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Home Other Building Blocks 2-cyclopropyl-5-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one

2-cyclopropyl-5-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one

CAS No.:
864864-17-5
Catalog Number:
AG003923
Molecular Formula:
C19H16FN5O
Molecular Weight:
349.3616
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
1 week
United States
$341
- +
10mg
98%
1 week
United States
$460
- +
25mg
98%
1 week
United States
$848
- +
50mg
98%
1 week
United States
$1515
- +
100mg
98%
1 week
United States
$2835
- +
Product Description
Catalog Number:
AG003923
Chemical Name:
2-cyclopropyl-5-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one
CAS Number:
864864-17-5
Molecular Formula:
C19H16FN5O
Molecular Weight:
349.3616
MDL Number:
MFCD17167018
IUPAC Name:
2-cyclopropyl-5-[1-(2-fluoropyridin-3-yl)-5-methyltriazol-4-yl]-3H-isoindol-1-one
InChI:
InChI=1S/C19H16FN5O/c1-11-17(22-23-25(11)16-3-2-8-21-18(16)20)12-4-7-15-13(9-12)10-24(19(15)26)14-5-6-14/h2-4,7-9,14H,5-6,10H2,1H3
InChI Key:
XZBFQWRAIYRPPZ-UHFFFAOYSA-N
SMILES:
O=C1N(Cc2c1ccc(c2)c1nnn(c1C)c1cccnc1F)C1CC1
Properties
Complexity:
558  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
349.134g/mol
Formal Charge:
0
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
349.369g/mol
Monoisotopic Mass:
349.134g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
63.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.4  
Literature
Title Journal
Pharmacological effects of metabotropic glutamate receptor ligands on prepulse inhibition in DBA/2J mice. European journal of pharmacology 20100810
Effect of CFMTI, an allosteric metabotropic glutamate receptor 1 antagonist with antipsychotic activity, on Fos expression in regions of the brain related to schizophrenia. Neuroscience 20100714
Discovery and biological profile of isoindolinone derivatives as novel metabotropic glutamate receptor 1 antagonists: a potential treatment for psychotic disorders. Bioorganic & medicinal chemistry letters 20090915
Unique antipsychotic activities of the selective metabotropic glutamate receptor 1 allosteric antagonist 2-cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one. The Journal of pharmacology and experimental therapeutics 20090701
Properties