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Home Other Building Blocks Tyrphostin ag 835

Tyrphostin ag 835

CAS No.:
133550-37-5
Catalog Number:
AG003988
Molecular Formula:
C18H16N2O3
Molecular Weight:
308.3312
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
25mg
>98.0%(HPLC)
1 week
United States
$288
- +
Product Description
Catalog Number:
AG003988
Chemical Name:
Tyrphostin ag 835
CAS Number:
133550-37-5
Molecular Formula:
C18H16N2O3
Molecular Weight:
308.3312
MDL Number:
MFCD00209855
IUPAC Name:
(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]prop-2-enamide
InChI:
InChI=1S/C18H16N2O3/c1-12(14-5-3-2-4-6-14)20-18(23)15(11-19)9-13-7-8-16(21)17(22)10-13/h2-10,12,21-22H,1H3,(H,20,23)/b15-9+/t12-/m0/s1
InChI Key:
UMGQVUWXNOJOSJ-DGGAMASNSA-N
SMILES:
N#C/C(=C\c1ccc(c(c1)O)O)/C(=O)N[C@H](c1ccccc1)C
Properties
Complexity:
488  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
1  
Exact Mass:
308.116g/mol
Formal Charge:
0
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
308.337g/mol
Monoisotopic Mass:
308.116g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
93.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.7  
Literature
Title Journal
S-adenosylmethionine-dependent protein methylation in mammalian cytosol via tyrphostin modification by catechol-O-methyltransferase. The Journal of biological chemistry 20071019
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. Journal of medicinal chemistry 19910601
Properties