Home Other Building Blocks Salvianolic Acid A

Salvianolic Acid A

CAS No.:
96574-01-5
Catalog Number:
AG0039H9
Molecular Formula:
C26H22O10
Molecular Weight:
494.4469
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
98%(HPLC)
In Stock USA
United States
$60
- +
5mg
98%(HPLC)
In Stock USA
United States
$151
- +
25mg
98%(HPLC)
In Stock USA
United States
$546
- +
Product Description
Catalog Number:
AG0039H9
Chemical Name:
Salvianolic Acid A
CAS Number:
96574-01-5
Molecular Formula:
C26H22O10
Molecular Weight:
494.4469
MDL Number:
MFCD20527310
IUPAC Name:
(2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-[2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]prop-2-enoyl]oxypropanoic acid
InChI:
InChI=1S/C26H22O10/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15/h1-12,23,27-31,33H,13H2,(H,34,35)/b6-1+,10-5+/t23-/m1/s1
InChI Key:
YMGFTDKNIWPMGF-UCPJVGPRSA-N
SMILES:
O=C(O[C@@H](C(=O)O)Cc1ccc(c(c1)O)O)/C=C/c1ccc(c(c1/C=C/c1ccc(c(c1)O)O)O)O
Properties
Complexity:
798  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
2  
Exact Mass:
494.121g/mol
Formal Charge:
0
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
7  
Isotope Atom Count:
0
Molecular Weight:
494.452g/mol
Monoisotopic Mass:
494.121g/mol
Rotatable Bond Count:
9  
Topological Polar Surface Area:
185A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.9  
Literature
Title Journal
Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2. Chemico-biological interactions 20180601
Salvianolic Acid A Protects H9c2 Cells from Arsenic Trioxide-Induced Injury via Inhibition of the MAPK Signaling Pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20170101
Salvianolic acid A preconditioning confers protection against concanavalin A-induced liver injury through SIRT1-mediated repression of p66shc in mice. Toxicology and applied pharmacology 20131115
Salvianolic acid A protects the peripheral nerve function in diabetic rats through regulation of the AMPK-PGC1α-Sirt3 axis. Molecules (Basel, Switzerland) 20120920
Salvianolic acid A protects human SH-SY5Y neuroblastoma cells against H₂O₂-induced injury by increasing stress tolerance ability. Biochemical and biophysical research communications 20120511
Salvianolic acid A inhibits angiotensin II-induced proliferation of human umbilical vein endothelial cells by attenuating the production of ROS. Acta pharmacologica Sinica 20120101
Salvianolic acid A demonstrates cardioprotective effects in rat hearts and cardiomyocytes after ischemia/reperfusion injury. Journal of cardiovascular pharmacology 20111101
Salvianolic acid A suppress lipopolysaccharide-induced NF-κB signaling pathway by targeting IKKβ. International immunopharmacology 20111101
Salvianolic acid A protects against vascular endothelial dysfunction in high-fat diet fed and streptozotocin-induced diabetic rats. Journal of Asian natural products research 20111001
Comparative pharmacokinetic and bioavailability studies of three salvianolic acids after the administration of Salviae miltiorrhizae alone or with synthetical borneol in rats. Fitoterapia 20110901
Effects of salvianolic scid A on plantar microcirculation and peripheral nerve function in diabetic rats. European journal of pharmacology 20110831
Differential cardioprotective effects of salvianolic acid and tanshinone on acute myocardial infarction are mediated by unique signaling pathways. Journal of ethnopharmacology 20110601
Salvianolic acid A exerts antiamnesic effect on diazepam-induced anterograde amnesia in mice. Neurochemical research 20110101
Salvianolic acids: small compounds with multiple mechanisms for cardiovascular protection. Journal of biomedical science 20110101
Simultaneous determination of six phenolic constituents of Danshen injection in rat plasma by LC-ESI-MS and its application to a pharmacokinetic study. European journal of mass spectrometry (Chichester, England) 20110101
[Intestinal absorption properties of three components in salvianolic acid extract and the effect of borneol on their absorption in rats]. Yao xue xue bao = Acta pharmaceutica Sinica 20101201
Salvianolic acid A displays cardioprotective effects in in vitro models of heart hypoxia/reoxygenation injury. Journal of Asian natural products research 20101001
Antiplatelet and antithrombotic activities of salvianolic acid A. Thrombosis research 20100701
Salvianolic acid A inhibits platelet activation and arterial thrombosis via inhibition of phosphoinositide 3-kinase. Journal of thrombosis and haemostasis : JTH 20100601
Pharmacokinetic interactions induced by content variation of major water-soluble components of Danshen preparation in rats. Acta pharmacologica Sinica 20100501
Isolation of salvianolic acid A, a minor phenolic carboxylic acid of Salvia miltiorrhiza. Natural product communications 20100501
Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats. Toxicology and applied pharmacology 20100115
Anti-inflammation effects of picroside 2 in cerebral ischemic injury rats. Behavioral and brain functions : BBF 20100101
Cardioprotection and matrix metalloproteinase-9 regulation of salvianolic acids on myocardial infarction in rats. Planta medica 20091001
Effect of salvianolic acid A on vascular reactivity of streptozotocin-induced diabetic rats. Life sciences 20090923
Cardioprotective effect of salvianolic acid A on isoproterenol-induced myocardial infarction in rats. European journal of pharmacology 20090801
Natural product inhibitors of protein-protein interactions mediated by Src-family SH2 domains. Bioorganic & medicinal chemistry letters 20090615
Osteogenic effects of D+beta-3,4-dihydroxyphenyl lactic acid (salvianic acid A, SAA) on osteoblasts and bone marrow stromal cells of intact and prednisone-treated rats. Acta pharmacologica Sinica 20090301
Pharmacokinetic interaction between tanshinones and polyphenolic extracts of salvia miltinorrhiza BUNGE after intravenous administration in rats. Biological & pharmaceutical bulletin 20080801
A sensitive method for determination of salvianolic acid A in rat plasma using liquid chromatography/tandem mass spectrometry. Biomedical chromatography : BMC 20080701
Salvianolic acids prevent acute doxorubicin cardiotoxicity in mice through suppression of oxidative stress. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080501
[Absorption and isolation of macroporous resin for five salvianolic acids from Salviae mitiorrhizae]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080501
[Comparative research on pharmacodynamics of Danshen co-microemulsion on hemorheology in rats with hyperlipidemia]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080401
Interaction of salvianolic acids and notoginsengnosides in inhibition of ADP-induced platelet aggregation. The American journal of Chinese medicine 20080101
Three new derivatives of anti-HIV-1 polyphenols isolated from Salvia yunnanensis. Journal of Asian natural products research 20080101
[Analysis on biomasses and contents of active components in roots of Salvia miltiorrhiza from different populations]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071201
Chromatographic fingerprinting analysis of Danshen root (Salvia miltiorrhiza Radix et Rhizoma) and its preparations using high performance liquid chromatography with diode array detection and electrospray mass spectrometry (HPLC-DAD-ESI/MS). Journal of separation science 20070901
[Mechanism of salvianolate in preventing postoperative intestinal adhesion in rats]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20070901
[Studies on polyphenolic chemical constitutents from root of Salvia yunnansis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070901
Pharmacokinetic study of salvianolic acid A in rat after intravenous administration of Danshen injection. Biomedical chromatography : BMC 20070601
Effects of salvianolic acid a on oxidative stress and liver injury induced by carbon tetrachloride in rats. Basic & clinical pharmacology & toxicology 20070201
Protective effect of salvianic acid a on acute liver injury induced by carbon tetrachloride in rats. Biological & pharmaceutical bulletin 20070101
Antiproliferative effect of salvianolic acid A on rat hepatic stellate cells. The Journal of pharmacy and pharmacology 20060701
Effects of salvianolic acids on erythrocyte deformability in oleic acid induced acute lung injury in rabbits. Clinical hemorheology and microcirculation 20060101
[The qualitative analysis and quantitative analysis of purification of salvianolic acids by macroreticular resin]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050901
Salvianic acid A protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity. Neuroscience research 20050201
[Salvianolic acid A inhibits nucleoside transport and potentiates the antitumor activity of chemotherapeutic drugs]. Yao xue xue bao = Acta pharmaceutica Sinica 20040701
Simultaneous determination of magnesium lithospermate B, rosmarinic acid, and lithospermic acid in beagle dog serum by liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM 20040101
[Culture of neural stem cells from cerebral cortex of rat embryo and effects of drugs on the proliferation ability of stem cells]. Yao xue xue bao = Acta pharmaceutica Sinica 20031001
Effects of salvianolic acids on endothelial cells against damage induced by cholestane-3beta-5alpha-6beta-triol. Chinese medical journal 20030401
Inhibition of tumor growth by S-3-1, a synthetic intermediate of salvianolic acid A. Journal of Asian natural products research 20021201
Anti-lipid-peroxidative principles from Tournefortia sarmentosa. Journal of natural products 20020501
[Inhibition of human low-density lipoprotein oxidation by salvianolic acid-A]. Yao xue xue bao = Acta pharmaceutica Sinica 20020201
Effects of salviainolic acid A (SA-A) on liver injury: SA-A action on hepatic peroxidation. Liver 20011201
Salvianolate inhibits proliferation and endothelin release in cultured rat mesangial cells. Acta pharmacologica Sinica 20010701
Properties