Home Other Building Blocks [1-(4-Amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan-2-yl]oxymethylphosphonic acid

[1-(4-Amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan-2-yl]oxymethylphosphonic acid

CAS No.:
113852-37-2
Catalog Number:
AG00393G
Molecular Formula:
C8H14N3O6P
Molecular Weight:
279.1870
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
25mg
98%(HPLC)
In Stock USA
United States
$60
- +
50mg
98%(HPLC)
In Stock USA
United States
$93
- +
100mg
98%(HPLC)
In Stock USA
United States
$114
- +
Product Description
Catalog Number:
AG00393G
Chemical Name:
[1-(4-Amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan-2-yl]oxymethylphosphonic acid
CAS Number:
113852-37-2
Molecular Formula:
C8H14N3O6P
Molecular Weight:
279.1870
MDL Number:
MFCD16556167
IUPAC Name:
[(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethylphosphonic acid
InChI:
InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1
InChI Key:
VWFCHDSQECPREK-LURJTMIESA-N
SMILES:
OC[C@H](Cn1ccc(nc1=O)N)OCP(=O)(O)O
UNII:
768M1V522C
NSC Number:
742135
Properties
Complexity:
417  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
279.062g/mol
Formal Charge:
0
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
279.189g/mol
Monoisotopic Mass:
279.062g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
146A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-3.6  
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Prevalence and clinical management of cytomegalovirus retinitis in AIDS patients in Shanghai, China. BMC infectious diseases 20110101
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Intraocular pressure changes: an important determinant of the biocompatibility of intravitreous implants. PloS one 20110101
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Progressive multifocal leucoencephalopathy after autologous bone marrow transplantation: a treatment option. BMJ case reports 20110101
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Determination of cidofovir in human plasma after low dose drug administration using high-performance liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis 20101201
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The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: synthesis, cytostatic and antiviral activity evaluations. European journal of medicinal chemistry 20080601
Penciclovir is a potent inhibitor of feline herpesvirus-1 with susceptibility determined at the level of virus-encoded thymidine kinase. Antiviral research 20080601
Aggressive recurrent respiratory papillomatosis in a neonate. International journal of pediatric otorhinolaryngology 20080601
Successful cidofovir treatment in an adult heart transplant recipient with severe adenovirus pneumonia. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20080601
Prevalence of human herpesvirus 6 antibodies and DNA in allogeneic stem cell transplant patients: two-year single centre experience. Archivum immunologiae et therapiae experimentalis 20080601
Early complications following haematopoietic SCT in children. Bone marrow transplantation 20080601
Severe eczema vaccinatum in a household contact of a smallpox vaccinee. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080515
Cidofovir diphosphate inhibits molluscum contagiosum virus DNA polymerase activity. The Journal of investigative dermatology 20080501
Pharmaceutical particle engineering via spray drying. Pharmaceutical research 20080501
Treatment of locally recurrent Epstein-Barr virus-associated nasopharyngeal carcinoma using the anti-viral agent cidofovir. Journal of medical virology 20080501
An adenovirus type F41 outbreak in a pediatric bone marrow transplant unit: analysis of clinical impact and preventive strategies. The Pediatric infectious disease journal 20080501
Adult intralesional cidofovir therapy for laryngeal papilloma: a 10-year perspective. Archives of otolaryngology--head & neck surgery 20080501
Progressive multifocal leukoencephalopathy. Current treatment options in neurology 20080501
Polyomavirus in renal transplantation: a hot problem. Transplantation 20080415
BK virus nephropathy in renal transplant patients in London. Transplantation 20080415
Use of high-dose ganciclovir for a resistant cytomegalovirus infection due to UL97 mutation. Transplant infectious disease : an official journal of the Transplantation Society 20080401
Cidofovir in combination with HAART and survival in AIDS-associated progressive multifocal leukoencephalopathy. Journal of neurology 20080401
Differential pathogenesis of cowpox virus intranasal infections in mice induced by low and high inoculum volumes and effects of cidofovir treatment. International journal of antimicrobial agents 20080401
Lung involvement in juvenile onset recurrent respiratory papillomatosis: a systematic review of the literature. International journal of pediatric otorhinolaryngology 20080401
Cowpox virus infection: an emerging health threat. Current opinion in infectious diseases 20080401
[Treatment of pediatric genital condyloma]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20080401
BK virus-associated nephropathy in a kidney transplant recipient successfully treated with cidofovir, the first case in Japan. International journal of urology : official journal of the Japanese Urological Association 20080401
A single-center experience with BK virus nephropathy. Clinical nephrology 20080401
[Extensive oral condylomas treated by in situ cidofovir injection in an HIV patient]. Annales de dermatologie et de venereologie 20080401
Management of cutaneous hemangiomas in pediatric patients. Cutis 20080401
Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination. The Journal of biological chemistry 20080328
Fatal adenovirus hepatitis during maintenance therapy for childhood acute lymphoblastic leukemia. Pediatric blood & cancer 20080301
Late onset of autoimmune hemolytic anemia and pure red cell aplasia after allogeneic hematopoietic stem cell transplantation using in vivo alemtuzumab. American journal of hematology 20080301
Cowpox infection transmitted from a domestic cat. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20080301
Monitoring of Epstein-Barr virus load after hematopoietic stem cell transplantation for early intervention in post-transplant lymphoproliferative disease. Journal of medical virology 20080301
Characterization of a cidofovir-resistant HHV-6 mutant obtained by in vitro selection. Antiviral research 20080301
Outcome of management strategies for BK virus replication in pediatric renal transplant recipients. Pediatric transplantation 20080301
High-risk adenovirus-infected pediatric allogeneic hematopoietic progenitor cell transplant recipients and preemptive cidofovir therapy. Pediatric transplantation 20080301
[Resolution of recalcitrant condyloma acuminata in a patient with human immunodeficiency virus treated with cidofovir]. Actas dermo-sifiliograficas 20080301
Cidofovir injection for recurrent laryngeal papillomatosis. Journal of the Chinese Medical Association : JCMA 20080301
Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents. European journal of medicinal chemistry 20080201
Progressive multifocal leukoencephalopathy as first manifestation of sarcoidosis. Clinical neurology and neurosurgery 20080201
Valproic acid interferes with antiviral treatment in human cytomegalovirus-infected endothelial cells. Cardiovascular research 20080201
Successful outcome of a disseminated adenovirus infection 6 years after allogeneic bone marrow transplantation. Bone marrow transplantation 20080201
Recurrent respiratory papillomatosis: an overview of current thinking and treatment. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20080201
Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131. Antimicrobial agents and chemotherapy 20080201
Cytomegalovirus-associated chorioretinitis after liver transplantation: case report and review of the literature. Transplant infectious disease : an official journal of the Transplantation Society 20080201
Time course of juvenile onset recurrent respiratory papillomatosis caused by human papillomavirus. The Pediatric infectious disease journal 20080201
Cidofovir: to use or not to use? Current opinion in otolaryngology & head and neck surgery 20080201
1% topical cidofovir used as last alternative to treat viral infections. Journal of the European Academy of Dermatology and Venereology : JEADV 20080201
Effect of topical ophthalmic application of cidofovir on experimentally induced primary ocular feline herpesvirus-1 infection in cats. American journal of veterinary research 20080201
Novel inhibitors of human CMV. Current opinion in investigational drugs (London, England : 2000) 20080201
Histologic review of cidofovir-treated recurrent respiratory papillomatosis. The Annals of otology, rhinology, and laryngology 20080201
Efficacy of therapeutic intervention with an oral ether-lipid analogue of cidofovir (CMX001) in a lethal mousepox model. Antiviral research 20080101
Hydroxyurea enhances the activity of acyclovir and cidofovir against herpes simplex virus type 1 resistant strains harboring mutations in the thymidine kinase and/or the DNA polymerase genes. Antiviral research 20080101
Polyomavirus BK infection in blood and marrow transplant recipients. Bone marrow transplantation 20080101
Human cytomegalovirus DNA replication: antiviral targets and drugs. Reviews in medical virology 20080101
Quantification of cidofovir in human serum by LC-MS/MS for children. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080101
A case report of adenovirus-related acute interstitial nephritis in a patient with AIDS. American journal of kidney diseases : the official journal of the National Kidney Foundation 20080101
Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine. Virology journal 20080101
Acute renal failure in an AIDS patient on tenofovir: a case report. Journal of medical case reports 20080101
Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues. Antiviral therapy 20080101
[Polyoma virus in transplant recipients]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20080101
New advances in anti-HSV chemotherapy. Current medicinal chemistry 20080101
Isolation and characterization of cidofovir resistant vaccinia viruses. Virology journal 20080101
Serine peptide phosphoester prodrugs of cyclic cidofovir: synthesis, transport, and antiviral activity. Molecular pharmaceutics 20080101
Cell-permeable artificial zinc-finger proteins as potent antiviral drugs for human papillomaviruses. Archives of virology 20080101
Successful treatment of florid cutaneous warts with intravenous cidofovir in an 11-year-old girl. Pediatric dermatology 20080101
Clinical features and treatment of adenovirus infections. Reviews in medical virology 20080101
Regulation of cancer progression by inhibition of angiogenesis and induction of apoptosis. Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie 20080101
Bench-to-bedside review: rare and common viral infections in the intensive care unit--linking pathophysiology to clinical presentation. Critical care (London, England) 20080101
BKV reactivation in renal transplant recipients: diagnostic and therapeutic strategy--case reports. Transplantation proceedings 20080101
Human immunodeficiency virus and the ophthalmologist. Indian journal of ophthalmology 20080101
Anterior segment manifestations of human immunodeficiency virus/acquired immune deficiency syndrome. Indian journal of ophthalmology 20080101
Posterior segment manifestations of human immunodeficiency virus/acquired immune deficiency syndrome. Indian journal of ophthalmology 20080101
Medical management of human immunodeficiency virus infection. Indian journal of ophthalmology 20080101
Follow-up of HPV DNA copy number in cidofovir therapy of recurrent respiratory papillomatosis. Anticancer research 20080101
Progressive hypertrophic genital herpes in an HIV-infected woman despite immune recovery on antiretroviral therapy. Infectious diseases in obstetrics and gynecology 20080101
Sustained impairment of human cytomegalovirus (HCMV)-specific CD4+ and CD8+ T cell response is responsible for recurrent episodes of disseminated HCMV infection in a D+R- hand transplant recipient. Cases journal 20080101
[In vitro acyclovir and cidofovir susceptibilities of human herpesvirus type 1 clinical isolates]. Medycyna doswiadczalna i mikrobiologia 20080101
Robust intrapulmonary CD8 T cell responses and protection with an attenuated N1L deleted vaccinia virus. PloS one 20080101
Progressive multifocal leukoencephalopathy in a patient with idiopathic CD4+ cells deficit. La Clinica terapeutica 20080101
Progress in the discovery of compounds inhibiting orthopoxviruses in animal models. Antiviral chemistry & chemotherapy 20080101
Using biomarkers to stage disease progression in a lethal mousepox model treated with CMX001. Antiviral therapy 20080101
Drug-resistant herpes simplex virus in HIV infected patients. Acta dermatovenerologica Croatica : ADC 20080101
Low-dose cidofovir for the treatment of polyomavirus-associated nephropathy: two case reports and review of the literature. Antiviral therapy 20080101
Recurrent Respiratory Papillomatosis (RRP)-Juvenile Onset. Clinical medicine. Oncology 20080101
Cytomegalovirus retinitis: the neglected disease of the AIDS pandemic. PLoS medicine 20071201
Review of tenofovir-emtricitabine. Therapeutics and clinical risk management 20071201
Ganciclovir ophthalmic gel, 0.15%: a valuable tool for treating ocular herpes. Clinical ophthalmology (Auckland, N.Z.) 20071201
Influence of 6 or 8-substitution on the antiviral activity of 3-phenethylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (HCMV) and varicella-zoster virus (VZV). Bioorganic & medicinal chemistry 20071115
Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity. Journal of medicinal chemistry 20071115
Efficacy of N-methanocarbathymidine in treating mice infected intranasally with the IHD and WR strains of vaccinia virus. Antiviral research 20071101
A model of human cytomegalovirus infection in severe combined immunodeficient mice. Antiviral research 20071101
Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses. Antimicrobial agents and chemotherapy 20071101
Intraocular properties of an alkoxyalkyl derivative of cyclic 9-(S)-(3-hydroxyl-2-phosphonomehoxypropyl) adenine, an intravitreally injectable anti-HCMV drug in rabbit and guinea pig. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20071001
Anti-adenoviral effect of anti-HIV agents in vitro in serotypes inducing keratoconjunctivitis. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20070901
BK virus infection, replication, and diseases in pediatric kidney transplantation. Pediatric nephrology (Berlin, Germany) 20070901
In vivo imaging of cidofovir treatment of cowpox virus infection. Virus research 20070901
Progressive multifocal leukoencephalopathy developing in advanced pulmonal sarcoidosis. Clinical neurology and neurosurgery 20070901
Oral topical cidofovir: novel route of drug delivery in a severely immunosuppressed patient with refractory multidrug-resistant herpes simplex virus infection. Transplant infectious disease : an official journal of the Transplantation Society 20070901
Viral-associated trichodysplasia in a patient with lymphoma: a case report and review. Journal of cutaneous pathology 20070901
BK virus nephropathy in pediatric renal transplant recipients: an analysis of the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS) registry. Clinical journal of the American Society of Nephrology : CJASN 20070901
Efficacy of topical immunoglobulins against experimental adenoviral ocular infection. Investigative ophthalmology & visual science 20070901
BK virus-associated hemorrhagic cystitis in pediatric cancer patients receiving high-dose cyclophosphamide. Journal of pediatric hematology/oncology 20070901
Treatment of adenovirus pneumonia with cidofovir in pediatric lung transplant recipients. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20070901
Case report: severe gastrointestinal inflammation and persistent HHV-6B infection in a paediatric cancer patient. Herpes : the journal of the IHMF 20070901
Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives. Journal of medicinal chemistry 20070823
Effects of cidofovir on a novel cell-based test system for recurrent respiratory papillomatosis. Head & neck 20070801
Multidrug resistance protein 1 (MRP1) in rabbit conjunctival epithelial cells: its effect on drug efflux and its regulation by adenoviral infection. Pharmaceutical research 20070801
Can zinc be an adjuvant therapy for juvenile onset recurrent respiratory papillomatosis? International journal of pediatric otorhinolaryngology 20070801
Treatment of lentigo maligna with topical 1% cidofovir. The British journal of dermatology 20070801
Adenovirus-associated hemorrhagic cystitis in a pediatric renal transplant recipient. Pediatric transplantation 20070801
BK virus-associated nephropathy in sirolimus-treated renal transplant patients: incidence, course, and clinical outcomes. Transplantation 20070715
The acyclic nucleoside phosphonates from inception to clinical use: historical perspective. Antiviral research 20070701
In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA. Antiviral research 20070701
Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir. Antiviral research 20070701
Real-time quantitative PCR for assessment of antiviral drug effects against Epstein-Barr virus replication and EBV late mRNA expression. Journal of virological methods 20070701
Lichen planus remission is associated with a decrease of human herpes virus type 7 protein expression in plasmacytoid dendritic cells. Archives of dermatological research 20070701
Simultaneous development of Fanconi syndrome and acute renal failure associated with cidofovir. The Journal of antimicrobial chemotherapy 20070701
Human herpesvirus 6-associated retrobulbar optic neuritis in an HIV-infected patient: response to anti-herpesvirus therapy and long-term outcome. Journal of medical virology 20070701
[Progressive multifocal leukoencephalopathy in a non-AIDS patient: high efficiency of combined cytarabine and cidofovir]. La Revue de medecine interne 20070701
Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives -- a screening based on affinity for the UMP-CMP binding site. The FEBS journal 20070701
BK virus nephropathy and kidney transplantation. Clinical journal of the American Society of Nephrology : CJASN 20070701
Viral lower urinary tract infections. Current urology reports 20070701
Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations. Journal of medicinal chemistry 20070628
Cidofovir and foscarnet for treatment of human herpesvirus 6 encephalitis in a neutropenic stem cell transplant recipient. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070615
5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells. Journal of medicinal chemistry 20070614
Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient mice. American journal of respiratory and critical care medicine 20070601
Tubular basement membrane immune deposits in association with BK polyomavirus nephropathy. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20070601
Low-dose cidofovir treatment of BK virus-associated hemorrhagic cystitis in recipients of hematopoietic stem cell transplant. Bone marrow transplantation 20070601
Oral valganciclovir as preemptive therapy for cytomegalovirus infection post allogeneic stem cell transplantation. Transplant infectious disease : an official journal of the Transplantation Society 20070601
Invasive adenoviral infections in T-cell-depleted allogeneic hematopoietic stem cell transplantation: high mortality in the era of cidofovir. Transplant infectious disease : an official journal of the Transplantation Society 20070601
Dual infection with polyomavirus BK and acyclovir-resistant herpes simplex virus successfully treated with cidofovir in a bone marrow transplant recipient. Transplant infectious disease : an official journal of the Transplantation Society 20070601
Progressive ORF virus infection in a patient with lymphoma: successful treatment using imiquimod. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070601
Thalidomide therapy for the treatment of hypertrophic herpes simplex virus-related genitalis in HIV-infected individuals. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070601
Ureteric and urethral stenosis: a complication of BK virus infection in a pediatric renal transplant patient. Pediatric transplantation 20070601
Treatment of congenital cytomegalovirus: where are we now? Expert review of anti-infective therapy 20070601
Antiviral agents for the treatment of recurrent respiratory papillomatosis: a systematic review of the English-language literature. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20070601
Synthesis of cidofovir and (S)-HPMPA ether lipid prodrugs. Current protocols in nucleic acid chemistry 20070601
In vitro susceptibility of six isolates of equine herpesvirus 1 to acyclovir, ganciclovir, cidofovir, adefovir, PMEDAP and foscarnet. Veterinary microbiology 20070516
Cidofovir is effective against caprine herpesvirus 1 infection in goats. Antiviral research 20070501
[Intravesical cidofovir--instillation therapy for polyomavirus-associated hemorrhagic cystitis after bone marrow transplantation]. Der Urologe. Ausg. A 20070501
Progressive multifocal leucoencephalopathy in a patient with sarcoidosis--successful treatment with cidofovir and mirtazapine. Rheumatology (Oxford, England) 20070501
[Disseminated molluscum contagiosum during topical treatment of atopic dermatitis with tacrolimus: efficacy of cidofovir]. Annales de dermatologie et de venereologie 20070501
Progressive multifocal leukoencephalopathy in a patient with common variable immunodeficiency and abnormal CD8+ T-cell subset distribution. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20070501
SAR studies on a novel series of human cytomegalovirus primase inhibitors. Bioorganic & medicinal chemistry letters 20070415
The Ugi reaction in the generation of new nucleosides as potential antiviral and antileishmanial agents. Bioorganic chemistry 20070401
Acyclic nucleoside phosphonates: past, present and future. Bridging chemistry to HIV, HBV, HCV, HPV, adeno-, herpes-, and poxvirus infections: the phosphonate bridge. Biochemical pharmacology 20070401
Assessment of disseminated adenovirus infections using quantitative plasma PCR in adult allogeneic stem cell transplant recipients receiving reduced intensity or myeloablative conditioning. European journal of haematology 20070401
Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2). Pharmaceutical research 20070401
Human immunodeficiency virus-associated progressive multifocal leucoencephalopathy: epidemiology and predictive factors for prolonged survival. European journal of neurology 20070401
Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds. Journal of medicinal chemistry 20070308
Antiviral activity of HPMPC (cidofovir) against orf virus infected lambs. Antiviral research 20070301
Progressive multifocal leukoencephalopathy mimicking cerebral vasculitis in systemic granulomatosis. The Journal of infection 20070301
Oral 1-O-octadecyl-2-O-benzyl-sn-glycero-3-cidofovir targets the lung and is effective against a lethal respiratory challenge with ectromelia virus in mice. Antiviral research 20070301
Encapsulation of mono- and oligo-nucleotides into aqueous-core nanocapsules in presence of various water-soluble polymers. International journal of pharmaceutics 20070301
The nucleotide analog cidofovir suppresses basic fibroblast growth factor (FGF2) expression and signaling and induces apoptosis in FGF2-overexpressing endothelial cells. Molecular pharmacology 20070301
Local administration of cidofovir for human papilloma virus associated skin lesions in transplant recipients. Transplant international : official journal of the European Society for Organ Transplantation 20070301
Leflunomide failure to control recurrent cytomegalovirus infection in the setting of renal failure after allogeneic stem cell transplantation. Transplant infectious disease : an official journal of the Transplantation Society 20070301
Management of recurrent oral herpes simplex infections. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20070301
[Mechanism of drug-resistance in human cytomegalovirus]. Nihon rinsho. Japanese journal of clinical medicine 20070227
Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir. Molecular pharmacology 20070201
Development of new cytomegalovirus UL97 and DNA polymerase mutations conferring drug resistance after valganciclovir therapy in allogeneic stem cell recipients. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20070201
Synthesis and biological activation of an ethylene glycol-linked amino acid conjugate of cyclic cidofovir. Bioorganic & medicinal chemistry letters 20070201
A case of 'red eye' post allogeneic stem cell transplantation. Bone marrow transplantation 20070201
Antivirals for the treatment of polyomavirus BK replication. Expert review of anti-infective therapy 20070201
Improved outcome from invasive adenovirus infection in pediatric patients after hemopoietic stem cell transplantation using intensive clinical surveillance and early intervention. Journal of pediatric hematology/oncology 20070201
Improvement of progressive multifocal leukoencephalopathy after cidofovir therapy in a patient with a destructive polyarthritis. Infection 20070201
[Neuropathology of progressive multifocal leukoencephalopathy]. No to shinkei = Brain and nerve 20070201
[Progressive multifocal leukoencephalopathy--epidemiology, clinical pictures, diagnosis and therapy]. No to shinkei = Brain and nerve 20070201
Adenovirus infection after allogeneic stem cell transplantation. Leukemia & lymphoma 20070201
Viral mRNA expression but not DNA replication is required for lipogenic effect of human adenovirus Ad-36 in preadipocytes. International journal of obesity (2005) 20070101
Cell line dependency for antiviral activity and in vivo efficacy of N-methanocarbathymidine against orthopoxvirus infections in mice. Antiviral research 20070101
Intralesional Cidofovir application in recurrent laryngeal papillomatosis. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20070101
Treatment of adenovirus disease in stem cell transplant recipients with cidofovir. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20070101
From actually toxic to highly specific--novel drugs against poxviruses. Virology journal 20070101
Inhibition of NF-kappaB activation in vivo impairs establishment of gammaherpesvirus latency. PLoS pathogens 20070101
Pathogeneses of respiratory infections with virulent and attenuated vaccinia viruses. Virology journal 20070101
Transplacental murine cytomegalovirus infection in the brain of SCID mice. Virology journal 20070101
Pharmacological treatments for basal cell carcinoma. Drugs 20070101
Immune reconstitution inflammatory syndrome (IRIS): review of common infectious manifestations and treatment options. AIDS research and therapy 20070101
Successful pregnancy in renal transplant recipient with previous known polyomavirus nephropathy. Clinical transplantation 20070101
DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions. Antiviral therapy 20070101
Potent inhibition of genital herpesvirus infection in goats by cidofovir. Antiviral therapy 20070101
N-1 regioselective Michael-type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate. Beilstein journal of organic chemistry 20070101
Looking for new pyrimidine acyclic nucleotide analogues designed for phosphorylation by human UMP-CMP kinase. Nucleosides, nucleotides & nucleic acids 20070101
Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCMV. Nucleosides, nucleotides & nucleic acids 20070101
Some novel aminopropyl nucleoside phosphonates. Nucleosides, nucleotides & nucleic acids 20070101
Chlorpromazine combined with cidofovir for treatment of a patient suffering from progressive multifocal leukoencephalopathy. Intervirology 20070101
Novel therapies for cytomegalovirus disease. Recent patents on anti-infective drug discovery 20070101
[Diagnosis of interstitial nephropathy caused by BK virus in renal transplantation. Therapeutic management with cidofovir plus probenecid]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20070101
A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport. The Journal of biological chemistry 20061208
A non-chemotherapy treatment of a primary effusion lymphoma: durable remission after intracavitary cidofovir in HIV negative PEL refractory to chemotherapy. Annals of oncology : official journal of the European Society for Medical Oncology 20061201
Polyomavirus (BK) in pediatric renal transplants: evaluation of viremic patients with and without BK associated nephritis. Pediatric transplantation 20061201
Utilization of vero cells for primary and chronic BK virus infection. Transplantation proceedings 20061201
Antiviral activity of diverse classes of broad-acting agents and natural compounds in HHV-6-infected lymphoblasts. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20061201
In search of effective anti-HHV-6 agents. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20061201
Qualitative assessment of risk for monkeypox associated with domestic trade in certain animal species, United States. Emerging infectious diseases 20061201
Effects of cidofovir treatment on cytokine induction in murine models of cowpox and vaccinia virus infection. Antiviral research 20061101
3.5-Year follow-up of intralesional cidofovir protocol for pediatric recurrent respiratory papillomatosis. International journal of pediatric otorhinolaryngology 20061101
Encapsulation of antiviral nucleotide analogues azidothymidine-triphosphate and cidofovir in poly(iso-butylcyanoacrylate) nanocapsules. International journal of pharmaceutics 20061031
Synthesis and antiviral evaluation of alkoxyalkyl esters of acyclic purine and pyrimidine nucleoside phosphonates against HIV-1 in vitro. Antiviral research 20061001
Antiviral properties of new arylsulfone derivatives with activity against human betaherpesviruses. Antiviral research 20061001
A rapid quantitative PCR-based assay for testing antiviral agents against human adenoviruses demonstrates type specific differences in ribavirin activity. Antiviral research 20061001
Maribavir sensitivity of cytomegalovirus isolates resistant to ganciclovir, cidofovir or foscarnet. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20061001
Cidofovir administered with radiation displays an antiangiogenic effect mediated by E6 inhibition and subsequent TP53-dependent VEGF repression in HPV18+ cell lines. Radiation research 20061001
Anterior uveitis associated with treatment with intravenous cidofovir in kidney transplant patients with BK virus nephropathy. Transplantation proceedings 20061001
Discovery of a novel series of inhibitors of human cytomegalovirus primase. Bioorganic & medicinal chemistry letters 20060915
Antiviral therapy for adenovirus infections. Antiviral research 20060901
Antiviral drugs for cytomegalovirus diseases. Antiviral research 20060901
Pivotal role of animal models in the development of new therapies for cytomegalovirus infections. Antiviral research 20060901
Papillomavirus and treatment. Antiviral research 20060901
Antiviral acyclic nucleoside phosphonates structure activity studies. Antiviral research 20060901
Intravenous cidofovir-induced resolution of disfiguring cutaneous human papillomavirus infection. Journal of the American Academy of Dermatology 20060901
Intermediate-term and long-term results after treatment by cidofovir and excision in juvenile laryngeal papillomatosis. The Annals of otology, rhinology, and laryngology 20060901
Membrane transporter proteins: a challenge for CNS drug development. Dialogues in clinical neuroscience 20060901
Three-dimensional modeling of cytomegalovirus DNA polymerase and preliminary analysis of drug resistance. Proteins 20060801
Adenovirus infections in transplant recipients. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060801
Progressive multifocal leukoencephalopathy: value of diffusion-weighted and contrast-enhanced magnetic resonance imaging for diagnosis and treatment control. European journal of neurology 20060801
Chronic hypertrophic acyclovir-resistant genital herpes treated with topical cidofovir and with topical foscarnet at recurrence in an HIV-positive man. Journal of the European Academy of Dermatology and Venereology : JEADV 20060801
Efficacy of antiviral compounds in human herpesvirus-6-infected glial cells. Journal of neurovirology 20060801
[Advances in the study of nucleoside antiviral drugs]. Yao xue xue bao = Acta pharmaceutica Sinica 20060801
Toward orthopoxvirus countermeasures: a novel heteromorphic nucleoside of unusual structure. Journal of medicinal chemistry 20060713
Remission of AIDS-associated progressive multifocal leukoencephalopathy with combined cidofovir and radiotherapy: a case report. AIDS (London, England) 20060713
British Association of Paediatric Otorhinolaryngology members experience with recurrent respiratory papillomatosis. International journal of pediatric otorhinolaryngology 20060701
Cidofovir bladder instillation for the treatment of BK hemorrhagic cystitis after allogeneic stem cell transplantation. American journal of hematology 20060701
Effect of local application of cidofovir on the control of recurrences in recurrent laryngeal papillomatosis. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20060701
Office-based intralesional cidofovir injections for nasal septal papilloma: a pilot study. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20060701
Is intralesional cidofovir worthwhile in juvenile recurrent respiratory papillomatosis? The Journal of laryngology and otology 20060701
A pyrimidine-pyrazolone nucleoside chimera with potent in vitro anti-orthopoxvirus activity. Bioorganic & medicinal chemistry letters 20060615
5-(Dimethoxymethyl)-2'-deoxyuridine: a novel gem diether nucleoside with anti-orthopoxvirus activity. Journal of medicinal chemistry 20060601
Polyomavirus-associated nephropathy: update of clinical management in kidney transplant patients. Transplant infectious disease : an official journal of the Transplantation Society 20060601
Polyomavirus-associated nephropathy: update on antiviral strategies. Transplant infectious disease : an official journal of the Transplantation Society 20060601
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Clinical applications of a novel sustained-release injectable drug delivery system: DepoFoam technology. Cancer journal (Sudbury, Mass.) 20010101
Cidofovir in the treatment of HPV-associated lesions. Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie 20010101
Treatment of lethal vaccinia virus respiratory infections in mice with cidofovir. Antiviral chemistry & chemotherapy 20010101
[Oncogenic human papillomaviruses in extra-genital Bowen disease revealed by in situ hybridization]. Annales de dermatologie et de venereologie 20010101
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Economic evaluation of systemic treatments for cytomegalovirus retinitis in patients with AIDS. PharmacoEconomics 20010101
Adenoviral infections and a prospective trial of cidofovir in pediatric hematopoietic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20010101
An efficient process for the synthesis of cyclic HPMPC. Nucleosides, nucleotides & nucleic acids 20010101
Pharmacokinetics of salicylate ester prodrugs of cyclic HPMPC in dogs. Nucleosides, nucleotides & nucleic acids 20010101
Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs. Nucleosides, nucleotides & nucleic acids 20010101
Predictive efficacy of SCID-hu mouse models for treatment of human cytomegalovirus infections. Antiviral chemistry & chemotherapy 20010101
Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8. Reviews in medical virology 20010101
Combined surgical-medical treatment of genital warts in HIV positive patients. Tumori 20010101
A clinical, molecular and cytogenetic study of 12 cases of human herpesvirus 8 associated primary effusion lymphoma in HIV-infected patients. The hematology journal : the official journal of the European Haematology Association 20010101
Cytomegalovirus drug resistance and clinical implications. Transplant infectious disease : an official journal of the Transplantation Society 20010101
In vivo anti-papillomavirus activity of nucleoside analogues including cidofovir on CRPV-induced rabbit papillomas. Antiviral research 20001101
Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes. The Biochemical journal 20001015
Nonnucleoside human cytomegalovirus inhibitors: synthesis and antiviral evaluation of (chlorophenylmethyl)benzothiadiazine dioxide derivatives. Journal of medicinal chemistry 20000824
Treatment of cowpox virus respiratory infections in mice with ribavirin as a single agent or followed sequentially by cidofovir. Antiviral chemistry & chemotherapy 20000701
Antiviral activity of ganciclovir elaidic acid ester against herpesviruses. Antiviral research 20000301
The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine. Journal of medicinal chemistry 20000224
A novel peptide aldehyde with activity against human cytomegalovirus in two different in vivo models. Antiviral chemistry & chemotherapy 20000101
Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncology research 20000101
Hydroxyurea potentiates the antiherpesvirus activities of purine and pyrimidine nucleoside and nucleoside phosphonate analogs. Antimicrobial agents and chemotherapy 19991201
Cidofovir-induced end-stage renal failure. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 19991001
Human cytomegalovirus: challenges, opportunities and new drug development. Antiviral chemistry & chemotherapy 19990901
Remission of AIDS-associated progressive multifocal leukoencephalopathy after cidofovir therapy. Journal of neurology 19990801
Comparative study of the anti-human cytomegalovirus activities and toxicities of a tetrahydrofuran phosphonate analogue of guanosine and cidofovir. Antimicrobial agents and chemotherapy 19990301
Design and SAR study of a novel class of nucleotide analogues as potent anti-HCMV agents. Nucleosides & nucleotides 19990101
Identification of novel nucleotide phosphonate analogs with potent anti-HCMV activity. Bioorganic & medicinal chemistry letters 19981215
Comparison of antiviral compounds against human herpesvirus 6 and 7. Antiviral research 19981201
Inhibitory effects of novel nucleoside and nucleotide analogues on Epstein-Barr virus replication. Antiviral chemistry & chemotherapy 19980501
Randomized, controlled study of the safety and efficacy of intravenous cidofovir for the treatment of relapsing cytomegalovirus retinitis in patients with AIDS. Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 19980401
Fomivirsen. BETA : bulletin of experimental treatments for AIDS : a publication of the San Francisco AIDS Foundation 19980401
Antiviral drug susceptibility of human herpesvirus 8. Antimicrobial agents and chemotherapy 19971201
(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) inhibits HIV-1 replication in epithelial cells, but not T-lymphocytes. Antiviral research 19970601
Carbocyclic oxetanocins lacking the C-3' methylene. Journal of medicinal chemistry 19970425
Effect of incorporation of cidofovir into DNA by human cytomegalovirus DNA polymerase on DNA elongation. Antimicrobial agents and chemotherapy 19970301
Susceptibility of human cytomegalovirus to two-drug combinations in vitro. Antiviral therapy 19961201
Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents. Journal of medicinal chemistry 19960705
Synthesis and antiviral activity of pyranosylphosphonic acid nucleotide analogues. Journal of medicinal chemistry 19960315
Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6. Antiviral research 19951201
Biochemical basis for increased susceptibility to Cidofovir of herpes simplex viruses with altered or deficient thymidine kinase activity. Antimicrobial agents and chemotherapy 19950901
Susceptibilities of several drug-resistant herpes simplex virus type 1 strains to alternative antiviral compounds. Antimicrobial agents and chemotherapy 19950701
Comparative activity of selected antiviral compounds against clinical isolates of varicella-zoster virus. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 19950401
Antiviral activities of nucleosides and nucleotides against wild-type and drug-resistant strains of murine cytomegalovirus. Antiviral research 19950101
1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo. Antimicrobial agents and chemotherapy 19941001
Evaluation of HPMPC therapy for primary and recurrent genital herpes in mice and guinea pigs. Antiviral research 19930501
Treatment of murine cytomegalovirus infections in severe combined immunodeficient mice with ganciclovir, (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine, interferon, and bropirimine. Antimicrobial agents and chemotherapy 19920901
Prolonged and potent therapeutic and prophylactic effects of (S)-1-[(3-hydroxy-2-phosphonylmethoxy)propyl]cytosine against herpes simplex virus type 2 infections in mice. Antimicrobial agents and chemotherapy 19910801
Antiviral activity of anti-cytomegalovirus agents (HPMPC, HPMPA) assessed by a flow cytometric method and DNA hybridization technique. Antiviral research 19910701
Particular characteristics of the anti-human cytomegalovirus activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) in vitro. Antiviral research 19910701
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine in various models of herpes simplex virus infection in mice. Antimicrobial agents and chemotherapy 19910401
Inhibitory effects of selected antiviral compounds on human hepatitis B virus DNA synthesis. Antimicrobial agents and chemotherapy 19910201
Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro. Antiviral research 19900601
Synthesis and antiviral activity of (S)-9-[4-hydroxy-3-(phosphonomethoxy)butyl]guanine. Journal of medicinal chemistry 19900601
Synthesis and antiviral activity of the nucleotide analogue (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine. Journal of medicinal chemistry 19890701
(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication. Antimicrobial agents and chemotherapy 19881201
Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents. Antimicrobial agents and chemotherapy 19880701
Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines. Antiviral research 19871201
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