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Home Other Building Blocks Azd-9291 mesylate

Azd-9291 mesylate

CAS No.:
1421373-66-1
Catalog Number:
AG003960
Molecular Formula:
C29H37N7O5S
Molecular Weight:
595.7130
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
99%
1 week
United States
$140
- +
10mg
99%
1 week
United States
$154
- +
50mg
99%
1 week
United States
$196
- +
100mg
99%
1 week
United States
$223
- +
200mg
99%
1 week
United States
$251
- +
500mg
99%
1 week
United States
$279
- +
1g
99%
1 week
United States
$321
- +
Product Description
Catalog Number:
AG003960
Chemical Name:
Azd-9291 mesylate
CAS Number:
1421373-66-1
Molecular Formula:
C29H37N7O5S
Molecular Weight:
595.7130
MDL Number:
MFCD28137994
IUPAC Name:
N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide;methanesulfonic acid
InChI:
InChI=1S/C28H33N7O2.CH4O3S/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24;1-5(2,3)4/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32);1H3,(H,2,3,4)
InChI Key:
FUKSNUHSJBTCFJ-UHFFFAOYSA-N
SMILES:
CS(=O)(=O)O.C=CC(=O)Nc1cc(Nc2nccc(n2)c2cn(c3c2cccc3)C)c(cc1N(CCN(C)C)C)OC
UNII:
RDL94R2A16
Properties
Complexity:
845  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
595.258g/mol
Formal Charge:
0
Heavy Atom Count:
42  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
595.719g/mol
Monoisotopic Mass:
595.258g/mol
Rotatable Bond Count:
10  
Topological Polar Surface Area:
150A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes. Toxicology letters 20180701
Osimertinib induces autophagy and apoptosis via reactive oxygen species generation in non-small cell lung cancer cells. Toxicology and applied pharmacology 20170415
Osimertinib: First Global Approval. Drugs 20160201
Third-generation inhibitors targeting EGFR T790M mutation in advanced non-small cell lung cancer. Journal of hematology & oncology 20160101
Properties