre syndrome: a case of postanginal sepsis. The Korean journal of internal medicine 20070901
Sulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamase. Biochemistry 20070807
Quantitative analysis of clavulanic acid in porcine tissues by liquid chromatography combined with electrospray ionization tandem mass spectrometry. Analytica chimica acta 20070806
Treating diabetic foot infections with sequential intravenous to oral moxifloxacin compared with piperacillin-tazobactam/amoxicillin-clavulanate. The Journal of antimicrobial chemotherapy 20070801
Implementation of antibiotic rotation protocol improves antibiotic susceptibility profile in a surgical intensive care unit. The Journal of trauma 20070801
New primary management for appendiceal masses in children: laparoscopic drainage. Journal of laparoendoscopic & advanced surgical techniques. Part A 20070801
Control of multi-resistant bacteria and ventilator-associated pneumonia: is it possible with changes in antibiotics? The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20070801
Efficient inhibition of class A and class D beta-lactamases by Michaelis complexes. The Journal of biological chemistry 20070727
Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors. Biochemistry 20070724
Appropriate comparators for alternate dosing strategies. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070715
An improved high-performance liquid chromatographic method with a solid-phase extraction for the determination of piperacillin and tazobactam: application to pharmacokinetic study of different dosage in Chinese healthy volunteers. Biomedical chromatography : BMC 20070701
In vitro efficacy of ceftriaxone/sulbactam against Escherichia coli isolates producing CTX-M-15 extended-spectrum beta-lactamase. The Journal of antimicrobial chemotherapy 20070701
Inadequate antimicrobial prophylaxis during surgery: a study of beta-lactam levels during burn debridement. The Journal of antimicrobial chemotherapy 20070701
Sensitivity pattern of gram negative bacilli to three beta-lactam/beta-lactamase inhibitor combinations using the automated API system. Indian journal of medical microbiology 20070701
Clostridium difficile small-bowel enteritis after total proctocolectomy: a rare but fatal, easily missed diagnosis. Report of a case. Diseases of the colon and rectum 20070601
[Peritonsillar abscess: a life threatening disease--diagnostic and therapeutic aspects]. Laryngo- rhino- otologie 20070501
Susceptibility of Pseudomonas aeruginosa to antimicrobials: a 2004 French multicentre hospital study. The Journal of antimicrobial chemotherapy 20070501
Evaluating empiric treatment options for secondary peritonitis using pharmacodynamic profiling. Surgical infections 20070401
[Infection with Aeromonas hydrophila after use of leeches (Hirudo medicinalis) in a free microvascular osteo-(myo-)cutaneous flap--suggestions for successful management]. Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V... 20070401
Comparative activities of cefepime and piperacillin/tazobactam tested against a global collection of Escherichia coli and Klebsiella spp. with an ESBL phenotype. Diagnostic microbiology and infectious disease 20070301
Extended-spectrum beta-lactamase-producing Shigella strains in Israel, 2000-2004. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20070301
Pattern of nosocomial infection in two intensive care units of a tertiary care hospital in Karachi. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20070301
Successful treatment and limb salvage of mucor necrotizing fasciitis after kidney transplantation with posaconazole. Hawaii medical journal 20070301
In vitro activities of various piperacillin and sulbactam combinations against bacterial pathogens isolated from Intensive Care Units in Taiwan: SMART 2004 programme data. International journal of antimicrobial agents 20070201
Biochemical characterisation of the CTX-M-14 beta-lactamase. International journal of antimicrobial agents 20070201
Experience with the use of piperacillin-tazobactam in pediatric non-renal solid organ transplantation. Pediatric transplantation 20070201
Ertapenem resistance of Escherichia coli. Emerging infectious diseases 20070201
Differences in the changes in resistance patterns to third- and fourth-generation cephalosporins and piperacillin/tazobactam among Klebsiella pneumoniae and Escherichia coli clinical isolates following a restriction policy in a Greek tertiary care hospital. International journal of antimicrobial agents 20070101
Antimicrobial therapy for acute cholangitis: Tokyo Guidelines. Journal of hepato-biliary-pancreatic surgery 20070101
Antimicrobial therapy for acute cholecystitis: Tokyo Guidelines. Journal of hepato-biliary-pancreatic surgery 20070101
Acute esophageal necrosis: 'black esophagus'. JSLS : Journal of the Society of Laparoendoscopic Surgeons 20070101
Acute cholecystitis - early laparoskopic surgery versus antibiotic therapy and delayed elective cholecystectomy: ACDC-study. Trials 20070101
Enterobacter endophthalmitis: treatment with intravitreal tazobactam - piperacillin. Indian journal of ophthalmology 20070101
Clinical case of the month. A 48-year-old man with a non-healing wound. The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society 20070101
Randomized, open-label, comparative study of piperacillin-tazobactam administered by continuous infusion versus intermittent infusion for treatment of hospitalized patients with complicated intra-abdominal infection. Antimicrobial agents and chemotherapy 20061101
[Hepatic abscess due to Klebsiella pneumoniae in an Asian immigrant]. Enfermedades infecciosas y microbiologia clinica 20061101
European Academy of Paediatrics, Barcelona, Spain, October 7-10, 2006. Abstracts. European journal of pediatrics 20061101
High prevalence of ceftazidime-resistant Klebsiella pneumoniae and increase of imipenem-resistant Pseudomonas aeruginosa and Acinetobacter spp. in Korea: a KONSAR program in 2004. Yonsei medical journal 20061031
Case-control comparison of at-home to total hospital care for autologous stem-cell transplantation for hematologic malignancies. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20061020
Rational design of a beta-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 A crystal structure of wt SHV-1 complex with a penam sulfone. Journal of the American Chemical Society 20061011
Effect of the inhibitor-resistant M69V substitution on the structures and populations of trans-enamine beta-lactamase intermediates. Biochemistry 20061003
Comparison of piperacillin/tazobactam and imipenem/cilastatin, both in combination with tobramycin, administered every 6 h for treatment of nosocomial pneumonia. Respiratory medicine 20060901
Amphibian peptides prevent endotoxemia and bacterial translocation in bile duct-ligated rats. Critical care medicine 20060901
Can the ravages of uncontrolled systemic inflammatory response be regulated by amphibian antimicrobial peptides? Critical care medicine 20060901
Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods. Journal of medicinal chemistry 20060727
In vitro activities of tigecycline against recently isolated Gram-negative anaerobic bacteria in Greece, including metronidazole-resistant strains. Diagnostic microbiology and infectious disease 20060701
Influence of culture site-specific MIC distributions on the pharmacokinetic and pharmacodynamic properties of piperacillin/tazobactam and piperacillin: a data analysis. Clinical therapeutics 20060701
Antimicrobial resistance in gram-positive bacteria. The American journal of medicine 20060601
[Antibiotic prophylaxis in cesarean section -- piperacillin versus piperacillin/tazobactam in 300 cesarean sections]. Zentralblatt fur Gynakologie 20060601
Piperacillin/tazobactam vs imipenem/cilastatin in the treatment of nosocomial pneumonia--a double blind prospective multicentre study. Infection 20060601
Pharmacoeconomics of continuous versus intermittent infusion of piperacillin-tazobactam for the treatment of complicated intraabdominal infection. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20060415
Piperacillin-tazobactam monotherapy in high-risk febrile and neutropenic cancer patients. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20060301
Picture of the month. Infected urachal cyst. Archives of pediatrics & adolescent medicine 20060301
Further increase of vancomycin-resistant Enterococcus faecium, amikacin- and fluoroquinolone-resistant Klebsiella pneumoniae, and imipenem-resistant Acinetobacter spp. in Korea: 2003 KONSAR surveillance. Yonsei medical journal 20060227
Empirical antibiotic monotherapy for febrile neutropenia: systematic review and meta-analysis of randomized controlled trials. The Journal of antimicrobial chemotherapy 20060201
Piperacillin/tazobactam vs ceftazidime in the treatment of neutropenic fever in patients with acute leukemia or following autologous peripheral blood stem cell transplantation: a prospective randomized trial. Bone marrow transplantation 20060201
[The combination effects of antibacterial agents against clinical isolated multiple-drug resistant Pseudomonas aeruginosa]. The Japanese journal of antibiotics 20060201
Comparative study of antibiotic-containing polymethylmetacrylate capsules and beads. Chemotherapy 20060101
In vitro susceptibility to meropenem and other antimicrobial agents among gram-negative bacilli isolated from hospitalized patients in central India. Chemotherapy 20060101
Trends in antimicrobial susceptibility in UK centres: the MYSTIC Programme (1997-2002). International journal of antimicrobial agents 20060101
Efficiency of tazobactam/piperacillin in lethal peritonitis is enhanced after preconditioning of rats with O3/O2-pneumoperitoneum. Shock (Augusta, Ga.) 20060101
Clinical experience with three combination regimens for the treatment of high-risk febrile neutropenia. Annals of the Academy of Medicine, Singapore 20060101
Detection of bacterial strains producing sulbactam- or tazobactam-sensitive beta-lactamases by the use of disks containing the inhibitors alone instead of combining them with antibiotics. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20060101
Piperacillin/tazobactam in treatment of brain abscess. Scandinavian journal of infectious diseases 20060101
Pseudomonas aeruginosa bloodstream infections: risk factors and treatment outcome related to expression of the PER-1 extended-spectrum beta-lactamase. BMC infectious diseases 20060101
Examination of a novel, specified local antibiotic therapy through polymethylmethacrylate capsules in a rabbit osteomyelitis model. Chemotherapy 20060101
In-vitro evaluation of 'piperacillin and tazobactum' combination in a tertiary-care hospital--a preliminary study. Indian journal of pathology & microbiology 20060101
Elimination of piperacillin and tazobactam by renal replacement therapies with AN69 and polysulfone hemofilters: evaluation of the sieving coefficient. Blood purification 20060101
Liver abscess after radiofrequency ablation of tumors in patients with a biliary tract procedure. Gastroenterologie clinique et biologique 20060101
[Treatment of bronchial superinfections: data related to stability of antibiotics in portable pumps]. Therapie 20060101
Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole: an increasing problem. Annals of clinical microbiology and antimicrobials 20060101
[Antimicrobial susceptibility of Proteus mirabilis urinary tract isolates from 1999 to 2005 at Nîmes University Hospital]. Pathologie-biologie 20060101
Clinical pseudomonas aeruginosa: potential factors of pathogenicity and resistance to antimicrobials. Folia microbiologica 20060101
Cefepime- and cefixime-induced encephalopathy in a patient with normal renal function. Neurology 20051213
Pseudomonal sepsis with subcutaneous nodules in an HIV-infected individual with high CD4 counts. The Journal of infection 20051201
[Analysis of drug resistance spectrum and its mechanism in 1017 clinical bacterial isolates]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20051201
High resolution crystal structures of the trans-enamine intermediates formed by sulbactam and clavulanic acid and E166A SHV-1 {beta}-lactamase. The Journal of biological chemistry 20051014
Quantitation and stability of piperacillin and tazobactam in plasma and ultrafiltrate from patients undergoing continuous venovenous hemofiltration by HPLC. Biomedical chromatography : BMC 20051001
Fever, pulmonary haemorrhage, and acute renal failure in a young girl. Hong Kong medical journal = Xianggang yi xue za zhi 20051001
Infectious complications after simultaneous pancreas-kidney transplantation. Transplantation proceedings 20051001
[Uterine gas gangrene through clostridium perfringens sepsis after uterus rupture postpartum]. Zeitschrift fur Geburtshilfe und Neonatologie 20051001
Shelf lives of aseptically prepared medicines--stability of piperacillin/tazobactam in PVC and non-PVC bags. Journal of pharmaceutical and biomedical analysis 20050901
Index of suspicion. Pediatrics in review 20050901
Group C streptococcal sepsis complicating Fournier gangrene. Southern medical journal 20050901
Population pharmacokinetics and pharmacodynamics of piperacillin/tazobactam in patients with complicated intra-abdominal infection. The Journal of antimicrobial chemotherapy 20050801
[Dynamic analysis of drug resistance of Pseudomonas aeruginosa in laboratory and clinical two-drug regimen]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20050801
Empirical antimicrobial monotherapy in patients after high-dose chemotherapy and autologous stem cell transplantation: a randomised, multicentre trial. British journal of haematology 20050701
In vitro activity of ceftriaxone plus tazobactam against members of Enterobacteriaceae. The Journal of the Association of Physicians of India 20050701
Effects of piperacillin/tazobactam on Clostridium difficile growth and toxin production in a human gut model. The Journal of antimicrobial chemotherapy 20050601
Prediction of genotoxicity of chemical compounds by statistical learning methods. Chemical research in toxicology 20050601
Antibacterial susceptibility of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae and Escherichia coli. The Israel Medical Association journal : IMAJ 20050501
Imipenem/cilastatin versus piperacillin/tazobactam plus amikacin for empirical therapy in febrile neutropenic patients: results of the COSTINE study. Current medical research and opinion 20050501
[Preliminary study on the release of DNA from Pseudomona aeruginosa induced by piperacillin/tazobactam in vitro]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20050401
Severe intra-abdominal infection due to Streptococcus Milleri following adjustable gastric banding. Obesity surgery 20050401
[Extended-spectrum beta-lactamases: their role in clinical microbiology laboratory, treatment and infection control]. Mikrobiyoloji bulteni 20050401
A comparison of intravitreal piperacillin/tazobactam with ceftazidime in experimental Pseudomonas aeruginosa endophthalmitis. Experimental eye research 20050301
Influence of renal function on the pharmacokinetics of piperacillin/tazobactam in intensive care unit patients during continuous venovenous hemofiltration. Journal of clinical pharmacology 20050201
Carbapenemase-producing Enterobacteriaceae, U.S. rivers. Emerging infectious diseases 20050201
Simultaneous analysis of piperacillin and tazobactam in rabbits: application to pharmacokinetic study. Biomedical chromatography : BMC 20050101
Pharmacokinetics of piperacillin-tazobactam: intermittent dosing versus continuous infusion. International journal of antimicrobial agents 20050101
Activities of various beta-lactams and beta-lactam/beta-lactamase inhibitor combinations against Acinetobacter baumannii and Acinetobacter DNA group 3 strains. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20050101
The efficacy of piperacillin/tazobactam in experimental Pseudomonas aeruginosa endophthalmitis: a histopathological and microbiological evaluation. Current eye research 20050101
The antimicrobial susceptibility of Stenotrophomonas maltophilia isolates using three different methods and their genetic relatedness. BMC microbiology 20050101
Comparison of antimicrobial resistance of Acinetobacter baumannii clinical isolates from Shanghai and Hong Kong. Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20050101
[Comparison of frequency and susceptibility to antimicrobials of bacterial strains of the family Enterobacteriaceae isolated from patients hospitalised in intensive care units]. Medycyna doswiadczalna i mikrobiologia 20050101
Pharmacodynamic modeling of beta-lactam antibiotics for the empiric treatment of secondary peritonitis: a report from the OPTAMA program. Surgical infections 20050101
Extended spectrum beta-lactamases among Gram-negative bacteria of nosocomial origin from an intensive care unit of a tertiary health facility in Tanzania. BMC infectious diseases 20050101
Bench-to-bedside review: antimicrobial utilization strategies aimed at preventing the emergence of bacterial resistance in the intensive care unit. Critical care (London, England) 20050101
Overexpression system and biochemical profile of CTX-M-3 extended-spectrum beta-lactamase expressed in Escherichia coli. FEMS microbiology letters 20041215
Novel imidazole substituted 6-methylidene-penems as broad-spectrum beta-lactamase inhibitors. Bioorganic & medicinal chemistry 20041115
Inhibitor-resistant class A beta-lactamases: consequences of the Ser130-to-Gly mutation seen in Apo and tazobactam structures of the SHV-1 variant. Biochemistry 20041109
Piperacillin-tazobactam and netilmicin as a safe and efficacious empirical treatment of febrile neutropenic children. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20041001
Beta-lactamase inhibitors: evolving compounds for evolving resistance targets. Expert opinion on investigational drugs 20041001
Effect of subinhibitory concentration of piperacillin/tazobactam on Pseudomonas aeruginosa. Journal of medical microbiology 20040901
In vitro activity of AVE1330A, an innovative broad-spectrum non-beta-lactam beta-lactamase inhibitor. The Journal of antimicrobial chemotherapy 20040801
Empirical antibiotic treatment with piperacillin-tazobactam in patients with microbiologically-documented biliary tract infections. World journal of gastroenterology 20040801
Mechanism of inactivation of beta-lactamases by novel 6-methylidene penems elucidated using electrospray ionization mass spectrometry. Journal of medicinal chemistry 20040701
Randomized comparison of piperacillin/tazobactam versus imipenem/cilastatin in the treatment of patients with intra-abdominal infection. Asian journal of surgery 20040701
[A 4-year study of Pseudomonas aeruginosa susceptibility to antibiotics (1998-2001) in northern Lebanon]. Medecine et maladies infectieuses 20040701
CTX-M-type beta-lactamases affect community Escherichia coli treatment, Greece. Emerging infectious diseases 20040601
Tazobactam inactivation of SHV-1 and the inhibitor-resistant Ser130 -->Gly SHV-1 beta-lactamase: insights into the mechanism of inhibition. The Journal of biological chemistry 20040507
Steady-state plasma and intrapulmonary concentrations of piperacillin/tazobactam 4 g/0.5 g administered to critically ill patients with severe nosocomial pneumonia. Intensive care medicine 20040501
Piperacillin/tazobactam-induced acute delirium in a peritoneal dialysis patient. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040501
Exploring the effectiveness of tazobactam against ceftazidime resistant Escherichia coli: insights from the comparison between susceptibility testing and beta-lactamase inhibition. FEMS microbiology letters 20040501
Impact of tazobactam pharmacokinetics on the antimicrobial effect of piperacillin-tazobactam combinations. International journal of antimicrobial agents 20040501
In vitro killing of parenteral beta-lactams against standard and high inocula of extended-spectrum beta-lactamase and non-ESBL producing Klebsiella pneumoniae. Diagnostic microbiology and infectious disease 20040501
Increased susceptibility to vancomycin-resistant Enterococcus intestinal colonization persists after completion of anti-anaerobic antibiotic treatment in mice. Infection control and hospital epidemiology 20040501
Effect of the increasing use of piperacillin/tazobactam on the incidence of vancomycin-resistant enterococci in four academic medical centers. Infection control and hospital epidemiology 20040501
Serum bactericidal activity of piperacillin/tazobactam against Staphylococcus aureus, piperacillin-susceptible and piperacillin-resistant Escherichia coli and Pseudomonas aeruginosa. Chemotherapy 20040401
Safety evaluation of piperacillin/tazobactam in very low birth weight infants. Journal of chemotherapy (Florence, Italy) 20040401
Increase in the rate of nosocomial Clostridium difficile-associated diarrhoea during shortages of piperacillin-tazobactam and piperacillin. The Journal of antimicrobial chemotherapy 20040301
Cefotaximases (CTX-M-ases), an expanding family of extended-spectrum beta-lactamases. Canadian journal of microbiology 20040301
[Pyogenic sacroiliitis complicated by iliopsoas muscle abscess]. Recenti progressi in medicina 20040301
Meropenem plus amikacin versus piperacillin-tazobactam plus netilmicin as empiric therapy for high-risk febrile neutropenia in children. Pediatric hematology and oncology 20040301
Tazobactam forms a stoichiometric trans-enamine intermediate in the E166A variant of SHV-1 beta-lactamase: 1.63 A crystal structure. Biochemistry 20040203
Pharmacodynamic study of beta-lactams alone and in combination with beta-lactamase inhibitors against Pseudomonas aeruginosa possessing an inducible beta-lactamase. The Journal of antimicrobial chemotherapy 20040201
Vancomycin does not benefit persistently febrile neutropenic people with cancer. Cancer treatment reviews 20040201
Tazobactam-induced haemolytic anaemia, possibly caused by non-immunological adsorption of IgG onto patient's red cells. Transfusion medicine (Oxford, England) 20040201
Evaluation of penicillin-based inhibitors of the class A and B beta-lactamases from Bacillus anthracis. Biochemical and biophysical research communications 20040116
Evaluation of outpatient treatment with ertapenem in a double blind controlled clinical trial of complicated skin/skin structure infections. The Journal of infection 20040101
Acute diverticulitis of the colon--current medical therapeutic management. Expert opinion on pharmacotherapy 20040101
[Thoracic wall crossing (pseudo-?) tumor in a child: abscess-forming thoracic actinomycosis caused by Actinomyces meyeri et israeli]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 20040101
Comparison in a rat thigh abscess model of imipenem, meropenem and cefoperazone-sulbactam against Acinetobacter baumannii strains in terms of bactericidal efficacy and resistance selection. Annals of clinical microbiology and antimicrobials 20040101
[Simple method to detect factors influencing drug expenditures]. Harefuah 20040101
Once-daily oral levofloxacin monotherapy versus piperacillin/tazobactam three times a day: a randomized controlled multicenter trial in patients with febrile neutropenia. International journal of hematology 20040101
Determination of nontoxic concentrations of piperacillin/tazobactam for intravitreal application. An electroretinographic, histopathologic and morphometric analysis. Ophthalmic research 20040101
Double-disk synergy test positivity in Stenotrophomonas maltophilia clinical strains. Folia microbiologica 20040101
Emerging resistance among bacterial pathogens in the intensive care unit--a European and North American Surveillance study (2000-2002). Annals of clinical microbiology and antimicrobials 20040101
[Antibiotic prophylaxis in laparotomic and laparoscopic cholecystectomy]. Chirurgia italiana 20040101
[Mechanisms of resistance in Enterobacteriaceae towards beta-lactamase antibiotics]. Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti 20040101
[Antibiotic susceptibility and occurrence of ESBL in Pseudomonas aeruginosa strains isolated from different clinical specimens]. Medycyna doswiadczalna i mikrobiologia 20040101
Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130. The Journal of biological chemistry 20031226
False positive test for aspergillus antigenemia related to concomitant administration of piperacillin and tazobactam. The New England journal of medicine 20031211
Following the reactions of mechanism-based inhibitors with beta-lactamase by Raman crystallography. Biochemistry 20031125
Argentinean collaborative multicenter study on the in vitro comparative activity of piperacillin-tazobactam against selected bacterial isolates recovered from hospitalized patients. Diagnostic microbiology and infectious disease 20031101
Antimicrobial therapy of unexplained fever in neutropenic patients--guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO), Study Group Interventional Therapy of Unexplained Fever, Arbeitsgemeinschaft Supportivmassnahmen in der Onkologie (ASO) of the Deutsche Krebsgesellschaft (DKG-German Cancer Society). Annals of hematology 20031001
Severe acute respiratory syndrome: clinical outcome and prognostic correlates. Emerging infectious diseases 20030901
Intracameral antibiotic agents for endophthalmitis prophylaxis: a pharmacokinetic model. Journal of cataract and refractive surgery 20030901
Nosocomial bacteremia and catheter infection by Bacillus cereus in an immunocompetent patient. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20030901
Thrombocytosis under ciprofloxacin and tazobactam/piperacillin. Platelets 20030801
Risk factors for piperacillin/tazobactam-resistant Escherichia coli in ICU patients: a clinical study. Intensive care medicine 20030701
Positive direct antiglobulin tests and haemolytic anaemia following therapy with the beta-lactamase inhibitor, tazobactam, may also be associated with non-immunologic adsorption of protein onto red blood cells. Vox sanguinis 20030701
[Phenotypes of beta-lactam resistance in the genus Aeromonas]. Pathologie-biologie 20030701
Spirocyclopropyl beta-lactams as mechanism-based inhibitors of serine beta-lactamases. Synthesis by rhodium-catalyzed cyclopropanation of 6-diazopenicillanate sulfone. Journal of medicinal chemistry 20030619
Piperacillin-tazobactam is more effective than ceftriaxone plus gentamicin in febrile neutropenic patients with hematological malignancies: a randomized comparison. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20030601
Penetration of piperacillin and tazobactam into pneumonic human lung tissue measured by in vivo microdialysis. British journal of clinical pharmacology 20030601
Efficacy of ertapenem in the treatment of serious infections caused by Enterobacteriaceae: analysis of pooled clinical trial data. The Journal of antimicrobial chemotherapy 20030501
[Assay of Acinetobacter SPP drug-resistance by Kirby-Bauer and Etest method]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030501
Role of pharmacodynamics in designing dosage regimens for beta-lactams. Connecticut medicine 20030501
Variable susceptibility to piperacillin/tazobactam amongst Klebsiella spp. with extended-spectrum beta-lactamases. The Journal of antimicrobial chemotherapy 20030301
[beta-Lactamase-inhibitor combinations]. Nihon rinsho. Japanese journal of clinical medicine 20030301
Sciatic nerve palsy as presenting sign of a perianal abscess. Joint, bone, spine : revue du rhumatisme 20030201
Current status of drug resistance among gram-negative bacilli isolated from admitted cases in a tertiary care centre. The Journal of the Association of Physicians of India 20030101
[Carbapenem antibiotic ertapenem in the treatment of extrahospital intraabdominal infections]. Khirurgiia 20030101
Piperacillin induced bone marrow suppression: a case report. BMC clinical pharmacology 20030101
Ertapenem once a day versus piperacillin-tazobactam every 6 hours for treatment of acute pelvic infections: a prospective, multicenter, randomized, double-blind study. Infectious diseases in obstetrics and gynecology 20030101
Bacteraemia and sinusitis due to Flavimonas oryzihabitans infection. Scandinavian journal of infectious diseases 20030101
[Pharmacokinetics of antibiotics in inflamed and healthy lung tissue]. Wiener medizinische Wochenschrift (1946) 20030101
[New Beta-lactam agent in the treatment of intra-abdominal sepsis: double blind and randomized stage III study of ertapenem versus piperacillin/tazobactam]. Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru 20030101
[Evaluation of the sensitivity to meropenem of some bacterial strains with nosocomial potential]. Bacteriologia, virusologia, parazitologia, epidemiologia (Bucharest, Romania : 1990) 20030101
Biochemical analysis of the ceftazidime-hydrolysing extended-spectrum beta-lactamase CTX-M-15 and of its structurally related beta-lactamase CTX-M-3. The Journal of antimicrobial chemotherapy 20021201
Postoperative infection with group A beta-hemolytic Streptococcus after blepharoplasty. American journal of ophthalmology 20021201
[Initial empirical antimicrobial therapy with piperacillin/tazobactam in intra-abdominal infections due to perforation of the large intestine and rectum and in postoperative complications after resection of the large intestine and rectum]. Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti 20021201
Antimicrobial prophylaxis for transrectal prostatic biopsy: a prospective study of ciprofloxacin vs piperacillin/tazobactam. BJU international 20021101
Influence of a new prophylactic antibiotic therapy on the incidence of liver abscesses after chemoembolization treatment of liver tumors. Journal of vascular and interventional radiology : JVIR 20021101
Two cases of immune haemolytic anaemia, associated with anti-piperacillin, detected by the 'immune complex' method. Vox sanguinis 20021001
Piperacillin/Tazobactam inducing seizures in a hemodialysed patient. Clinical nephrology 20021001
General microbiology and in vitro susceptibility of anaerobes isolated from complicated skin and skin-structure infections in patients enrolled in a comparative trial of ertapenem versus piperacillin-tazobactam. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020901
Cefepime, piperacillin/tazobactam, gentamicin, ciprofloxacin, and levofloxacin alone and in combination against Pseudomonas aeruginosa. Diagnostic microbiology and infectious disease 20020901
Pharmacodynamic profiling of continuously infused piperacillin/tazobactam against Pseudomonas aeruginosa using Monte Carlo analysis. Diagnostic microbiology and infectious disease 20020901
Morganella morganii causing solitary liver abscess complicated by pyopericardium and left pleural effusion in a nondiabetic patient. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20020901
Efficacy and tolerability of prophylactic treatment with intravenous piperacillin/tazobactam in patients undergoing hematopoietic stem cell transplantation. Transplant infectious disease : an official journal of the Transplantation Society 20020901
Susceptibility patterns of Escherichia coli: prevalence of multidrug-resistant isolates and extended spectrum beta-lactamase phenotype. JPMA. The Journal of the Pakistan Medical Association 20020901
Successful medical management of emphysematous pyelonephritis. The American journal of medicine 20020815
Molecular dynamics at the root of expansion of function in the M69L inhibitor-resistant TEM beta-lactamase from Escherichia coli. Journal of the American Chemical Society 20020814
New and rapid fully automated method for determination of tazobactam and piperacillin in fatty tissue and serum by column-switching liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020805
Development and optimization of a reversed-phase high-performance liquid chromatographic method for the determination of piperacillin and tazobactam in tazocin injectable powder. Journal of pharmaceutical and biomedical analysis 20020731
Cefepime plus amikacin versus piperacillin-tazobactam plus amikacin for initial antibiotic therapy in haematology patients with febrile neutropenia: results of an open, randomized, multicentre trial. The Journal of antimicrobial chemotherapy 20020701
Geographic variations in activity of broad-spectrum beta-lactams against Pseudomonas aeruginosa: summary of the worldwide SENTRY Antimicrobial Surveillance Program (1997-2000). Diagnostic microbiology and infectious disease 20020701
Infecting one animal with two different strains of the same bacteria may cause misleading results. Chemotherapy 20020701
Pharmacokinetics and pharmacodynamics of piperacillin/tazobactam when administered by continuous infusion and intermittent dosing. Clinical therapeutics 20020701
Cephalosporin-derived inhibitors of beta-lactamase. Part 4: The C3 substituent. Bioorganic & medicinal chemistry letters 20020617
Ertapenem once daily versus piperacillin-tazobactam 4 times per day for treatment of complicated skin and skin-structure infections in adults: results of a prospective, randomized, double-blind multicenter study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020601
Emerging antimicrobial resistances among Proteus mirabilis in Europe: report from the MYSTIC Program (1997-2001). Meropenem Yearly Susceptibility Test Information Collection. Journal of chemotherapy (Florence, Italy) 20020601
Substitution of Met-69 by Ala or Gly in TEM-1 beta-lactamase confer an increased susceptibility to clavulanic acid and other inhibitors. FEMS microbiology letters 20020521
[Piperacillin/tazobactam--Tazocin. A penicillin-based alternative to 3rd generation cephalosporins and carbapenems]. Ugeskrift for laeger 20020513
Comparative pharmacokinetic and pharmacodynamic profile of piperacillin/tazobactam 3.375G Q4H and 4.5G Q6H. Chemotherapy 20020501
Pharmacokinetic and pharmacodynamic evaluation of two dosing regimens for piperacillin-tazobactam. Pharmacotherapy 20020501
Gateways to Clinical Trials. Methods and findings in experimental and clinical pharmacology 20020401
[A multicenter clinical trial of piperacillin/tazobactam in burn infection]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20020401
[Candida parapsilosis endocarditis after prolonged antibiotic therapy]. Revista espanola de anestesiologia y reanimacion 20020401
[Piperacillin-tazobactam in the treatment of severe nosocomial infections]. Recenti progressi in medicina 20020301
Piperacillin 2 g/tazobactam 0.5 g is as effective as imipenem 0.5 g/cilastatin 0.5 g for the treatment of acute uncomplicated pyelonephritis and complicated urinary tract infections. International journal of antimicrobial agents 20020201
[Susceptibility of Pseudomonas aeruginosa to antibiotics isolated from patients of intensive care units in France in 1998. Resistant phenotypes to beta-lactams]. Pathologie-biologie 20020201
Antibacterial activities of beta-lactamase inhibitors associated with morphological changes of cell wall in Helicobacter pylori. Helicobacter 20020201
Penetration of piperacillin/tazobactam (4 g/500 mg) into synovial tissue. Journal of chemotherapy (Florence, Italy) 20020201
[In vitro interaction of tazobactam/piperacillin combined with aminoglycosides against Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli AND Staphylococcus aureus]. The Japanese journal of antibiotics 20020201
[Study on water of crystallization in tazobactam]. Yao xue xue bao = Acta pharmaceutica Sinica 20020201
Clinafloxacin versus piperacillin/tazobactam in the treatment of severe skin and soft-tissue infections in adults at a Veterans Affairs medical center. Clinical therapeutics 20020101
Probing substrate binding to metallo-beta-lactamase L1 from Stenotrophomonas maltophilia by using site-directed mutagenesis. BMC biochemistry 20020101
Localised necrosis of scrotum (Fournier's gangrene) in a spinal cord injury patient - a case report. BMC family practice 20020101
[Identification and susceptibility to antimicrobial agents of strictly anaerobic bacteria isolated from hospitalized patients]. Medycyna doswiadczalna i mikrobiologia 20020101
Hepatotoxic reactions induced by beta-lactamase inhibitors. European journal of medical research 20011217
Elimination of the piperacillin/tazobactam combination during continuous venovenous haemofiltration and haemodiafiltration in patients with acute renal failure. The Journal of antimicrobial chemotherapy 20011201
Treatment of pulmonary nocardiosis in heart-transplant patients: importance of susceptibility studies. Clinical transplantation 20011201
Molecular epidemiology of antibiotic-resistant gram-negative bacilli in a neonatal intensive care unit during a nonoutbreak period. Pediatrics 20011101
Hand infections in patients with diabetes mellitus. Orthopedics 20011101
Spectrum and activity of three contemporary fluoroquinolones tested against Pseudomonas aeruginosa isolates from urinary tract infections in the SENTRY Antimicrobial Surveillance Program (Europe and the Americas; 2000): more alike than different! Diagnostic microbiology and infectious disease 20011101
De-escalation antimicrobial chemotherapy in critically III patients: pros and cons. Journal of chemotherapy (Florence, Italy) 20011101
Evaluating possible pharmacokinetic interactions between tobramycin, piperacillin, and a combination of piperacillin and tazobactam in patients with various degrees of renal impairment. Journal of clinical pharmacology 20010901
[Survey of the antibiotic sensitivity of Pseudomonas aeruginosa in France and the distribution of beta-lactam resistance mechanisms: the GERPB 1999 study]. Pathologie-biologie 20010901
[Comparison of 2 administration protocols (continuous or discontinuous) of a time-dependent antibiotic, Tazocin]. Pathologie-biologie 20010901
Piperacillin/Tazobactam versus cefotaxime plus metronidazole for treatment of children with intra-abdominal infections requiring surgery. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20010901
Pharmacokinetic and pharmacodynamic profile of high dose extended interval piperacillin-tazobactam. The Journal of antimicrobial chemotherapy 20010801
An observational study on the epidemiology of respiratory tract bacterial pathogens and their susceptibility to four injectable beta-lactam antibiotics: piperacillin, piperacillin/tazobactam, ceftazidime and ceftriaxone. Journal of chemotherapy (Florence, Italy) 20010801
Faecal concentrations of piperacillin and tazobactam in elderly patients. The Journal of antimicrobial chemotherapy 20010701
Piperacillin, beta-lactam inhibitor plus gentamicin as empirical therapy of a sequential regimen in febrile neutropenia of pediatric cancer patients. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20010701
Epidemiology and frequency of resistance among pathogens causing urinary tract infections in 1,510 hospitalized patients: a report from the SENTRY Antimicrobial Surveillance Program (North America). Diagnostic microbiology and infectious disease 20010701
A randomized prospective multicentre trial of cefpirome versus piperacillin-tazobactam in febrile neutropenia. Leukemia & lymphoma 20010701
Penicillins and beta-lactamase inhibitor combinations. Journal of the American Veterinary Medical Association 20010615
Inactivation of CMY-2 beta-lactamase by tazobactam: initial mass spectroscopic characterization. Biochimica et biophysica acta 20010611
Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors. Bioorganic & medicinal chemistry letters 20010423
[Fundamental and clinical studies on beta-lactamase inhibitors]. Nihon rinsho. Japanese journal of clinical medicine 20010401
[Antibiotics--TAZ/PIPC, synercid, linezolid, everninomicin]. Nihon rinsho. Japanese journal of clinical medicine 20010401
Systemic antibiotics fail to clear multidrug-resistant Klebsiella from a pediatric ICU. Chest 20010301
Treatment of nosocomial postoperative pneumonia in cancer patients: a prospective randomized study. Annals of surgical oncology 20010301
Efficacy and tolerability of piperacillin/tazobactam versus ceftazidime in association with amikacin for treating nosocomial pneumonia in intensive care patients: a prospective randomized multicenter trial. Intensive care medicine 20010301
Inhibition of the SHV-1 beta-lactamase by sulfones: crystallographic observation of two reaction intermediates with tazobactam. Biochemistry 20010213
Properties of multidrug-resistant, ESBL-producing Proteus mirabilis isolates and possible role of beta-lactam/beta-lactamase inhibitor combinations. International journal of antimicrobial agents 20010201
The role of topical antibiotic prophylaxis in patients undergoing contaminated head and neck surgery with flap reconstruction. The Laryngoscope 20010201
[Correlation between sensitivity to fosfomycin and the presence of penicillinase PSE-1 in Pseudomonas aeruginosa]. Pathologie-biologie 20010201
Thermophilic multidrug-resistant Campylobacter fetus infection with hypersplenism and histiocytic phagocytosis in a patient with acquired immunodeficiency syndrome. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010115
[Multicentre clinical trial on efficacy and safety of domestic piperacillin/tazobactam for treatment of acute bacterial infections]. Zhonghua yi xue za zhi 20010110
Possible role of cellular immunity: a case of cellulitis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010101
Piperacillin with and without tazobactam against extended-spectrum beta-lactamase-producing Pseudomonas aeruginosa in a rat thigh abscess model. Chemotherapy 20010101
Conjugative resistance to tazobactam plus piperacillin among extended-spectrum beta-lactamase-producing nosocomial Klebsiella pneumoniae. Scandinavian journal of infectious diseases 20010101
[Occurrence of beta-lactamase type ESBL and IBL in Pseudomonas aeruginosa rods]. Medycyna doswiadczalna i mikrobiologia 20010101
[Use of the Etest method for antimicrobial susceptibility testing of obligate anaerobes]. Medycyna doswiadczalna i mikrobiologia 20010101
CAPD-associated peritonitis caused by Alcaligenes xylosoxidans sp. xylosoxidans. American journal of nephrology 20010101
Suppression of the growth of six potentially-pathogenic mycobacteria by beta-lactam/beta-lactamase-inhibitors. Microbios 19970101
Reversible bone marrow depression by high-dose piperacillin/tazobactam. British journal of haematology 19961201
beta-Lactamase activity in mycobacteria including Mycobacterium avium and suppression of their growth by a beta-lactamase-stable antibiotic. Microbios 19950101
beta-Lactamase inhibitors and the inducibility of the beta-lactamase of Mycobacterium tuberculosis. The American review of respiratory disease 19920301
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