Ginsenoside Rh2
| Title | Journal |
|---|---|
| Ginsenoside F1 suppresses astrocytic senescence-associated secretory phenotype. | Chemico-biological interactions 20180301 |
| Ginsenoside 20(s)-Rh2 as potent natural histone deacetylase inhibitors suppressing the growth of human leukemia cells. | Chemico-biological interactions 20151205 |
| Sulfated derivative of 20(S)-ginsenoside Rh2 inhibits inflammatory cytokines through MAPKs and NF-kappa B pathways in LPS-induced RAW264.7 macrophages. | Inflammation 20121001 |
| Key role of nuclear factor-κB in the cellular pharmacokinetics of adriamycin in MCF-7/Adr cells: the potential mechanism for synergy with 20(S)-ginsenoside Rh2. | Drug metabolism and disposition: the biological fate of chemicals 20121001 |
| In vitro studies on the oxidative metabolism of 20(s)-ginsenoside Rh2 in human, monkey, dog, rat, and mouse liver microsomes, and human liver s9. | Drug metabolism and disposition: the biological fate of chemicals 20121001 |
| Ginsenoside Rh2 inhibits osteoclastogenesis through down-regulation of NF-κB, NFATc1 and c-Fos. | Bone 20120601 |
| Microbial transformation of ginsenoside Rg3 to ginsenoside Rh2 by Esteya vermicola CNU 120806. | World journal of microbiology & biotechnology 20120401 |
| Structural modification of ginsenoside Rh(2) by fatty acid esterification and its detoxification property in antitumor. | Bioorganic & medicinal chemistry letters 20120115 |
| A dynamic study on reversal of multidrug resistance by ginsenoside Rh₂ in adriamycin-resistant human breast cancer MCF-7 cells. | Talanta 20120115 |
| Cellular pharmacokinetic mechanisms of adriamycin resistance and its modulation by 20(S)-ginsenoside Rh2 in MCF-7/Adr cells. | British journal of pharmacology 20120101 |
| Antihyperglycemic effect of ginsenoside Rh2 by inducing islet β-cell regeneration in mice. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20120101 |
| Stereoselective regulations of P-glycoprotein by ginsenoside Rh2 epimers and the potential mechanisms from the view of pharmacokinetics. | PloS one 20120101 |
| Ginsenoside Rh2(S) induces differentiation and mineralization of MC3T3-E1 cells through activation of the PKD/AMPK signaling pathways. | International journal of molecular medicine 20111101 |
| Co-treatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, bax translocation, and cytochrome c release. | Molecular carcinogenesis 20111001 |
| Enhancement of oral bioavailability of 20(S)-ginsenoside Rh2 through improved understanding of its absorption and efflux mechanisms. | Drug metabolism and disposition: the biological fate of chemicals 20111001 |
| [Effects of 20 (S) -ginsenoside Rh2 and 20 (R) -ginsenoside Rh2 on proliferation and apoptosis of human lung adenocarcinoma A549 cells]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110601 |
| Ginsenoside Rh2 inhibits glioma cell proliferation by targeting microRNA-128. | Acta pharmacologica Sinica 20110301 |
| Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53. | Cancer letters 20110227 |
| Ginsenoside Rh2 induces Bcl-2 family proteins-mediated apoptosis in vitro and in xenografts in vivo models. | Journal of cellular biochemistry 20110101 |
| 20(S)-ginsenoside Rh2 noncompetitively inhibits P-glycoprotein in vitro and in vivo: a case for herb-drug interactions. | Drug metabolism and disposition: the biological fate of chemicals 20101201 |
| Cholesterol-dependent induction of dendrite formation by ginsenoside Rh2 in cultured melanoma cells. | International journal of molecular medicine 20101201 |
| Stereospecificity of hydroxyl group at C-20 in antiproliferative action of ginsenoside Rh2 on prostate cancer cells. | Fitoterapia 20101001 |
| Rh2 or its aglycone aPPD in combination with docetaxel for treatment of prostate cancer. | The Prostate 20100915 |
| Intestinal absorption mechanisms of ginsenoside Rh2: stereoselectivity and involvement of ABC transporters. | Xenobiotica; the fate of foreign compounds in biological systems 20100901 |
| Induction of apoptosis by the ginsenoside Rh2 by internalization of lipid rafts and caveolae and inactivation of Akt. | British journal of pharmacology 20100701 |
| [Effect of ginsenoside Rh2 on the development of transferred tumors and chemotherapy efficiency]. | Eksperimental'naia i klinicheskaia farmakologiia 20100401 |
| Improving enzymatic production of ginsenoside Rh2 from Rg3 by using nonionic surfactant. | Applied biochemistry and biotechnology 20100201 |
| [Research on the mechanism of ginsenoside Rh2 reversing the resistance of lung adenocarcinoma cells to cisplatin]. | Zhonghua yi xue za zhi 20100126 |
| Pre-clinical evaluation of Rh2 in PC-3 human xenograft model for prostate cancer in vivo: formulation, pharmacokinetics, biodistribution and efficacy. | Cancer chemotherapy and pharmacology 20091101 |
| Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1-dependent inhibition of cyclin-dependent kinases. | Pharmaceutical research 20091001 |
| Ginsenoside Rh2 ameliorates scopolamine-induced learning deficit in mice. | Biological & pharmaceutical bulletin 20091001 |
| Pharmacokinetic characterization of ginsenoside Rh2, an anticancer nutrient from ginseng, in rats and dogs. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090901 |
| Ginsenoside Rh2 induces ligand-independent Fas activation via lipid raft disruption. | Biochemical and biophysical research communications 20090724 |
| 20(R)-ginsenoside Rh2, not 20(S), is a selective osteoclastgenesis inhibitor without any cytotoxicity. | Bioorganic & medicinal chemistry letters 20090615 |
| Anxiolytic-like effects of ginsenosides Rg3 and Rh2 from red ginseng in the elevated plus-maze model. | Planta medica 20090601 |
| Increase of adipogenesis by ginsenoside (Rh2) in 3T3-L1 cell via an activation of glucocorticoid receptor. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20090401 |
| [Effect of ginsenoside Rh2 on transplanted-tumor and expression of JAM in mice]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901 |
| 20(S)-protopanaxadiol and the ginsenoside Rh2 inhibit Na+ channel-activated depolarization and Na+ channel-dependent amino acid neurotransmitter release in synaptic fractions isolated from mammalian brain. | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20080401 |
| Role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the action of ginsenoside Rh2 against beta-amyloid-induced inhibition of rat brain astrocytes. | Neuroscience letters 20080321 |
| 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and in vivo and mechanisms of action. | British journal of cancer 20080226 |
| Anti-obesity effects of ginsenoside Rh2 are associated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte. | Biochemical and biophysical research communications 20071228 |
| Repression of matrix metalloproteinase gene expression by ginsenoside Rh2 in human astroglioma cells. | Biochemical pharmacology 20071203 |
| Characterizing the mechanism for ginsenoside-induced cytotoxicity in cultured leukemia (THP-1) cells. | Canadian journal of physiology and pharmacology 20071101 |
| Determination of 25-OH-PPD in rat plasma by high-performance liquid chromatography-mass spectrometry and its application in rat pharmacokinetic studies. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071015 |
| [Effect of ginsenoside Rh2 on immunocompetence of alveolar macrophages in patients with non-small cell lung cancer]. | Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20071001 |
| Bifidus fermentation increases hypolipidemic and hypoglycemic effects of red ginseng. | Journal of microbiology and biotechnology 20070701 |
| Ginsenosides compound K and Rh(2) inhibit tumor necrosis factor-alpha-induced activation of the NF-kappaB and JNK pathways in human astroglial cells. | Neuroscience letters 20070621 |
| Ginsenoside Rh2 is one of the active principles of Panax ginseng root to improve insulin sensitivity in fructose-rich chow-fed rats. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20070501 |
| Ginsenoside-Rh2-induced mitochondrial depolarization and apoptosis are associated with reactive oxygen species- and Ca2+-mediated c-Jun NH2-terminal kinase 1 activation in HeLa cells. | The Journal of pharmacology and experimental therapeutics 20061201 |
| Quantitative determination of ginsenoside Rh2 in rat biosamples by liquid chromatography electrospray ionization mass spectrometry. | Analytical and bioanalytical chemistry 20061201 |
| Inhibitory effects of Korean red ginseng and its genuine constituents ginsenosides Rg3, Rf, and Rh2 in mouse passive cutaneous anaphylaxis reaction and contact dermatitis models. | Biological & pharmaceutical bulletin 20060901 |
| [Determination of ginsenoside Rd and its metabolites in rat urine by LC-MS]. | Yao xue xue bao = Acta pharmaceutica Sinica 20060801 |
| Ginsenosides Rg3 and Rh2 inhibit the activation of AP-1 and protein kinase A pathway in lipopolysaccharide/interferon-gamma-stimulated BV-2 microglial cells. | Planta medica 20060601 |
| Rh2 synergistically enhances paclitaxel or mitoxantrone in prostate cancer models. | The Journal of urology 20060501 |
| In vitro assessment of plasma protein binding of 20(R)-ginsenoside Rh2 by equilibrium dialysis and LC-MS analysis: a case of species differences. | Biological & pharmaceutical bulletin 20060501 |
| 20(S)-ginsenoside Rh2, a newly identified active ingredient of ginseng, inhibits NMDA receptors in cultured rat hippocampal neurons. | European journal of pharmacology 20060424 |
| Ginsenoside Rh(2) enhances antitumour activity and decreases genotoxic effect of cyclophosphamide. | Basic & clinical pharmacology & toxicology 20060401 |
| [Determination of 20 (S)-ginsengnoside Rh2 in the alkali-hydrolysis product of saponins from leaves of Panax qinquefolium by RP-HPLC]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060301 |
| Natural products from ginseng inhibit [3H]batrachotoxinin A 20-alpha-benzoate binding to Na+ channels in mammalian brain. | European journal of pharmacology 20060113 |
| Increase of insulin secretion by ginsenoside Rh2 to lower plasma glucose in Wistar rats. | Clinical and experimental pharmacology & physiology 20060101 |
| Mediation of beta-endorphin by ginsenoside Rh2 to lower plasma glucose in streptozotocin-induced diabetic rats. | Planta medica 20060101 |
| Caspase-3-dependent protein kinase C delta activity is required for the progression of Ginsenoside-Rh2-induced apoptosis in SK-HEP-1 cells. | Cancer letters 20051218 |
| Hepatoprotective effect of 20(S)-ginsenosides Rg3 and its metabolite 20(S)-ginsenoside Rh2 on tert-butyl hydroperoxide-induced liver injury. | Biological & pharmaceutical bulletin 20051001 |
| [Effects of ginsenoside Rh2(GS-Rh2) on cell cycle of Eca-109 esophageal carcinoma cell line]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051001 |
| High performance liquid chromatographic-mass spectrometric determination of ginsenoside Rg3 and its metabolites in rat plasma using solid-phase extraction for pharmacokinetic studies. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050425 |
| Uptake and metabolism of ginsenoside Rh2 and its aglycon protopanaxadiol by Caco-2 cells. | Biological & pharmaceutical bulletin 20050201 |
| Liquid chromatography/tandem mass spectrometry for pharmacokinetic studies of 20(R)-ginsenoside Rg3 in dog. | Rapid communications in mass spectrometry : RCM 20050101 |
| Development of a HPLC-MS assay for ginsenoside Rh2, a new anti-tumor substance from natural product and its pharacokinetic study in dogs. | European journal of drug metabolism and pharmacokinetics 20050101 |
| Liquid chromatography/mass spectrometric analysis of rat samples for in vivo metabolism and pharmacokinetic studies of ginsenoside Rh2. | Rapid communications in mass spectrometry : RCM 20050101 |
| [Effect of telomerase on ginsenoside Rh2-induced differentiation of hepatocarcinoma cell line SMMC-7721]. | Ai zheng = Aizheng = Chinese journal of cancer 20041201 |
| [Effects of ginsenoside Rh2 on signal transduction in hepatocarcinoma SMMC-7721 cells]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20040901 |
| [Induction of differentiation by ginsenoside Rh2 in hepatocarcinoma cell SMMC-7721]. | Ai zheng = Aizheng = Chinese journal of cancer 20040801 |
| Ginsenoside Rh2 induces apoptosis via activation of caspase-1 and -3 and up-regulation of Bax in human neuroblastoma. | Archives of pharmacal research 20040801 |
| Rh2, a compound extracted from ginseng, hypersensitizes multidrug-resistant tumor cells to chemotherapy. | Canadian journal of physiology and pharmacology 20040701 |
| Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells. | Archives of pharmacal research 20040401 |
| Ginsenoside Rh2 reduces ischemic brain injury in rats. | Biological & pharmaceutical bulletin 20040301 |
| Ginsenosides 20(S)-protopanaxadiol and Rh2 reduce cell proliferation and increase sub-G1 cells in two cultured intestinal cell lines, Int-407 and Caco-2. | Canadian journal of physiology and pharmacology 20040301 |
| Transformation of ginseng saponins to ginsenoside Rh2 by acids and human intestinal bacteria and biological activities of their transformants. | Archives of pharmacal research 20040101 |
| Mechanistic studies on protopanaxadiol, Rh2, and ginseng (Panax quinquefolius) extract induced cytotoxicity in intestinal Caco-2 cells. | Journal of biochemical and molecular toxicology 20040101 |
| The c-Jun N-terminal kinase 1 activity is differentially regulated by specific mechanisms during apoptosis. | The Journal of biological chemistry 20031212 |
| In vitro induction of differentiation by ginsenoside Rh2 in SMMC-7721 hepatocarcinoma cell line. | Pharmacology & toxicology 20031201 |
| Antiallergic activity of ginsenoside Rh2. | Biological & pharmaceutical bulletin 20031101 |
| SEK1-dependent JNK1 activation prolongs cell survival during G-Rh2-induced apoptosis. | Biochemical and biophysical research communications 20030502 |
| Apoptotic effects of ginsenoside Rh2 on human malignant melanoma A375-S2 cells. | Acta pharmacologica Sinica 20020401 |
| [Saponins with low sugar chain from the leaves of Panax notoginseng (Burk) F. H. Chen]. | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020301 |
| Anticarcinogenic effect and enhancement of metastatic potential of BALB/c 3T3 cells by ginsenoside Rh(2). | Japanese journal of cancer research : Gann 20011101 |
| The antimetastatic and immunomodulating activities of ginseng minor glycosides. | Doklady. Biochemistry and biophysics 20010101 |
| Ginsenoside RH-2 induces apoptotic cell death in rat C6 glioma via a reactive oxygen- and caspase-dependent but Bcl-X(L)-independent pathway. | Life sciences 19990101 |