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Isofraxidin

CAS No.:
486-21-5
Catalog Number:
AG003927
Molecular Formula:
C11H10O5
Molecular Weight:
222.1941
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
95%
In Stock USA
United States
$87
- +
25mg
95%
In Stock USA
United States
$180
- +
100mg
95%
In Stock USA
United States
$501
- +
Product Description
Catalog Number:
AG003927
Chemical Name:
Isofraxidin
CAS Number:
486-21-5
Molecular Formula:
C11H10O5
Molecular Weight:
222.1941
MDL Number:
MFCD00221757
IUPAC Name:
7-hydroxy-6,8-dimethoxychromen-2-one
InChI:
InChI=1S/C11H10O5/c1-14-7-5-6-3-4-8(12)16-10(6)11(15-2)9(7)13/h3-5,13H,1-2H3
InChI Key:
HOEVRHHMDJKUMZ-UHFFFAOYSA-N
SMILES:
COc1c(O)c(OC)cc2c1oc(=O)cc2
UNII:
304915F056
NSC Number:
324637
Properties
Complexity:
301  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
222.053g/mol
Formal Charge:
0
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
222.196g/mol
Monoisotopic Mass:
222.053g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
65A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.5  
Literature
Title Journal
Isofraxidin exhibited anti-inflammatory effects in vivo and inhibited TNF-α production in LPS-induced mouse peritoneal macrophages in vitro via the MAPK pathway. International immunopharmacology 20121001
Simultaneous quantification of five bioactive components of Acanthopanax senticosus and its extract by ultra performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry. Molecules (Basel, Switzerland) 20120629
Enrichment and purification of syringin, eleutheroside E and isofraxidin from Acanthopanax senticosus by macroporous resin. International journal of molecular sciences 20120101
Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons. Journal of natural medicines 20110701
Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits matrix metalloproteinase-7 expression and cell invasion of human hepatoma cells. Biological & pharmaceutical bulletin 20100101
[Studies on flavonoid glycosides of Sarcandra glabra]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080701
Authentication of the traditional medicinal plant Eleutherococcus senticosus by DNA and chemical analyses. Planta medica 20080601
(+)-Syringaresinol-di-O-beta-D-glucoside, a phenolic compound from Acanthopanax senticosus Harms, suppresses proinflammatory mediators in SW982 human synovial sarcoma cells by inhibiting activating protein-1 and/or nuclear factor-kappaB activities. Toxicology in vitro : an international journal published in association with BIBRA 20071201
A rapid and sensitive UPLC-ESI MS method for analysis of isofraxidin, a natural antistress compound, and its metabolites in rat plasma. Journal of separation science 20071201
HPLC method for preliminary analysis of constituents in rat blood after oral administration of the extract of Acanthopanax senticosus. Journal of separation science 20071201
Pharmacokinetics of isofraxidin in rat plasma after oral administration of the extract of Acanthopanax senticosus using HPLC with solid phase extraction method. Chemical & pharmaceutical bulletin 20070901
Identification of herb Acanthopanax senticosus (Rupr. Et Maxim.) harms by capillary electrophoresis with electrochemical detection. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20070601
Method development for the determination of coumarin compounds by capillary electrophoresis with indirect laser-induced fluorescence detection. Journal of chromatography. A 20070427
[High-performance liquid chromatography-electrospray ionization/tandem mass spectrometry of isofraxidin in Sarcandra glabra]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20061201
Simultaneous determination of protocatechuic acid, syringin, chlorogenic acid, caffeic acid, liriodendrin and isofraxidin in Acanthopanax senticosus Harms by HPLC-DAD. Biological & pharmaceutical bulletin 20060301
[Study on the extraction process for free isofraxidin and hydrolytic condition of combined isofraxidin in Ciwujia with orthogonal design]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20040301
Constituents and pharmacological effects of Eucommia and Siberian ginseng. Acta pharmacologica Sinica 20011201
Four new coumarin derivatives from Artemisia keiskeana. Journal of natural products 20010801
Properties