3D engineered In vitro hepatospheroids for studying drug toxicity and metabolism.

Toxicology in vitro : an international journal published in association with BIBRA 20170201

Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class.

Toxicology letters 20160122

Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways.

Toxicology letters 20150716

Effect of Dimethoate on the Activity of Hepatic CYP450 Based on Pharmacokinetics of Probe Drugs.

Pharmacology 20150101

Genotoxicity of phenacetin in the kidney and liver of Sprague-Dawley gpt delta transgenic rats in 26-week and 52-week repeated-dose studies.

Toxicology 20141003

Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system.

Toxicology in vitro : an international journal published in association with BIBRA 20130901

Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans.

Toxicological sciences : an official journal of the Society of Toxicology 20130301

Direct and metabolism-dependent cytochrome P450 inhibition assays for evaluating drug-drug interactions.

Journal of applied toxicology : JAT 20130201

Toxicogenomic biomarkers for renal papillary injury in rats.

Toxicology 20130107

Metabolic activation by human arylacetamide deacetylase, CYP2E1, and CYP1A2 causes phenacetin-induced methemoglobinemia.

Biochemical pharmacology 20121101

Generation of proliferating human hepatocytes using Upcyte® technology: characterisation and applications in induction and cytotoxicity assays.

Xenobiotica; the fate of foreign compounds in biological systems 20121001

In-vitro metabolism of glycyrrhetinic acid by human and rat liver microsomes and its interactions with six CYP substrates.

The Journal of pharmacy and pharmacology 20121001

Enzyme kinetic and molecular docking studies on the metabolic interactions of 1-hydroxy-2,3,5-trimethoxy-xanthone, isolated from Halenia elliptica D. Don, with model probe substrates of human cytochrome P450 enzymes.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20120915

Application of incoherent inelastic neutron scattering in pharmaceutical analysis: relaxation dynamics in phenacetin.

Molecular pharmaceutics 20120904

Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction.

Journal of hepatology 20120901

An ex vivo perfusion system emulating in vivo conditions in noncirrhotic and cirrhotic human liver.

The Journal of pharmacology and experimental therapeutics 20120901

Scutellarin inhibits cytochrome P450 isoenzyme 1A2 (CYP1A2) in rats.

Phytotherapy research : PTR 20120801

Development and validation of an LC-MS/MS-ESI method for the determination of lorglumide, a CCK-1 antagonist in mouse plasma: application to a pharmacokinetic study.

Biomedical chromatography : BMC 20120701

Electron attachment to antipyretics: possible implications of their metabolic pathways.

The Journal of chemical physics 20120621

Phenacetin O-deethylation is a useful tool for evaluation of hepatic functional reserve in rats with CCl(4)-induced chronic liver injury.

The Journal of surgical research 20120615

Development and validation of a highly sensitive method for the determination of abiraterone in rat and human plasma by LC-MS/MS-ESI: application to a pharmacokinetic study.

Biomedical chromatography : BMC 20120601

A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity.

Drug metabolism and disposition: the biological fate of chemicals 20120601

Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

Journal of medicinal chemistry 20120524

Human cytochrome P450s: the work of Frederick Peter Guengerich.

The Journal of biological chemistry 20120504

Effect of albumin on human liver microsomal and recombinant CYP1A2 activities: impact on in vitro-in vivo extrapolation of drug clearance.

Drug metabolism and disposition: the biological fate of chemicals 20120501

The impaired disposition of probe drugs is due to both liver and kidney dysfunctions in CCl(4)-model rats.

Environmental toxicology and pharmacology 20120501

Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse.

Drug metabolism and disposition: the biological fate of chemicals 20120401

Preliminary evaluation of the human relevance of respiratory tumors observed in rodents exposed to naphthalene.

Regulatory toxicology and pharmacology : RTP 20120401

Simultaneous determination of pimpinellin, isopimpinellin and phellopterin in rat plasma by a validated UPLC-MS/MS and its application to a pharmacokinetic study after administration of Toddalia asiatica extract.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120401

Polysaccharide peptides from Coriolus versicolor competitively inhibit model cytochrome P450 enzyme probe substrates metabolism in human liver microsomes.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20120315

Effects of Ougan juice on P450 activities using a cocktail method.

Die Pharmazie 20120301

[Influence of jinlingzi powder with different compatibility on activity of cytochrome P1 A2 from rat liver microsomes].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120301

Investigation of cytochrome P450 1A2 and 3A inhibitory properties of Danshen tincture.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20120215

Highly sensitive LC-MS/MS-ESI method for simultaneous quantitation of albendazole and ricobendazole in rat plasma and its application to a rat pharmacokinetic study.

Biomedical chromatography : BMC 20120201

The in vitro inhibition of human CYP1A2, CYP2D6 and CYP3A4 by tetrahydropalmatine, neferine and berberine.

Phytotherapy research : PTR 20120201

Phenacetin pharmacokinetics in CYP1A2-deficient beagle dogs.

Drug metabolism and disposition: the biological fate of chemicals 20120201

A fast, sensitive, and high throughput method for the determination of cefuroxime lysine in dog plasma by UPLC-MS/MS.

Talanta 20120130

Tanshinone I increases CYP1A2 protein expression and enzyme activity in primary rat hepatocytes.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20120115

Highly sensitive method for the determination of adenosine by LC-MS/MS-ESI: method validation and scope of application to a pharmacokinetic/pharmacodynamic study.

Biomedical chromatography : BMC 20120101

Neuroprotective effect of cyclooxygenase inhibitors in ICV-STZ induced sporadic Alzheimer's disease in rats.

Journal of molecular neuroscience : MN 20120101

Differential role of cyclooxygenase isozymes on neuronal density in hippocampus CA1 region of intracerebroventricular streptozotocin treated rat brain.

Journal of chemical neuroanatomy 20120101

Combined chemical oxidation and membrane filtration techniques applied to the removal of some selected pharmaceuticals from water systems.

Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 20120101

In Vitro Assessment of Cytochrome P450 2C19 Potential of Naoxintong.

Evidence-based complementary and alternative medicine : eCAM 20120101

The safety of cruciferous plants in humans: a systematic review.

Journal of biomedicine & biotechnology 20120101

Effect of a New Prokinetic Agent DA-9701 Formulated with Corydalis Tuber and Pharbitidis Semen on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes.

Evidence-based complementary and alternative medicine : eCAM 20120101

Regulation of epithelial cell morphology and functions approaching to more in vivo-like by modifying polyethylene glycol on polysulfone membranes.

PloS one 20120101

Sudden onset methaemoglobinaemia in a previously well Ugandan child: a case report and literature review.

The Pan African medical journal 20120101

Functional characterization of a first avian cytochrome P450 of the CYP2D subfamily (CYP2D49).

PloS one 20120101

[Inhibitory effects of astragaloside IV on cytochrome P450 enzyme of rat liver microsomes].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120101

Quantitation of pyrrole-imidazole polyamide in rat plasma by high-performance liquid chromatography coupled with UV detection.

Journal of biomedicine & biotechnology 20120101

The emerging role of human esterases.

Drug metabolism and pharmacokinetics 20120101

Electrochemical oxidation by square-wave potential pulses in the imitation of phenacetin to acetaminophen biotransformation.

The Analyst 20111207

Influence of mild and moderate hepatic impairment on axitinib pharmacokinetics.

Investigational new drugs 20111201

Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity.

Toxicological sciences : an official journal of the Society of Toxicology 20111201

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

PLoS computational biology 20111201

Effect of dimethyl sulfoxide on in vitro cytochrome P4501A2 mediated phenacetin O-deethylation in human liver microsomes.

Drug metabolism and disposition: the biological fate of chemicals 20111101

Bromination of selected pharmaceuticals in water matrices.

Chemosphere 20111101

Analysis of illicit cocaine and heroin samples seized in Luxembourg from 2005-2010.

Forensic science international 20111010

Preparation of human drug metabolites using fungal peroxygenases.

Biochemical pharmacology 20111001

The effect of St John's wort (hypericum perforatum) on cytochrome p450 1a2 activity in perfused rat liver.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20110901

A highly sensitive LC-MS/MS method for the determination of S-raclopride in rat plasma: application to a pharmacokinetic study in rats.

Biomedical chromatography : BMC 20110801

Highly sensitive method for the determination of a novel triple kinase inhibitor with anti-cancer activity, JI-101, in rat plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: application to a pharmacokinetic study.

Biomedical chromatography : BMC 20110701

Methaemoglobinaemia associated with the use of cocaine and volatile nitrites as recreational drugs: a review.

British journal of clinical pharmacology 20110701

[Rapid analysis of added ingredients in heroin].

Guang pu xue yu guang pu fen xi = Guang pu 20110701

Early drug discovery and the rise of pharmaceutical chemistry.

Drug testing and analysis 20110601

Inhibitory effects of caffeic acid ester analogues on free radicals and human liver microsome CYP1A2 activities.

Medicinal chemistry (Shariqah (United Arab Emirates)) 20110301

Present state and future perspectives of using pluripotent stem cells in toxicology research.

Archives of toxicology 20110201

An in vitro, high throughput, seven CYP cocktail inhibition assay for the evaluation of new chemical entities using LC-MS/MS.

Drug metabolism letters 20110101

Combined analgesics in (headache) pain therapy: shotgun approach or precise multi-target therapeutics?

BMC neurology 20110101

Renal cell cancer among African Americans: an epidemiologic review.

BMC cancer 20110101

A physiologically based pharmacokinetic model characterizing mechanism-based inhibition of CYP1A2 for predicting theophylline/antofloxacin interaction in both rats and humans.

Drug metabolism and pharmacokinetics 20110101

Drug nanoparticle formulation using ascorbic Acid derivatives.

Journal of drug delivery 20110101

Preparation of herbal tea as infusion or by maceration at room temperature using mistletoe tea as an example.

Scientia pharmaceutica 20110101

Novel natural inhibitors of CYP1A2 identified by in silico and in vitro screening.

International journal of molecular sciences 20110101

Diagnostic value of the C methacetin breath test in various stages of chronic liver disease.

Gastroenterology research and practice 20110101

Reverse-phase liquid chromatography with electrospray ionization/mass spectrometry for the quantification of pseudoephedrine in human plasma and application to a bioequivalence study.

Arzneimittel-Forschung 20110101

Phenacetin and analgesic mixtures containing phenacetin.

Report on carcinogens : carcinogen profiles 20110101

Eudragit nanoparticles containing genistein: formulation, development, and bioavailability assessment.

International journal of nanomedicine 20110101

A fungal P450 (CYP5136A3) capable of oxidizing polycyclic aromatic hydrocarbons and endocrine disrupting alkylphenols: role of Trp(129) and Leu(324).

PloS one 20110101

Protective effects of goldenseal (Hydrastis canadensis L.) on acetaminophen-induced hepatotoxicity through inhibition of CYP2E1 in rats.

Pharmacognosy research 20110101

Development and validation of liquid chromatography-mass spectrometry method for the estimation of rifampicin in plasma.

Indian journal of pharmaceutical sciences 20110101

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Drug metabolism and disposition: the biological fate of chemicals 20101201

Evaluating human liver reserve function by measuring serum concentrations of phenacetin and its metabolites.

Journal of digestive diseases 20101201

Drug structure-transport relationships.

Journal of pharmacokinetics and pharmacodynamics 20101201

A practical deuterium-free NMR method for the rapid determination of 1-octanol/water partition coefficients of pharmaceutical agents.

Bioorganic & medicinal chemistry letters 20101115

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Bioorganic & medicinal chemistry letters 20101101

Anesthetic experience of methemoglobinemia detected during general anesthesia for gastrectomy of advanced gastric cancer -A case report-.

Korean journal of anesthesiology 20101101

Glomerulocystic kidney disease.

Pediatric nephrology (Berlin, Germany) 20101001

A highly sensitive LC-MS/MS method for the determination of S-citalopram in rat plasma: application to a pharmacokinetic study in rats.

Biomedical chromatography : BMC 20101001

Composition, purity and perceived quality of street cocaine in France.

The International journal on drug policy 20100901

Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo.

Drug metabolism and disposition: the biological fate of chemicals 20100901

Arylacetamide deacetylase is a determinant enzyme for the difference in hydrolase activities of phenacetin and acetaminophen.

Drug metabolism and disposition: the biological fate of chemicals 20100901

Simultaneous quantification of capsaicin and dihydrocapsaicin in rat plasma using HPLC coupled with tandem mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100815

Small scale screening to determine the ability of different polymers to inhibit drug crystallization upon rapid solvent evaporation.

Molecular pharmaceutics 20100802

Simultaneous HPLC determination of tolbutamide, phenacetin and their metabolites as markers of cytochromes 1A2 and 2C6/11 in rat liver perfusate.

Journal of pharmaceutical and biomedical analysis 20100801

Accumulation and metabolism of drugs and CYP probe substrates in zebrafish larvae.

Xenobiotica; the fate of foreign compounds in biological systems 20100801

Evaluation of cytochrome P450 inhibition assays using human liver microsomes by a cassette analysis /LC-MS/MS.

Drug metabolism letters 20100801

Assessment of the role of renal organic anion transporters in drug-induced nephrotoxicity.

Toxins 20100801

Significant increase in phenacetin oxidation on L382V substitution in human cytochrome P450 1A2.

Drug metabolism and disposition: the biological fate of chemicals 20100701

Expression and characterization of dog cytochrome P450 2A13 and 2A25 in baculovirus-infected insect cells.

Drug metabolism and disposition: the biological fate of chemicals 20100701

Kinetics of aqueous chlorination of some pharmaceuticals and their elimination from water matrices.

Water research 20100701

Solubility enhancement of hydrophobic compounds by cosolvents: role of solute hydrophobicity on the solubilization effect.

International journal of pharmaceutics 20100630

Engineering bacterial cytochrome P450 (P450) BM3 into a prototype with human P450 enzyme activity using indigo formation.

Drug metabolism and disposition: the biological fate of chemicals 20100501

Molecular characterization of a novel bacterial aryl acylamidase belonging to the amidase signature enzyme family.

Molecules and cells 20100501

Effect of buagafuran on liver microsomal cytochrome P450 in rats.

Journal of Asian natural products research 20100501

In-vitro and in-vivo evaluations of cytochrome P450 1A2 interactions with nuciferine.

The Journal of pharmacy and pharmacology 20100501

Evaluation of a liver micronucleus assay in young rats (III): a study using nine hepatotoxicants by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS).

Mutation research 20100430

Ethyl (2E)-2-(hydroxy-imino)propanoate.

Acta crystallographica. Section E, Structure reports online 20100401

Determination and toxicokinetics comparison of ketamine and S(+)-ketamine in dog plasma by HPLC-MS method.

Biomedical chromatography : BMC 20100301

Application of the improved BALB/c 3T3 cell transformation assay to the examination of the initiating and promoting activities of chemicals: the second interlaboratory collaborative study by the non-genotoxic carcinogen study group of Japan.

Alternatives to laboratory animals : ATLA 20100301

A pilot study of nuclear instability in archived renal and upper urinary tract tumours with putative ochratoxin aetiology.

Toxins 20100301

Population-based case-control study of Chinese herbal products containing aristolochic acid and urinary tract cancer risk.

Journal of the National Cancer Institute 20100203

Activity of sulfotransferase 1A1 is dramatically upregulated in patients with hepatocellular carcinoma secondary to chronic hepatitis B virus infection.

Cancer science 20100201

Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage.

Journal of biotechnology 20100201

Hepatic zonation of carbon and nitrogen fluxes derived from glutamine and ammonia transformations.

Journal of biomedical science 20100101

[Sporadic upper urinary tract urothelial cell carcinomas: identification of interaction between toxic carcinogens and individuals genetic susceptibility].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie 20100101

Development of a high throughput single nucleotide polymorphism screening method for the cytochrome P450 1A2 polymorphisms CYP1A2*1C and CYP1A2*1F: are they useful as predictive markers in mental disorders?

Clinical laboratory 20100101

Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver.

Frontiers in pharmacology 20100101

Molecular biosensing mechanisms in the spleen for the removal of aged and damaged red cells from the blood circulation.

Sensors (Basel, Switzerland) 20100101

Adverse drug effects in hospitalized elderly: data from the healthcare cost and utilization project.

Clinical pharmacology : advances and applications 20100101

Analysis of benzo[a]pyrene metabolites formed by rat hepatic microsomes using high pressure liquid chromatography: optimization of the method.

Interdisciplinary toxicology 20091201

Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database.

Toxicology 20091109

Environmental factors involved in carcinogenesis of urothelial cell carcinomas of the upper urinary tract.

BJU international 20091101

Phenacetin isolated from Bursera grandifolia, a herbal remedy with antipyretic properties.

Natural product communications 20091101

Ozonation of pharmaceutical compounds: Rate constants and elimination in various water matrices.

Chemosphere 20090901

Comparison of intrinsic metabolic clearance in fresh and cryopreserved human hepatocytes.

Xenobiotica; the fate of foreign compounds in biological systems 20090901

Effects of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on rat CYP1A2 expression and metabolism of model CYP1A2 probe substrates.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20090801

Methemoglobinemia and sulfhemoglobinemia in two pediatric patients after ingestion of hydroxylamine sulfate.

The western journal of emergency medicine 20090801

International perspective from singapore on 'methemoglobinemia and sulfhemoglobinemia in two pediatric patients after ingestion of hydroxylamine sulfate'.

The western journal of emergency medicine 20090801

Efficacy of acetaminophen in skin B16-F0 melanoma tumor-bearing C57BL/6 mice.

International journal of oncology 20090701

Inhibitive effect of diphenytriazol on rat cytochrome P450 enzyme in vitro.

Die Pharmazie 20090701

A study of the thermal decomposition of adulterated cocaine samples under optimized aerobic pyrolytic conditions.

Forensic science international 20090530

In vitro assessment of P450 induction potential of novel chemopreventive agents SR13668, 9-cis-UAB30, and pentamethychromanol in primary cultures of human hepatocytes.

Chemico-biological interactions 20090515

Two-dimensional liquid chromatography-ion trap mass spectrometry for the simultaneous determination of ketorolac enantiomers and paracetamol in human plasma: application to a pharmacokinetic study.

Journal of chromatography. A 20090501

An analysis of cocaine powder in the Netherlands: content and health hazards due to adulterants.

Addiction (Abingdon, England) 20090501

Non-phenacetin analgesics and analgesic nephropathy: clinical assessment of high users from a case-control study.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090401

Mechanism-based inhibition of CYP1A2 by antofloxacin, an 8-NH2 derivative of levofloxacin in rats.

Xenobiotica; the fate of foreign compounds in biological systems 20090401

Thermodynamics of cosolvent action: phenacetin, salicylic acid and probenecid.

Journal of pharmaceutical sciences 20090301

Effect of adrenergic stimulation on drug absorption via passive diffusion in Caco-2 cells.

International journal of pharmaceutics 20090223

Simultaneous determination of tetrahydropalmatine, protopine, and palmatine in rat plasma by LC-ESI-MS and its application to a pharmacokinetic study.

Journal of pharmaceutical and biomedical analysis 20090220

Nuclear magnetic resonance spectroscopy as a quantitative tool to determine the concentrations of biologically produced metabolites: implications in metabolites in safety testing.

Chemical research in toxicology 20090201

Identification of tumor promotion marker genes for predicting tumor promoting potential of chemicals in BALB/c 3T3 cells.

Toxicology in vitro : an international journal published in association with BIBRA 20090201

The pharmaceutical industry and the German National Socialist Regime: I.G. Farben and pharmacological research.

Journal of clinical pharmacy and therapeutics 20090201

In vitro nimesulide studies toward understanding idiosyncratic hepatotoxicity: diiminoquinone formation and conjugation.

Chemical research in toxicology 20090101

Controlled-release carbamazepine matrix granules and tablets comprising lipophilic and hydrophilic components.

Drug delivery 20090101

A unique case of urinary bladder simple melanosis: a case report and review of the literature.

Diagnostic pathology 20090101

Bladder tumor in women with microscopic hematuria: an Iranian experience and a review of the literature.

Advances in urology 20090101

Evaluation of quantitative liver function tests in HIV-positive patients under anti-retroviral therapy.

European journal of medical research 20090101

Text mining and manual curation of chemical-gene-disease networks for the comparative toxicogenomics database (CTD).

BMC bioinformatics 20090101

Fixed drug eruption resulting from fluconazole use: a case report.

Journal of medical case reports 20090101

Perazine at therapeutic drug concentrations inhibits human cytochrome P450 isoenzyme 1A2 (CYP1A2) and caffeine metabolism--an in vitro study.

Pharmacological reports : PR 20090101

Evaluation of the activity of P450 enzymes in rats: use of the single marker or combined drug administration.

Neuro endocrinology letters 20090101

Oxidative metabolism of the trifluoromethoxy moiety of OSI-930.

Drug metabolism and drug interactions 20090101

Epidemiologic characteristics and risk factors for renal cell cancer.

Clinical epidemiology 20090101

EROD and MROD as Markers of Cytochrome P450 1A Activities in Hepatic Microsomes from Entire and Castrated Male Pigs.

Sensors (Basel, Switzerland) 20090101

Key residues controlling phenacetin metabolism by human cytochrome P450 2A enzymes.

Drug metabolism and disposition: the biological fate of chemicals 20081201

Determination of the inhibitory potential of 6 fluoroquinolones on CYP1A2 and CYP2C9 in human liver microsomes.

Acta pharmacologica Sinica 20081201

Technical modification of the Balb/c 3T3 cell transformation assay: the use of serum-reduced medium to optimise the practicability of the protocol.

Alternatives to laboratory animals : ATLA 20081201

Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.

The Journal of biological chemistry 20081114

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal of medicinal chemistry 20081113

Effect of berberine on hepatocyte proliferation, inducible nitric oxide synthase expression, cytochrome P450 2E1 and 1A2 activities in diethylnitrosamine- and phenobarbital-treated rats.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20081101

Liquor made quicker: alcohol as a synthetic reagent for molecules in anesthesia.

Journal of clinical anesthesia 20081101

The effect of transcatheter arterial chemoembolization on CYP1A2 activity in patients with hepatocellular carcinoma.

Journal of clinical pharmacy and therapeutics 20081001

High performance liquid chromatographic determination of thalidomide in patients affected by hepatocellular carcinoma.

Journal of pharmaceutical and biomedical analysis 20080929

Characterization of substrate specificity of dog CYP1A2 using CYP1A2-deficient and wild-type dog liver microsomes.

Drug metabolism and disposition: the biological fate of chemicals 20080901

Rat cytochromes P450 oxidize 3-aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone.

Interdisciplinary toxicology 20080901

Experimental approaches to evaluate activities of cytochromes P450 3A.

Interdisciplinary toxicology 20080901

Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2.

Interdisciplinary toxicology 20080901

Prevention of acetaminophen (APAP)-induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine.

Toxicology letters 20080828

Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping studies in rats.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080801

[Effect of ketoconazole on the activity of CYP4503A4 and CYP450 1A2 of hepatic microsomes in healthy adults].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20080801

ECVAM retrospective validation of in vitro micronucleus test (MNT).

Mutagenesis 20080701

Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

Journal of medicinal chemistry 20080612

Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies.

Drug metabolism and disposition: the biological fate of chemicals 20080601

Towards the first inhibitors of trihydroxynaphthalene reductase from Curvularia lunata: synthesis of artificial substrate, homology modelling and initial screening.

Bioorganic & medicinal chemistry 20080601

Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer.

Carcinogenesis 20080601

Development and validation of a high-performance liquid chromatographic assay for the determination of fluconazole in human whole blood using solid phase extraction.

Therapeutic drug monitoring 20080601

Use of prediction methods to estimate true density of active pharmaceutical ingredients.

International journal of pharmaceutics 20080501

Heterologous expression and characterization of wild-type human cytochrome P450 1A2 without conventional N-terminal modification in Escherichia coli.

Protein expression and purification 20080201

Determination of phenacetin and salophen analgetics in solid binary mixtures with caffeine by infrared linear dichroic and Raman spectroscopy.

Journal of pharmaceutical and biomedical analysis 20080122

Benzocaine and lidocaine induced methemoglobinemia after bronchoscopy: a case report.

Journal of medical case reports 20080101

In vitro and in vivo evaluations of cytochrome P450 1A2 interactions with duloxetine.

Clinical pharmacokinetics 20080101

Kidney cancer mortality in Spain: geographic patterns and possible hypotheses.

BMC cancer 20080101

Role of cytochrome P450 in drug interactions.

Nutrition & metabolism 20080101

Epidemiology of kidney cancer.

Advances in urology 20080101

Evaluation of the assumptions of an ontogeny model of rat hepatic cytochrome P450 activity.

Drug metabolism and disposition: the biological fate of chemicals 20071201

L-arginine reverses alterations in drug disposition induced by spinal cord injury by increasing hepatic blood flow.

Journal of neurotrauma 20071201

Effect of sodium ozagrel on the activity of rat CYP2D6.

European journal of pharmacology 20071114

Toxicogenomics of drug-induced hemolytic anemia by analyzing gene expression profiles in the spleen.

Toxicological sciences : an official journal of the Society of Toxicology 20071101

Simultaneous determination of two active components in compound aspirin tablets using principal component artificial neural networks (PC-ANNs) on NIR spectroscopy.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20071101

Characterization of tableting using the OSDRC system.

Pharmaceutical research 20071001

[Effect of Qingkailing injection on rat CYP1A2 and CYP2D6 activity].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071001

Properties of pellets manufactured by wet extrusion/spheronization process using kappa-carrageenan: effect of process parameters.

AAPS PharmSciTech 20071001

Bladder tumor associated with phenacetin abuse: a case report and a review of the literature.

The Tokai journal of experimental and clinical medicine 20070920

Acute spinal cord injury changes the disposition of some, but not all drugs given intravenously.

Spinal cord 20070901

A validated high-performance liquid chromatographic method for the determination of moclobemide and its two metabolites in human plasma and application to pharmacokinetic studies.

Biomedical chromatography : BMC 20070901

In vitro assessment of cytochrome P450 inhibition: strategies for increasing LC/MS-based assay throughput using a one-point IC(50) method and multiplexing high-performance liquid chromatography.

Journal of pharmaceutical sciences 20070901

Effect of acetaminophen, a cyclooxygenase inhibitor, on Morris water maze task performance in mice.

Journal of psychopharmacology (Oxford, England) 20070901

Effects of Ganoderma lucidum polysaccharide on CYP2E1, CYP1A2 and CYP3A activities in BCG-immune hepatic injury in rats.

Biological & pharmaceutical bulletin 20070901

Analgesic nephropathy.

Kidney international 20070801

Analgesic nephropathy selectively affecting a unilateral non-functioning hypoplastic kidney.

Clinical nephrology 20070801

Evidence on unusual way of cocaine smuggling: cocaine-polymethyl methacrylate (PMMA) solid solution--study of clandestine laboratory samples.

Forensic science international 20070704

In vitro interaction cocktail assay for nine major cytochrome P450 enzymes with 13 probe reactions and a single LC/MSMS run: analytical validation and testing with monoclonal anti-CYP antibodies.

Journal of mass spectrometry : JMS 20070701

Validated method for rapid inhibition screening of six cytochrome P450 enzymes by liquid chromatography-tandem mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601

An optimized analytical method of fluconazole in human plasma by high-performance liquid chromatography with ultraviolet detection and its application to a bioequivalence study.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601

In vitro cytotoxicity assay with selected chemicals using human cells to predict target-organ toxicity of liver and kidney.

Toxicology in vitro : an international journal published in association with BIBRA 20070601

Epidemiology of urinary bladder cancer: from tumor development to patient's death.

World journal of urology 20070601

[Simultaneous determination of the inhibitory potency of compounds on the activity of five cytochrome P-450 enzymes using a cocktail probe substrates method].

Yao xue xue bao = Acta pharmaceutica Sinica 20070601

Nonsteroidal antiinflammatory drug use and risk of bladder cancer in the health professionals follow-up study.

International journal of cancer 20070515

Development and full validation of six inhibition assays for five major cytochrome P450 enzymes in human liver microsomes using an automated 96-well microplate incubation format and LC-MS/MS analysis.

Journal of pharmaceutical and biomedical analysis 20070509

In memoriam 'analgesic nephropathy' (circa 1972-2006).

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070401

[Study on the potential impact of bromomethane on medicinal products following simulated container fumigation].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 20070401

Stereoselective analysis of hydroxybupropion and application to drug interaction studies.

Chirality 20070301

CYP2A13 metabolizes the substrates of human CYP1A2, phenacetin, and theophylline.

Drug metabolism and disposition: the biological fate of chemicals 20070301

Microemulsion electrokinetic chromatography with on-line atmospheric pressure photoionization mass spectrometric detection.

Analytical chemistry 20070215

A toxicogenomic approach revealed hepatic gene expression changes mechanistically linked to drug-induced hemolytic anemia.

Toxicological sciences : an official journal of the Society of Toxicology 20070201

Impaired clearance of phenacetin in hepatic cirrhosis and fibrosis.

International journal of clinical pharmacology and therapeutics 20070101

Glomerulocystic kidney disease and its rare associations: an autopsy report of two unrelated cases.

Diagnostic pathology 20070101

Effects of nebulized ketamine on allergen-induced airway hyperresponsiveness and inflammation in actively sensitized Brown-Norway rats.

Journal of inflammation (London, England) 20070101

Arthritis and pain. Future targets to control osteoarthritis pain.

Arthritis research & therapy 20070101

Acetaminophen, phenacetin and dipyrone do not modulate pressor responses to arachidonic Acid or to pressor agents.

Pharmacology 20070101

Analgesic and anti-inflammatory drug use and risk of bladder cancer: a population based case control study.

BMC urology 20070101

Quantitation of nimesulide in human plasma by high-performance liquid chromatography with ultraviolet absorbance detection and its application to a bioequivalence study.

Arzneimittel-Forschung 20070101

Analgesics use and ESRD in younger age: a case-control study.

BMC nephrology 20070101

Piroxicam-induced hepatic and renal histopathological changes in mice.

The Libyan journal of medicine 20070101

Rofecoxib is a potent, metabolism-dependent inhibitor of CYP1A2: implications for in vitro prediction of drug interactions.

Drug metabolism and disposition: the biological fate of chemicals 20061201

cDNA cloning and characterization of feline CYP1A1 and CYP1A2.

Life sciences 20061125

Elucidation of the effects of the CYP1A2 deficiency polymorphism in the metabolism of 4-cyclohexyl-1-ethyl-7-methylpyrido[2,3-d]pyrimidine-2-(1h)-one (YM-64227), a phosphodiesterase type 4 inhibitor, and its metabolites in dogs.

Drug metabolism and disposition: the biological fate of chemicals 20061101

Obituary to analgesic nephropathy--an autopsy study.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20061101

Towards an understanding of the molecular mechanism of solvation of drug molecules: a thermodynamic approach by crystal lattice energy, sublimation, and solubility exemplified by paracetamol, acetanilide, and phenacetin.

Journal of pharmaceutical sciences 20061001

Characterization of CYP1A enzyme in Adélie penguin liver.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20061001

Kinetic study of paracetamol on prolidase activity in erythrocytes by capillary electrophoresis with Ru(bpy)(3) (2+) electrochemiluminescence detection.

Electrophoresis 20061001

An evaluation of para toluene-sulfonamide metabolism and effect with regard to CYP isoforms, P-glycoprotein, and drug interactions.

Die Pharmazie 20061001

Solubility parameter of drugs for predicting the solubility profile type within a wide polarity range in solvent mixtures.

International journal of pharmaceutics 20060914

Radial basis function neural networks in non-destructive determination of compound aspirin tablets on NIR spectroscopy.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20060901

Comparison of intrinsic clearance in liver microsomes and hepatocytes from rats and humans: evaluation of free fraction and uptake in hepatocytes.

Drug metabolism and disposition: the biological fate of chemicals 20060901

Use of analgesics and nonsteroidal anti-inflammatory drugs, genetic predisposition, and bladder cancer risk in Spain.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20060901

[Tissue-like cultures of rat hepatocytes in study of phase I and phase II drug metabolism].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20060901

Identification of phenacetin metabolites in human urine after administration of phenacetin-C2H3: measurement of futile metabolic deacetylation via HPLC/MS-SPE-NMR and HPLC-ToF MS.

Xenobiotica; the fate of foreign compounds in biological systems 20060701

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Non-contrast-enhanced computerized tomography and analgesic-related kidney disease: report of the national analgesic nephropathy study.

Journal of the American Society of Nephrology : JASN 20060501

Determination of compound aminopyrine phenacetin tablets by using artificial neural networks combined with principal components analysis.

Analytical biochemistry 20060415

Phenacetin acts as a weak genotoxic compound preferentially in the kidney of DNA repair deficient Xpa mice.

Mutation research 20060411

Determination of AKF-PD in whole blood of rat by HPLC-UV.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060403

Serum sickness-like reaction to Pamabrom.

Journal of drugs in dermatology : JDD 20060301

Thalidomide enantiomers: determination in biological samples by HPLC and vancomycin-CSP.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060202

Understanding drug disposition alterations induced by acute spinal cord injury: role of injury level and route of administration for agents submitted to extensive liver metabolism.

Journal of neurotrauma 20060101

[Effect of some non-steroidal antiinflammatory drugs and isomeric dihydroxy benzoic acids on the AAPH initiated degradation of crocin].

Acta pharmaceutica Hungarica 20060101

Interaction of thioamides, selenoamides, and amides with diiodine.

Bioinorganic chemistry and applications 20060101

Measurement of human cytochrome P4501A2 (CYP1A2) activity in vitro.

Current protocols in toxicology 20060101

Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: evidence for intron 1 retention.

The Journal of pharmacology and experimental therapeutics 20051201

Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of anticancer agents.

Bioorganic & medicinal chemistry letters 20051201

The history of barbiturates a century after their clinical introduction.

Neuropsychiatric disease and treatment 20051201

Automated assessment of time-dependent inhibition of human cytochrome P450 enzymes using liquid chromatography-tandem mass spectrometry analysis.

Drug metabolism and disposition: the biological fate of chemicals 20051101

Spectroscopic investigation of the novel charge-transfer complex [(phen)(TCNE)(12)] formed in the reaction of phenacetin with tetracyanoethylene.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051101

[The combined effect of isoniazid and rifampicin on the activities of CYP4501A2 and CYP4503A4 in primary hepatocytes from healthy human adults].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20051101

Biomarker measurements in a coastal fish-eating population environmentally exposed to organochlorines.

Environmental health perspectives 20051001

Characterization of microsomal cytochrome P450-dependent monooxygenases in the rat olfactory mucosa.

Drug metabolism and disposition: the biological fate of chemicals 20050801

Long-term erythropoietin therapy improves response in myelodysplastic syndrome.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20050801

Development of a novel cytochrome p450 bioaffinity detection system coupled online to gradient reversed-phase high-performance liquid chromatography.

Journal of biomolecular screening 20050801

The use of a substrate cassette strategy to improve the capacity and throughput of cytochrome P450 induction studies in human hepatocytes.

Drug metabolism and disposition: the biological fate of chemicals 20050701

Thermodynamic study of the transfer of acetanilide and phenacetin from water to different organic solvents.

Acta pharmaceutica (Zagreb, Croatia) 20050601

Controlled release of drug via methylcellulose-carboxyvinylpolymer interpolymer complex solid dispersion.

AAPS PharmSciTech 20050601

Selective inhibition of dog hepatic CYP2B11 and CYP3A12.

The Journal of pharmacology and experimental therapeutics 20050501

PCB exposure and in vivo CYP1A2 activity among Native Americans.

Environmental health perspectives 20050301

Molecular cloning and functional analysis of cytochrome P450 1A2 from Japanese monkey liver: comparison with marmoset cytochrome P450 1A2.

Chemico-biological interactions 20050227

Preparative synthesis of drug metabolites using human cytochrome P450s 3A4, 2C9 and 1A2 with NADPH-P450 reductase expressed in Escherichia coli.

Journal of industrial microbiology & biotechnology 20050201

War syndromes: the impact of culture on medically unexplained symptoms.

Medical history 20050101

Prevalence of von Hippel-Lindau gene mutations in sporadic renal cell carcinoma: results from The Netherlands cohort study.

BMC cancer 20050101

HPLC and TLC methodology for determination or purity evaluation of 4-methoxy-2-(3(4-phenyl-1-piperazinyl))propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine.

Acta poloniae pharmaceutica 20050101

Case-control study on analgesics and nephropathy (SAN): protocol.

BMC nephrology 20050101

High-throughput screening of inhibitory potential of nine cytochrome P450 enzymes in vitro using liquid chromatography/tandem mass spectrometry.

Rapid communications in mass spectrometry : RCM 20050101

Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841].

Malaria journal 20050101

[Effect of some nonsteroid antiinflammatory drugs on Fenton-reaction initiated degradation of 2-deoxy-D-ribose].

Acta pharmaceutica Hungarica 20050101

Generic three-column parallel LC-MS/MS system for high-throughput in vitro screens.

Journal of chromatography. A 20041126

Quinones as antimycobacterial agents.

Bioorganic & medicinal chemistry 20040915

[Examination of the stability of hydrogen peroxide solutions].

Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20040901

Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison.

Xenobiotica; the fate of foreign compounds in biological systems 20040901

[Determination of three components in compound acetylsalicylic acid tablet by dual-wavelength ratio spectrometry].

Guang pu xue yu guang pu fen xi = Guang pu 20040701

Validated assays for human cytochrome P450 activities.

Drug metabolism and disposition: the biological fate of chemicals 20040601

Phenacetin and chlorzoxazone biotransformation in aging male Fischer 344 rats.

The Journal of pharmacy and pharmacology 20040601

[Prevention of bladder cancer].

Der Urologe. Ausg. A 20040501

Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes.

Xenobiotica; the fate of foreign compounds in biological systems 20040501

Phenacetin and cocaine in a body packer.

Forensic science international 20040420

Inhibition of cytochrome P450 activities by oleanolic acid and ursolic acid in human liver microsomes.

Life sciences 20040416

Analgesic nephropathy in Hungary: the HANS study.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040401

Induction of diphenytriazol on cytochrome CYP1A.

Acta pharmacologica Sinica 20040401

In vitro metabolism and inductive or inhibitive effect of DL111 on rat cytochrome P4501A enzyme.

Chemico-biological interactions 20040315

Evaluation of the patient with hematuria.

The Medical clinics of North America 20040301

Phase I and II enzyme characterization of two sources of HepG2 cell lines.

Xenobiotica; the fate of foreign compounds in biological systems 20040301

Sex-dependent modulation of treatment response.

Dialogues in clinical neuroscience 20040301

Atomoxetine hydrochloride: clinical drug-drug interaction prediction and outcome.

The Journal of pharmacology and experimental therapeutics 20040201

Functional characterization of four allelic variants of human cytochrome P450 1A2.

Archives of biochemistry and biophysics 20040201

Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes.

The Journal of pharmacology and experimental therapeutics 20040101

Interaction of cyclooxygenase isoenzymes, nitric oxide, and afferent neurons in gastric mucosal defense in rats.

The Journal of pharmacology and experimental therapeutics 20040101

Antipyretic therapy.

Frontiers in bioscience : a journal and virtual library 20040101

Evaluation of the Xpa-deficient transgenic mouse model for short-term carcinogenicity testing: 9-month studies with haloperidol, reserpine, phenacetin, and D-mannitol.

Toxicologic pathology 20040101

13C-breath tests in the study of microsomal liver function.

European review for medical and pharmacological sciences 20040101

High-performance liquid chromatography/inductively coupled plasma mass spectrometry and tandem mass spectrometry for the detection of carbon-containing compounds.

Rapid communications in mass spectrometry : RCM 20040101

Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study.

Breast cancer research : BCR 20040101

Rapid determination of five probe drugs and their metabolites in human plasma and urine by liquid chromatography/tandem mass spectrometry: application to cytochrome P450 phenotyping studies.

Rapid communications in mass spectrometry : RCM 20040101

Use of a cocktail of probe substrates for drug-metabolizing enzymes for the assessment of the metabolic capacity of hepatocyte preparations.

Xenobiotica; the fate of foreign compounds in biological systems 20040101

Phenacetin and analgesic mixtures containing phenacetin.

Report on carcinogens : carcinogen profiles 20040101

Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain.

Biochemistry 20031209

'Open access' generic method for continuous determination of major human CYP450 probe substrates/metabolites and its application in drug metabolism studies.

Xenobiotica; the fate of foreign compounds in biological systems 20031201

Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor.

Drug metabolism and disposition: the biological fate of chemicals 20031101

Assessment of tableting properties using infinitesimal quantities of powdered medicine.

International journal of pharmaceutics 20030916

HPLC analyses and pharmacokinetic studies of baicalin and oxymatrine in rabbits.

Die Pharmazie 20030901

Analgesics and renal disease in the postphenacetin era.

American journal of kidney diseases : the official journal of the National Kidney Foundation 20030801

Identification of CYP1A2 as the main isoform for the phase I hydroxylated metabolism of genistein and a prodrug converting enzyme of methylated isoflavones.

Drug metabolism and disposition: the biological fate of chemicals 20030701

Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation.

Drug metabolism and disposition: the biological fate of chemicals 20030701

Effects of phenacetin and its metabolite p-phenetidine on COX-1 and COX-2 activities and expression in vitro.

Thrombosis research 20030615

[Novel potential uses of thalidomide in the management of pain? A review of the literature].

Schmerz (Berlin, Germany) 20030601

Caffeine as a promoter of analgesic-associated nephropathy--where is the evidence?

Fundamental & clinical pharmacology 20030601

Determination of matrine in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies.

Talanta 20030410

Identification of cytochrome P450 1A2 as enzyme involved in the microsomal metabolism of Huperzine A.

European journal of pharmacology 20030214

Simultaneous liquid chromatography-tandem mass spectrometric determination of albendazole sulfoxide and albendazole sulfone in plasma.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030105

High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry.

Journal of pharmaceutical and biomedical analysis 20030101

Epidemiology of non-steroidal anti-inflammatory drugs and cancer.

Progress in experimental tumor research 20030101

Effects of non-steroidal anti-inflammatory drugs on cancer sites other than the colon and rectum: a meta-analysis.

BMC cancer 20030101

In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations catalyzed by human cytochrome P450 enzymes: a comparison with SKF-525A and ketoconazole.

Drug metabolism and pharmacokinetics 20030101

Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions.

Drug metabolism and disposition: the biological fate of chemicals 20021201

Validated HPLC method for determination of chlorzoxazone in human serum and its application in a clinical pharmacokinetic study.

Die Pharmazie 20021201

Monolithic silica rod liquid chromatography with ultraviolet or fluorescence detection for metabolite analysis of cytochrome P450 marker reactions.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021125

Phenotype of CYP2C19 and CYP3A4 by determination of omeprazole and its two main metabolites in plasma using liquid chromatography with liquid-liquid extraction.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021125

Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs.

The Journal of pharmacology and experimental therapeutics 20021101

Hydrogen bonding with adsorbent during storage governs drug dissolution from solid-dispersion granules.

Pharmaceutical research 20021101

Polymer particle erosion controlling drug release. II. Swelling investigations to clarify the release mechanism.

International journal of pharmaceutics 20021024

COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression.

Proceedings of the National Academy of Sciences of the United States of America 20021015

Correlation between induction of DNA fragmentation in urinary bladder cells from rats and humans and tissue-specific carcinogenic activity.

Toxicology 20020930

Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method.

Drug metabolism and disposition: the biological fate of chemicals 20020801

Evaluation of the surfactant properties of ascorbyl palmitate sodium salt.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020701

Method development and validation of a high-performance liquid chromatographic method for tramadol in human plasma using liquid-liquid extraction.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020525

[A case of renal pelvic tumor due to phenacetin abuse].

Hinyokika kiyo. Acta urologica Japonica 20020501

Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat.

Biochemical pharmacology 20020301

[Simultaneous determination of four components in the compound child phenobarbital tablet using ultraviolet spectrophotometry].

Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 20020227

Cytochrome p450 assays.

Current protocols in pharmacology 20020201

A straightforward means of coupling preparative high-performance liquid chromatography and mass spectrometry.

Rapid communications in mass spectrometry : RCM 20020101

PISA. The effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute stroke: protocol for a phase II double-blind randomised placebo-controlled trial [ISRCTN98608690].

BMC cardiovascular disorders 20020101

The onset of action and the analgesic efficacy of Saridon (a propyphenazone/paracetamol/ caffeine combination) in comparison with paracetamol, ibuprofen, aspirin and placebo (pooled statistical analysis).

Current medical research and opinion 20020101

Comparison of vasoconstrictor responses to selected NSAIDs in rabbit renal and femoral arteries.

Bratislavske lekarske listy 20020101

Phenacetin O-deethylation in extrahepatic tissues of rats.

European journal of drug metabolism and pharmacokinetics 20020101

In vivo effect of diallyl sulfide and cimetidine on phenacetin metabolism and bioavailability in rat.

Acta biochimica Polonica 20020101

Use of analgesics in self-medication.

Therapie 20020101

Decreased hepatic drug metabolising enzyme activity in rats with nitrosamine-induced tumours.

Drug metabolism and drug interactions 20020101

Fondaparinux sodium is not metabolised in mammalian liver fractions and does not inhibit cytochrome P450-mediated metabolism of concomitant drugs.

Clinical pharmacokinetics 20020101

Alteration of phenacetin pharmacokinetics after experimental spinal cord injury.

Proceedings of the Western Pharmacology Society 20020101

Hospitalized poisonings after renal transplantation in the United States.

BMC nephrology 20020101

Renal papillary necrosis.

Toxicologic pathology 20020101

Drug-induced hepatitis with hepatic granuloma due to saridon.

Journal of gastroenterology 20020101

Renal PGE2 production in the human and rat following phenacetin, acetaminophen and p-aminophenol.

Research communications in molecular pathology and pharmacology 20020101

Phenacetin.

Report on carcinogens : carcinogen profiles 20020101

Analgesic mixtures containing phenacetin.

Report on carcinogens : carcinogen profiles 20020101

Identification of inhibitory component in cinnamon--O-methoxycinnamaldehyde inhibits CYP1A2 and CYP2E1-.

Drug metabolism and pharmacokinetics 20020101

Application of microtiter plate assay to evaluate inhibitory effects of various compounds on nine cytochrome P450 isoforms and to estimate their inhibition patterns.

Drug metabolism and pharmacokinetics 20020101

Kinetic impact of presystemic intestinal metabolism on drug absorption: experiment and data analysis for the prediction of in vivo absorption from in vitro data.

Drug metabolism and pharmacokinetics 20020101

Role of cytochrome P450 isoenzymes in metabolism of O(6)-benzylguanine: implications for dacarbazine activation.

Clinical cancer research : an official journal of the American Association for Cancer Research 20011201

Relationship between nonphenacetin combined analgesics and nephropathy.

Kidney international 20011101

[Etiopathology, risk factors, environmental influences and epidemiology of bladder cancer].

Der Urologe. Ausg. A 20011101

Differential inhibition of human CYP1A1 and CYP1A2 by quinidine and quinine.

Xenobiotica; the fate of foreign compounds in biological systems 20011101

Review of potential risk factors for kidney (renal cell) cancer.

Seminars in urologic oncology 20011101

Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients.

Immunopharmacology and immunotoxicology 20011101

In vitro metabolism of tegaserod in human liver and intestine: assessment of drug interactions.

Drug metabolism and disposition: the biological fate of chemicals 20011001

A case of phenacetin-induced skin cancer in Hong Kong.

Hong Kong medical journal = Xianggang yi xue za zhi 20010901

'No, Duke. No divorce'.

Medical economics 20010820

Detailed characterization of experimentally derived human hepatic CYP1A1 activity and expression using differential inhibition of ethoxyresorufin O-deethylation by fluvoxamine.

European journal of clinical pharmacology 20010801

[Simultaneous determination of aspirin, phenacetin and caffeine in compound APC by derivative ratio UV adsorption spectrum method].

Guang pu xue yu guang pu fen xi = Guang pu 20010801

A rapid reversed phase high performance liquid chromatographic method for determination of etoposide (VP-16) in human plasma.

Journal of pharmaceutical and biomedical analysis 20010601

Relationship between nonphenacetin-combined analgesics and nephropathy.

Kidney international 20010601

Relationship between nonphenacetin-combined analgesics and nephropathy.

Kidney international 20010601

Relationship between nonphenacetin-combined analgesics and nephropathy.

Kidney international 20010601

Relationship between nonphenacetin-combined analgesics and nephropathy.

Kidney international 20010601

[Analgesics-induced chronic renal failure in patients on dialysis therapy in Hungary].

Orvosi hetilap 20010513

Optimization of an exogenous metabolic activation system for FETAX. II. Preliminary evaluation.

Drug and chemical toxicology 20010501

Polymer particle erosion controlling drug release. I. Factors influencing drug release and characterization of the release mechanism.

International journal of pharmaceutics 20010417

Oxidations of p-alkoxyacylanilides catalyzed by human cytochrome P450 1A2: structure-activity relationships and simulation of rate constants of individual steps in catalysis.

Biochemistry 20010410

[Determination of three components in compound chlorophenamine tablet by iterative target transformation factor analysis].

Guang pu xue yu guang pu fen xi = Guang pu 20010401

Suppression of agglomeration in fluidized bed coating. IV. Effects of sodium citrate concentration on the suppression of particle agglomeration and the physical properties of HPMC film.

International journal of pharmaceutics 20010314

Trends of analgesic nephropathy in two high-endemic regions with different legislation.

Journal of the American Society of Nephrology : JASN 20010301

Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline.

Xenobiotica; the fate of foreign compounds in biological systems 20010301

Interindividual variations in levels and activities of cytochrome P-450 in liver microsomes of Chinese subjects.

Acta pharmacologica Sinica 20010301

Analysis of the phase solubility diagram of a phenacetin/competitor/beta-cyclodextrin ternary system, involving competitive inclusion complexation.

Chemical & pharmaceutical bulletin 20010101

Xpa and Xpa/p53+/- knockout mice: overview of available data.

Toxicologic pathology 20010101

Neonatal mouse model: review of methods and results.

Toxicologic pathology 20010101

The syrian hamster embryo (SHE) cell transformation assay: review of the methods and results.

Toxicologic pathology 20010101

Tg.AC genetically altered mouse: assay working group overview of available data.

Toxicologic pathology 20010101

[Optimal conditions for extraction of 'caffetin' and 'saridon' tablet components from aqueous solutions].

Sudebno-meditsinskaia ekspertiza 20010101

A population approach to enzyme characterization and identification: application to phenacetin O-deethylation.

Pharmaceutical research 20001201

Rate-determining steps in phenacetin oxidations by human cytochrome P450 1A2 and selected mutants.

Biochemistry 20000919

Expression and induction of CYP1A1/1A2, CYP2A6 and CYP3A4 in primary cultures of human hepatocytes: a 10-year follow-up.

Xenobiotica; the fate of foreign compounds in biological systems 20000601

Reduction of hydroxamic acids to the corresponding amides catalyzed by rabbit blood.

Xenobiotica; the fate of foreign compounds in biological systems 20000501

In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6.

British journal of clinical pharmacology 20000401

Epidemiology and etiology of premalignant and malignant urothelial changes.

Scandinavian journal of urology and nephrology. Supplementum 20000101

Regular use of analgesics is a risk factor for renal cell carcinoma.

British journal of cancer 19991001

Role of CYP1A2 in the toxicity of long-term phenacetin feeding in mice.

Toxicological sciences : an official journal of the Society of Toxicology 19990701

Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.

The Journal of pharmacology and experimental therapeutics 19980201

Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans.

Archives of toxicology 19970101

Intermolecular interactions of antimicrobial fluoroquinolones with purified rat liver CYP1A2 studied by proton nuclear magnetic resonance spectroscopy.

Xenobiotica; the fate of foreign compounds in biological systems 19961001

Habitual use of acetaminophen as a risk factor for chronic renal failure: a comparison with phenacetin.

American journal of kidney diseases : the official journal of the National Kidney Foundation 19960701

Metabolism of the food derived mutagen and carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) by human liver microsomes.

Carcinogenesis 19940601

[Paracetamol--kidney and urinary tract. A cause of analgetic nephropathy or cancer?].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 19940420

Different roles for phenacetin and paracetamol in cancer of the kidney and renal pelvis.

International journal of cancer 19930121

Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae.

Drug metabolism and disposition: the biological fate of chemicals 19930101

Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450IA2.

Archives of biochemistry and biophysics 19920501

The role of N-hydroxyphenetidine in phenacetin-induced hemolytic anemia.

Toxicology and applied pharmacology 19911001

An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987).

The New England journal of medicine 19910117

[A case of chronic renal failure caused by 20-year intake of pyrcophen].

Klinicheskaia meditsina 19900801

The Copenhagen case-control study of renal pelvis and ureter cancer: role of analgesics.

International journal of cancer 19891215

Analgesic use and chronic renal disease.

The New England journal of medicine 19890511

Progression of renal failure in analgesic-associated nephropathy.

Nephron 19890101

Metabolic oxidation of the carcinogens 4-aminobiphenyl and 4,4'-methylene-bis(2-chloroaniline) by human hepatic microsomes and by purified rat hepatic cytochrome P-450 monooxygenases.

Cancer research 19890101

Does paracetamol cause urothelial cancer or renal papillary necrosis?

Nephron 19880101

Polymorphism of human cytochrome P-450.

Xenobiotica; the fate of foreign compounds in biological systems 19870301

Age-related sensitivity of rats to induction of anaemia.

Folia haematologica (Leipzig, Germany : 1928) 19870101

Renal disease from habitual antipyretic analgesic consumption: an assessment of the epidemiologic evidence.

Medicine 19860901

N-hydroxy-2-acetylaminofluorene as effective inhibitor of aldehyde oxidase.

Biochemical and biophysical research communications 19860716

Analgesic and non-steroidal anti-inflammatory drug-associated acute renal failure: a prospective collaborative study.

Clinical nephrology 19860601

Drug- and chemical-induced methaemoglobinaemia. Clinical features and management.

Medical toxicology 19860101

Relation of analgesic use to renal cancer: population-based findings.

National Cancer Institute monograph 19851201

Heavy phenacetin use and bladder cancer in women aged 20 to 49 years.

The New England journal of medicine 19850801

Acute abstinence syndrome after epidural injection of butorphanol.

Anesthesia and analgesia 19850401

[Capillarosclerosis of the efferent urinary tract as an indication of analgesic abuse. Incidence in unselected autopsies in a large West German town].

Deutsche medizinische Wochenschrift (1946) 19850301

Drugs, food additives and natural products as promoters in rat urinary bladder carcinogenesis.

IARC scientific publications 19840101

The influence of phenacetin or mechanical perforation on the development of renal pelvic and urinary bladder tumors in FANFT-induced urinary tract carcinogenesis.

Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology 19830901

A new reproducible experimental model of analgesic nephropathy.

The Journal of pathology 19830101

Analgesics and cancer of the renal pelvis in New South Wales.

Cancer 19820615

Optic atrophy after propoxyphene overdose: report of a case.

Annals of ophthalmology 19820601

Nephropathy as a hazard of analgesic abuse.

American journal of hospital pharmacy 19811001

Hepatotoxicity of phenacetin and paracetamol in the Gunn rat.

Pathology 19811001

Cardiovascular lesions in Sprague-Dawley rats induced by long-term treatment with caffeine.

Acta pathologica et microbiologica Scandinavica. Section A, Pathology 19810501

Analgesic nephropathy induced by common proprietary mixtures.

The Medical journal of Australia 19800517

Nephrotoxicity of mild analgesics in the Gunn strain of rat.

British journal of clinical pharmacology 19800101

Eighteen month oral study of aspirin, phenacetin and caffeine, in C57Bl/6 mice.

Drug and chemical toxicology 19800101

[Methemoglobinemia by phenacetin abuse].

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 19790101

Experimental renal papillary necrosis.

Kidney international 19780101

Analgesic nephropathy in Canada: clinical syndrome, management, and outcome.

Kidney international 19780101

Aspirin, phenacetin, and the kidney: a rheumatism clinic study.

The Medical journal of Australia 19770625

Dyskinesia after discountinuation of compound analgesic containing oxycodone.

Lancet (London, England) 19770402

[Side effects of nalidixic acid in a patient with severe renal failure. Clinical study and proposal of a pharmacokinetic model].

Schweizerische medizinische Wochenschrift 19770305

Analgesic-induced renal papillary necrosis in the Gunn rat: the comparative nephrotoxicity of aspirin and phenacetin.

The Journal of pathology 19761101

Phenacetin-induced sulfhemoglobinemia: report of a case and review of the literature.

The Johns Hopkins medical journal 19761001

Constrictive pericarditis due to methysergide therapy.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 19760925

Studies on the modification of renal lesions due to aspirin and oxyphenbutazone in the rat and the effects on the kidney of 2:4 dinitrophenol.

Pathology 19760701

Pathology, aetiology and pathogenesis of analgesic nephropathy.

Australian and New Zealand journal of medicine 19760101

Letter: The clinical course of patients with analgesic nephropathy.

Canadian Medical Association journal 19750809

The radiological diagnosis of analgesic nephropathy.

Clinical radiology 19750701

Analgesic abuse, ureteric obstruction, and retroperitoneal fibrosis.

British medical journal 19750412

The induction of renal papillary necrosis in Gunn rats by analgesics and analgesic mixtures.

British journal of experimental pathology 19750201

Effect of 3-methylcholanthrene treatment on phenacetin O-dealkylation in several inbred mouse strains.

Drug metabolism and disposition: the biological fate of chemicals 19750101

The degradation of paracetamol (4-hydroxyacetanilide) and other substituted acetanilides by a Penicillium species.

Antonie van Leeuwenhoek 19750101

Phenacetin-induced methemoglobinemia and renal failure.

Anesthesiology 19740701

Aspirin and the kidney. New Zealand Rheumatism Association Study.

British medical journal 19740330

The origins of analgesic nephropathy.

The British journal of psychiatry : the journal of mental science 19730701

Ureteric stricture with analgesic nephropathy.

British medical journal 19730505

Renal pelvic tumour associated with analgesic abuse.

Canadian Medical Association journal 19721021

Papillary necrosis in the Gunn rat: rapid induction by analgesics.

Pathology 19720701

Comparative nephrotoxicity of aspirin and phenacetin derivatives.

British medical journal 19711127

Analgesic nephropathy: clinical syndrome and prognosis.

British medical journal 19710227

Clonixin: a clinical evaluation of a new oral analgesic.

The Journal of clinical pharmacology and new drugs 19710101

Phenacetin nephropathy, with particular reference to the effect of surgery.

British medical journal 19701017

Papillary necrosis in rats caused by aspirin and aspirin-containing mixtures.

British medical journal 19700905

Analgesic abuse in psychiatric patients.

Lancet (London, England) 19700620

[Kidney disorders caused by various drugs and metals, with special reference to epitetracycline and phenacetin].

Saishin igaku. Modern medicine 19680910

Syndrome associated with the abuse of analgesics.

Annals of internal medicine 19680401

Analgesic nephropathy.

Lancet (London, England) 19680323

Lesions in the vasa recta in experimental analgesic nephropathy.

Lancet (London, England) 19680106

Short-term study of the effect of phenacetin, phenazone and amidopyrine on the rat kidney.

British journal of pharmacology and chemotherapy 19680101

The toxicity of phenacetin at the range of the oral LD50(100 days) in albino rats.

Toxicology and applied pharmacology 19680101

Renal papillary necrosis following phenacetin excess.

Scottish medical journal 19670701

Paracetamol and the kidney.

British medical journal 19670603

IS PHENACETIN A NEPHROTOXIN?A REPORT ON TWENTY-THREE USERS OF THE DRUG.

California medicine 19640801